LOCUS       NM_031354               1715 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus voltage-dependent anion channel 2 (Vdac2), mRNA.
ACCESSION   NM_031354
VERSION     NM_031354.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Ramos,S.V., Hughes,M.C. and Perry,C.G.R.
  TITLE     Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is
            related to bioenergetic impairments after paclitaxel but not
            vinblastine chemotherapies
  JOURNAL   Am J Physiol Cell Physiol 316 (3), C449-C455 (2019)
   PUBMED   30624982
  REMARK    GeneRIF: Paclitaxel increased both alpha- and betaII-tubulin-VDAC2
            interactions.
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Fork,C., Hitzel,J., Nichols,B.J., Tikkanen,R. and Brandes,R.P.
  TITLE     Flotillin-1 facilitates toll-like receptor 3 signaling in human
            endothelial cells
  JOURNAL   Basic Res Cardiol 109 (6), 439 (2014)
   PUBMED   25204797
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Petit,F.M., Serres,C., Bourgeon,F., Pineau,C. and Auer,J.
  TITLE     Identification of sperm head proteins involved in zona pellucida
            binding
  JOURNAL   Hum Reprod 28 (4), 852-865 (2013)
   PUBMED   23355646
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   Feng,Y.Q., Chai,J.K., Chu,W.L., Duan,H.J., Ma,L. and Zhang,H.J.
  TITLE     [Voltage dependent anion channel 2 involved mitochondrial apoptosis
            and its possible regulatory signal pathway in hearts of rats with
            severe scalds]
  JOURNAL   Zhonghua Yi Xue Za Zhi 93 (12), 939-943 (2013)
   PUBMED   23863682
REFERENCE   5  (bases 1 to 1715)
  AUTHORS   Min,C.K., Yeom,D.R., Lee,K.E., Kwon,H.K., Kang,M., Kim,Y.S.,
            Park,Z.Y., Jeon,H. and Kim,D.H.
  TITLE     Coupling of ryanodine receptor 2 and voltage-dependent anion
            channel 2 is essential for Ca(2)+ transfer from the sarcoplasmic
            reticulum to the mitochondria in the heart
  JOURNAL   Biochem J 447 (3), 371-379 (2012)
   PUBMED   22867515
  REMARK    GeneRIF: the coupling of VDAC2 with RyR2 is essential for Ca2+
            transfer from the sarcoplasmic reticulum to mitochondria in the
            heart.
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1715)
  AUTHORS   Cheng,E.H., Sheiko,T.V., Fisher,J.K., Craigen,W.J. and
            Korsmeyer,S.J.
  TITLE     VDAC2 inhibits BAK activation and mitochondrial apoptosis
  JOURNAL   Science 301 (5632), 513-517 (2003)
   PUBMED   12881569
REFERENCE   8  (bases 1 to 1715)
  AUTHORS   Shinohara,Y., Ishida,T., Hino,M., Yamazaki,N., Baba,Y. and
            Terada,H.
  TITLE     Characterization of porin isoforms expressed in tumor cells
  JOURNAL   Eur J Biochem 267 (19), 6067-6073 (2000)
   PUBMED   10998068
REFERENCE   9  (bases 1 to 1715)
  AUTHORS   Blachly-Dyson,E., Zambronicz,E.B., Yu,W.H., Adams,V., McCabe,E.R.,
            Adelman,J., Colombini,M. and Forte,M.
  TITLE     Cloning and functional expression in yeast of two human isoforms of
            the outer mitochondrial membrane channel, the voltage-dependent
            anion channel
  JOURNAL   J Biol Chem 268 (3), 1835-1841 (1993)
   PUBMED   8420959
REFERENCE   10 (bases 1 to 1715)
  AUTHORS   Bureau,M.H., Khrestchatisky,M., Heeren,M.A., Zambrowicz,E.B.,
            Kim,H., Grisar,T.M., Colombini,M., Tobin,A.J. and Olsen,R.W.
