LOCUS       NM_017238               3360 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus vasoactive intestinal peptide receptor 2 (Vipr2),
            mRNA.
ACCESSION   NM_017238
VERSION     NM_017238.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3360)
  AUTHORS   Zhao,X., Deng,L., Ren,L., Yang,H., Wang,B., Zhu,X., Zhang,X.,
            Guo,C., Zhang,Y. and Liu,Y.
  TITLE     VPAC2 receptor mediates VIP-potentiated insulin secretion via ion
            channels in rat pancreatic beta cells
  JOURNAL   Exp Cell Res 423 (2), 113471 (2023)
   PUBMED   36642263
  REMARK    GeneRIF: VPAC2 receptor mediates VIP-potentiated insulin secretion
            via ion channels in rat pancreatic beta cells.
REFERENCE   2  (bases 1 to 3360)
  AUTHORS   Tasma,Z., Siow,A., Harris,P.W.R., Brimble,M.A., O'Carroll,S.J.,
            Hay,D.L. and Walker,C.S.
  TITLE     PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human
            Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor
            Antibodies
  JOURNAL   Int J Mol Sci 23 (22), 13797 (2022)
   PUBMED   36430275
  REMARK    GeneRIF: PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and
            Human Trigeminal Ganglia: Characterization of PACAP-Responsive
            Receptor Antibodies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3360)
  AUTHORS   Han,X., Ran,Y., Su,M., Liu,Y., Tang,W., Dong,Z. and Yu,S.
  TITLE     Chronic changes in pituitary adenylate cyclase-activating
            polypeptide and related receptors in response to repeated chemical
            dural stimulation in rats
  JOURNAL   Mol Pain 13, 1744806917720361 (2017)
   PUBMED   28776455
  REMARK    GeneRIF: the protein and mRNA expression of pituitary adenylate
            cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and
            VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to
            identify changes associated with repetitive applications of
            chemical dural stimulations.
REFERENCE   4  (bases 1 to 3360)
  AUTHORS   Li,D., Jiao,J., Shatos,M.A., Hodges,R.R. and Dartt,D.A.
  TITLE     Effect of VIP on intracellular [Ca2+], extracellular regulated
            kinase 1/2, and secretion in cultured rat conjunctival goblet cells
  JOURNAL   Invest Ophthalmol Vis Sci 54 (4), 2872-2884 (2013)
   PUBMED   23518767
  REMARK    GeneRIF: In cultured rat conjunctival goblet cells, VPAC1 and 2
            receptors are functional; VIP stimulates a cAMP-dependent increase
            in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2
            activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3360)
  AUTHORS   Lakk,M., Szabo,B., Volgyi,B., Gabriel,R. and Denes,V.
  TITLE     Development-related splicing regulates pituitary adenylate
            cyclase-activating polypeptide (PACAP) receptors in the retina
  JOURNAL   Invest Ophthalmol Vis Sci 53 (12), 7825-7832 (2012)
   PUBMED   23099490
  REMARK    GeneRIF: both VPAC1 and VPAC2 could have roles at all stages of
            retinal development, that PACAP acts through a specific set of PAC1
            isoforms, and that Hip and Hop1 are predominantly involved in the
            postnatal development of rat retina.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3360)
  AUTHORS   Akesson,L., Ahren,B., Edgren,G. and Degerman,E.
  TITLE     VPAC2-R mediates the lipolytic effects of pituitary adenylate
            cyclase-activating polypeptide/vasoactive intestinal polypeptide in
            primary rat adipocytes
  JOURNAL   Endocrinology 146 (2), 744-750 (2005)
   PUBMED   15514088
  REMARK    GeneRIF: all three PACAP/VIP receptor subtypes are expressed in
            primary rat adipocytes, but that the VPAC2-R subtype is responsible
            for mediating the lipolytic effects induced by PACAP38 and VIP.
REFERENCE   7  (bases 1 to 3360)
  AUTHORS   Kallo,I., Kalamatianos,T., Piggins,H.D. and Coen,C.W.
  TITLE     Ageing and the diurnal expression of mRNAs for vasoactive
            intestinal peptide and for the VPAC2 and PAC1 receptors in the
            suprachiasmatic nucleus of male rats
  JOURNAL   J Neuroendocrinol 16 (9), 758-766 (2004)
   PUBMED   15344914
  REMARK    GeneRIF: Aging reduces vasoactive intestinal peptide (VIP) receptor
            mRNA within the suprachiasmatic nucleus of aged male rats. A
            diurnal rhythm of VPAC2 receptor mRNA was present but reduced in
            the aged rats.
REFERENCE   8  (bases 1 to 3360)
  AUTHORS   Kalamatianos,T., Kallo,I., Piggins,H.D. and Coen,C.W.
  TITLE     Expression of VIP and/or PACAP receptor mRNA in peptide
            synthesizing cells within the suprachiasmatic nucleus of the rat
            and in its efferent target sites
  JOURNAL   J Comp Neurol 475 (1), 19-35 (2004)
   PUBMED   15176082
  REMARK    GeneRIF: Presence of vasoactive intestinal peptide (VIP) receptor 2
            mRNA is demonstrated at sites putatively innervated by
            VIP-containing projections from the suprachiasmatic nucleus.
