LOCUS       NM_053991               1532 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus vasoactive intestinal peptide (Vip), mRNA.
ACCESSION   NM_053991 XM_001065820 XM_217838
VERSION     NM_053991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1532)
  AUTHORS   Broome,S.T., Mandwie,M., Gorrie,C.A., Musumeci,G., Marzagalli,R.
            and Castorina,A.
  TITLE     Early Alterations of PACAP and VIP Expression in the Female Rat
            Brain Following Spinal Cord Injury
  JOURNAL   J Mol Neurosci 73 (9-10), 724-737 (2023)
   PUBMED   37646964
  REMARK    GeneRIF: Early Alterations of PACAP and VIP Expression in the
            Female Rat Brain Following Spinal Cord Injury.
REFERENCE   2  (bases 1 to 1532)
  AUTHORS   An,Y., Hu,S., Zhang,Y., Song,Z., Li,R., Li,Y., Li,Y., Ren,W. and
            Wan,P.
  TITLE     Knockdown of miR-19a suppresses gastrointestinal dysmotility
            diarrhea after TBI by regulating VIP expression
  JOURNAL   Brain Behav 13 (7), e3071 (2023)
   PUBMED   37218372
  REMARK    GeneRIF: Knockdown of miR-19a suppresses gastrointestinal
            dysmotility diarrhea after TBI by regulating VIP expression.
REFERENCE   3  (bases 1 to 1532)
  AUTHORS   Ghimire,M., Cai,R., Ling,L., Brownell,K.A., Hackett,T.A.,
            Llano,D.A. and Caspary,D.M.
  TITLE     Increased pyramidal and VIP neuronal excitability in rat primary
            auditory cortex directly correlates with tinnitus behaviour
  JOURNAL   J Physiol 601 (12), 2493-2511 (2023)
   PUBMED   37119035
  REMARK    GeneRIF: Increased pyramidal and VIP neuronal excitability in rat
            primary auditory cortex directly correlates with tinnitus
            behaviour.
REFERENCE   4  (bases 1 to 1532)
  AUTHORS   Zverev Acapital,A. Cyrillic, Leonov,N.V., capital A, Cyrillicnikina
            capital TE, Cyrilliccapital,A. Cyrillic and Zefirov capital,T.E.
            CyrillicL.
  TITLE     Vasoactive Intestinal Peptide Changes the Frequency and Force of
            Myocardial Contraction in Rats
  JOURNAL   Bull Exp Biol Med 169 (6), 787-790 (2020)
   PUBMED   33098516
  REMARK    GeneRIF: Vasoactive Intestinal Peptide Changes the Frequency and
            Force of Myocardial Contraction in Rats.
REFERENCE   5  (bases 1 to 1532)
  AUTHORS   Liu,F.X., Abudureyimujiang,R., Maowulan,M., Zhuyan,L.Y., Nizamu,A.,
            Zhang,P.P. and Adilijiang,Y.
  TITLE     [Expressions of calcitonin gene-related peptide and vasoactive
            intestinal peptide in the penile tissue of the ED rat model and
            their action mechanisms]
  JOURNAL   Zhonghua Nan Ke Xue 24 (12), 1111-1115 (2018)
   PUBMED   32212492
  REMARK    GeneRIF: The expressions of CGRP and VIP were significantly
            down-regulated in the erectile dysfunction rat model
REFERENCE   6  (bases 1 to 1532)
  AUTHORS   Ishihara,T., Shigemoto,R., Mori,K., Takahashi,K. and Nagata,S.
  TITLE     Functional expression and tissue distribution of a novel receptor
            for vasoactive intestinal polypeptide
  JOURNAL   Neuron 8 (4), 811-819 (1992)
   PUBMED   1314625
REFERENCE   7  (bases 1 to 1532)
  AUTHORS   Lamperti,E.D., Rosen,K.M. and Villa-Komaroff,L.
  TITLE     Characterization of the gene and messages for vasoactive intestinal
            polypeptide (VIP) in rat and mouse
  JOURNAL   Brain Res Mol Brain Res 9 (3), 217-231 (1991)
   PUBMED   1851524
REFERENCE   8  (bases 1 to 1532)
  AUTHORS   Giladi,E., Shani,Y. and Gozes,I.
  TITLE     The complete structure of the rat VIP gene
  JOURNAL   Brain Res Mol Brain Res 7 (3), 261-267 (1990)
   PUBMED   2159586
REFERENCE   9  (bases 1 to 1532)
  AUTHORS   Goetzl,E.J., Sreedharan,S.P. and Turck,C.W.
