LOCUS       NM_012889               3005 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus vascular cell adhesion molecule 1 (Vcam1), mRNA.
ACCESSION   NM_012889
VERSION     NM_012889.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3005)
  AUTHORS   Wang,L., Zhang,H. and Xie,C.
  TITLE     Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain
            injury in neonatal rats through targeting VCAM1
  JOURNAL   Toxicol Mech Methods 33 (4), 307-315 (2023)
   PUBMED   36177783
  REMARK    GeneRIF: Down-regulation of miR-204-5p ameliorates
            sevoflurane-induced brain injury in neonatal rats through targeting
            VCAM1.
REFERENCE   2  (bases 1 to 3005)
  AUTHORS   Sun,R., Shang,J., Yan,X., Zhao,J., Wang,W., Wang,W., Li,W., Gao,C.,
            Wang,F., Zhang,H., Wang,Y., Cao,H. and Zhang,J.
  TITLE     VCAM1 Drives Vascular Inflammation Leading to Continuous Cortical
            Neuronal Loss Following Chronic Cerebral Hypoperfusion
  JOURNAL   J Alzheimers Dis 91 (4), 1541-1555 (2023)
   PUBMED   36641679
  REMARK    GeneRIF: VCAM1 Drives Vascular Inflammation Leading to Continuous
            Cortical Neuronal Loss Following Chronic Cerebral Hypoperfusion.
REFERENCE   3  (bases 1 to 3005)
  AUTHORS   Ran,Y., Dong,Y., Li,Y., Xie,J., Zeng,S., Liang,C., Dai,W., Tang,W.,
            Wu,Y. and Yu,S.
  TITLE     Mesenchymal stem cell aggregation mediated by integrin
            alpha4/VCAM-1 after intrathecal transplantation in MCAO rats
  JOURNAL   Stem Cell Res Ther 13 (1), 507 (2022)
   PUBMED   36273220
  REMARK    GeneRIF: Mesenchymal stem cell aggregation mediated by integrin
            alpha4/VCAM-1 after intrathecal transplantation in MCAO rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3005)
  AUTHORS   Yang,Y., Wang,Z., Xu,Y., Liu,X., Sun,Y. and Li,W.
  TITLE     Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs
            inflammation and injury by mediating miR-20a-5p/HDAC4 axis
  JOURNAL   Inflamm Res 71 (9), 1109-1121 (2022)
   PUBMED   35854140
  REMARK    Erratum:[Inflamm Res. 2023 Apr;72(4):893. doi:
            10.1007/s00011-023-01701-7.. PMID: 36806965]
REFERENCE   5  (bases 1 to 3005)
  AUTHORS   Bilen,A., Calik,I., Yayla,M., Dincer,B., Tavaci,T., Cinar,I.,
            Bilen,H., Cadirci,E., Halici,Z. and Mercantepe,F.
  TITLE     Does daily fasting shielding kidney on hyperglycemia-related
            inflammatory cytokine via TNF-alpha, NLRP3, TGF-beta1 and VCAM-1
            mRNA expression
  JOURNAL   Int J Biol Macromol 190, 911-918 (2021)
   PUBMED   34492249
  REMARK    GeneRIF: Does daily fasting shielding kidney on
            hyperglycemia-related inflammatory cytokine via TNF-alpha, NLRP3,
            TGF-beta1 and VCAM-1 mRNA expression.
REFERENCE   6  (bases 1 to 3005)
  AUTHORS   Pepinsky,B., Hession,C., Chen,L.L., Moy,P., Burkly,L.,
            Jakubowski,A., Chow,E.P., Benjamin,C., Chi-Rosso,G., Luhowskyj,S.
            et al.
  TITLE     Structure/function studies on vascular cell adhesion molecule-1
  JOURNAL   J Biol Chem 267 (25), 17820-17826 (1992)
   PUBMED   1381355
REFERENCE   7  (bases 1 to 3005)
  AUTHORS   Osborn,L., Vassallo,C. and Benjamin,C.D.
  TITLE     Activated endothelium binds lymphocytes through a novel binding
            site in the alternately spliced domain of vascular cell adhesion
            molecule-1
  JOURNAL   J Exp Med 176 (1), 99-107 (1992)
   PUBMED   1377228
REFERENCE   8  (bases 1 to 3005)
  AUTHORS   Williams,A.J., Atkins,R.C., Fries,J.W., Gimbrone,M.A. Jr.,
            Cybulsky,M.I. and Collins,T.
  TITLE     Nucleotide sequence of rat vascular cell adhesion molecule-1 cDNA
  JOURNAL   Biochim Biophys Acta 1131 (2), 214-216 (1992)
   PUBMED   1377031
REFERENCE   9  (bases 1 to 3005)
  AUTHORS   Hession,C., Moy,P., Tizard,R., Chisholm,P., Williams,C., Wysk,M.,
            Burkly,L., Miyake,K., Kincade,P. and Lobb,R.