REFERENCE   9  (bases 1 to 3360)
  AUTHORS   Usdin,T.B., Bonner,T.I. and Mezey,E.
  TITLE     Two receptors for vasoactive intestinal polypeptide with similar
            specificity and complementary distributions
  JOURNAL   Endocrinology 135 (6), 2662-2680 (1994)
   PUBMED   7988457
REFERENCE   10 (bases 1 to 3360)
  AUTHORS   Lutz,E.M., Sheward,W.J., West,K.M., Morrow,J.A., Fink,G. and
            Harmar,A.J.
  TITLE     The VIP2 receptor: molecular characterisation of a cDNA encoding a
            novel receptor for vasoactive intestinal peptide
  JOURNAL   FEBS Lett 334 (1), 3-8 (1993)
   PUBMED   8224221
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017238.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09631.1, SRR26643296.18703.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               JAXUCZ010000006.1  143144523-143144684
            163-262             JAXUCZ010000006.1  143146725-143146824
            263-370             JAXUCZ010000006.1  143160493-143160600
            371-468             JAXUCZ010000006.1  143162562-143162659
            469-566             JAXUCZ010000006.1  143191348-143191445
            567-708             JAXUCZ010000006.1  143198527-143198668
            709-859             JAXUCZ010000006.1  143204553-143204703
            860-920             JAXUCZ010000006.1  143205354-143205414
            921-990             JAXUCZ010000006.1  143206714-143206783
            991-1082            JAXUCZ010000006.1  143207181-143207272
            1083-1212           JAXUCZ010000006.1  143210135-143210264
            1213-1254           JAXUCZ010000006.1  143210331-143210372
            1255-3360           JAXUCZ010000006.1  143211504-143213609
FEATURES             Location/Qualifiers
     source          1..3360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..3360
                     /gene="Vipr2"
                     /note="vasoactive intestinal peptide receptor 2"
                     /db_xref="GeneID:29555"
                     /db_xref="RGD:3962"
     exon            1..162
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1428
                     /gene="Vipr2"
                     /note="vasoactive intestinal polypeptide receptor 2;
                     VIP-R-2; PACAP-R-3; PACAP type III receptor; pituitary
                     adenylate cyclase-activating polypeptide type III
                     receptor; PACAP-R3; vasopressive intestinal peptide
                     receptor 2"
                     /codon_start=1
                     /product="vasoactive intestinal polypeptide receptor 2
                     precursor"
                     /protein_id="NP_058934.2"
                     /db_xref="GeneID:29555"
                     /db_xref="RGD:3962"
                     /translation="MRASVVLTCYCWLLVRVSSIHPECRFHLEIQEEETKCAELLSSQ
                     MENHRACSGVWDNITCWRPADIGETVTVPCPKVFSNFYSRPGNISKNCTSDGWSETFP
                     DFIDACGYNDPEDESKITFYILVKAIYTLGYSVSLMSLTTGSIIICLFRKLHCTRNYI
                     HLNLFLSFMLRAISVLVKDSVLYSSSGTLRCHDQPGSWVGCKLSLVFFQYCIMANFYW
                     LLVEGLYLHTLLVAILPPSRCFLAYLLIGWGIPSVCIGAWIATRLSLEDTGCWDTNDH
                     SIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIP
                     LFGVHYMVFAAFPIGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQCELKRRWRGL
                     CLTQPGSRDYRLHSWSMSRNGSESALQIHRGSRTQSFLQSETSVI"
     exon            163..262
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..370
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..468
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..566
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..708
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..859
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..920
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..990
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1082
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1212
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1254
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..3360
                     /gene="Vipr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaggcaga gagggcgata ggcgcgagac tgaggaaatc cgcgctggga ggccccgagc
