LOCUS       NM_013155               3417 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus very low density lipoprotein receptor (Vldlr),
            mRNA.
ACCESSION   NM_013155
VERSION     NM_013155.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3417)
  AUTHORS   Kysenius,K. and Huttunen,H.J.
  TITLE     Stress-induced upregulation of VLDL receptor alters Wnt-signaling
            in neurons
  JOURNAL   Exp Cell Res 340 (2), 238-247 (2016)
   PUBMED   26751967
  REMARK    GeneRIF: neuronal stress differentially regulates lipoprotein
            receptor expression in neurons, with VLDLR upregulation as a common
            element as a modulator of neuronal Wnt signaling
REFERENCE   2  (bases 1 to 3417)
  AUTHORS   DiBattista,A.M., Dumanis,S.B., Song,J.M., Bu,G., Weeber,E.,
            Rebeck,G.W. and Hoe,H.S.
  TITLE     Very low density lipoprotein receptor regulates dendritic spine
            formation in a RasGRF1/CaMKII dependent manner
  JOURNAL   Biochim Biophys Acta 1853 (5), 904-917 (2015)
   PUBMED   25644714
  REMARK    GeneRIF: VLDLR requires RasGRF1/CaMKII to alter dendritic spine
            formation.
REFERENCE   3  (bases 1 to 3417)
  AUTHORS   Do,H.T., Bruelle,C., Tselykh,T., Jalonen,P., Korhonen,L. and
            Lindholm,D.
  TITLE     Reciprocal regulation of very low density lipoprotein receptors
            (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and
            Reelin: involvement of the E3 ligase Mylip/Idol
  JOURNAL   J Biol Chem 288 (41), 29613-29620 (2013)
   PUBMED   23990472
  REMARK    GeneRIF: Data indicate that down-regulation of Mylip/Idol using
            shRNAs abrogated the decrease in VLDLRs induced by Reelin.
REFERENCE   4  (bases 1 to 3417)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 3417)
  AUTHORS   Dumanis,S.B., Chamberlain,K.A., Jin Sohn,Y., Jin Lee,Y.,
            Guenette,S.Y., Suzuki,T., Mathews,P.M., Pak,D.Ts., Rebeck,G.W.,
            Suh,Y.H., Park,H.S. and Hoe,H.S.
  TITLE     FE65 as a link between VLDLR and APP to regulate their trafficking
            and processing
  JOURNAL   Mol Neurodegener 7, 9 (2012)
   PUBMED   22429478
  REMARK    GeneRIF: our data suggest that FE65 serves as a link between VLDLR
            and APP
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3417)
  AUTHORS   Kobayashi,K., Oka,K., Forte,T., Ishida,B., Teng,B.,
            Ishimura-Oka,K., Nakamuta,M. and Chan,L.
  TITLE     Reversal of hypercholesterolemia in low density lipoprotein
            receptor knockout mice by adenovirus-mediated gene transfer of the
            very low density lipoprotein receptor
  JOURNAL   J Biol Chem 271 (12), 6852-6860 (1996)
   PUBMED   8636110
REFERENCE   7  (bases 1 to 3417)
  AUTHORS   Masuzaki,H., Jingami,H., Matsuoka,N., Nakagawa,O., Ogawa,Y.,
            Mizuno,M., Yoshimasa,Y., Yamamoto,T. and Nakao,K.
  TITLE     Regulation of very-low-density lipoprotein receptor in hypertrophic
            rat heart
  JOURNAL   Circ Res 78 (1), 8-14 (1996)
   PUBMED   8603509
REFERENCE   8  (bases 1 to 3417)
  AUTHORS   Okuizumi,K., Onodera,O., Namba,Y., Ikeda,K., Yamamoto,T., Seki,K.,
            Ueki,A., Nanko,S., Tanaka,H., Takahashi,H., Oyanagi,K.,
            Mizusawa,H., Kanazawa,I. and Tsuji,S.
  TITLE     Genetic association of the very low density lipoprotein (VLDL)
            receptor gene with sporadic Alzheimer's disease
  JOURNAL   Nat Genet 11 (2), 207-209 (1995)
   PUBMED   7550352
REFERENCE   9  (bases 1 to 3417)
  AUTHORS   Jokinen,E.V., Landschulz,K.T., Wyne,K.L., Ho,Y.K., Frykman,P.K. and
            Hobbs,H.H.
  TITLE     Regulation of the very low density lipoprotein receptor by thyroid
            hormone in rat skeletal muscle
  JOURNAL   J Biol Chem 269 (42), 26411-26418 (1994)
   PUBMED   7929362
REFERENCE   10 (bases 1 to 3417)
  AUTHORS   Battey,F.D., Gafvels,M.E., FitzGerald,D.J., Argraves,W.S.,
            Chappell,D.A., Strauss,J.F. 3rd and Strickland,D.K.
