LOCUS       NM_176857               3864 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus valosin containing protein interacting protein 1
            (Vcpip1), mRNA.
ACCESSION   NM_176857
VERSION     NM_176857.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3864)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   2  (bases 1 to 3864)
  AUTHORS   Totsukawa,G., Kaneko,Y., Uchiyama,K., Toh,H., Tamura,K. and
            Kondo,H.
  TITLE     VCIP135 deubiquitinase and its binding protein, WAC, in
            p97ATPase-mediated membrane fusion
  JOURNAL   EMBO J 30 (17), 3581-3593 (2011)
   PUBMED   21811234
  REMARK    GeneRIF: WAC is hence thought to function in p97/p47-mediated Golgi
            membrane fusion by activating the deubiquitinating function of
            VCIP135.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3864)
  AUTHORS   Arakawa,T., Katada,A., Shigyo,H., Kishibe,K., Adachi,M., Nonaka,S.
            and Harabuchi,Y.
  TITLE     Electrical stimulation prevents apoptosis in denervated skeletal
            muscle
  JOURNAL   NeuroRehabilitation 27 (2), 147-154 (2010)
   PUBMED   20871144
  REMARK    GeneRIF: Electrical stimulation increased valosin-containing
            protein (VCP) expression and decreased cleaved caspase-12
            expression in denervated muscles.
REFERENCE   4  (bases 1 to 3864)
  AUTHORS   Faouzi,S., Medzihradszky,K.F., Hefner,C., Maher,J.J. and
            Correia,M.A.
  TITLE     Characterization of the physiological turnover of native and
            inactivated cytochromes P450 3A in cultured rat hepatocytes: a role
            for the cytosolic AAA ATPase p97?
  JOURNAL   Biochemistry 46 (26), 7793-7803 (2007)
   PUBMED   17550236
  REMARK    GeneRIF: findings clearly reveal that native CYPs 3A undergo UPD
            and implicate a role for p97 in this process.
REFERENCE   5  (bases 1 to 3864)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   6  (bases 1 to 3864)
  AUTHORS   Yamamoto,S., Tomita,Y., Hoshida,Y., Iizuka,N., Kidogami,S.,
            Miyata,H., Takiguchi,S., Fujiwara,Y., Yasuda,T., Yano,M.,
            Nakamori,S., Sakon,M., Monden,M. and Aozasa,K.
  TITLE     Expression level of valosin-containing protein (p97) is associated
            with prognosis of esophageal carcinoma
  JOURNAL   Clin Cancer Res 10 (16), 5558-5565 (2004)
   PUBMED   15328197
  REMARK    GeneRIF: Expression is ignificant in the prognosis of esophageal
            squamous cell carcinoma
REFERENCE   7  (bases 1 to 3864)
  AUTHORS   Wang,Y., Satoh,A., Warren,G. and Meyer,H.H.
  TITLE     VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated
            reassembly of mitotic Golgi fragments
  JOURNAL   J Cell Biol 164 (7), 973-978 (2004)
   PUBMED   15037600
  REMARK    GeneRIF: p97-p47-mediated reassembly of Golgi cisternae requires
            ubiquitin, but is not dependent on proteasome-mediated proteolysis.
            Erratum:[J Cell Biol. 2004 Aug 2;166(3):433. Wang, Yangzhuang
            [corrected to Wang, Yanzhuang]]
REFERENCE   8  (bases 1 to 3864)
  AUTHORS   Uchiyama,K., Jokitalo,E., Lindman,M., Jackman,M., Kano,F.,
            Murata,M., Zhang,X. and Kondo,H.
  TITLE     The localization and phosphorylation of p47 are important for Golgi
            disassembly-assembly during the cell cycle
  JOURNAL   J Cell Biol 161 (6), 1067-1079 (2003)
   PUBMED   12810701
  REMARK    GeneRIF: P47 localizes to the nucleus during interphase and is
            phosphorylated on Serine-140 by Cdc2 at mitosis. Phosphorylated p47
            does not bind to Golgi membranes.
REFERENCE   9  (bases 1 to 3864)
  AUTHORS   Uchiyama,K., Jokitalo,E., Kano,F., Murata,M., Zhang,X., Canas,B.,
            Newman,R., Rabouille,C., Pappin,D., Freemont,P. and Kondo,H.
  TITLE     VCIP135, a novel essential factor for p97/p47-mediated membrane
            fusion, is required for Golgi and ER assembly in vivo
  JOURNAL   J Cell Biol 159 (5), 855-866 (2002)
   PUBMED   12473691
  REMARK    GeneRIF: VCIP135 is required for golgi and endoplasmic reticulum
            assembly.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB045378.2.
