LOCUS       NM_031353               1802 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus voltage-dependent anion channel 1 (Vdac1), mRNA.
ACCESSION   NM_031353
VERSION     NM_031353.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Tiwari,S., Singh,A., Gupta,P., K,A. and Singh,S.
  TITLE     UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and
            Dopaminergic Neuronal Death
  JOURNAL   ACS Chem Neurosci 14 (5), 839-850 (2023)
   PUBMED   36755387
  REMARK    GeneRIF: UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and
            Dopaminergic Neuronal Death.
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Zhou,X., Tang,X., Li,T., Li,D., Gong,Z., Zhang,X., Li,Y., Zhu,J.,
            Wang,Y. and Zhang,B.
  TITLE     Inhibition of VDAC1 Rescues Abeta1-42-Induced Mitochondrial
            Dysfunction and Ferroptosis via Activation of AMPK and
            Wnt/beta-Catenin Pathways
  JOURNAL   Mediators Inflamm 2023, 6739691 (2023)
   PUBMED   36816741
  REMARK    GeneRIF: Inhibition of VDAC1 Rescues Abeta 1-42-Induced
            Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK
            and Wnt/beta-Catenin Pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   de Sousa,E., Movio,M.I., de Lima-Vasconcellos,T.H., Dos
            Santos,G.B., Dos Santos Gomes,T., Walter,L.T., da Silva,D.A.,
            Rodrigues,T., Cerchiaro,G. and Kihara,A.H.
  TITLE     VDAC1 regulates neuronal cell loss after retinal trauma injury by a
            mitochondria-independent pathway
  JOURNAL   Cell Death Dis 13 (4), 393 (2022)
   PUBMED   35449127
  REMARK    GeneRIF: VDAC1 regulates neuronal cell loss after retinal trauma
            injury by a mitochondria-independent pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Yang,X., Zhou,Y., Liang,H., Meng,Y., Liu,H., Zhou,Y., Huang,C.,
            An,B., Mao,H. and Liao,Z.
  TITLE     VDAC1 promotes cardiomyocyte autophagy in anoxia/reoxygenation
            injury via the PINK1/Parkin pathway
  JOURNAL   Cell Biol Int 45 (7), 1448-1458 (2021)
   PUBMED   33675282
  REMARK    GeneRIF: VDAC1 promotes cardiomyocyte autophagy in
            anoxia/reoxygenation injury via the PINK1/Parkin pathway.
REFERENCE   5  (bases 1 to 1802)
  AUTHORS   Klapper-Goldstein,H., Verma,A., Elyagon,S., Gillis,R.,
            Murninkas,M., Pittala,S., Paul,A., Shoshan-Barmatz,V. and Etzion,Y.
  TITLE     VDAC1 in the diseased myocardium and the effect of
            VDAC1-interacting compound on atrial fibrosis induced by
            hyperaldosteronism
  JOURNAL   Sci Rep 10 (1), 22101 (2020)
   PUBMED   33328613
  REMARK    GeneRIF: VDAC1 in the diseased myocardium and the effect of
            VDAC1-interacting compound on atrial fibrosis induced by
            hyperaldosteronism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1802)
  AUTHORS   Moon,J.I., Jung,Y.W., Ko,B.H., De Pinto,V., Jin,I. and Moon,I.S.
  TITLE     Presence of a voltage-dependent anion channel 1 in the rat
            postsynaptic density fraction
  JOURNAL   Neuroreport 10 (3), 443-447 (1999)
   PUBMED   10208569
REFERENCE   7  (bases 1 to 1802)
  AUTHORS   Narita,M., Shimizu,S., Ito,T., Chittenden,T., Lutz,R.J., Matsuda,H.
            and Tsujimoto,Y.
  TITLE     Bax interacts with the permeability transition pore to induce
            permeability transition and cytochrome c release in isolated
            mitochondria
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14681-14686 (1998)
   PUBMED   9843949
REFERENCE   8  (bases 1 to 1802)
  AUTHORS   Anflous,K., Blondel,O., Bernard,A., Khrestchatisky,M. and
            Ventura-Clapier,R.
  TITLE     Characterization of rat porin isoforms: cloning of a cardiac type-3
            variant encoding an additional methionine at its putative
            N-terminal region
  JOURNAL   Biochim Biophys Acta 1399 (1), 47-50 (1998)
   PUBMED   9714728
REFERENCE   9  (bases 1 to 1802)
  AUTHORS   Beutner,G., Ruck,A., Riede,B. and Brdiczka,D.
  TITLE     Complexes between porin, hexokinase, mitochondrial creatine kinase
            and adenylate translocator display properties of the permeability
            transition pore. Implication for regulation of permeability
            transition by the kinases
  JOURNAL   Biochim Biophys Acta 1368 (1), 7-18 (1998)
   PUBMED   9459579
REFERENCE   10 (bases 1 to 1802)
  AUTHORS   Blachly-Dyson,E., Zambronicz,E.B., Yu,W.H., Adams,V., McCabe,E.R.,
            Adelman,J., Colombini,M. and Forte,M.