  TITLE     Cloning of murine and rat vascular cell adhesion molecule-1
  JOURNAL   Biochem Biophys Res Commun 183 (1), 163-169 (1992)
   PUBMED   1371918
REFERENCE   10 (bases 1 to 3005)
  AUTHORS   Ryan,D.H., Nuccie,B.L., Abboud,C.N. and Winslow,J.M.
  TITLE     Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate
            adhesion of human B cell precursors to cultured bone marrow
            adherent cells
  JOURNAL   J Clin Invest 88 (3), 995-1004 (1991)
   PUBMED   1715889
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012889.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M84488.1, BC089812.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000002.1  206742663-206742783 c
            122-397             JAXUCZ010000002.1  206741924-206742199 c
            398-718             JAXUCZ010000002.1  206739413-206739733 c
            719-985             JAXUCZ010000002.1  206737860-206738126 c
            986-1261            JAXUCZ010000002.1  206733843-206734118 c
            1262-1582           JAXUCZ010000002.1  206730268-206730588 c
            1583-1849           JAXUCZ010000002.1  206729000-206729266 c
            1850-2116           JAXUCZ010000002.1  206727071-206727337 c
            2117-3005           JAXUCZ010000002.1  206723050-206723938 c
FEATURES             Location/Qualifiers
     source          1..3005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..3005
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /note="vascular cell adhesion molecule 1"
                     /db_xref="GeneID:25361"
                     /db_xref="RGD:3952"
     exon            1..121
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2277
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /note="vascular cell adhesion protein 1; V-CAM 1; VCAM-1;
                     vascular cell adhesion protein 1-like"
                     /codon_start=1
                     /product="vascular cell adhesion protein 1 precursor"
                     /protein_id="NP_037021.1"
                     /db_xref="GeneID:25361"
                     /db_xref="RGD:3952"
                     /translation="MPVKMVAIFGASTVLWILFAVSQAFKIEISPEYKTLAQIGDSML
                     LTCSTTGCESPSFSWRTQIDSPLNGKVKTEGAKSVLTMDPVSFENEHSYLCTATCNSG
                     KLERGIQVDIYSFPKDPEIQFSGPLEVGKPVMVKCLAPDVYPIDRLEIELFKGDRLMK
                     KQDFVDEMAKKSLETKSLEVIFTPVIEDIEKALVCRAKLYIDQTDSIPKERETVRELQ
                     VYTSPKNTEISVHPSTRLHEGAAVTMTCASEGLPAPEIFWSKKLDNGVLQLLSGNATL
                     TLIAMRMEDSGIYVCEGVNLVGRDKTEVELIVQEKPFTVDISPGSQVAAQVGDSVVLT
                     CAAVGCDSPSFSWRTQTDSPLNGEVRDEGATSTLTLSPVGVEDEHSYLCTVTCQRRKL
                     EKTIQVEVYSFPEDPEIEISGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLLNK
                     FLREEIGTKSLETKSLEMTFIPTAEDTGKALVCLAKLHSSQMESEPKQRQSTQTLYVN
                     VAPKEPTIWVSPSPVPEEGSPVNLTCSSDGFPTPKILWSRQLKNGELQPLSQNTTLSF
                     MATKMEDSGIYVCEGINEAGISKKSVELIIQGSSKDIQLTVFPSKSVKEGDTVIISCT
                     CGSVPEIWIILKKKAKTGDMVLKSVNGSYTIRKAQLQDAGVYECESKTEVGSQLRSLT
                     LDVKGKENNKDYFSPELLALYFASSLVIPAIGMIIYFARKANMKGSYSLVEAQKSKV"
     exon            122..397
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            398..718
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            719..985
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1261
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1582
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1849
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2116
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..3005
                     /gene="Vcam1"
                     /gene_synonym="VCAM1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttcccag acactttcac gtggggcaca aagaaggctt tgaagcagag acttgaaatg