            
            On Jun 10, 2007 this sequence version replaced NM_176857.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB045378.2, AF289091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3864
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..3864
                     /gene="Vcpip1"
                     /gene_synonym="Vcip135"
                     /note="valosin containing protein interacting protein 1"
                     /db_xref="GeneID:286761"
                     /db_xref="RGD:708520"
     exon            1..2824
                     /gene="Vcpip1"
                     /gene_synonym="Vcip135"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3783
                     /gene="Vcpip1"
                     /gene_synonym="Vcip135"
                     /EC_number="3.4.19.12"
                     /note="deubiquitinating protein VCIP135;
                     valosin-containing protein p97/p47 complex-interacting
                     protein 1; valosin-containing protein p97/p47
                     complex-interacting protein p135; VCP(p97)/p47-interacting
                     protein; valosin-containing protein (p97)/p47
                     complex-interacting protein 135; VCP/p47
                     complex-interacting 135-kDa protein"
                     /codon_start=1
                     /product="deubiquitinating protein VCPIP1"
                     /protein_id="NP_789827.3"
                     /db_xref="GeneID:286761"
                     /db_xref="RGD:708520"
                     /translation="MSQPPPPPPLPPPPPPPEAPQTSSSLAAAATPGGLSKRRDRRIL
                     SGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNAL
                     LGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCA
                     LLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHC
                     LVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLF
                     VPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGR
                     DGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEE
                     DGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPE
                     EVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRPDKNYS
                     FPLNNLVCSYDPVKDVLLPDYGLSNLTACNWCHGTSVRRVRGDGSIVYLDGDRTNSRS
                     TGGKCGCGFKHFWEGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDPSLNSNVYDV
                     AMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRIGDVQGQE
                     LESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKG
                     QPRTVSPSTIRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKSSTTFFE
                     LQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKGKAEG
                     GPSTAAHSAHTVRQEEIAVTGKLSSKELQEQADKEMYSLCLLATLMGEDVWSYAKGLP
                     HMFQQGGVFYNIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGP
                     DVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHS
                     LGTASSNPHMDPRARETLAVRKHNTGTDFSNSSIKTEPPVFTAASSNSELIRIAPGVV
                     TMRDGRQIDPDVVEAQRKKLQEMVSSIQASMDKHLRDQSTEQTPSDLSQRKVEAVSSS
                     VRPGNLQTGLPESFSLTGGTENLNTETTDSRVADVLGAAFATRSKAQKENSMEEPEEM
                     DSQDAETTNTTEPMDHS"
     exon            2825..2911
                     /gene="Vcpip1"
                     /gene_synonym="Vcip135"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3864
                     /gene="Vcpip1"
                     /gene_synonym="Vcip135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtaggga aaggaaagcc attcgctctg ggcctggact agacctcgtc gggccggcgg
       61 aggtctggct atgtgccttt gagggtcgct tgggacgcag agcgagagcc gagagcgatg
      121 tctcagccgc cgccgcctcc tccgctgccg ccgccgccgc ctccccccga ggctccgcag
      181 acttcgtcgt ccctggcggc ggcggctact ccggggggcc tttcgaaacg aagggaccgg
      241 agaatccttt ccgggagctg cccggatccc aagtgccagg cgcggctctt cttcccggcc
      301 tcaggttctg tcagcatcga gtgtaccgag tgcggacagc ggcacgagca gcaacagctg
      361 ctgggagtgg aggaggtgac cgacccggac gtagtgctgc acaatctgct gcggaacgcg
      421 ctactcgggg tgacgggggc tcccaagaag aacacggaac tggtaaaggt gatgggcctc
      481 tccaactacc actgcaaatt attgtcgccc atattggcac gctatggaat ggacaaacaa
