LOCUS       NM_012685               4945 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus vasoactive intestinal peptide receptor 1 (Vipr1),
            mRNA.
ACCESSION   NM_012685
VERSION     NM_012685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4945)
  AUTHORS   Tasma,Z., Siow,A., Harris,P.W.R., Brimble,M.A., O'Carroll,S.J.,
            Hay,D.L. and Walker,C.S.
  TITLE     PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human
            Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor
            Antibodies
  JOURNAL   Int J Mol Sci 23 (22), 13797 (2022)
   PUBMED   36430275
  REMARK    GeneRIF: PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and
            Human Trigeminal Ganglia: Characterization of PACAP-Responsive
            Receptor Antibodies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4945)
  AUTHORS   Zverev Acapital,A. Cyrillic, Leonov,N.V., capital A, Cyrillicnikina
            capital TE, Cyrilliccapital,A. Cyrillic and Zefirov capital,T.E.
            CyrillicL.
  TITLE     Vasoactive Intestinal Peptide Changes the Frequency and Force of
            Myocardial Contraction in Rats
  JOURNAL   Bull Exp Biol Med 169 (6), 787-790 (2020)
   PUBMED   33098516
  REMARK    GeneRIF: Vasoactive Intestinal Peptide Changes the Frequency and
            Force of Myocardial Contraction in Rats.
REFERENCE   3  (bases 1 to 4945)
  AUTHORS   Han,X., Ran,Y., Su,M., Liu,Y., Tang,W., Dong,Z. and Yu,S.
  TITLE     Chronic changes in pituitary adenylate cyclase-activating
            polypeptide and related receptors in response to repeated chemical
            dural stimulation in rats
  JOURNAL   Mol Pain 13, 1744806917720361 (2017)
   PUBMED   28776455
  REMARK    GeneRIF: the protein and mRNA expression of pituitary adenylate
            cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and
            VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to
            identify changes associated with repetitive applications of
            chemical dural stimulations.
REFERENCE   4  (bases 1 to 4945)
  AUTHORS   Nunan,R., Sivasathiaseelan,H., Khan,D., Zaben,M. and Gray,W.
  TITLE     Microglial VPAC1R mediates a novel mechanism of
            neuroimmune-modulation of hippocampal precursor cells via IL-4
            release
  JOURNAL   Glia 62 (8), 1313-1327 (2014)
   PUBMED   24801739
  REMARK    GeneRIF: Stimulating hippocampal microglia with the peptide
            neurotransmitter VIP via VPAC1 receptors increases production of
            IL-4 which promotes their trophic and proliferative effects on
            neural stem/progenitor cells
REFERENCE   5  (bases 1 to 4945)
  AUTHORS   Li,D., Jiao,J., Shatos,M.A., Hodges,R.R. and Dartt,D.A.
  TITLE     Effect of VIP on intracellular [Ca2+], extracellular regulated
            kinase 1/2, and secretion in cultured rat conjunctival goblet cells
  JOURNAL   Invest Ophthalmol Vis Sci 54 (4), 2872-2884 (2013)
   PUBMED   23518767
  REMARK    GeneRIF: In cultured rat conjunctival goblet cells, VPAC1 and 2
            receptors are functional; VIP stimulates a cAMP-dependent increase
            in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2
            activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4945)
  AUTHORS   Guidone,G., Muller,D., Vogt,K. and Mukhopadhyay,A.K.
  TITLE     Characterization of VIP and PACAP receptors in cultured rat penis
            corpus cavernosum smooth muscle cells and their interaction with
            guanylate cyclase-B receptors
  JOURNAL   Regul Pept 108 (2-3), 63-72 (2002)
   PUBMED   12220728
  REMARK    GeneRIF: characterization of this receptor in cultured rat penis
            corpus cavernosum smooth muscle cells and its interaction with
            guanylate cyclase-B receptors
REFERENCE   7  (bases 1 to 4945)
  AUTHORS   Dorsam,G. and Goetzl,E.J.
