LOCUS       NM_001108224            3376 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus villin 1 (Vil1), mRNA.
ACCESSION   NM_001108224 XM_001057825 XM_237288
VERSION     NM_001108224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3376)
  AUTHORS   Decuypere JP, Ceulemans LJ, Wylin T, Martinet W, Monbaliu D,
            Pirenne J and Jochmans I.
  TITLE     Plasmatic Villin 1 Is a Novel In Vivo Marker of Proximal Tubular
            Cell Injury During Renal Ischemia-Reperfusion
  JOURNAL   Transplantation 101 (11), e330-e336 (2017)
   PUBMED   28704336
  REMARK    GeneRIF: Villin 1 is released in plasma during acute kidney injury
            and shows potential as an early marker for proximal tubular
            injury/necrosis.
REFERENCE   2  (bases 1 to 3376)
  AUTHORS   Revenu C, Ubelmann F, Hurbain I, El-Marjou F, Dingli F, Loew D,
            Delacour D, Gilet J, Brot-Laroche E, Rivero F, Louvard D and Robine
            S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   3  (bases 1 to 3376)
  AUTHORS   Krasteva G, Canning BJ, Hartmann P, Veres TZ, Papadakis T, Muhlfeld
            C, Schliecker K, Tallini YN, Braun A, Hackstein H, Baal N, Weihe E,
            Schutz B, Kotlikoff M, Ibanez-Tallon I and Kummer W.
  TITLE     Cholinergic chemosensory cells in the trachea regulate breathing
  JOURNAL   Proc Natl Acad Sci U S A 108 (23), 9478-9483 (2011)
   PUBMED   21606356
REFERENCE   4  (bases 1 to 3376)
  AUTHORS   Buhrke T, Lengler I and Lampen A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   5  (bases 1 to 3376)
  AUTHORS   Tomar A, George SP, Mathew S and Khurana S.
  TITLE     Differential effects of lysophosphatidic acid and
            phosphatidylinositol 4,5-bisphosphate on actin dynamics by direct
            association with the actin-binding protein villin
  JOURNAL   J Biol Chem 284 (51), 35278-35282 (2009)
   PUBMED   19808673
REFERENCE   6  (bases 1 to 3376)
  AUTHORS   Kumar N, Tomar A, Parrill AL and Khurana S.
  TITLE     Functional dissection and molecular characterization of
            calcium-sensitive actin-capping and actin-depolymerizing sites in
            villin
  JOURNAL   J Biol Chem 279 (43), 45036-45046 (2004)
   PUBMED   15272027
REFERENCE   7  (bases 1 to 3376)
  AUTHORS   Vermeulen W, Vanhaesebrouck P, Van Troys M, Verschueren M, Fant F,
            Goethals M, Ampe C, Martins JC and Borremans FA.
  TITLE     Solution structures of the C-terminal headpiece subdomains of human
            villin and advillin, evaluation of headpiece F-actin-binding
            requirements
  JOURNAL   Protein Sci 13 (5), 1276-1287 (2004)
   PUBMED   15096633
REFERENCE   8  (bases 1 to 3376)
  AUTHORS   Kumar N, Zhao P, Tomar A, Galea CA and Khurana S.
  TITLE     Association of villin with phosphatidylinositol 4,5-bisphosphate
            regulates the actin cytoskeleton
  JOURNAL   J Biol Chem 279 (4), 3096-3110 (2004)
   PUBMED   14594952
REFERENCE   9  (bases 1 to 3376)
  AUTHORS   Athman R, Louvard D and Robine S.
  TITLE     Villin enhances hepatocyte growth factor-induced actin cytoskeleton
            remodeling in epithelial cells
  JOURNAL   Mol Biol Cell 14 (11), 4641-4653 (2003)
   PUBMED   12937273
REFERENCE   10 (bases 1 to 3376)
  AUTHORS   Zhai L, Zhao P, Panebra A, Guerrerio AL and Khurana S.
