LOCUS       NM_053864               3214 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus valosin-containing protein (Vcp), mRNA.
ACCESSION   NM_053864
VERSION     NM_053864.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3214)
  AUTHORS   Kartal,B., Alimogullari,E. and Cayli,S.
  TITLE     The immunoexpression of valosin-containing protein and small
            VCP-interacting protein in rat ovaries
  JOURNAL   Anat Histol Embryol 52 (4), 546-551 (2023)
   PUBMED   36843060
  REMARK    GeneRIF: The immunoexpression of valosin-containing protein and
            small VCP-interacting protein in rat ovaries.
REFERENCE   2  (bases 1 to 3214)
  AUTHORS   Turakhiya,A., Meyer,S.R., Marincola,G., Bohm,S., Vanselow,J.T.,
            Schlosser,A., Hofmann,K. and Buchberger,A.
  TITLE     ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance
            of Arsenite-Induced Stress Granules
  JOURNAL   Mol Cell 70 (5), 906-919 (2018)
   PUBMED   29804830
REFERENCE   3  (bases 1 to 3214)
  AUTHORS   Zhou,N., Ma,B., Stoll,S., Hays,T.T. and Qiu,H.
  TITLE     The valosin-containing protein is a novel repressor of
            cardiomyocyte hypertrophy induced by pressure overload
  JOURNAL   Aging Cell 16 (5), 1168-1179 (2017)
   PUBMED   28799247
  REMARK    GeneRIF: Valosin-containing protein is a novel repressor of
            cardiomyocyte hypertrophy induced by pressure overload.
REFERENCE   4  (bases 1 to 3214)
  AUTHORS   Flack,J.E., Mieszczanek,J., Novcic,N. and Bienz,M.
  TITLE     Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the
            HECT E3 Ubiquitin Ligase Hyd/UBR5
  JOURNAL   Mol Cell 67 (2), 181-193 (2017)
   PUBMED   28689657
REFERENCE   5  (bases 1 to 3214)
  AUTHORS   Papadopoulos,C., Kirchner,P., Bug,M., Grum,D., Koerver,L.,
            Schulze,N., Poehler,R., Dressler,A., Fengler,S., Arhzaouy,K.,
            Lux,V., Ehrmann,M., Weihl,C.C. and Meyer,H.
  TITLE     VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of
            ruptured lysosomes by autophagy
  JOURNAL   EMBO J 36 (2), 135-150 (2017)
   PUBMED   27753622
REFERENCE   6  (bases 1 to 3214)
  AUTHORS   Zhang,S.H., Liu,J., Kobayashi,R. and Tonks,N.K.
  TITLE     Identification of the cell cycle regulator VCP (p97/CDC48) as a
            substrate of the band 4.1-related protein-tyrosine phosphatase
            PTPH1
  JOURNAL   J Biol Chem 274 (25), 17806-17812 (1999)
   PUBMED   10364224
REFERENCE   7  (bases 1 to 3214)
  AUTHORS   Rabouille,C., Kondo,H., Newman,R., Hui,N., Freemont,P. and
            Warren,G.
  TITLE     Syntaxin 5 is a common component of the NSF- and p97-mediated
            reassembly pathways of Golgi cisternae from mitotic Golgi fragments
            in vitro
  JOURNAL   Cell 92 (5), 603-610 (1998)
   PUBMED   9506515
REFERENCE   8  (bases 1 to 3214)
  AUTHORS   Dai,R.M., Chen,E., Longo,D.L., Gorbea,C.M. and Li,C.C.
  TITLE     Involvement of valosin-containing protein, an ATPase Co-purified
            with IkappaBalpha and 26 S proteasome, in
            ubiquitin-proteasome-mediated degradation of IkappaBalpha
  JOURNAL   J Biol Chem 273 (6), 3562-3573 (1998)
   PUBMED   9452483
REFERENCE   9  (bases 1 to 3214)
  AUTHORS   Kondo,H., Rabouille,C., Newman,R., Levine,T.P., Pappin,D.,
            Freemont,P. and Warren,G.