       61 cctgtgaaga tggtcgcgat cttcggagcc tcaacggtac tttggatact gtttgcagtc
      121 tctcaagctt ttaaaatcga gatctcccct gaatacaaaa cgctcgctca gattggagac
      181 tccatgctcc tgacttgcag caccacaggc tgtgagtcgc catcattctc ttggagaacc
      241 cagatagaca gtccactaaa tgggaaggtg aagacagagg gggccaagtc cgttctgacc
      301 atggaccctg tcagctttga gaatgaacac tcttacctgt gcacagcaac atgtaactct
      361 gggaaactgg aaagaggaat ccaagtggac atctactcat tccctaagga tccagagatt
      421 caattcagtg gccccctgga ggttgggaag ccggtcatgg tcaagtgttt ggctcctgat
      481 gtttacccaa ttgacagact ggagatagaa ctgttcaagg gtgaccgtct catgaagaaa
      541 caggattttg tagacgagat ggcaaagaag tctctggaaa ccaagagttt ggaagtcatc
      601 tttactcctg tcattgagga tattgaaaag gctcttgttt gccgagctaa attatacatt
      661 gaccaaactg attctattcc caaagaaagg gagactgtca gagaactaca agtctacacc
      721 tcccccaaga atacagagat ctctgtacat ccctccacaa ggctacatga gggtgctgct
      781 gtgacgatga catgtgccag cgagggtcta ccagctcctg agattttctg gagcaagaaa
      841 ttagataatg gagttctaca gctcctctcg ggaaatgcca ccctcacctt aattgctatg
      901 aggatggaag attctggaat ctatgtgtgt gaaggagtga atctggttgg gagagacaaa
      961 acagaagtgg aattaattgt tcaagagaaa ccatttactg ttgacatctc ccctggatct
     1021 caggtggctg cacaggttgg ggattccgtt gttctgacat gtgctgctgt tggctgtgac
     1081 tctccctcct tttcttggag aacccagaca gacagtcccc tcaatgggga ggtgagggat
     1141 gaaggggcta catccacact gacgctgagc cctgtgggtg ttgaggatga gcactcttac
     1201 ctgtgcactg tgacctgtca gcgaaggaaa ctggagaaga caatccaagt ggaggtctac
     1261 tcattccctg aagacccaga aattgaaata agtggaccac ttgtacacgg gagacctgtc
     1321 actgtcaact gcacggtccc taatgtgtac ccctttgacc atctggagat tgaactactg
     1381 aagggggaga caacactgtt gaataaattt ttaagggagg aaattggcac aaagtctcta
     1441 gagaccaaaa gtttggaaat gaccttcatc cccaccgctg aagacaccgg gaaagctctt
     1501 gtttgcctcg ctaagttaca cagcagtcaa atggagtctg aacccaaaca aaggcagagt
     1561 acacagactc tttatgtcaa cgttgctccg aaagaaccca ccatctgggt tagcccctct
     1621 cctgtcccag aggagggcag tcctgtgaac ctgacctgct caagtgatgg ttttccaact
     1681 cccaaaatcc tgtggagcag acagctaaag aacggggaac tgcagcctct ttctcaaaat
     1741 acaacactct ccttcatggc tacaaaaatg gaagattccg gcatttatgt atgtgaaggg
     1801 attaatgagg ctggaattag caaaaaatca gttgaactga ttatccaagg ctcttcgaag
     1861 gacatacagc ttacagtctt cccatctaag agcgtcaaag agggagacac tgtcattatc
     1921 tcctgtactt gtggaagtgt gcccgaaata tggataattc tgaaaaagaa agccaagaca
     1981 ggagacatgg tgctaaagtc tgttaatggc tcgtacacca tccgcaaggc acagctgcag
     2041 gatgccggag tatacgagtg tgaatcgaaa accgaagtcg gctcgcagtt gcgaagttta
     2101 acacttgatg tgaaaggaaa agaaaataac aaggactatt tttcccctga actccttgca
     2161 ctctactttg catcctcctt ggtaataccc gccattggga tgatcattta ctttgcaaga
     2221 aaagccaaca tgaaaggatc gtacagtctg gtggaggcac agaagtcaaa agtgtagcta
     2281 acgtctgaac tgttggagaa aagacattat ttataaaccc cggacccttc atactcttta
     2341 ttgcagcact gttccccctc cacaaaccaa gctatgcatt cagacttctc agaacccttc
     2401 tcggcaaaga aggaaaagaa gtggccactt gatcccttgc tgagtgcaag aagccaacta
     2461 gaaatcttct gctcggcaag tccccattgc tgaagagacc ggaacagtac catgacatgt
     2521 atataaatag cctcagtgta catatgtaaa ataaaatgat gtcattgcga ggtcgtttag
     2581 agtagtagca ctccagatgt aggtcagaac aaaatcaaaa cgtgttgctt ggactgactg
     2641 ttgtaacttc atgcttctta ggaaagttta atgttggtgt taatgttgag taggcagctg
     2701 accagtgtca cctttttgta ctttattttc ttcagcctaa ttttattcct atgcatttta
     2761 ttgacaatga tttcattttt ttttaaagaa gccagggttt tatattttta taggcaaatg
     2821 gtaaaaaggt cactgggttg actttcaggt actactttcc taattcatgg tatactgatt
     2881 aagtagtttt ctcaactgta cggtacgggg acgtgtttct tcatcaggat cttgtataat
     2941 gactaacatg gtttaaatgc aacttcattt gacttataaa tactacagta aagtgaaagt
     3001 ttctg
//