  TITLE     Structurally distinctive vasoactive intestinal peptides from rat
            basophilic leukemia cells
  JOURNAL   J Biol Chem 263 (19), 9083-9086 (1988)
   PUBMED   3379062
REFERENCE   10 (bases 1 to 1532)
  AUTHORS   Nishizawa,M., Hayakawa,Y., Yanaihara,N. and Okamoto,H.
  TITLE     Nucleotide sequence divergence and functional constraint in VIP
            precursor mRNA evolution between human and rat
  JOURNAL   FEBS Lett 183 (1), 55-59 (1985)
   PUBMED   3838518
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC158798.1 and CB583853.1.
            
            On or before Oct 23, 2008 this sequence version replaced
            XM_217838.4, XM_001065820.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: CO393333.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760393, SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               BC158798.1         1-478
            479-582             CB583853.1         493-596
            583-1532            BC158798.1         580-1529
FEATURES             Location/Qualifiers
     source          1..1532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1532
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /note="vasoactive intestinal peptide"
                     /db_xref="GeneID:117064"
                     /db_xref="RGD:621647"
     exon            1..133
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /inference="alignment:Splign:2.1.0"
     exon            134..250
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..656
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /note="VIP peptides; vasoactive intestinal polypeptide"
                     /codon_start=1
                     /product="VIP peptides preproprotein"
                     /protein_id="NP_446443.1"
                     /db_xref="GeneID:117064"
                     /db_xref="RGD:621647"
                     /translation="MESRSKPQFLAILTLFSVLFSQSLAWPLYGPPSSVRLDDRLQFE
                     GAGDPDQVSLKADSDILQNALAENDTPYYDVSRNARHADGVFTSDYSRLLGQISAKKY
                     LESLIGKRISSSISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGD
                     SPDFLEELEK"
     exon            251..373
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /inference="alignment:Splign:2.1.0"
     exon            374..478
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /inference="alignment:Splign:2.1.0"
     exon            479..610
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /inference="alignment:Splign:2.1.0"
     exon            611..692
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1501
                     /gene="Vip"
                     /gene_synonym="vip/phi27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagcggcta ctgccaacct ttccccagga ccaggggcag actccgtgga gccttctccc
       61 aagcagaact tcagcacccc agacagctcc cccgcgccgg agagacggtc ctgccagaag
      121 gaaagaccca aggaggcacc gagatggaat ccagaagcaa gcctcagttc ctggcgatcc
      181 tgacactctt cagtgtgctg ttctcacagt cgctggcctg gcctctctat gggccacctt
      241 cttcagtgag gttggatgac aggctgcagt tcgaaggagc aggtgaccct gatcaagtct
      301 ctttaaaagc agactctgac atcttgcaga atgccttagc ggagaatgac acgccctatt
      361 atgatgtgtc cagaaatgcc aggcatgctg atggagtttt caccagcgac tacagtagac
      421 ttctgggtca gatttctgcc aaaaaatacc ttgagtcact cattggcaaa cgaatcagca
      481 gtagcatctc ggaagacccc gtgccggtca aacgacactc tgatgcagtc ttcacagata
      541 actacacccg ccttagaaag caaatggctg tgaagaaata cttgaactcc attctaaatg
      601 ggaagaggag cagtgaggga gattctccag acttccttga agagctagag aaatgatgag
      661 aagggtcctc tgggcagagc tgaagatcag agaattcttg aaggaaaaca accaagtgat
      721 tacattatga gttctacata tctaattcaa gaaaacaact tccatagcaa aaccaaataa
      781 aatgtgttgt gaatattgtg gtttccttta tgtaataact gtgatgttta cattgtaaat
      841 atatttagca ctctaaaatt catctttagc tcgtgaaagg cttataattt catatgctat
      901 atattcttta aaaaatatat ttaatgatag gtagatacta gattaattgc aattatctga
      961 agctttctgc aagggtagca atcgaggaaa attgatgggc ttatttatag catgcagtta
     1021 actattcaac agagcagaac agataatcag tgtgaccaag tctgaatgct aagcagatag
     1081 gctgccgtgt tacataaagc aaaatatcta agggaaaacc aaacatatgg aaaatggaga
     1141 tacttgacaa aaggattttc aaaattgtat tcctccagtg atagggactc cacctctcat
     1201 ggattcatct ctccgactag gatttgcaat ccccaaaagc ttcttcgagt tgcttcagct
     1261 aggaaaagct caacttccaa cctggagctt ccccttcctg cttgtgctgt ggatgtgtaa
     1321 gctagaagcc taacggagtg cttgatttcc agtagtaaat actctttccg taatcactca
     1381 caacagtatt ttgtcttatt ggcttccttt gctgaaagta catttgtaga cacaactatt
     1441 tttccaatgt gattgtatga aattaaagac aggaataaag atctttggtt atcattgcaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