       61 tggggccggt gctgctgagg gcgccaagga ccgaggcggc acgctgagcc caggatgagg
      121 gcgtcggtgg tgctgacctg ctactgctgg ttgctggtgc gggtgagcag catccaccca
      181 gaatgccggt ttcatctgga aatacaggaa gaggagacaa aatgcgcaga gctgctaagc
      241 agccaaatgg agaatcacag agcttgcagc ggtgtctggg acaacatcac atgctggcgc
      301 cctgcagaca ttggggaaac tgtcacagtg ccctgcccca aagtgttcag caatttctac
      361 agcagaccag gaaacataag caaaaactgc actagtgatg ggtggtcgga gacatttccg
      421 gatttcatag atgcgtgtgg ctacaacgac cccgaggatg agagtaagat cacgttttat
      481 attctggtga aggccattta taccttgggc tacagtgttt ctctgatgtc tcttacaaca
      541 ggaagcataa ttatctgcct cttcaggaag ctgcactgca caaggaacta catccacctg
      601 aatctgttcc tctccttcat gctgagagcc atctctgtgc tggtcaagga cagtgtgctc
      661 tactccagct caggtacact gcgctgccac gaccagccgg gctcctgggt tggctgcaag
      721 ctcagcctgg tattcttcca gtactgtatc atggcgaact tctactggct tctggtggag
      781 ggtctctacc tgcacaccct cctggtagcc atccttcctc ccagcaggtg tttcctggcc
      841 taccttctta ttggatgggg tatccccagt gtgtgtatag gtgcatggat agcaactcgc
      901 ctttctttag aagacacagg ttgctgggac acgaacgacc acagcatccc ctggtgggtc
      961 attcggatgc ccattctaat ttctattgta gtcaactttg ccctcttcat cagcattgta
     1021 aggatcttac ttcagaagct aacttctcca gatgttggtg gcaatgacca gtcacagtac
     1081 aagaggctcg ccaagtccac actgctgcta atcccactgt ttggcgtcca ctacatggtg
     1141 tttgctgcct tccccattgg catctcctcc acgtaccaga tcctgtttga gttatgtgtt
     1201 ggttccttcc agggcctggt ggtcgcagtt ctatattgct ttctgaacag tgaggtacag
     1261 tgtgaactga aaagaaggtg gagaggcctg tgcctgaccc agcctgggag ccgggactac
     1321 cggctgcaca gctggtccat gtcccggaat ggctcagaaa gcgccctaca gatacaccgt
     1381 ggctcccgta cccagtcctt cctgcagtca gagacctcag tcatttagct gtgtccctca
     1441 tacagagctg acagtgctgc tgggtttgac atatgtgttt gccagcttcc tctgcttgcc
     1501 ccagtgtctg gtgccttatt gggtcagccc tggtccttaa ctcgattgta acttgattga
     1561 aacaccagtt attgttgaca gactctagcg tttaagccat cctcttcata atatggcaca
     1621 gccatattct actttcaaag agagcaagga aaccaggtgg ccctgaacat caaaactggg
     1681 ttctagaacg tccgaaaaaa aacaaggagg aagattccag tttctccact gcctcctgtc
     1741 agggagaacc acgtccagaa ccagctgagc atcaccaccc tgtggcccag cgcatgccta
     1801 tggttgtctc tgacattcct ctcaatctat ggcataccag ggaaagtgga tgaaagcaac
     1861 cttctcatcc tacaagcttc ctggtgcccc cggccttgag ttctgtcctg tggactacat
     1921 ctggacagcc acacccttgc cattccctgg accatctggt agtgaccaaa gataagtcag
     1981 ggaggatatt catggttcag cggccaagcc aggaactcat ctcctcccag ggcacttagc
     2041 atctgctgct tcctacaagt ggtgagcagc cctggatccc aggccggctg ctggcatgaa
     2101 ggccctcatt catgacttgt ccattcagcc caaggttgtt ctctagctgg tagaaaactt
     2161 cgatttttat tttaaagaaa accaccatct taaaattgct taaagagatt tattttatca
     2221 aagtatgaag aggcatcaag ttttcctatc caacatttgc cagtaacaat ccttattttt
     2281 ccagtgttat ttgcaactgt gggcaggcag acctgaggga atgcttgctg tgattgaaaa
     2341 gcagctgcag acagagagtg cctttccttg cggtgtccaa agaccctggg agaccatgtc
     2401 atggcccagt gcaagggctg taggttctgg acctagtgtt caggcatagt ctatgtaact
     2461 tacaccccaa cacacacaca cacacacaca cacacaggat aaaagctgca aaatgttttc
     2521 ctgtgctttc tgaggcatgt aggccacggc cagcatgaat accaatgatc tcagcaattg
     2581 taccagagcc agaggttttg gggtcagaaa aatcacaaaa gtaggggctc cacttctggt
     2641 acatgggggc tttagtacag cagagaagta tctagaaact agctgaggcc cgggggccag
     2701 acatctgtcc tgaatgtctg tccacagaac ccctcctgca cttttgcctc tatccactct
     2761 tgaaaggcct ccagtttgtc tgcaactgca caggatagac acctcagatg atctagaaaa
     2821 caccactaac ctgctgcctt gcagggctac caggctagag aacaggttgt ggggaacaaa
     2881 tggcctaggt cagaaacact taaaagagct gttggcagtg acaaaaggtg ggtgctacaa
     2941 gccctggtgt cagccttgcc tgtctttata cagagctcac tgcttactcc agcagctcgg
     3001 cggacacaca gccctcccat atctgaaagt tgtcctatca accactaggc gtgaccctgc
     3061 catgaccctg aagagacatg tagatcctgt gaacacaagc agccactgag tacacacgga
     3121 acattcagaa caccattccc tcagcccagc atgtgctaat gctaactata gctgggtcct
     3181 cgtcctggga aagagatcgg ctgatcacaa agtggtcgct gctggaactc accagtagca
     3241 gaggtgtagt aaccatatgg ccagcgcgtg atcttacgtg ttgtatgtgg aatatctaca
     3301 aacacaccgc ggagtggaac tgagttgtgt atatactgca ataaacctga tttcattctg
//