      541 acgggccgcg ccaagcttct ccgggacatg aaccaaggcg aactgttcga ttgcgcgtta
      601 ctcggtgacc gggccttcct catcgaacca gagcacgtca acacagtggg ctatggcaag
      661 gaccgatctg gaagcctcct atatttgcat gacactctcg aggatatcaa acgggccaat
      721 aaaagtcaag aatgccttat tccagtgcat gtggatgggg atggacactg cctagtgcat
      781 gctgtgtcta gggctctagt aggccgagag ctcttctggc atgccctgag ggagaatctg
      841 aagcagcact ttcagcagca cctagcccga tatcaagccc tgtttcatga ctttattgat
      901 gctgcagagt gggaggacat tatcaatgaa tgtgaccctc tgtttgtgcc acctgaaggt
      961 gtccccttag gcctgaggaa tatccacata tttggccttg ccaatgtgtt acatcgtccc
     1021 ataattctct tagattccct cagtggcatg agaagctctg gtgattattc agccaccttt
     1081 ctacctgggc tcatacctgc agagaagtgc actgggagag atggtcattt gaacaagcca
     1141 atctgtattg cgtggagtag ctctggtaga aaccattata ttcccttggt aggcataaag
     1201 ggggctgcct tgcccaaact acccatgaat ttgctaccta aagcatgggg tgtgcctcag
     1261 gaccttatta aaaagtacat caagcttgag gaggatggtg gttgtgttat tggaggagac
     1321 agaagtttgc aggataagta cttacttagg ttggttgctg ctatggagga agtctttatg
     1381 gacaaacatg gtatccatcc tagtttggtt gctgatgtac atcagtattt ctacagaagg
     1441 actggggtga taggagttca gcctgaggaa gttacagcag ctgctaaaaa agcagtaatg
     1501 gataatcgcc ttcacaagtg tttgctttgt ggtgcccttt ctgaacttca tgtccctcct
     1561 gagtggttgg ctccaggagg aaaactgtat aacctggcaa aaagtactca tggacagctg
     1621 aggcctgaca aaaattacag ctttccttta aacaatttgg tttgttcata tgatccagtg
     1681 aaagatgttc tgttaccaga ctatggattg agtaatctaa cagcttgtaa ttggtgccat
     1741 ggcacatctg tgcgaagagt cagaggcgat ggctctattg tatatttgga tggagacaga
     1801 actaattcta ggtctactgg tggcaaatgt ggttgtggat tcaaacactt ttgggaaggt
     1861 aaagaatatg acaaccttcc agaagctttt cctatcactt tggagtgggg aggaagagta
     1921 gtcagagaaa cagtatattg gttccagtat gaaagtgatc catctttgaa tagtaatgtt
     1981 tatgatgttg caatgaaact tgttaccaag cactttccag gtgaatttgg gagtgagatc
     2041 ctagttcaga aagttgtcca cactatattg catcagactg caaaaaaaaa tcctgacgat
     2101 tacactcctg taaatataga tggtgctcat gctcagagaa ttggagatgt gcaaggacaa
     2161 gaattggagt ctcagctacc aactaaaatt attcttactg gacagaaaac aaaaactttg
     2221 cacaaggaag aattaaacat gagtaaaact gaaagaacta ttcaacagaa catcacagaa
     2281 caagcttctg tgatgcagaa acggaaaaca gagaaattaa aacaagagca aaaggggcaa
     2341 cccagaactg tttctccaag tactattcgt gatgggcctt catctgcacc tgccaccccc
     2401 acgaaggctc cctactcacc taccacttct aaggagaaga agattcgcat aacaactaat
     2461 gatggacggc agtccatggt tacccttaag tcttcaacaa ccttttttga acttcaggaa
     2521 agtatagcca gagagttcaa cattcctcca tatttacagt gtattcgata tggttttcct
     2581 cctaaagagt taatgccacc ccaagcagga atggaaaagg agccagttcc tttgcagcat
     2641 ggtgacagaa ttaccataga gatcttaaaa ggcaaagcag aaggtggtcc atccactgct
     2701 gcacactcag cccacactgt gagacaagaa gagattgctg ttactggcaa gctgtcctcc
     2761 aaggaacttc aggagcaagc tgacaaagaa atgtattcct tgtgtctttt agcaacatta
     2821 atgggagaag acgtgtggtc ttatgcaaag ggacttcctc acatgttcca gcagggtggt
     2881 gtattctaca atattatgaa gaaaactatg ggcatggctg atggcaaaca ttgtactttt
     2941 ccacatctac ctggcaaaac ctttgtttat aatgcttctg aagacagact ggagttgtgt
     3001 gtcgatgccg caggacattt ccccattggt cctgatgttg aagatttagt taaagaggct
     3061 gtaagtcagg ttcgagcaga ggctactaca agaagtaggg aatcaagccc ttcacatggg
     3121 ttattaaaac taggtagtgg tggagtagtg aaaaagaagt ctgagcaact tcacaatgta
     3181 actgcctttc aggggaaggg ccattctcta ggaactgcat ccagtaaccc gcacatggat
     3241 cccagagcta gggaaactct ggctgtaaga aagcataata cagggacaga ttttagtaat
     3301 agttccatta aaacagagcc tcctgtgttc acagctgctt ctagtaatag tgagcttatt
     3361 cgaatagctc ctggagtggt aacaatgaga gatggtaggc agattgatcc cgatgtggtt
     3421 gaggcccagc gaaaaaaatt gcaggaaatg gtttcttcta ttcaggcatc aatggacaag
     3481 cacttgcggg atcaaagtac agagcaaaca ccatctgatc tttctcaaag aaaagtagaa
     3541 gctgtgagtt cttctgtgag gcctgggaat cttcagactg gcttgcctga atctttttct
     3601 ttaactggtg gcactgagaa tttgaatact gaaacaactg atagtcgtgt agcagatgta
     3661 ctgggagcag catttgccac aaggtcaaaa gcacaaaaag aaaattccat ggaggaacct
     3721 gaagagatgg atagtcaaga tgctgagaca actaacacaa ctgagccgat ggatcactct
     3781 tgatttaatt tagaggctaa taaaggcaga tgtttattgt gaatatgtaa tatttgttgg
     3841 ctgggccaca taacttgagt agtc
//
