LOCUS       NM_052801               2807 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus von Hippel-Lindau tumor suppressor (Vhl), mRNA.
ACCESSION   NM_052801
VERSION     NM_052801.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Yang,M., Zhu,M., Song,K., Wuren,T., Yan,J., Ge,R.L., Ji,L. and
            Cui,S.
  TITLE     VHL gene methylation contributes to excessive erythrocytosis in
            chronic mountain sickness rat model by upregulating the
            HIF-2alpha/EPO pathway
  JOURNAL   Life Sci 266, 118873 (2021)
   PUBMED   33309718
  REMARK    GeneRIF: VHL gene methylation contributes to excessive
            erythrocytosis in chronic mountain sickness rat model by
            upregulating the HIF-2alpha/EPO pathway.
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Liu,Y., Tan,J., Ou,S., Chen,J. and Chen,L.
  TITLE     Adipose-derived exosomes deliver miR-23a/b to regulate tumor growth
            in hepatocellular cancer by targeting the VHL/HIF axis
  JOURNAL   J Physiol Biochem 75 (3), 391-401 (2019)
   PUBMED   31321740
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Kuwahara,Y., Kennedy,L.M., Karnezis,A.N., Mora-Blanco,E.L.,
            Rogers,A.B., Fletcher,C.D., Huntsman,D.G., Roberts,C.W.M.,
            Rathmell,W.K. and Weissman,B.E.
  TITLE     High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/- Mice
  JOURNAL   Am J Pathol 188 (7), 1510-1516 (2018)
   PUBMED   29684361
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Kanno,H., Xu,Y., Miyakawa,T., Kubo,A., Higashida,T.,
            Kobayashi,N.B., Yoshida,T. and Tanokura,M.
  TITLE     BC-Box Motif-Mediated Neuronal Differentiation of Somatic Stem
            Cells
  JOURNAL   Int J Mol Sci 19 (2), 466 (2018)
   PUBMED   29401731
  REMARK    GeneRIF: VHL functions to induce neuronal differentiation of neural
            stem/progenitor cells and skin-derived precursors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Hao,J., Chen,X., Fu,T., Liu,J., Yu,M., Han,W., He,S., Qian,R. and
            Zhang,F.
  TITLE     The Expression of VHL (Von Hippel-Lindau) After Traumatic Spinal
            Cord Injury and Its Role in Neuronal Apoptosis
  JOURNAL   Neurochem Res 41 (9), 2391-2400 (2016)
   PUBMED   27324785
  REMARK    GeneRIF: that the change of VHL protein expression was related to
            neuronal apoptosis after spinal cord injury
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Pause,A., Lee,S., Worrell,R.A., Chen,D.Y., Burgess,W.H.,
            Linehan,W.M. and Klausner,R.D.
  TITLE     The von Hippel-Lindau tumor-suppressor gene product forms a stable
            complex with human CUL-2, a member of the Cdc53 family of proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2156-2161 (1997)
   PUBMED   9122164
REFERENCE   7  (bases 1 to 2807)
  AUTHORS   Walker,C., Ahn,Y.T., Everitt,J. and Yuan,X.
  TITLE     Renal cell carcinoma development in the rat independent of
            alterations at the VHL gene locus
  JOURNAL   Mol Carcinog 15 (2), 154-161 (1996)
   PUBMED   8599582
REFERENCE   8  (bases 1 to 2807)
  AUTHORS   Kikuchi,Y., Kobayashi,E., Nishizawa,M., Hamazaki,S., Okada,S. and
            Hino,O.
  TITLE     Cloning of the rat homologue of the von Hippel-Lindau tumor
            suppressor gene and its non-somatic mutation in rat renal cell
            carcinomas
  JOURNAL   Jpn J Cancer Res 86 (10), 905-909 (1995)
   PUBMED   7493907
REFERENCE   9  (bases 1 to 2807)
  AUTHORS   Duan,D.R., Humphrey,J.S., Chen,D.Y., Weng,Y., Sukegawa,J., Lee,S.,
            Gnarra,J.R., Linehan,W.M. and Klausner,R.D.
