LOCUS       NM_017058               2042 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus vitamin D receptor (Vdr), mRNA.
ACCESSION   NM_017058
VERSION     NM_017058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Song,T., Li,J., Xia,Y., Hou,S., Zhang,X. and Wang,Y.
  TITLE     1,25-D3 ameliorates ischemic brain injury by alleviating
            endoplasmic reticulum stress and ferroptosis: Involvement of
            vitamin D receptor and p53 signaling
  JOURNAL   Cell Signal 122, 111331 (2024)
   PUBMED   39094671
  REMARK    GeneRIF: 1,25-D3 ameliorates ischemic brain injury by alleviating
            endoplasmic reticulum stress and ferroptosis: Involvement of
            vitamin D receptor and p53 signaling.
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Chen,H., Zhang,H., Li,A.M., Liu,Y.T., Liu,Y., Zhang,W., Yang,C.,
            Song,N., Zhan,M. and Yang,S.
  TITLE     VDR regulates mitochondrial function as a protective mechanism
            against renal tubular cell injury in diabetic rats
  JOURNAL   Redox Biol 70, 103062 (2024)
   PUBMED   38320454
  REMARK    GeneRIF: VDR regulates mitochondrial function as a protective
            mechanism against renal tubular cell injury in diabetic rats.
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Ding,Y. and Wu,Q.
  TITLE     1,25D/VDR inhibits pancreatic beta cell ferroptosis by
            downregulating FOXO1 expression in diabetes mellitus
  JOURNAL   Cell Signal 105, 110564 (2023)
   PUBMED   36581217
  REMARK    GeneRIF: 1,25D/VDR inhibits pancreatic beta cell ferroptosis by
            downregulating FOXO1 expression in diabetes mellitus.
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Zhang,X., Zhou,K., Tian,K., Zhu,Q., Liu,W., Liu,Z., An,X., Tian,C.,
            Li,Y., Lu,F., Sun,F. and Zha,D.
  TITLE     VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear
            Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
  JOURNAL   Cells 11 (23), 3746 (2022)
   PUBMED   36497006
  REMARK    GeneRIF: VDR Regulates BNP Promoting Neurite Growth and Survival of
            Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling
            Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Li,Z., Prahl,J.M., Hellwig,W. and DeLuca,H.F.
  TITLE     Immunoaffinity purification of active rat recombinant
            1,25-dihydroxyvitamin D3 receptor
  JOURNAL   Arch Biochem Biophys 310 (2), 347-351 (1994)
   PUBMED   8179318
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Balmain,N., Hauchecorne,M., Pike,J.W., Cuisinier-Gleizes,P. and
            Mathieu,H.
  TITLE     Distribution and subcellular immunolocalization of
            1,25-dihydroxyvitamin D3 receptors in rat epiphyseal cartilage
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 39 (3), 339-350 (1993)
   PUBMED   8392883
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Hughes,M.R., Malloy,P.J., Kieback,D.G., Kesterson,R.A., Pike,J.W.,
            Feldman,D. and O'Malley,B.W.
  TITLE     Point mutations in the human vitamin D receptor gene associated
            with hypocalcemic rickets
  JOURNAL   Science 242 (4886), 1702-1705 (1988)
   PUBMED   2849209
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Burmester,J.K., Wiese,R.J., Maeda,N. and DeLuca,H.F.
  TITLE     Structure and regulation of the rat 1,25-dihydroxyvitamin D3
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 85 (24), 9499-9502 (1988)
   PUBMED   2849110
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Burmester,J.K., Maeda,N. and DeLuca,H.F.
