LOCUS       NM_053653               1913 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus vascular endothelial growth factor C (Vegfc),
            mRNA.
ACCESSION   NM_053653
VERSION     NM_053653.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   He,H., Wang,J., Zhang,Y., Wang,Y., Liu,Y., Li,X., Zhang,Y.,
            Yang,J., Hao,X., Wang,H. and Liu,H.
  TITLE     miR-455-3p regulates lymphangiogenesis in silicosis by regulating
            VEGF-C/VEGFR3
  JOURNAL   Ecotoxicol Environ Saf 278, 116444 (2024)
   PUBMED   38728943
  REMARK    GeneRIF: miR-455-3p regulates lymphangiogenesis in silicosis by
            regulating VEGF-C/VEGFR3.
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Jonas,F., Kesa,P., Paral,P., Pankrac,J., Kalbacova,M.H.,
            Miletin,J., Sukop,A., Molitor,M., Stanek,K., Sefc,L. and Mestak,O.
  TITLE     The Effect of Vascular Endothelial Growth Factor C and
            Adipose-Derived Stem Cells on Lymphatic Regeneration in a Rat
            Vascularized Lymph Node Transfer Model
  JOURNAL   J Reconstr Microsurg 39 (4), 311-319 (2023)
   PUBMED   35817403
  REMARK    GeneRIF: The Effect of Vascular Endothelial Growth Factor C and
            Adipose-Derived Stem Cells on Lymphatic Regeneration in a Rat
            Vascularized Lymph Node Transfer Model.
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Shen,K.F., Duan,Q.T., Duan,W., Xu,S.L., An,N., Ke,Y.Y., Wang,L.T.,
            Liu,S.Y., Yang,H. and Zhang,C.Q.
  TITLE     Vascular endothelial growth factor-C modulates cortical NMDA
            receptor activity in cortical lesions of young patients and rat
            model with focal cortical dysplasia
  JOURNAL   Brain Pathol 32 (5), e13065 (2022)
   PUBMED   35259773
  REMARK    GeneRIF: Vascular endothelial growth factor-C modulates cortical
            NMDA receptor activity in cortical lesions of young patients and
            rat model with focal cortical dysplasia.
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Olariu,R., Tsai,C., Abd El Hafez,M., Milusev,A., Banz,Y., Lese,I.,
            Leckenby,J.I., Constantinescu,M., Rieben,R., Vogelin,E. and
            Taddeo,A.
  TITLE     Presence of Donor Lymph Nodes Within Vascularized Composite
            Allotransplantation Ameliorates VEGF-C-mediated Lymphangiogenesis
            and Delays the Onset of Acute Rejection
  JOURNAL   Transplantation 105 (8), 1747-1759 (2021)
   PUBMED   34291766
  REMARK    GeneRIF: Presence of Donor Lymph Nodes Within Vascularized
            Composite Allotransplantation Ameliorates VEGF-C-mediated
            Lymphangiogenesis and Delays the Onset of Acute Rejection.
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Liu,J., Sun,F., Wang,X. and Bi,Q.
  TITLE     miR-27b promotes angiogenesis and skin repair in scalded rats
            through regulating VEGF-C expression
  JOURNAL   Lasers Med Sci 35 (7), 1577-1588 (2020)
   PUBMED   32170506
  REMARK    GeneRIF: miR-27b promotes angiogenesis and skin repair in scalded
            rats through regulating VEGF-C expression.
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Tanaka,K., Kurebayashi,J., Sonoo,H., Otsuki,T., Yamamoto,Y.,
            Ohkubo,S., Yamamoto,S. and Shimozuma,K.
  TITLE     Expression of vascular endothelial growth factor family messenger
            RNA in diseased thyroid tissues
  JOURNAL   Surg Today 32 (9), 761-768 (2002)
   PUBMED   12203051
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Kirkin,V., Mazitschek,R., Krishnan,J., Steffen,A., Waltenberger,J.,
            Pepper,M.S., Giannis,A. and Sleeman,J.P.