  TITLE     The 39-kDa receptor-associated protein regulates ligand binding by
            the very low density lipoprotein receptor
  JOURNAL   J Biol Chem 269 (37), 23268-23273 (1994)
   PUBMED   8083232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2010 this sequence version replaced NM_013155.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L35767.1, SRR26360186.1143671.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000001.1  234240686-234240950
            266-385             JAXUCZ010000001.1  234253383-234253502
            386-508             JAXUCZ010000001.1  234257680-234257802
            509-631             JAXUCZ010000001.1  234259122-234259244
            632-1003            JAXUCZ010000001.1  234260856-234261227
            1004-1126           JAXUCZ010000001.1  234261313-234261435
            1127-1249           JAXUCZ010000001.1  234261529-234261651
            1250-1369           JAXUCZ010000001.1  234262228-234262347
            1370-1495           JAXUCZ010000001.1  234262451-234262576
            1496-1667           JAXUCZ010000001.1  234263061-234263232
            1668-1886           JAXUCZ010000001.1  234263806-234264024
            1887-2005           JAXUCZ010000001.1  234265472-234265590
            2006-2145           JAXUCZ010000001.1  234266149-234266288
            2146-2287           JAXUCZ010000001.1  234266593-234266734
            2288-2434           JAXUCZ010000001.1  234267940-234268086
            2435-2518           JAXUCZ010000001.1  234268973-234269056
            2519-2599           JAXUCZ010000001.1  234269389-234269469
            2600-2769           JAXUCZ010000001.1  234270238-234270407
            2770-3417           JAXUCZ010000001.1  234271503-234272150
FEATURES             Location/Qualifiers
     source          1..3417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3417
                     /gene="Vldlr"
                     /note="very low density lipoprotein receptor"
                     /db_xref="GeneID:25696"
                     /db_xref="RGD:3963"
     exon            1..265
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2805
                     /gene="Vldlr"
                     /note="VLDL-R; VLDL receptor"
                     /codon_start=1
                     /product="very low-density lipoprotein receptor precursor"
                     /protein_id="NP_037287.2"
                     /db_xref="GeneID:25696"
                     /db_xref="RGD:3963"
                     /translation="MGTSARWALWLLLALCWAPRDSGATASGKKAKCDSSQFQCTNGR
                     CITLLWKCDGDEDCTDGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSD
                     ESPEQCHMRTCRINEISCGARSTQCIPESWRCDGENDCDNGEDEENCGNITCSADEFT
                     CSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCSTSSCIPLSWVCDDDADC
                     SDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR
                     TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
                     TKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK
                     TCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD
                     IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKM
                     IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL
                     SGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHML
                     SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLV
                     NNLNDAQDIIIYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPNGY
                     NLEENGRECQSTSTPVTYSETKDVNTTDILRTSGLVPGGINVTTAVSEVSVPPKGTSA
                     AWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASV
                     GHTYPAISVVSTDDDLA"
     exon            266..385
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            386..508
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            509..631
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            632..1003
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1126
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1249
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1369
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1495
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1667
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1886
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2005
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2145
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2287
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2434