  TITLE     Characterization of the VHL tumor suppressor gene product:
            localization, complex formation, and the effect of natural
            inactivating mutations
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6459-6463 (1995)
   PUBMED   7604013
REFERENCE   10 (bases 1 to 2807)
  AUTHORS   Seeburg,P.H., Wisden,W., Verdoorn,T.A., Pritchett,D.B., Werner,P.,
            Herb,A., Luddens,H., Sprengel,R. and Sakmann,B.
  TITLE     The GABAA receptor family: molecular and functional diversity
  JOURNAL   Cold Spring Harb Symp Quant Biol 55, 29-40 (1990)
   PUBMED   1966765
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_052801.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U14746.1, SRR22399481.623678.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               JAXUCZ010000004.1  148328099-148328455
            358-480             JAXUCZ010000004.1  148331599-148331721
            481-2807            JAXUCZ010000004.1  148332666-148334992
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2807
                     /gene="Vhl"
                     /gene_synonym="Vhlh"
                     /note="von Hippel-Lindau tumor suppressor"
                     /db_xref="GeneID:24874"
                     /db_xref="RGD:3960"
     exon            1..357
                     /gene="Vhl"
                     /gene_synonym="Vhlh"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..677
                     /gene="Vhl"
                     /gene_synonym="Vhlh"
                     /note="pVHL; von Hippel-Lindau syndrome homolog; von
                     Hippel-Lindau tumor suppressor, E3 ubiquitin protein
                     ligase; von Hippel-Lindau protein"
                     /codon_start=1
                     /product="von Hippel-Lindau disease tumor suppressor"
                     /protein_id="NP_434688.1"
                     /db_xref="GeneID:24874"
                     /db_xref="RGD:3960"
                     /translation="MPRKAASPEEAERMPGSEEIEAGRPRPVLRSVNSREPSQVIFCN
                     RSPRVVLPLWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELF
                     VPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNV
                     RKDIQRLTQEHLENQALGEEPEGVH"
     exon            358..480
                     /gene="Vhl"
                     /gene_synonym="Vhlh"
                     /inference="alignment:Splign:2.1.0"
     exon            481..2807
                     /gene="Vhl"
                     /gene_synonym="Vhlh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgttaaa gccggacgga gtacttctat tgctggcaga cctgccccgg agcgcgtaaa
       61 cccgcacgct cgcgccgccc acgtccagct cgcgaatccg gaggcgtccg gttccaataa
      121 tgccccggaa ggcagctagt ccagaggagg cagaaaggat gccgggctct gaagagatag
      181 aggctgggcg gccgcggccg gttttacgct ctgtgaactc gcgcgaaccc tctcaggtca
      241 tcttctgcaa ccgcagcccg cgcgtcgtgc tgcctttgtg gctcaacttt gatggtgagc
      301 ctcagcccta cccgacctta ccaccgggca ccggccgccg catccacagc taccgaggtc
      361 acctttggct cttcagggat gcggggaccc atgatggact tctggttaac caaacggaac
