LOCUS       NM_022637               1284 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus ventral anterior homeobox 2 (Vax2), mRNA.
ACCESSION   NM_022637
VERSION     NM_022637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Vacik,T., Stubbs,J.L. and Lemke,G.
  TITLE     A novel mechanism for the transcriptional regulation of Wnt
            signaling in development
  JOURNAL   Genes Dev 25 (17), 1783-1795 (2011)
   PUBMED   21856776
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Kim,J.W. and Lemke,G.
  TITLE     Hedgehog-regulated localization of Vax2 controls eye development
  JOURNAL   Genes Dev 20 (20), 2833-2847 (2006)
   PUBMED   17043310
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Mui,S.H., Kim,J.W., Lemke,G. and Bertuzzi,S.
  TITLE     Vax genes ventralize the embryonic eye
  JOURNAL   Genes Dev 19 (10), 1249-1259 (2005)
   PUBMED   15905411
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Barbieri,A.M., Broccoli,V., Bovolenta,P., Alfano,G.,
            Marchitiello,A., Mocchetti,C., Crippa,L., Bulfone,A., Marigo,V.,
            Ballabio,A. and Banfi,S.
  TITLE     Vax2 inactivation in mouse determines alteration of the eye
            dorsal-ventral axis, misrouting of the optic fibres and eye
            coloboma
  JOURNAL   Development 129 (3), 805-813 (2002)
   PUBMED   11830579
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Mui,S.H., Hindges,R., O'Leary,D.D., Lemke,G. and Bertuzzi,S.
  TITLE     The homeodomain protein Vax2 patterns the dorsoventral and
            nasotemporal axes of the eye
  JOURNAL   Development 129 (3), 797-804 (2002)
   PUBMED   11830578
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Schulte,D., Furukawa,T., Peters,M.A., Kozak,C.A. and Cepko,C.L.
  TITLE     Misexpression of the Emx-related homeobox genes cVax and mVax2
            ventralizes the retina and perturbs the retinotectal map
  JOURNAL   Neuron 24 (3), 541-553 (1999)
   PUBMED   10595508
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Barbieri,A.M., Lupo,G., Bulfone,A., Andreazzoli,M., Mariani,M.,
            Fougerousse,F., Consalez,G.G., Borsani,G., Beckmann,J.S.,
            Barsacchi,G., Ballabio,A. and Banfi,S.
  TITLE     A homeobox gene, vax2, controls the patterning of the eye
            dorsoventral axis
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10729-10734 (1999)
   PUBMED   10485894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000148.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022637.3.
            
            On Oct 5, 2022 this sequence version replaced NM_022637.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF113516.1, SRR8487226.173920.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JACYVU010000148.1  13525530-13525824
            296-483             JACYVU010000148.1  13545485-13545672
            484-1284            JACYVU010000148.1  13548799-13549599
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1284
                     /gene="Vax2"
                     /note="ventral anterior homeobox 2"
                     /db_xref="GeneID:64572"
                     /db_xref="RGD:621133"
     exon            1..295
                     /gene="Vax2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..927
                     /gene="Vax2"
                     /note="ventral anterior homeobox containing gene 2"
                     /codon_start=1
                     /product="ventral anterior homeobox 2"
                     /protein_id="NP_072159.2"
                     /db_xref="GeneID:64572"
                     /db_xref="RGD:621133"
                     /translation="MGDGGAERDRGPKRREEPGGRSGCRGEHRGAEDLRADTGSTSPR
                     EIAGTSASSPAGSRESGGDSDGQQALGETDHCRRILVRDAKGTIREIVLPKGLDLDRP
                     KRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKD
                     QSRDLEKRASSSASEAFATSNVLRLLEQGRLLSVPRAPSLLALSPGLPGLTAGHRGTS
                     LGDPRNSSQRLNPMPSASASSPLPPPLPAVCFSAAPLLDLPASYKLGSSAFEPYSRLE
                     QQKVGSPGQSDKKADI"
     exon            296..483
                     /gene="Vax2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1284
                     /gene="Vax2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccaggac tagcggctgc tgtgggccag gcagcagtgg cggcgggcat gggcgatggg
       61 ggcgcggagc gggaccgcgg ccccaagcgc cgggaggagc ctggtggccg cagcgggtgt
      121 cgtggggagc accgcggagc ggaagatttg cgtgctgaca cgggtagcac gagtccgagg
      181 gagattgctg ggacctccgc ctccagccct gcaggctcca gggagagcgg cggggacagc
      241 gacggacaac aggcgctcgg tgagacggac cactgccgcc gcatcctggt acgagatgcc
      301 aaggggacca ttcgggaaat tgtcctgccc aagggcctgg acctcgaccg acccaagagg
      361 acccgtacct ccttcacagc agaacagctg tatcgtttgg agatggagtt ccagcgctgc
      421 cagtatgtgg tgggccgaga gcgcacagag ctggcccgcc agctgaacct ctctgagact
      481 caggtgaagg tctggttcca gaaccgccgc accaagcaga agaaggacca gagcagagac
      541 ctggaaaagc gggcatcctc ctccgcctcc gaggcctttg ccacctccaa cgttctgcga
      601 cttctggaac agggccggct gctctccgtg cccagagctc ccagcctcct agcactgagc
      661 cctggcctgc caggtctaac cgctggccac aggggcacct ccttgggtga ccccaggaac
      721 tcctcccaac gcctcaatcc aatgccctca gcctcagcgt cgtcccctct gccaccccct
      781 ctgccagccg tctgcttttc cgcagctcca ctcctggact tgcccgccag ctacaaactg
      841 gggtcctcgg cttttgagcc ctacagcaga ctagaacaac agaaagtagg cagccctggc
      901 caaagtgaca agaaagctga catttaagag tcccatcccc gtgtgacact gagtccccag
      961 cacagcacta ccctagcctc ctggcccctg tggactatac tgagcaggcc tggaagagga
     1021 aggatgggca cagcatgagc ctctccacct gccctcagct cagagactga accaaaatga
     1081 ctttgtactc tctgatgtgt gagtgctatg tgcgtgcgtg cgtgtgtgcg tgtgtgtgtg
     1141 cgtgcgtgtg tgcgtgtgtg tgtgcatgag agagagagag agagagagag agagagagag
     1201 agagagagag agagagagag agagagagag agagagaatg tgtcactgaa ataaagaagg
     1261 gaactgtccc agcatcacca actc
//