  TITLE     Characterization of indolinones which preferentially inhibit
            VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than
            VEGFR-2
  JOURNAL   Eur J Biochem 268 (21), 5530-5540 (2001)
   PUBMED   11683876
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Pepper,M.S., Baetens,D., Mandriota,S.J., Di Sanza,C., Oikemus,S.,
            Lane,T.F., Soriano,J.V., Montesano,R. and Iruela-Arispe,M.L.
  TITLE     Regulation of VEGF and VEGF receptor expression in the rodent
            mammary gland during pregnancy, lactation, and involution
  JOURNAL   Dev Dyn 218 (3), 507-524 (2000)
   PUBMED   10878616
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Fitz,L.J., Morris,J.C., Towler,P., Long,A., Burgess,P., Greco,R.,
            Wang,J., Gassaway,R., Nickbarg,E., Kovacic,S., Ciarletta,A.,
            Giannotti,J., Finnerty,H., Zollner,R., Beier,D.R., Leak,L.V.,
            Turner,K.J. and Wood,C.R.
  TITLE     Characterization of murine Flt4 ligand/VEGF-C
  JOURNAL   Oncogene 15 (5), 613-618 (1997)
   PUBMED   9247316
REFERENCE   10 (bases 1 to 1913)
  AUTHORS   Kukk,E., Lymboussaki,A., Taira,S., Kaipainen,A., Jeltsch,M.,
            Joukov,V. and Alitalo,K.
  TITLE     VEGF-C receptor binding and pattern of expression with VEGFR-3
            suggests a role in lymphatic vascular development
  JOURNAL   Development 122 (12), 3829-3837 (1996)
   PUBMED   9012504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 22, 2021 this sequence version replaced NM_053653.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY032729.1, SRR26360190.801312.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN16676784 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-422               JAXUCZ010000016.1  44560466-44560887   c
            423-624             JAXUCZ010000016.1  44489191-44489392   c
            625-815             JAXUCZ010000016.1  44487025-44487215   c
            816-967             JAXUCZ010000016.1  44476231-44476382   c
            968-1074            JAXUCZ010000016.1  44453090-44453196   c
            1075-1408           JAXUCZ010000016.1  44452477-44452810   c
            1409-1913           JAXUCZ010000016.1  44445293-44445797   c
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1913
                     /gene="Vegfc"
                     /note="vascular endothelial growth factor C"
                     /db_xref="GeneID:114111"
                     /db_xref="RGD:619800"
     exon            1..422
                     /gene="Vegfc"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1523
                     /gene="Vegfc"
                     /note="VRP; VEGF-C; flt4-L; flt4 ligand; vascular
                     endothelial growth factor-related protein"
                     /codon_start=1
                     /product="vascular endothelial growth factor C precursor"
                     /protein_id="NP_446105.1"
                     /db_xref="GeneID:114111"
                     /db_xref="RGD:619800"
                     /translation="MHLLCFLSLACSLLAAALIPGPREAPATVAAFESGLGFSEAEPD
                     GGEVKGFEGKDLEEQLRSVSSVDELMSVLYPDYWKMYKCQLRKGGWQQPSLNMRTGDT
                     VKLAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGAATNTFFKPPCVSVYRCGG
                     CCNSEGLQCMNTSTGYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVH
                     SIIRRSLPATLPQCQAANKTCPANYVWNNYMCQCLAQQDFIFYSNVEDDSSNGFHDVC
                     GPNKELDEDTCQCVCKGGLRPSSCGPHKELDRDSCQCVCKNKLFLNSCGANREFDENT
                     CQCVCKRTCPRNQPLNPGKCACECTENTQKCFLKGKKFHHQTCSCYRRPCTNRLKHCD
                     PGLSFSEEVCRCVPSYWKRPHLN"
     exon            423..624
                     /gene="Vegfc"
                     /inference="alignment:Splign:2.1.0"
     exon            625..815
                     /gene="Vegfc"
                     /inference="alignment:Splign:2.1.0"
     exon            816..967
                     /gene="Vegfc"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1074
                     /gene="Vegfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1408
                     /gene="Vegfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1913
                     /gene="Vegfc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccggcgcc ctcgcttcac ctcgccggcc gccactgagg gcagttcgga tgtccggttt
       61 cctgtgaggc tcgtacctga cactcagagc ctctccccgg cgcgggctgc catatccgag
      121 ggcaaaagtt ggaagccgct gagtcccagg agacgctcgc ccacgggggg tccccgggag
      181 gaaaccacgg gactgggacg aggagcggac ctcagcctcg caccccagcc tgcgcctgcc
      241 atcggaccgg cctcctcgct cccggtccat ccaccatgca cttgctgtgc ttcttgtctc
      301 tggcgtgttc cttgctcgcc gctgcgctga tccccggtcc gcgcgaggcg cccgccaccg
      361 tcgccgcctt cgagtcggga ctgggcttct cggaagcaga gccggacggg ggcgaggtca
      421 agggtttcga aggcaaagac ctggaggagc agttgcggtc tgtgtccagt gtagatgagc
      481 tcatgtctgt cctgtaccca gactactgga aaatgtacaa gtgccagcta aggaaaggcg
      541 gctggcagca gccctccctc aacatgagga caggggacac tgtaaaactt gctgctgcac
      601 attacaacac tgagatcctg aaaagtattg ataatgagtg gagaaagact caatgcatgc
      661 cacgtgaggt gtgtatagat gtggggaagg agtttggagc agccacaaac accttcttta
      721 aacctccatg tgtgtccgtc tacagatgtg ggggttgctg caacagtgaa gggctgcaat
      781 gcatgaacac cagcacaggt tacctcagca agacgttgtt tgaaattaca gtgcctctct
      841 ctcaaggccc caaaccagtc acaatcagtt ttgccaatca cacttcctgc cggtgcatgt
      901 ctaaactgga tgtttacaga caagttcatt caattattag acgttctctg ccagcaacat
      961 taccacagtg tcaggcagct aacaagactt gtccagcaaa ctacgtgtgg aataactaca
     1021 tgtgtcaatg cctggctcag caggatttta tcttttattc aaatgttgag gatgactcat
     1081 ccaatggatt ccatgatgtc tgtggaccca acaaggagtt ggatgaagac acctgccagt
     1141 gtgtctgcaa gggggggctt cgaccatcca gctgtggacc ccacaaagag ctagatagag
     1201 actcatgcca gtgtgtctgt aaaaacaaac ttttccttaa ttcatgtgga gccaacaggg
     1261 aatttgatga gaacacatgc cagtgtgtct gcaagagaac atgtccaaga aatcaacccc
     1321 tgaatcctgg aaaatgtgcc tgtgaatgta cagaaaacac acagaagtgc ttcctaaaag
     1381 ggaagaaatt ccaccatcaa acatgcagct gttacagacg accatgtaca aatcgactga
     1441 agcattgtga tccgggactg tcatttagtg aagaggtgtg tcgctgtgtc ccatcatatt
     1501 ggaaaagacc acatctgaac taagatcata ccagtttttc agtccatcat tttgctgcct
     1561 tgaaaaactg ttgccacatt agaactgtca atgcacagaa agactctgtg ggaccatggt
     1621 aacagggtcc aagtctctgt ttcctgaacc atgtggatta ctgtgggaat ggactggcat
     1681 tcatgtgcat aaagcctttt aagagactgg ttttctgcca gtgaccagac agctgaggtt
     1741 tttctcttgt gattttaaaa aagaaaaaaa agaatgacta tataatttat ttccactaaa
     1801 aatattgttc ctgcattcat ttttatagca ataacaattg ttaaagctca ttgtgatcag
     1861 tatttttata acatgcaaac tatgtttaaa ataaaaggaa aaatgtatta taa
//