      421 tgtttgtgcc atccctcaat gttgatggac agcctatttt tgccaacatc acattgccag
      481 tgtataccct gaaagagcgg tgccttcagg ttgtacggag cctggtcaag cctgagaact
      541 acaggaggct ggacatcgtc aggtcgctct atgaagactt ggaagaccac ccaaatgtgc
      601 ggaaagacat acagcggctg acccaagagc acctcgagaa tcaggccctg ggagaggagc
      661 ctgaaggagt ccactgagat tactggtcct gaatttcggc cttgatggtc tgaaattgat
      721 ctacacatag gacaggtcac tttctttcgg ttttaaaatg gttcattctt ggagtaaaat
      781 atccatcatg taaaagaaag ttaactaaca tcactgagct ttgtagtgtt taagactaaa
      841 cctgcaaagt gccaccgagt ctgccctttc tagagcattc atcagaagaa gctgttttca
      901 gttttgcttc ctagtaaggc tggatgttca gcataaggat gttagtgtga gcaattcgca
      961 ggagttgctc tgtgtcctct aatctgaaga atacagcctc gtatgaacag agccccaccg
     1021 ctcacttggg gaaggctgag aaggccctaa tgctgggatg gacatcctgt agaggcccag
     1081 tgcctaatgt gtgtggagtc ttcagtcagt gttggaggaa caaaccattg ggtacttagt
     1141 gggagagttg gagggcctgg ctctctgtct gaggaaatct taagtgtaca tgtaaaggaa
     1201 cagcttagca gcttctgttt agaaagaact ttctcttgag tttccatgtc tcagcacttt
     1261 ctttctactt tgttagttta ttttatttta tttttgagac ttgtgtagcc caggtcagcc
     1321 tcagtcactc cggaggggat gctggtcttg aattccggat cctctgggag tgtgtcagca
     1381 ttgggagcac atgggtgcac cacagtctgc tctgttcttg cttttcccat tttgagacgg
     1441 gctcatactg tagccctgcc tggcctcaag ctagagtcag ccctgtctcc ccacccagtc
     1501 tggctgctta gactgggtgg gcttcccata ttcactgccc cagacagcag agacgagctg
     1561 tccttgtgtt taggtctggt tttgagagtt ccttctctga ggaagctgct ggcaggagca
     1621 gggtttctgt tccttcccgt cagcccctag cattccaact gggcgccgca ctctgctttg
     1681 gcaggcgcta gttatgcttc gatgggagag gggagtgaag ctcccctcag ccacacactc
     1741 caaaccatgg gtcccagagc agtctgcaat gagtagtagt ttgtgggcag tcacagcttt
     1801 tcttacatat tcaaatattg atgttcacta cttctatcaa acattttgta gaacataatt
     1861 ttttatttgt ttttaattcc tcagcagaga aaaatgagag aagcttgggc attgtgtgtg
     1921 gcacacacca gaaaggacag tcagctgaga gggtgcagaa aggctcttgt gcgctggctc
     1981 tcagctgcat gtagtcctgt aacccagtgt tctctctagt acacatttta attggttaaa
     2041 gcactttgtc ctggccgaga tcataaggta tatacagttt tgtggcctga tttttcattg
     2101 aacttcattg ttttgttttc ccctcttttt cgtttttggt tttgtttttg gtttgttttt
     2161 tgctttttgt tttatcaaga tagagtttct ctgtgtagcc caggctgtcc tggaactccc
     2221 tttgtagacc aaacaactga ttactggcct caaacggaga tctgtctgcc tctgcctctc
     2281 cagtgctggg attgaagtat gcctaatctt catctaactt agtaacttgt cttttccatg
     2341 ttactgcaca cactgtctaa attccggtgt gctagcctct ccctttgagg gtgactgttg
     2401 ggagtatttg tctcagtcct gggctccttg agtgcagtct gatgctctaa gatcagcaaa
     2461 atcactgaac ttaatactga cactcctgcc gccctctcag cgtctctcct tagtctgcag
     2521 cattccatga gtgaaggggc cacaggccag tgtggagcct gtgtgtggga agtcagcagg
     2581 tgccgagcta ttgcaacatt ggttttattt tttaaaccta tctctgtctc taaaagatgt
     2641 aatgtttgtc ttatttaact ggaagtttga atactgttct ctgtgcctta ggacatgagt
     2701 cacttgtcct tgcacatcct gtaagtgtgt tcctcagact ttgtactctc ctttgagttc
     2761 tctgaaaaag ctgaccttta gtacaataaa cggtgctaag tgaagga
//
