LOCUS       NM_031761               1494 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus vascular endothelial growth factor D (Vegfd),
            mRNA.
ACCESSION   NM_031761 XM_346872
VERSION     NM_031761.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1494)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 1494)
  AUTHORS   Zhao,T., Zhao,W., Chen,Y., Liu,L., Ahokas,R.A. and Sun,Y.
  TITLE     Differential expression of vascular endothelial growth factor
            isoforms and receptor subtypes in the infarcted heart
  JOURNAL   Int J Cardiol 167 (6), 2638-2645 (2013)
   PUBMED   22818386
  REMARK    GeneRIF: Expression of VEGF-D and its receptor, VEGFR-3, are
            enhanced in various cell types in the infarcted heart.
REFERENCE   3  (bases 1 to 1494)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 1494)
  AUTHORS   Schwartz,C.M., Tavakoli,T., Jamias,C., Park,S.S., Maudsley,S.,
            Martin,B., Phillips,T.M., Yao,P.J., Itoh,K., Ma,W., Rao,M.S.,
            Arenas,E. and Mattson,M.P.
  TITLE     Stromal factors SDF1alpha, sFRP1, and VEGFD induce dopaminergic
            neuron differentiation of human pluripotent stem cells
  JOURNAL   J Neurosci Res 90 (7), 1367-1381 (2012)
   PUBMED   22535492
REFERENCE   5  (bases 1 to 1494)
  AUTHORS   Pezzilli,R., Fabbri,D., Corsi,M.M., Imbrogno,A., Barassi,A.,
            Morselli-Labate,A.M., Dogliotti,G., Casadei,R., Corinaldesi,R. and
            Melzi d'Eril,G.
  TITLE     Plasma concentrations of angiogenetic factors and angiogenetic
            inhibitors in patients with ductal pancreatic neoplasms. A pilot
            study
  JOURNAL   Clin Chem Lab Med 49 (6), 1047-1051 (2011)
   PUBMED   21410412
REFERENCE   6  (bases 1 to 1494)
  AUTHORS   Baldwin,M.E., Catimel,B., Nice,E.C., Roufail,S., Hall,N.E.,
            Stenvers,K.L., Karkkainen,M.J., Alitalo,K., Stacker,S.A. and
            Achen,M.G.
  TITLE     The specificity of receptor binding by vascular endothelial growth
            factor-d is different in mouse and man
  JOURNAL   J Biol Chem 276 (22), 19166-19171 (2001)
   PUBMED   11279005
REFERENCE   7  (bases 1 to 1494)
  AUTHORS   Tretter,V., Hauer,B., Nusser,Z., Mihalek,R.M., Hoger,H.,
            Homanics,G.E., Somogyi,P. and Sieghart,W.
  TITLE     Targeted disruption of the GABA(A) receptor delta subunit gene
            leads to an up-regulation of gamma 2 subunit-containing receptors
            in cerebellar granule cells
  JOURNAL   J Biol Chem 276 (13), 10532-10538 (2001)
   PUBMED   11136737
REFERENCE   8  (bases 1 to 1494)
  AUTHORS   Achen,M.G., Jeltsch,M., Kukk,E., Makinen,T., Vitali,A., Wilks,A.F.,
            Alitalo,K. and Stacker,S.A.
  TITLE     Vascular endothelial growth factor D (VEGF-D) is a ligand for the
            tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 548-553 (1998)
   PUBMED   9435229
REFERENCE   9  (bases 1 to 1494)
  AUTHORS   Yamada,Y., Nezu,J., Shimane,M. and Hirata,Y.
  TITLE     Molecular cloning of a novel vascular endothelial growth factor,
            VEGF-D
  JOURNAL   Genomics 42 (3), 483-488 (1997)
   PUBMED   9205122
REFERENCE   10 (bases 1 to 1494)
  AUTHORS   Orlandini,M., Marconcini,L., Ferruzzi,R. and Oliviero,S.
  TITLE     Identification of a c-fos-induced gene that is related to the
            platelet-derived growth factor/vascular endothelial growth factor
            family
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11675-11680 (1996)
   PUBMED   8876195
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1603]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_031761.3.