  TITLE     Isolation and expression of rat 1,25-dihydroxyvitamin D3 receptor
            cDNA
  JOURNAL   Proc Natl Acad Sci U S A 85 (4), 1005-1009 (1988)
   PUBMED   2829212
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017058.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04147.1, SRR26643288.32172.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                JAXUCZ010000007.1  130916741-130916757 c
            18-92               JAXUCZ010000007.1  130897323-130897397 c
            93-240              JAXUCZ010000007.1  130893795-130893942 c
            241-371             JAXUCZ010000007.1  130885288-130885418 c
            372-556             JAXUCZ010000007.1  130879346-130879530 c
            557-665             JAXUCZ010000007.1  130879005-130879113 c
            666-837             JAXUCZ010000007.1  130876809-130876980 c
            838-989             JAXUCZ010000007.1  130869460-130869611 c
            990-1106            JAXUCZ010000007.1  130869148-130869264 c
            1107-2042           JAXUCZ010000007.1  130867070-130868005 c
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2042
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /note="vitamin D receptor"
                     /db_xref="GeneID:24873"
                     /db_xref="RGD:3959"
     exon            1..17
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            18..92
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..240
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1366
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /note="1,25-dihydroxyvitamin D3 receptor; vitamin D (1,25-
                     dihydroxyvitamin D3) receptor; nuclear receptor subfamily
                     1 group I member 1"
                     /codon_start=1
                     /product="vitamin D3 receptor"
                     /protein_id="NP_058754.2"
                     /db_xref="GeneID:24873"
                     /db_xref="RGD:3959"
                     /translation="MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGC
                     KGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQR
                     KREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRVD
                     GSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLS
                     PLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFT
                     MDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICI
                     VSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEE
                     HSKQYRSLSFQPENSMKLTPLVLEVFGNEIS"
     exon            241..371
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..556
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..665
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..837
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..989
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1106
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..2042
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccaccgcc agaccagagt tcttttggtc ggacagatct gtgagacttc ccaggagagc
       61 acccttgggc tctactcacc ctgctccttc agggatggag gcaacagcgg ccagcacctc
      121 cctgcccgac cctggtgact ttgaccggaa cgtgccccgg atctgtggag tgtgtggaga
      181 ccgagccaca ggcttccact tcaatgctat gacctgtgaa ggctgcaaag gtttcttcag
      241 gcggagcatg aagcgcaagg ccctgttcac ctgtcccttc aatggagatt gccgcatcac
      301 caaggacaac cggcgacact gccaggcctg ccggctcaaa cgctgtgtgg acatcggcat
      361 gatgaaggag ttcatcctga cagatgagga ggtacagcgt aagagggaga tgataatgaa
      421 gagaaaagag gaagaggcct tgaaggacag tctgaggccc aagctatctg aagaacaaca
      481 gcacatcata gccatcctgc tggacgccca ccacaagacc tatgacccca cctacgctga
      541 cttcagggac ttccggcctc cagttcgtgt ggacggaagt acagggagct attctccaag
      601 gcccacactc agcttctccg ggaactcctc ctcctccagc tctgacctgt acaccacctc
      661 actagacatg atggaaccat ccggcttttc caacctggat ctgaacggag aggattctga
      721 tgacccgtct gtgactctgg acctgtctcc tctctccatg ctgccccacc tggctgacct
      781 tgtcagttac agcatccaaa aggtcatcgg ctttgccaag atgatcccag gattcaggga
      841 tctcacctcc gatgaccaga ttgtcctgct taagtcaagc gccattgagg tgatcatgtt
      901 acgctccaac cagtctttca ccatggatga tatgtcctgg gactgtggca gccaggacta
      961 caagtacgac gtcaccgatg tctccaaagc tgggcacacc ctggagctga tcgagcccct
     1021 cataaagttc caggtggggc tgaagaagct gaacttacat gaggaagagc atgtccttct
     1081 catggccatc tgcattgtct ccccggaccg acctggggtc caggacgcca agctggtgga
     1141 agccattcag gaccgcctat ccaacacgct gcagacctac atccgctgcc gccacccgcc
     1201 cccaggcagc caccagctct atgccaagat gatccagaaa ctggccgacc tgcggagcct
     1261 caacgaggaa cactccaaac aataccgctc cctctccttc cagcccgaga atagcatgaa
     1321 gctcacaccc cttgtgctgg aggtgttcgg caatgagatc tcctgaccag ggtggcccac
     1381 agtggtgcct gggtagggcc gctcctccag agccctgtgc ccaggccctg ggctggttgc
     1441 agcccagcag tgcctcctgc cctttctgga gttcagtcct tcctctgcca tggcctctgt
     1501 ctgtctgcct catcctttct cctgcccagc ctaacacctg gtctcccttt cctgtagacc
     1561 tcgagttgct cctgtctctt gagacctcag ttaggagagg ctgctgttta tctgacaaag
     1621 gaactcaatt ggggatagag ggcaggggct gaaggcagaa ctctgcctag gggatgcctc
     1681 caccacaagg ggctgctgct tgtgtcaagg gaggcaggca gaagagacgc attcactcct
     1741 cagggacagg tacctgcacc tcccctcact ccagccctac ctgcccaaag cctggtgaga
     1801 aatctggccc ctgcctgcga agggtacaca acctacccat catccctact gtgtcccgtc
     1861 tcatcctgcc gcctgtctgt gttattctga cccgggggag taggtcactg aggggcctcc
     1921 ttcctctgcc tttatactca cggggctcac tcactgccaa gatgaccaaa tacactacca
     1981 cacgaaccaa ggagcactca cccagccctg cagttcccac ctttgaggtt ttgccatggg
     2041 aa
//