  TITLE     Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene
            target of the hemolymphopoietic transcription factor Ikaros
  JOURNAL   J Biol Chem 277 (16), 13488-13493 (2002)
   PUBMED   11812772
REFERENCE   8  (bases 1 to 4945)
  AUTHORS   Pei,L. and Melmed,S.
  TITLE     Characterization of the rat vasoactive intestinal polypeptide
            receptor gene 5' region
  JOURNAL   Biochem J 308 (Pt 3) (Pt 3), 719-723 (1995)
   PUBMED   8948424
REFERENCE   9  (bases 1 to 4945)
  AUTHORS   Sreedharan,S.P., Patel,D.R., Huang,J.X. and Goetzl,E.J.
  TITLE     Cloning and functional expression of a human neuroendocrine
            vasoactive intestinal peptide receptor
  JOURNAL   Biochem Biophys Res Commun 193 (2), 546-553 (1993)
   PUBMED   8390245
REFERENCE   10 (bases 1 to 4945)
  AUTHORS   Ishihara,T., Shigemoto,R., Mori,K., Takahashi,K. and Nagata,S.
  TITLE     Functional expression and tissue distribution of a novel receptor
            for vasoactive intestinal polypeptide
  JOURNAL   Neuron 8 (4), 811-819 (1992)
   PUBMED   1314625
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087136.1.
            
            On Dec 26, 2004 this sequence version replaced NM_012685.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087136.1, M86835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4945
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /note="vasoactive intestinal peptide receptor 1"
                     /db_xref="GeneID:24875"
                     /db_xref="RGD:3961"
     exon            1..167
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1469
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /note="vasoactive intestinal polypeptide receptor 1; PACAP
                     type II receptor; pituitary adenylate cyclase-activating
                     polypeptide type II receptor"
                     /codon_start=1
                     /product="vasoactive intestinal polypeptide receptor 1
                     precursor"
                     /protein_id="NP_036817.1"
                     /db_xref="GeneID:24875"
                     /db_xref="RGD:3961"
                     /translation="MRPPSPPHVRWLCVLAGALACALRPAGSQAASPQHECEYLQLIE
                     IQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPRGQAVVLDCPLIFQLFAPIHGYNIS
                     RSCTEEGWSQLEPGPYHIACGLNDRASSLDEQQQTKFYNTVKTGYTIGYSLSLASLLV
                     AMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNSGEIDHCSEASVGCKA
                     AVVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSVFITIWTV
                     VRIYFEDFGCWDTIINSSLWWIIKAPILLSILVNFVLFICIIRILVQKLRPPDIGKND
                     SSPYSRLAKSTLLLIPLFGIHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCF
                     LNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGATCSTQVSMLTRVSPSARRSS
                     SFQAEVSLV"
     exon            168..273
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..381
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..488
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..595
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..728
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..882
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..943
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1013