  TITLE     p47 is a cofactor for p97-mediated membrane fusion
  JOURNAL   Nature 388 (6637), 75-78 (1997)
   PUBMED   9214505
REFERENCE   10 (bases 1 to 3214)
  AUTHORS   Zhang,L., Ashendel,C.L., Becker,G.W. and Morre,D.J.
  TITLE     Isolation and characterization of the principal ATPase associated
            with transitional endoplasmic reticulum of rat liver
  JOURNAL   J Cell Biol 127 (6 Pt 2), 1871-1883 (1994)
   PUBMED   7806566
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060518.1.
            
            On Dec 20, 2003 this sequence version replaced NM_053864.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060518.1, U11760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3214
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3214
                     /gene="Vcp"
                     /note="valosin-containing protein"
                     /db_xref="GeneID:116643"
                     /db_xref="RGD:621595"
     exon            1..228
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2632
                     /gene="Vcp"
                     /EC_number="3.6.4.6"
                     /note="TER ATPase; 15S Mg(2+)-ATPase p97 subunit"
                     /codon_start=1
                     /product="transitional endoplasmic reticulum ATPase"
                     /protein_id="NP_446316.1"
                     /db_xref="GeneID:116643"
                     /db_xref="RGD:621595"
                     /translation="MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQP
                     KMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISI
                     QPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRA
                     VEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKE
                     MVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMS
                     KLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDG
                     LKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLAD
                     DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMD
                     DFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGM
                     TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKA
                     RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATN
                     RPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGF
                     SGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAM
                     RFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGNVYTE
                     DNDDDLYG"
     exon            229..340
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            341..513
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            514..656
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            657..787
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            788..919
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1022
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1156
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1292
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1405
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1570
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1693
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1906
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2215
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2371
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2526
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..3195
                     /gene="Vcp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcctctc gcggattagg agctagcgtc tcccgcccgc ctgccgcccc ggtgccgctg
       61 ggaggaagcg agagggaggc tgcctgtggg tttgtcactg ctgttgctcc tccacctgag
      121 tgagtcaagc ccgggcctag tcggtcgcct accattctcg tagccgttac cctcaggccg