            
            On Nov 26, 2020 this sequence version replaced NM_031761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF014827.1, AY032728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676788 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               JAXUCZ010000021.1  33739534-33739892   c
            360-585             JAXUCZ010000021.1  33721260-33721485   c
            586-776             JAXUCZ010000021.1  33715343-33715533   c
            777-925             JAXUCZ010000021.1  33712594-33712742   c
            926-1026            JAXUCZ010000021.1  33711218-33711318   c
            1027-1494           JAXUCZ010000021.1  33706055-33706522   c
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..1494
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /note="vascular endothelial growth factor D"
                     /db_xref="GeneID:360457"
                     /db_xref="RGD:620695"
     exon            1..359
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1250
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /note="c-fos-induced growth factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor D precursor"
                     /protein_id="NP_113949.2"
                     /db_xref="GeneID:360457"
                     /db_xref="RGD:620695"
                     /translation="MYGEWAAVNILMMSYVYLVQGFSSEHRAVKDVSFERSSRSVLER
                     SEQQIRAASSLEELLQVAHSEDWKLWRCRLKLKSLASVDSRSTSHRSTRFAATFYDTE
                     TLKVIDEEWQRTQCSPRETCVEVASELGKTTNTFFKPPCVNVFRCGGCCNEESVMCMN
                     TSTSYISKQLFEISVPLTSVPELVPVKIANHTGCKCLPTGPRHPYSIIRRSIQIPEED
                     QCPHSKKLCPVDMLWDNTKCKCVLQDENPLPGTEDHSYLQEPALCGPHMMFDEDRCEC
                     VCKAPCPGDLIQHPENCSCFECKESLESCCQKHKMFHPDTCRSMVFSLSP"
     exon            360..585
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /inference="alignment:Splign:2.1.0"
     exon            586..776
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /inference="alignment:Splign:2.1.0"
     exon            777..925
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1026
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1494
                     /gene="Vegfd"
                     /gene_synonym="Figf; Vegf-d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacctctt gattatttgt gcagcgggaa actttgaaat agttttcatc tctttctccc
       61 atactaagat tgtgtgtggc cgtgggggag tccttgacta actcaagtca tttcattgga
      121 ttttgattac aactgatcat gtgatatttt tttccatgta aagttttggg gcttcaaact
      181 ttgcttctgg agaatgcctt ttgcaacact tttcagtagc tgcctggaaa caactgctta
      241 gccatcagtg gacatttgaa atattcaaaa tgtatggaga gtgggccgca gtgaatattc
      301 tcatgatgtc ctatgtgtac ctggtgcagg gcttcagtag tgaacaccga gcagtgaagg
      361 atgtttcttt tgagcgatca tcccggtctg tgttggaacg ttctgaacaa cagatccgcg
      421 cggcttctag tttggaggag ttgctgcaag tcgcacactc tgaggactgg aagctgtggc
      481 ggtgccggtt gaagcttaaa agtcttgcca gtgtggactc gcgctcaaca tcccatcgct
      541 ccaccagatt tgcggcaact ttctatgata ctgaaacact aaaagttata gatgaagaat
      601 ggcagaggac ccaatgcagc cctagagaga catgcgtaga agtcgccagt gagctcggga
      661 agacaaccaa cacattcttc aagccccctt gtgtaaatgt cttccggtgt ggaggatgct
      721 gcaatgaaga gagcgtgatg tgtatgaaca caagcacctc ctacatctcc aaacagctct
      781 ttgagatatc agtgcctctg acatcagtgc ccgagttagt gcctgttaaa attgccaacc
      841 atacgggttg taagtgcttg cccacgggcc cccggcatcc ctactcaatt atcagaagat
      901 ccattcagat cccagaagaa gatcaatgtc ctcattccaa gaaactctgt cctgttgaca
      961 tgctgtggga taacaccaaa tgtaaatgtg ttttacaaga tgagaatcca ctgcctggga
     1021 cagaagacca ctcttacctc caggaacccg ctctctgtgg accacacatg atgtttgatg
     1081 aagatcgctg cgagtgtgtc tgtaaagcac catgtcctgg agatctcatt cagcacccgg
     1141 aaaactgcag ttgctttgaa tgcaaagaaa gtctggaaag ctgttgccaa aagcacaaga
     1201 tgtttcaccc tgacacctgc agatcaatgg tcttttcact gtccccttaa tttggtttac
     1261 tggtgacatt taaaggacat actaacctga tttattgggg ctcttttctc tcagggccca
     1321 agcacactct taaaggaaca cagacgtttg gcctctaaga aatacatgga agtattatag
     1381 agtgatgatt aaattgtctt cttgtttcaa aacagggtct catgagttac agacccgtat
     1441 tgccatgcct gccgtcatgc tatcatgagc ggaaaagaag tcactggcat ttaa
//