  TITLE     Cloning and functional expression in yeast of two human isoforms of
            the outer mitochondrial membrane channel, the voltage-dependent
            anion channel
  JOURNAL   J Biol Chem 268 (3), 1835-1841 (1993)
   PUBMED   8420959
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000219.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_031353.3.
            
            On Nov 27, 2020 this sequence version replaced NM_031353.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039662.1, BC104684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JACYVU010000219.1  24565620-24565682
            64-133              JACYVU010000219.1  24578057-24578126
            134-183             JACYVU010000219.1  24578668-24578717
            184-336             JACYVU010000219.1  24579579-24579731
            337-389             JACYVU010000219.1  24579825-24579877
            390-617             JACYVU010000219.1  24587226-24587453
            618-768             JACYVU010000219.1  24589272-24589422
            769-826             JACYVU010000219.1  24591024-24591081
            827-1802            JACYVU010000219.1  24591981-24592956
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1802
                     /gene="Vdac1"
                     /note="voltage-dependent anion channel 1"
                     /db_xref="GeneID:83529"
                     /db_xref="RGD:621575"
     exon            1..63
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..133
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..918
                     /gene="Vdac1"
                     /note="VDAC-1; rVDAC1; outer mitochondrial membrane
                     protein porin 1"
                     /codon_start=1
                     /product="voltage-dependent anion-selective channel
                     protein 1"
                     /protein_id="NP_112643.1"
                     /db_xref="GeneID:83529"
                     /db_xref="RGD:621575"
                     /translation="MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSS
                     GSANTETTKVNGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSS
                     FSPNTGKKNAKIKTGYKREHINLGCDVDFDIAGPSIRGALVLGYEGWLAGYQMNFETS
                     KSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTR
                     FGIAAKYQVDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLG
                     LGLEFQA"
     exon            134..183
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..336
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..389
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..617
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..768
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..826
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1802
                     /gene="Vdac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcctcc tcgccgcaac ccccgccgta gctgccgctg ctctcgccgt caccgcctcc
       61 gagaacatgg ctgtgcctcc cacatatgct gatcttggca agtccgccag ggatgtcttc
      121 accaagggct acggctttgg cttaataaaa cttgatttga aaacgaagtc cgagaatgga
      181 ttggaattta ctagctcagg ttctgccaac acggagacca ccaaagtgaa cggcagtctg
      241 gaaaccaagt acagatggac cgagtatggg ctgacgttta ctgagaagtg gaacacagac
      301 aacaccctgg gcactgagat caccgtggaa gaccagcttg ctcgtggact gaagctgacc
      361 tttgattcat ctttctcgcc taacactggg aaaaaaaatg ctaaaatcaa gacagggtac
      421 aagagggagc atatcaacct gggctgtgat gtggactttg acatcgctgg gccctcaatc
      481 cggggcgctc tggtgcttgg ctatgagggt tggctggctg gctaccagat gaattttgag
      541 acctcgaagt cccgagtgac ccagagcaac tttgcagttg gctacaagac ggacgaattc
      601 cagcttcata ctaatgtgaa tgatgggacg gagtttggtg gctccattta ccagaaggtg
      661 aacaagaagt tggagactgc tgtcaatctc gcctggaccg caggaaacag taacactcgc
      721 tttggaatag cagccaagta tcaggtcgac cctgatgcct gcttttcggc caaagtgaac
      781 aactccagtc taattggctt agggtacact cagaccctaa aaccaggtat caaactgaca
      841 ctgtcagccc tgctggatgg caagaacgtc aatgcgggtg gccacaagct tggtttagga
      901 ctggaatttc aagcataaat gaatattgta caatcgttaa ttttaaacta ttttgcagca
      961 tagctacctt cagagtttag tgtacctttt aatgtcatat gttggggatg cgagagttga
     1021 ttgataccac gttagacctc caggctaagg atgactcggc tttaaggtgt ttaccgtttc
     1081 agaggtacag cggaaacccc attccaggaa gggtcctttt tagctgtagg cgtgggctgg
     1141 ggaggagctc ctctagagat gccaggctgc aagtggaagc tgggaacgtg tggacccttt
     1201 gtaaatctgt atccagtccg cacatgaaat tgtgacttcc tgaacatcga accccggtgt
     1261 cccgatcctg tctgctcgga agcatgtaca cacctacgtg aaagggacgg tttttttttt
     1321 ttttttatcg gatggtcacg ccctgttccc atcgtgccct gttcccatcc tagcccatca
     1381 gttacctgtt ttacaccaaa agtagtcttt agggtgtagt tagcaatttc ttttgtgcca
     1441 ttttagggtg gagagggtgg gcatgatgaa gccagtcatt caggacttaa ttcttccttg
     1501 tgttgtggtg tggttttctt cctttcttct gttttttttt tttaattcct ttttttttgc
     1561 cattgcacca gagtatgaaa tagcttccag gttctccggc tcagagctgg gcgggtgatt
     1621 gtggtcacac cctgacaaca ctagggatct caacggactc ctcttgtagc cgcaccacta
     1681 tttttagcag tttaatgggt acattataga gtcttccatt ttgtgtggaa ttagctcctc
     1741 cccttcaaat gctgtaatta acatcactta aaataaaact tgaataaaat actgaaacct
     1801 ca
//