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1105
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1235
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1277
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..4920
                     /gene="Vipr1"
                     /gene_synonym="PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352;
                     VASREC; VIP-R-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgctggc ccgcgccact ctcccgcgct gcaccggcca cagaccccgt tgccgctccc
       61 ggccgcttgc cgccggctca gggcggacca tgcgccctcc gagcccaccg catgtccgct
      121 ggctctgcgt gctggcagga gcccttgcct gcgccctcag acccgcgggc agccaggcag
      181 ccagcccgca gcacgagtgt gagtacctgc agttgattga gatacagcgt cagcagtgcc
      241 tggaggaggc ccagctggag aatgaaacca caggctgcag caagatgtgg gacaacctca
      301 cctgctggcc gacaaccccg aggggccagg cggtagtcct ggactgcccc ctcatctttc
      361 agctgtttgc ccccattcat ggttataaca tcagccgtag ctgcactgaa gagggctggt
      421 cacaactgga accaggcccc taccacattg cctgcggcct gaatgacagg gcatcgagtc
      481 tggatgagca gcaacagacc aagttctaca ataccgtgaa gaccggctac accatcggct
      541 acagcttgtc ccttgccagc ctcctggttg ccatggctat cttgagcctg ttcaggaagc
      601 tgcactgtac ccgaaactac atccacatgc atctcttcat gtccttcatc ctgagggcca
      661 ctgccgtctt catcaaggat atggccctct tcaacagcgg ggagatagac cactgctctg
      721 aggcctcggt ggggtgcaag gcagcggtgg ttttcttcca gtattgtgtc atggccaact
      781 tcttctggct gctggtagag ggcctctacc tatacaccct gctggccgtc tccttcttct
      841 ccgagcggaa gtacttctgg gggtacattc tcatcggctg gggagtgccc agtgtgttca
      901 tcaccatatg gacggtcgtc aggatatatt ttgaggattt cgggtgctgg gacaccatca
      961 tcaactcctc cctgtggtgg atcataaagg cccccatcct cctctccatc ctggtgaact
     1021 tcgtcctgtt tatctgcatc atccggatcc tggttcagaa actacggcca cccgacattg
     1081 ggaagaatga tagcagccca tattcgaggc tggccaagtc cacgcttctg ctcatccccc
     1141 tgtttggaat tcactatgtc atgtttgcct tcttccccga caacttcaag gcccaggtga
     1201 aaatggtctt cgaacttgtc gtgggctctt tccagggttt cgtggtggcc atcctctact
     1261 gcttcctcaa tggtgaggtg caggcggagc tgcggcggaa gtggcggcgt tggcatctgc
     1321 agggcgtcct gggctggagc tccaaatccc agcatccgtg gggaggcagc aacggcgcca
     1381 catgcagcac gcaggtatcc atgctgaccc gcgtcagccc gagcgcacgc cgctcctcca
     1441 gcttccaagc ggaggtctcc ctggtctgac cgccagaggc cgccaggccc cttcacaccc
     1501 tctccacaac ggcccctgga gcagaggtct gtagcgacac cgttggctcc agcttttcat
     1561 agggacacac tcctttgccg cagccaggac cgggtctatg ctagctggag agcggggagc
     1621 tctaaccttg gaggatggta ggaggatcca gcatcagact ccacctccca aggccattct
     1681 gccagtcatg cgcacaaaat ctgcatacac ctggaaagca accgcttgcc ctcaaagctt
     1741 tggaactcgc ggggcagaag gttccgcccg ccctgtggtg cctagaatcc actgggacgc
     1801 tcgtgtcgct ttgggttaag cgttgccatt gagactcctc tctgaggatg cagccccctc
     1861 cctgcgttta tctgccagct cttctgggtg ggtgagttct tctacctcag gcagatggtt
     1921 atgacctgga gtttcagttt ggggatcgca gctgtgttgt ggtcctctct caggatggaa
     1981 ttgtcccagt gtatcctcag acctgggagc tcagggacct acctctgggg agggagaaga
     2041 caaccccagt cagtgctcac caagtgactt tgtccaacaa ataggaccag tcccactagc
     2101 cttatgtaca accaaagcaa tatcgagctg cctgctctgg gcgctcatct acacacgcca
     2161 accactgctg caagggtcag aggcatgaac acacaggccc cttgatcctg aggtcaccct
     2221 aacatcactg gtagtgacac ctgggtctcg gtgagagtgg gtatcctttc ccgtggctag
