LOCUS       NM_001015004            2868 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus vestigial-like family member 4 (Vgll4),
            transcript variant 1, mRNA.
ACCESSION   NM_001015004 XM_216249
VERSION     NM_001015004.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2868)
  AUTHORS   Farley,A., Gao,Y., Sun,Y., Zohrabian,S., Pu,W.T. and Lin,Z.
  TITLE     Activation of VGLL4 Suppresses Cardiomyocyte Maturational
            Hypertrophic Growth
  JOURNAL   Cells 13 (16), 1342 (2024)
   PUBMED   39195232
  REMARK    GeneRIF: Activation of VGLL4 Suppresses Cardiomyocyte Maturational
            Hypertrophic Growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2868)
  AUTHORS   Jiao,S., Li,C., Hao,Q., Miao,H., Zhang,L., Li,L. and Zhou,Z.
  TITLE     VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo
            signalling in colorectal cancer
  JOURNAL   Nat Commun 8, 14058 (2017)
   PUBMED   28051067
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2868)
  AUTHORS   Lin,Z., Guo,H., Cao,Y., Zohrabian,S., Zhou,P., Ma,Q., VanDusen,N.,
            Guo,Y., Zhang,J., Stevens,S.M., Liang,F., Quan,Q., van Gorp,P.R.,
            Li,A., Dos Remedios,C., He,A., Bezzerides,V.J. and Pu,W.T.
  TITLE     Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal
            Cardiac Growth
  JOURNAL   Dev Cell 39 (4), 466-479 (2016)
   PUBMED   27720608
REFERENCE   4  (bases 1 to 2868)
  AUTHORS   Chen,H.H., Mullett,S.J. and Stewart,A.F.
  TITLE     Vgl-4, a novel member of the vestigial-like family of transcription
            cofactors, regulates alpha1-adrenergic activation of gene
            expression in cardiac myocytes
  JOURNAL   J Biol Chem 279 (29), 30800-30806 (2004)
   PUBMED   15140898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 26, 2021 this sequence version replaced NM_001015004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091399.1, SRR26360186.608955.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-497               JAXUCZ010000004.1  149660098-149660594 c
            498-687             JAXUCZ010000004.1  149627698-149627887 c
            688-883             JAXUCZ010000004.1  149602177-149602372 c
            884-1007            JAXUCZ010000004.1  149601062-149601185 c
            1008-2868           JAXUCZ010000004.1  149598883-149600743 c
FEATURES             Location/Qualifiers
     source          1..2868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2868
                     /gene="Vgll4"
                     /note="vestigial-like family member 4"
                     /db_xref="GeneID:297523"
                     /db_xref="RGD:1311653"
     exon            1..497
                     /gene="Vgll4"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1279
                     /gene="Vgll4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription cofactor vestigial-like protein 4; vestigial
                     like 4"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 4
                     isoform 1"
                     /protein_id="NP_001015004.1"
                     /db_xref="GeneID:297523"
                     /db_xref="RGD:1311653"
                     /translation="MLFMKMDLLNYQYLDKMNNNIGVLCYEGEASLRGEPRMQTLPVA
                     SALSSHRTGPPPISPSKRKFSLEHGDKDLDCENDHVSKMSRIFSPHLNKTVNGDCRRD
                     PRERSRSPIERAAAPAVSLHGGHLYASLPSLMEQPLALTKNSSDTGRSAVERQQNRPS
                     VITCASAGARNCNLSHCPIAHSGCSAPGSASYRRPPSATATCDPVVEEHFRRSLGKNY
                     KEPEPAPNSVSITGSVDDHFAKALGDTWLQIKAAKDSASSSPESASRRGQPASPTAHM
                     VSHSHSPSVVS"
     exon            498..687
                     /gene="Vgll4"
                     /inference="alignment:Splign:2.1.0"
     exon            688..883
                     /gene="Vgll4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1007