  TITLE     Isolation and cloning of a voltage-dependent anion channel-like Mr
            36,000 polypeptide from mammalian brain
  JOURNAL   J Biol Chem 267 (12), 8679-8684 (1992)
   PUBMED   1373732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB039663.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039663.1, BC063164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..1715
                     /gene="Vdac2"
                     /note="voltage-dependent anion channel 2"
                     /db_xref="GeneID:83531"
                     /db_xref="RGD:621576"
     exon            1..146
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..205
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1059
                     /gene="Vdac2"
                     /note="voltage-dependent anion-selective channel protein
                     2; VDAC-2; B36-VDAC; outer mitochondrial membrane protein
                     porin 2"
                     /codon_start=1
                     /product="non-selective voltage-gated ion channel VDAC2"
                     /protein_id="NP_112644.1"
                     /db_xref="GeneID:83531"
                     /db_xref="RGD:621576"
                     /translation="MAECCVPVCQRPICIPPPYADLGKAARDIFNKGFGFGLVKLDVK
                     TKSCSGVEFSTSGSSNTDTGKVSGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQ
                     ICQGLKLTFDTTFSPNTGKKSGKIKSAYKRECINLGCDVDFDFAGPAIHGSAVFGYEG
                     WLAGYQMTFDSAKSKLTRSNFAVGYRTGDFQLHTNVNNGTEFGGSIYQKVCEDFDTSV
                     NLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVD
                     GKSFNAGGHKLGLALELEA"
     exon            206..274
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..324
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..530
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..758
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..909
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..967
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1702
                     /gene="Vdac2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaggcca ggcttgcggc ggggcgcaac ggtgtctcct tcacttcgcc ctccagccgc
       61 ggtggctgca gcgcaacttc cagatagcgg agtggcctca gctgcgagcc gagcggtggc
      121 ggcagcgccc ctcaggacac ccgcagatca ccttttcccc gcgacttcgc catggctgaa
      181 tgttgtgtac cggtatgcca acggccaatt tgtatccctc caccctatgc tgaccttggc
      241 aaagctgcca gagatatttt caacaaagga tttggttttg ggttggtaaa gctggatgtg
      301 aaaacgaagt catgcagtgg tgtggaattt tcaacatctg gctcatctaa tacagacact
      361 ggtaaagtca gtgggacctt ggagaccaag tacaaatggt gtgagtatgg tctgactttc
      421 acagagaaat ggaacactga caacactctg gggacggaga ttgcaattga agaccagatt
      481 tgtcaaggtt tgaaactgac ctttgacacc acgttttcac caaacacagg aaagaaaagt
      541 ggtaaaatca agtctgctta caagagggaa tgtataaacc ttggctgtga tgttgatttt
      601 gattttgctg gacctgccat ccatgggtca gccgtctttg gttacgaggg ctggcttgct
      661 gggtaccaga tgacctttga cagtgccaag tcaaagctga caaggagtaa cttcgcagtt
      721 ggctacagga ctggggactt ccagctacac acaaatgtaa ataatgggac agaatttgga
      781 ggatcaattt atcagaaagt atgtgaagat tttgacactt cagtaaacct tgcttggaca
      841 tcaggtacca actgcactcg ttttggcatt gcagctaaat accagttgga ccccactgct
      901 tctatttctg caaaggtcaa caactctagt ttaattggag tgggctatac tcagactctg
      961 aggcctggtg tgaagcttac actgtctgct ctggtagacg ggaagagctt taatgctgga
     1021 ggccacaaac ttgggcttgc cttggaattg gaggcttaat ccagttaaaa gaaacctctg
     1081 ggaacggata tcagaagatt tggccttaat atatttccat gcgaccagca ggctccccct
     1141 cccccccaga aggtgatcac atcaaaggat gattaagcaa gagcgtgttt taaatattta
     1201 gacagtcacc cgttggctgg tttctagttg gatggttatc tcgttatcag tgctgccgtc
     1261 gtgcggcctc ctctacatta tttaatgtac ttaactgtta aatgtgctac ccaccaatga
     1321 tgaaatagac gtttatgaaa accgtgccat ggtgtgcatg tttgttttat gttcctttta
     1381 cccttgactc ttgtactgaa tgagatggat cagtggatgt tttaagatga ggatgaagat
     1441 cttttttgtg atattcaccc atcactagaa tcactttggt aaccccaaac atgacaaatt
     1501 atgaataaaa cgagtgtaca caactaatgc ctcacgtatg tgcagtcaga ttgcagccta
     1561 ggggctaatc ttcttggtaa atacttctgg tgagcacttt gctctttacc gaaacttggg
     1621 caaccaaact ccctgtgtcc ctagcataat caatccacga ggtctttgag actacaataa
     1681 aatacaagga tacatgcttt aaaaaaaaaa aaaaa
//