  TITLE     Tyrosine phosphorylation of villin regulates the organization of
            the actin cytoskeleton
  JOURNAL   J Biol Chem 276 (39), 36163-36167 (2001)
   PUBMED   11500485
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168981.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001108224.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..3376
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /note="villin 1"
                     /db_xref="GeneID:316521"
                     /db_xref="RGD:1307048"
     exon            1..179
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            180..265
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2674
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /codon_start=1
                     /product="villin-1"
                     /protein_id="NP_001101694.1"
                     /db_xref="GeneID:316521"
                     /db_xref="RGD:1307048"
                     /translation="MTKLTAQVKGSLNTTTPGIQIWRIEAMQMVPVPSSTFGSFFDGD
                     CYVVLAIHKTGSTLSYDIHYWIGQDSSQDEQGAAAIYTTQMDDYLKGRAVQHREVQGH
                     ESDTFRSYFKQGLVIRKGGVASGMKHVETNSCDVQRLLHVKGKRNVLAGEVEMSWKSF
                     NRGDVFLLDLGKLIIQWNGPESNRMERLRGMTLAKEIRDQERGGRTYVGVVDGENEGD
                     SPQLMAIMNHVLGPRKELKAAISDSVVEPAAKAALKLYHVSDSEGKMVVREVATQPLT
                     QDLLSHEDCYILDQGGLKIFVWKGKNANAQERSGAMNQALNFIKAKQYPPSTQVEVQN
                     DGAESAIFQQLFQKWTVPNRTSGLGKTHTVGSVAKVEQVKFDALSMHVRPQVAAQQKM
                     VDDGSGEVQVWRIEDLELVPVESKWLGHFYGGDCYLLLYTYLIGEKEHYLLYIWQGSQ
                     ASQDEIAASAYQAVNLDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVVYQGGTSRKNN
                     VEPVPSTRLFQVRGTSADNTKAFEVTARATSLNSNDVFILKTPSCCYLWCGKGCSGDE
                     REMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENQVITPRLFEC
                     SNQTGRFLATEIFDFTQDDLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYL
                     KTHPGNRDPETPIIVVKQGHEPSTFTGWFLAWDPFKWSNTKSYDDLKAELGNSGDWSQ
                     IADEVMSPKVDVFTANTSFSSGPLPIYPLEQLVNKPVEELPEGVDPTRKEEHLSTEDF
                     TKALGMTPAAFSALPRWKQQNLKKEKGLF"
     exon            266..340
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            341..537
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            538..646
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            647..757
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            758..960
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1039
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1138
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1292
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1393
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1531
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1690
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1870
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2016
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2161
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2350
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2419
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2560
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..3303
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggacctg ggcacctact tccccacccc ctcatccatt ctctctgggg ccctatcttc
       61 ccttatatgg tgaaggaagt tcctgggggt gggggggtga ggacaaaggt cggtctcctg
      121 cagccagctt gccacaactt cctaagatct cccaggtggt ggctgcctct tccagacagg
      181 ctcatccacc atgactaaac tgactgccca agtcaaaggc tctctcaaca ccaccactcc
      241 aggaatacaa atatggagga tagaggctat gcagatggtg ccggttcctt ccagcacctt
      301 tggaagcttc ttcgatggtg actgctatgt agtcctggct atccacaaga ccggcagcac