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2518
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2599
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2769
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..3417
                     /gene="Vldlr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaggggt gcccgctcct tgcgtgctct ccgtgctccc ggctcctcac tccttccccc
       61 tcctcctcgc ctcctccctc cccgccccca cctccttcct cctctccgaa gggctggtaa
      121 cttgttgtgc ggagcgaacg gcgacaacga cggcgcgacg gaggcaccat ccgggcgggc
      181 agcatgggca cgtccgcgcg ttgggcgctg tggctgctgc tcgcgctgtg ctgggcgccc
      241 cgggacagcg gcgccactgc aagcgggaag aaagccaaat gtgacagctc ccaattccag
      301 tgcacaaatg gtcgctgcat tactctgctg tggaaatgtg atggagacga agactgtact
      361 gatggcagtg acgagaagaa ctgtgtgaag aagacatgtg ctgagtcaga cttcgtgtgc
      421 aaaaacggcc agtgtgttcc caacagatgg cagtgtgatg gggaccctga ttgtgaagat
      481 ggttctgatg aaagcccaga acagtgccat atgagaacat gccgcataaa tgaaatcagc
      541 tgtggcgccc gttctactca gtgtatccca gagtcctgga gatgcgatgg tgaaaatgat
      601 tgtgacaatg gagaagatga agaaaactgt ggcaacatta catgtagcgc ggatgagttc
      661 acttgctcca gtggccgctg tgtctccagg aactttgtgt gcaatggaca ggatgactgt
      721 gacgatggca gtgatgagct ggactgtgct ccaccgacct gcggtgccca cgagttccag
      781 tgcagcacct cctcctgcat cccgctcagc tgggtgtgtg acgatgacgc agactgttcc
      841 gaccaatcag acgagtctct tgagcagtgt ggccgtcagc ctgtgataca caccaaatgt
      901 cccaccagtg agatccagtg tggctctggc gagtgcattc acaaaaaatg gcggtgtgac
      961 ggagacccgg actgcaagga cggcagcgac gaggtcaact gtccttctcg aacctgcaga
     1021 cctgaccagt ttgaatgtga ggacggtagc tgtatccatg gcagcagaca atgcaacggc
     1081 atccgagact gtgttgacgg ctctgatgaa gtcaactgca aaaacgtcaa tcagtgcctg
     1141 ggccctggaa agtttaagtg cagaagtggg gaatgcatag acatcaccaa agtatgtgac
     1201 caggaacagg actgcagaga ctggagcgac gagcccctga aggagtgcca tatcaacgaa
     1261 tgcttggtca ataacggtgg ctgttcccat atctgcaaag acctagttat aggttatgaa
     1321 tgtgactgtg cagctgggtt tgaactgata gacaggaaaa cctgtggaga tattgatgaa
     1381 tgccaaaatc cggggatctg cagtcaaatt tgtatcaact taaaaggcgg ttacaaatgt
     1441 gaatgtagtc gtggctatca aatggatctt gccactggcg tgtgcaaggc agtaggcaaa
     1501 gagccaagtc tgatcttcac taatcggaga gacatcagga agattggact agagaggaag
     1561 gaatacatcc aacttgtaga acaactaaga aacacggtgg ctctcgatgc tgacattgca
     1621 gctcagaagc tattttgggc tgatctaagc caaaaggcca tcttcagtgc ctcaattgat
     1681 gacaaggttg gtagacattt taaaatgatc gacaatgtct ataatcctgc agccattgct
     1741 gttgattggg tgtacaagac catctactgg actgatgcgg cttctaagac tatttcagta
     1801 gctactctag acggaaccaa gaggaagttc ctgtttaact ctgatttgcg agagcctgcc
     1861 tccatagctg tggatccgtt gtctggcttt gtttactggt cagactgggg tgagccagct
     1921 aaaatagaaa aagcaggaat gaatggattt gatagacgtc cactggtgac agaggacatc
     1981 caatggccta atggaattac cctcgacctt gtcaaaagcc gcctctactg gctggattcc
     2041 aagttgcaca tgctctctag tgtggacctg aatggtcaag atcgtaggat agtgctcaag
     2101 tctctggagt tcctagctca tcctcttgca ctcaccatat ttgaggatcg tgtctactgg
     2161 atagatggag aaaatgaagc agtgtatggt gccaataaat tcactgggtc agagctggcc
     2221 actctagtga acaatctcaa tgatgcccaa gacatcatta tctaccatga actcgtccag
     2281 ccttcaggta aaaactggtg tgaggaagat atggagaatg gaggatgtga atatctctgc
     2341 ctgccagcac cacagatcaa tgatcactct ccaaaatata cctgttcctg tcccaatggg
     2401 tacaatcttg aagaaaatgg acgcgagtgt caaagtactt caactcctgt gacttacagt
     2461 gagacaaaag atgtcaacac aacagacatc ctacgaacta gtggacttgt tcctggaggg
     2521 atcaatgtga ccacagcagt atcagaagtc agtgttcccc caaaagggac ttcagctgcc
     2581 tgggccatcc ttcctctctt gctcttagtg atggcagcag taggtggcta cttgatgtgg
     2641 aggaattggc aacataaaaa catgaaaagc atgaactttg acaatcccgt gtacttgaag
     2701 accactgaag aggacctctc aatagacatt ggtagacata gcgcttctgt aggacacaca
     2761 tacccagcaa tctcagttgt aagcacagat gatgatttgg cttgagttct gaacaagtct
     2821 tgctctatga ggtctacacc cataacaccc tactccggaa tggtaacaga gccagcgctg
     2881 aagtttcttt tcttcctccc atctggaaga acatcaagat atcttttcgt ggatcaagct
     2941 tgtgtacttg atcattttta tattactttt gtaaatattc ttggccacgt tctacttcag
     3001 ctttggatgt ggttaccaag tatctgtaac ccttgaatcc ctagacagta ttgccatctc
     3061 tggccaaata tgcactttcc ctagaaagcc atattccagc aatgaacctt gtgctatagt
     3121 gactcccacc tgtacatata ctgtataggc cacctgtaca tatcccagag aacaatcact
     3181 attcttaagc actttgaaga tatttctatg taaattattg taaacttttt caatggttgg
     3241 gacaatggca ataggataaa acgggttact aagatgaaat tgccaaaaat aaatttgtaa
     3301 ctaattttgt acggatgaat gaaacctttg acctctgtag aggtttgcaa agactgaatt
     3361 caaactactg tacatttttt ttcaagtgct aaaaaaaaat taaaccaagc agcttaa
//