                     /gene="Vgll4"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..2868
                     /gene="Vgll4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacgagtcat accaagcata gccagcatgt cagtgcagtc agcttgcagc gggctgtgag
       61 ggagagtgcc tttgtcctaa gaaatgtgct ttgtgttttt cttttttact gctttctttt
      121 taaaccccca agacaggctt gagaagactt ctgaaatgat tttttaaagc cgaatagaag
      181 acaggatccg acacctccca caagcccttg acgggttttg tttgagtctg atttttttgt
      241 gtgtatgatt ttttttttaa agccttttac atactttgtt ttgatcttgt gaggctgggc
      301 ctctgtcttc ctgaagtgtt aggagagcct ggtgctactc agctaaagac tgaattttga
      361 aactttctgg gggtaaaagc aaagaactgt ttttctttgc tagccggaca gataaatgct
      421 gtttatgaag atggacctgt tgaactacca gtacttggac aagatgaaca acaatatcgg
      481 cgttctgtgc tatgaaggtg aagcttccct caggggagaa cccagaatgc agaccctccc
      541 ggtggcctca gctcttagca gccaccgcac aggtccgcct cccatcagcc ccagcaagag
      601 gaaattcagc ctggaacacg gggacaagga cttggactgt gaaaatgacc acgtctccaa
      661 gatgagccga atcttcagcc cccatttgaa taagactgtc aacggagact gccgcagaga
      721 tccccgggaa cggagccgca gtcccatcga acgggctgca gcccccgctg taagcttgca
      781 tggtggccac ctgtatgcat ccctccccag cctcatggag cagcctcttg ccctgactaa
      841 gaacagcagt gacacaggaa ggtcagctgt ggagcggcag cagaaccggc cctccgtcat
      901 cacctgtgca tctgccggcg cccgcaactg caacctctct cactgtccca tcgcacacag
      961 tggctgttct gcgcctgggt ctgccagcta ccggagacca cccagtgcga ctgccacctg
     1021 tgaccctgtg gtggaagagc acttccgtcg gagcctgggc aagaactaca aggaaccaga
     1081 gccagcacct aactccgtgt ccatcactgg ctctgtggac gaccactttg ccaaagcact
     1141 aggtgacaca tggcttcaga tcaaagcggc caaggacagc gcatccagca gcccagagtc
     1201 agcctcacgc aggggccagc cagccagccc cactgcccac atggtcagcc acagtcactc
     1261 tccctctgtg gtctcctgaa ggggggagcc acccttccac cacacaggaa tctgcatggt
     1321 ttgcctgagc tttgaacagt cagtgcttaa aaaaaaaaag caaaaagaaa aaaaacaaaa
     1381 aaacaaaaca aaacaaaaaa aaaaaaaaaa gaaagaaaaa aatcccgggt tggggggtgg
     1441 ggggatggtt tattcgcaaa accatgttgt ctggactttt gttctgctct gttttatact
     1501 tgcttggtgt tcatacaagg ggcctcatgt ggcagcagaa cagcacggag cattatgtcc
     1561 agcagagcat ccttgcttcc tgccctggct accaaagaaa cttctgcagg tctgccgcct
     1621 ggcagccggg accctgcggc cctttctcag tcacaagcca tgatgacatg gggatccgga
     1681 cgctttgtgc tcttagcttt tgaggctggg cctgcacagc ttggcttcca cctgggggct
     1741 ggctccgtct gcatttgcat gtgtctgcct gaagagaact gtcctgattt gcactaggga
     1801 gggcagggct gcctgctggg cagtactgag ggcaaactgc tagggaacac ttctgacctt
     1861 gtgtgcttgc atttgttgct gaacttggaa ggtctctagc aggttctagg tctttctcta
     1921 ggcttgaggt gctcacagct ggactgcaga ctcccccgac catgggcatt taccgtctct
     1981 gaacactgca gtttgcgagg ctggtgccga ggctggagga ctctgtagtg cttctgacat
     2041 ggtgcatgtc tcaaagaaaa aaaaaaaata gctggtttct attgactaag cccagactgt
     2101 agcactgact ggcttcttgt cggcattagc ctgtttcgtc agtctcagcc ctggatacat
     2161 tcactgctgg cacagctgtg cttctgagat gagtcaacgc tcgctctgct ccaaagagga
     2221 gcgcacagcc agtgggtgtg gcaggctggg gaagcccgtt gctgctcatt ttctgcatcc
     2281 tgggctgggg acttggagtt catgtcttta gactccttga tacacagact gctcctttcc
     2341 aactcctggc caaacatcag gtgcctgaca gcctgcagca cggagctgcg tgctcgtcct
     2401 cctatgctgg ggccaaggct gtacacattc ctctgactat acagttattc ctgcaccact
     2461 attcctgcac tattaatagc tactaactag acattagaag ccagcaggac agacacggct
     2521 ggggatgcct aacagctgct gctcctccca gccttgagca tttctgtccc ctggcctggc
     2581 ccacctaagg gcgtcacttg gccaggagct ccttcctcac aaagcattat ggactcctgc
     2641 acgtgggagc ccatggggct gactttcagt aggaggaaac aggttagctg ttgaacttgg
     2701 gaaataggca caggtggaaa ggtggggact gattcccgta gtcgcagggt gactactggc
     2761 ctttacaaac atggacagcc ctcctcctgc cccgcacaag gttcactcca ctctcctggg
     2821 cttccaagct tggcattcag gcccttatat tttctgtagg aaaaaaaa
//