     2281 tgcgaacgta aagactacct ttttacatag tatgatctgc tggattctct tggggttgta
     2341 ctaccacaga tgctattgcc ccacagtccc cagttcttgc tgccttggag cgtgattatg
     2401 tggctgacat aaaagcccag gggtcaaggc atcttaagtc ctcctccacc cttaattcaa
     2461 cacggcttct aatccaagca gttgtcagca ggcccctgca gagctgcacc aggcttgtac
     2521 gacaataaac gttggctctg acaggcttag ttcccctggc cactgtgggt ctcctgcttc
     2581 tcctgagaag ctgtgtcacc tctgcagtgg tgagaggtga cccactaaag ctaccaccct
     2641 tcactcctcg gacaggcagg agccacctac ttccatggga ggacttatcc caagagcctt
     2701 tgattcacat tcgagtgtga agagattgta acaggggttc cgttgtgacc ctctctcccc
     2761 taaacccatc tggaaggaga cagatgctgc ctccgaccga atcaaaacag ccaacggagc
     2821 tgtcacaaac agcaagggtt cacgatcatt cctgaaaaca cagcaaagag gatatgcagc
     2881 caccaggttg ctgctgtcta cgggccaacc aagagggtcg ggtcagtgga ggttccccag
     2941 tgtaagtcag tgaggagagg ccatgtggct aagggaaagg agtagacaca gcaatggggc
     3001 aaagcaggtg acattggtca gagagagaga gagaaagaga gagagagagc actcccaagg
     3061 gtttgtgcaa acacacttgt gtaaacttgt ggagttgtct tgctgatgaa gccagaagtg
     3121 tatgctggtg tgaagaagcc agaatgggct agcaggggtt cagatctgcc tgcagtaccc
     3181 catttgaaag ctgctgccct cagcagtgaa tgggcccgag atcccccccc cccagcagtc
     3241 tgtgttgtgg caccggggta aggcacaggg ctctggaagt ggagcagtta ccagccaaga
     3301 ggacaaagtg ggtaaaacca gtgtgttcaa gagaggaaag acagcgttgg ggcaccgctc
     3361 taaggttagg aggtaagagg ctcagtggag ggcattcctg gatagagaga gactgagagg
     3421 cttgggtgag gagctgagaa aacttgtgct ggtatcctag gttagtgaca gccgtggggc
     3481 ttccagtcct ttgacaacac ccaggtcctt ctggccctgc caggtacctg tctagcccgg
     3541 agaactcatc tctatcgcca cctggtggac acttcaaaga ctataccagc tttggccacc
     3601 ttagggctta atactgtcaa gtaggtctca cactggggga caaccaacac agaaagcagg
     3661 gcttgagctc ccaaaagtga tatgtaggcc atatctaggg ctagccccac accacgtcct
     3721 cagatcaaac cactgacctc atgtgagtct tgccttgacc caaaagaacc tgatggaacc
     3781 cagcccctgg tggctcctta aaactggccc ctacccatag cctccaaggg caaagttcag
     3841 ttaactgaag cgggtgtgga tagggaactg taccgtctga gcacagagaa gccccgagga
     3901 gactggttta cctgctagca gaacggcact gaggtgtttg agggctagga gaggtgttgg
     3961 agtcccaagg gaatgtgttg agtgtcaggg atacccgagt atggctgagt cgatgttagg
     4021 ggtacttgcc agtagagaca gagaatgtct atcagatgga gctgagagat gagaatgggt
     4081 tggttaactc ggagaaggac ccaggtctgg aaagggtgcc aggccatggg caggaaaggg
     4141 aggaggtcag tcagtgagac aatggcctgg tttgggacat gctgaatgtt atgtctgcag
     4201 ggtgtctgag aagagcccct ccaaggcttt tagatatatg acctaaaggg acagaaaacg
     4261 gaaagaccga ggcagcccct ttggaaggaa cagtgagcat tggggcaagt ccccaggcac
     4321 cccatggggt gtgctggaca caatcaggag aggaggctga ctcagcccct tcatcctagc
     4381 tgccacacag ggtctgtttc aatgagcagt ggccagcttc cctaccccca tgtgggaaca
     4441 agaacagctc ttatctctct gggggaaggg gaaggggcgg agccacagct gctagtcatt
     4501 aaacaccctg ctctaggcag ggatggccaa gatattaata gccccgggag tctatggccc
     4561 cgaagactcg gcctcccagg gaaaggacag agcaaccgca gcaggccaga gggatgtgtc
     4621 aggaggccat cttggcaatg ccccagcctc cacacaaagc agatgggaga accagaaaac
     4681 agagaaggaa agtcctggta gaggccggtg ttgaacccaa ctttccaaat cccatggtcg
     4741 tgcctcagat agtctatacg ttgtcaaaga tggggtcatt tggctgcgcc gtacctggag
     4801 acgcagaaag agttgatccg gttagcaatc ctgattccgt cttgacatat tgtttatcct
     4861 gtatttttgc attaattttg atattttaaa atactgcatt aaaatattat ttaccttgaa
     4921 aaaaaaaaaa aaaaaaaaaa aaaaa
//
