LOCUS       NM_053549               1812 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus vascular endothelial growth factor B (Vegfb),
            mRNA.
ACCESSION   NM_053549 XM_342006
VERSION     NM_053549.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Tu,S., Wang,X.Y., Zeng,L.X., Shen,Z.J. and Zhang,Z.H.
  TITLE     LncRNA TINCR improves cardiac hypertrophy by regulating the
            miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway
  JOURNAL   Lab Invest 102 (3), 253-262 (2022)
   PUBMED   34732848
  REMARK    GeneRIF: LncRNA TINCR improves cardiac hypertrophy by regulating
            the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway.
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Shang,R., Lal,N., Lee,C.S., Zhai,Y., Puri,K., Seira,O.,
            Boushel,R.C., Sultan,I., Rasanen,M., Alitalo,K., Hussein,B. and
            Rodrigues,B.
  TITLE     Cardiac-specific VEGFB overexpression reduces lipoprotein lipase
            activity and improves insulin action in rat heart
  JOURNAL   Am J Physiol Endocrinol Metab 321 (6), E753-E765 (2021)
   PUBMED   34747201
  REMARK    GeneRIF: Cardiac-specific VEGFB overexpression reduces lipoprotein
            lipase activity and improves insulin action in rat heart.
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Lal,N., Chiu,A.P., Wang,F., Zhang,D., Jia,J., Wan,A., Vlodavsky,I.,
            Hussein,B. and Rodrigues,B.
  TITLE     Loss of VEGFB and its signaling in the diabetic heart is associated
            with increased cell death signaling
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (6), H1163-H1175 (2017)
   PUBMED   28314760
  REMARK    GeneRIF: Loss of VEGFB and its downstream signaling is an early
            event following hyperglycemia, is sustained with disease
            progression, and could explain diabetic cardiomyopathy.
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Monastero,R., Garcia-Serrano,S., Lago-Sampedro,A.,
            Rodriguez-Pacheco,F., Colomo,N., Morcillo,S., Martin-Nunez,G.M.,
            Gomez-Zumaquero,J.M., Garcia-Fuentes,E., Soriguer,F.,
            Rojo-Martinez,G. and Garcia-Escobar,E.
  TITLE     Methylation patterns of Vegfb promoter are associated with gene and
            protein expression levels: the effects of dietary fatty acids
  JOURNAL   Eur J Nutr 56 (2), 715-726 (2017)
   PUBMED   26707994
  REMARK    GeneRIF: Data suggest that dietary fatty acids create
            epigenetic/nutrigenomic changes in methylation levels of CpG island
            at Vegfb promoter and changes in Vegfb expression in white
            adipocytes in vivo and in vitro, with particular up-regulation of
            DNA methylation by linoleic acid; Vegfb promoter methylation levels
            are closely related to Vegfb gene expression in visceral and
            subcutaneous adipose tissue.
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Nag,S., Eskandarian,M.R., Davis,J. and Eubanks,J.H.
  TITLE     Differential expression of vascular endothelial growth factor-A
            (VEGF-A) and VEGF-B after brain injury
  JOURNAL   J Neuropathol Exp Neurol 61 (9), 778-788 (2002)
   PUBMED   12230324
REFERENCE   7  (bases 1 to 1812)
  AUTHORS   Ikuta,T., Ariga,H. and Matsumoto,K.
  TITLE     Extracellular matrix tenascin-X in combination with vascular
            endothelial growth factor B enhances endothelial cell proliferation
  JOURNAL   Genes Cells 5 (11), 913-927 (2000)
   PUBMED   11122379
REFERENCE   8  (bases 1 to 1812)
  AUTHORS   Bellomo,D., Headrick,J.P., Silins,G.U., Paterson,C.A., Thomas,P.S.,
            Gartside,M., Mould,A., Cahill,M.M., Tonks,I.D., Grimmond,S.M.,
            Townson,S., Wells,C., Little,M., Cummings,M.C., Hayward,N.K. and
            Kay,G.F.
  TITLE     Mice lacking the vascular endothelial growth factor-B gene (Vegfb)
            have smaller hearts, dysfunctional coronary vasculature, and
            impaired recovery from cardiac ischemia
  JOURNAL   Circ Res 86 (2), E29-E35 (2000)
   PUBMED   10666423
REFERENCE   9  (bases 1 to 1812)
  AUTHORS   Olofsson,B., Pajusola,K., von Euler,G., Chilov,D., Alitalo,K. and
            Eriksson,U.