      361 cctctcctac gatatccact actggattgg ccaggactcg tcccaggatg agcagggggc
      421 agctgccatc tacacaacac agatggatga ctacctgaag ggccgggctg tccagcaccg
      481 tgaggtccaa ggccatgaga gcgacacatt ccggagctac ttcaagcaag gccttgtgat
      541 ccggaaaggg ggcgtggctt ctggcatgaa gcacgtagaa acaaactcct gtgatgtcca
      601 gcgactgttg cacgtcaagg gcaagaggaa tgtgctggct ggagaggtgg aaatgtcctg
      661 gaagagtttc aacagagggg atgtcttcct gctggacctt gggaagctta tcatccagtg
      721 gaatgggcca gagagtaacc gcatggagag acttcggggc atgaccttgg ccaaagagat
      781 ccgagaccag gagcggggtg gacgcaccta cgtaggcgtg gtggatgggg agaatgaagg
      841 ggactcccca cagctgatgg caattatgaa ccacgtgctg ggcccacgca aggaactaaa
      901 ggctgcaatt tctgactcag tggtggagcc ggccgctaag gctgcactca agctgtacca
      961 tgtgtctgat tcagaaggaa aaatggtggt tagagaagtt gctactcagc cactcacaca
     1021 ggacttgctc agccatgagg actgttacat cctggaccag ggaggcctga agatctttgt
     1081 gtggaaggga aaaaatgcca atgcccagga gaggagcgga gccatgaacc aggctttgaa
     1141 cttcatcaaa gccaagcagt acccacctag cacgcaggtt gaggtgcaga atgatggggc
     1201 tgagtccgcc attttccagc agctcttcca gaagtggaca gtgcccaatc ggacctcagg
     1261 ccttggcaaa acccacacag tgggctctgt ggccaaggtg gaacaggtga agtttgatgc
     1321 tctgtccatg cacgtacggc ctcaagtggc tgcccagcag aaaatggtgg atgacgggag
     1381 tggggaagtg caggtgtggc gcatcgagga cttagagctg gtgcctgtgg agtccaagtg
     1441 gctgggccat ttctatggcg gcgactgcta cctgctgctc tatacctacc tcataggcga
     1501 gaaggagcac tacttgctgt atatctggca gggcagccag gccagccagg atgaaattgc
     1561 agcctcggct taccaagctg tcaacctgga ccagaagtac aacgacgagc cagtgcagat
     1621 ccgggtcacg atgggcaagg agccgccgca cctcatgtct atcttcaagg ggcgcatggt
     1681 ggtttatcag ggaggcacct cccgaaagaa caacgtggag cccgtgccct ctacaaggct
     1741 gtttcaggtc cgagggacca gtgctgataa caccaaggct tttgaggtta cagcccgggc
     1801 cacctccctc aactccaatg atgtcttcat actcaagact ccgtcctgct gctacctgtg
     1861 gtgtggaaag ggctgcagtg gggatgagcg ggagatggcc aagatggttg ctgataccat
     1921 ctctcggaca gagaaacaag tggtggtcga ggggcaggag ccagccaact tctggatggc
     1981 tctgggtggg aaggcgccat atgccaacac caagaggctg caggaggaaa accaagtcat
     2041 cactcctcgg ctctttgagt gctccaacca gactgggcgc tttctggcca cagagatctt
     2101 tgacttcact caggacgacc tggaagagga tgatgtgttc ctattggatg tctgggacca
     2161 ggtcttcttc tggataggga aacacgccaa cgaggaagag aagaaggctg cagctacaac
     2221 tgcacaggaa tacctcaaga cccaccccgg aaacagagac cctgagaccc ctatcattgt
     2281 ggtgaagcag gggcacgagc cctccacctt cacaggctgg ttcctggctt gggatccctt
     2341 caagtggagt aacaccaaat cttatgatga cctcaaggcc gagttgggaa actctgggga
     2401 ctggagccag attgctgatg aggttatgag ccccaaagtg gatgttttca ctgccaatac
     2461 cagcttcagt tctgggccct tgcccatcta tcccctggag cagctggtaa acaagcctgt
     2521 ggaggagctc cctgagggtg tggaccccac caggaaggag gagcacctgt ccactgaaga
     2581 tttcactaag gctttgggga tgactccagc tgccttctct gcgctgcctc gatggaagca
     2641 acaaaacctc aagaaggaga aaggactgtt ttgagaactg aagctcagcg tccagcagct
     2701 cctaccctgc cttcaagcct cctccccacc ccccattact ggctttagtc ctgtgccagt
     2761 tgaaaatgtc caattgtatc tgtgaaccac agtgtgaaag ttccttctgt ttataatagt
     2821 aatctgccca ttcctttaga aatatgccac agcccagtgg agtcttgttc tagagttttc
     2881 cttccttaga gcagctgagt actccaggag acatagcacc tgggcttttc tctcagctta
     2941 tccctcacag cagggagttg gggagtgttt ggcagtttga agtcattccc acagagaggt
     3001 ctttcctcat tgctgaggga cctgtttttt gaaagctaaa gcctacaagg aagtactgag
     3061 aatcaggtgt tgtctcatcc tctttcatac tcaaaagggg aagctaaggc caaggctggg
     3121 cttacaagct gtaactcaga agcctttgta aagcttcaca gactcctcaa atgacaacac
     3181 caggatcatg ggtttgctac atgaagtcca atcagaagcc gacagaaggt gattttctct
     3241 taaaacaact ggttatccag tgtccccagg aacatgtccc tttaaataaa taagtcaaac
     3301 taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3361 aaaaaaaaaa aaaaaa
//