      181 ccacagccgc cgaccgggag aggcgcgcgc catggcctct ggagccgatt caaaaggtga
      241 tgatttatca acagccattc tcaaacagaa gaaccgtccc aatcggttaa ttgttgatga
      301 agccatcaat gaagataaca gtgtggtgtc cttgtcccag cccaagatgg atgaactaca
      361 gttgttcaga ggtgacacgg tgttgctaaa aggaaagaag agaagggaag ctgtatgcat
      421 tgttctttct gatgacacgt gttctgatga gaagattcga atgaatagag ttgttcggaa
      481 taacctccga gttcgcctag gagatgtcat cagcatccag ccatgccctg atgtaaagta
      541 tggcaaacgt atccatgtgc tacccattga tgacacagtg gaaggcatca ctggcaatct
      601 ttttgaggta taccttaagc cgtacttcct ggaagcatat cggcccatcc gtaaaggaga
      661 tattttcctt gtccggggtg ggatgcgtgc tgtggagttc aaagtagtag agacagatcc
      721 cagcccttac tgtattgttg ctccagacac agtgatccac tgtgaggggg agccaatcaa
      781 gcgagaggat gaggaggagt ccttgaatga agtaggctat gatgacatcg gtggttgcag
      841 gaagcagcta gctcagataa aggagatggt ggagctgcca ctgagacatc ctgcactctt
      901 taaggcaatt ggtgtgaagc ctcctcgggg aatcttgcta tatggacctc ctgggacagg
      961 gaaaaccttg attgcccgag ctgtggcaaa tgaaactgga gccttcttct ttctgatcaa
     1021 tggtcctgaa atcatgagca aattggctgg tgagtctgag agcaaccttc gtaaagcctt
     1081 tgaggaagct gaaaagaatg ctcctgccat catcttcatc gacgagcttg atgccattgc
     1141 acccaaaaga gagaaaactc acggggaagt ggagcgtcgc atcgtgtctc agttgttgac
     1201 ccttatggat ggcctaaagc agagagcaca tgtgatagtt atggcagcaa ccaatagacc
     1261 caacagcatt gacccagccc tacggcgatt tggtcgcttt gacagagagg tagatattgg
     1321 aatccctgat gctacaggac gtttggaaat tcttcagatc cataccaaga acatgaaact
     1381 ggcagatgat gtggacttgg aacaggtagc caatgagact catggtcatg tgggtgctga
     1441 cttggcagcc ctgtgttcag aggctgctct acaggccatc cggaaaaaaa tggacctcat
     1501 tgacctagaa gatgagacca ttgacgctga ggtcatgaat tccctggcag ttactatgga
     1561 tgacttccgg tgggccttaa gtcaaagcaa cccatcagca cttcgggaaa ctgtggtaga
     1621 agtgccacaa gtaacctggg aagacattgg aggcctggag gatgtcaaac gggagcttca
     1681 ggagttggtt cagtatcctg tggagcatcc agacaaattc ctcaaatttg gcatgactcc
     1741 ttccaaaggt gttcttttct atggaccgcc tggctgtggg aaaaccttac tggccaaagc
     1801 cattgctaat gaatgccagg ctaacttcat ctccatcaag ggtcctgagc tgcttaccat
     1861 gtggtttggg gaatctgagg ccaatgtcag ggaaatattt gacaaggcac gacaagctgc
     1921 cccctgtgta ctcttctttg atgagttaga ttcaattgcc aaggctcgtg gtggtaatat
     1981 tggagatggt ggtggagctg cagaccgagt catcaatcag atcctgacag aaatggatgg
     2041 catgtccaca aaaaagaatg tgtttatcat tggagctacc aaccggcctg acatcattga
     2101 tcctgctatc ctaagacctg gccgtcttga tcagctcatt tatatcccac ttcctgatga
     2161 gaagtcccgt gttgccatcc taaaagccaa tctgcgaaaa tccccagttg ccaaggatgt
     2221 ggatttggag ttcttggcta agatgactaa tggcttttct ggagctgacc tgacagaaat
     2281 ttgccaacgt gcttgtaaac tagccattcg tgaatctatc gagagtgaga ttaggcgaga
     2341 acgagagagg cagacaaatc catcagctat ggaagtagaa gaggatgatc cagtgcctga
     2401 gatccgcaga gatcactttg aggaagccat gcgttttgcc cgacgttctg tcagtgataa
     2461 tgacattcgg aagtatgaaa tgtttgccca gacactgcag caaagtcgag gttttggcag
     2521 cttcagattc ccttcaggga accagggtgg agctggccca agtcagggca gtggaggtgg
     2581 cacaggtggc aatgtgtaca cagaagacaa tgacgatgac ctctatggct aagtgatgtg
     2641 ccagcatgca gcgagctggc ctggctggac cttgttccct gggggtgggg gcgctcgccc
     2701 aatgggaacc aggggtgtgc ccatggcctg ttccattcct cagtccgaac agttcagccc
     2761 cagtcagact ctggacaggg gttttctgtt gcaaaaaaaa attacaaaag cgataaaata
     2821 aaagtgattt tcatttggga ggtgaagagt gaattaccag caaggagctg ggccttgggc
     2881 cctcaccatt tctgttgtag tttgggtggt gcaggtaacc tgtgtggtgt gaaccgaggc
     2941 gctgccccca ccatcaccac agtaaagcat ctatactcaa tgctgtccaa gccctccctt
     3001 acctctagcc agcctgggta ggtggacaag gggcctcagt ttgctgggtg tttatataga
     3061 aagtaggttg atttttattt tacatgcttt tgagttactg ttggaagact aatcataagc
     3121 agtttctaaa ccaaaaaaaa aaaaaaaaaa aaaagacatg ttgtaaaagg ataataaatg
     3181 ttgggtcaaa atggaaaaaa aaaaaaaaaa aaaa
//