  TITLE     Genomic organization of the mouse and human genes for vascular
            endothelial growth factor B (VEGF-B) and characterization of a
            second splice isoform
  JOURNAL   J Biol Chem 271 (32), 19310-19317 (1996)
   PUBMED   8702615
REFERENCE   10 (bases 1 to 1812)
  AUTHORS   Olofsson,B., Pajusola,K., Kaipainen,A., von Euler,G., Joukov,V.,
            Saksela,O., Orpana,A., Pettersson,R.F., Alitalo,K. and Eriksson,U.
  TITLE     Vascular endothelial growth factor B, a novel growth factor for
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2576-2581 (1996)
   PUBMED   8637916
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076395.1.
            
            On Mar 26, 2005 this sequence version replaced XM_342006.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1812
                     /gene="Vegfb"
                     /note="vascular endothelial growth factor B"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
     exon            1..315
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..816
                     /gene="Vegfb"
                     /note="VRF; VEGF-B; VEGF-related factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor B precursor"
                     /protein_id="NP_446001.1"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
                     /translation="MSPLLRRLLLVALLQLACTQAPVSQFDGPSHQKKVVSWIDVYAR
                     ATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPIGQHQVRMQIL
                     MIQYPSSQLGEMSLEEHSQCECRPKRKESAVKPDSPRTLCPRCTQRRQRPDPRTCRCR
                     CRRRRFLHCQGRGLELNPDTCRSSET"
     exon            316..358
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            359..555
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            556..629
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            630..665
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            666..800
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1803
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctgcccg ccgtcccggc caccaccacc aacacaggcc gcctgcctgt ctcgttcctt
       61 ctgccgccgc tgaggcgcta cgttgcgctg cctgcgccca gggctcggga gggggccgcg
      121 gaggagccgc cccccgcgcc cggcccgggg tccccacacc cgggcccgcg ccatgggact
      181 ctggctgccg ccgccccccg cgccgccggg ctagggcaat gcggtcgccc ccggcgctcg
      241 gcccccgcgg gcaccatgag ccccctgctc cgtcgcttgc tgcttgttgc gctgctgcag
      301 ctggcctgta cccaggcccc tgtgtcccag tttgatggcc ccagccacca gaagaaagtg
      361 gtgtcatgga tagatgttta tgcacgtgcc acatgccagc ccagggaggt ggtggtacct
      421 ctgagcatgg aactcatggg taatgtggtc aaacaactcg tgcccagctg tgtgactgtg
      481 cagcgctgtg gtggctgctg tcctgacgat ggcctggagt gtgtgcccat tgggcaacac
      541 caagtccgaa tgcagatcct catgatccag tacccgagca gtcagctggg ggagatgtcc
      601 ctggaagaac acagccaatg tgaatgcaga ccaaaaagaa aggagagtgc tgtgaagcca
      661 gacagcccca ggaccctctg cccacgctgc acccagcgcc gtcagcgccc tgatccccgg
      721 acctgccgtt gccgctgcag acgccgccgc ttcctccatt gccaagggcg gggcttagag
      781 ctcaacccag atacctgcag atcatcagaa acttagctca agactagatg cacaaatcag
      841 atggtgagag agatggtgtc accaccaata gaagatgcta agctctatga cagggacaac
      901 gatctaatct aagccatcaa ccatctcctg gaggggaact caagaagact ttttccacgg
      961 gctttacacg atagatattt gctccattct gtaggctctg agagagcaga gatgtatgag
     1021 agagagcctc gaatacttaa gtagcccttc tctgttccat agtgaggccc tgggatgatt
     1081 tatgggccag gccctggcgg cttctagaga gtatcaaata aaacagggtt ccaaaaagga
     1141 aatgcatcaa gaaggctggg cctggacatg gtggtacata tggggagttt tggcaataca
     1201 gagagagttt gaagccagcc tgggctatat ggaaccttgt ttaaaagcaa aacccacaga
     1261 agacaaaaaa taactgttgc tttggaatgg cagtgcacac ctgtaactcc agctctcagg
     1321 aggcagaggc aggaggatac gattttgaga acaagctggg ctgtagagca aagtgatctc
     1381 aacaaacagc aagaataaag aggggccggg tgtgtagctc agccggtaga gtgcttgccc
     1441 agcattcaag aaaccatctg taatgggatc cgatgccctc ttctggtgtg tctgaagaca
     1501 gctacagtgt actcatatat aatacataaa taaatcttta aaaaaaagcc ttcagtttga
     1561 tcttcaccaa atggaacaag gcatgacagc actcaaaggt tcagggtcgg gctggagaga
     1621 tggctcagcg gttaagagca cccgactact cttccagagg tcctgagttc aattcccagc
     1681 aaccacatgg tggctcacaa ccatctgtaa agagatctga tgctctcttc tggtgtatct
     1741 gaaaacatct acagtgtact tatatataat aaatgaataa atctttaaaa aaaaaaaaaa
     1801 aaaaaaaaaa aa
//
