LOCUS       NM_001191714            4642 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus vav guanine nucleotide exchange factor 3 (Vav3),
            mRNA.
ACCESSION   NM_001191714 XM_227600
VERSION     NM_001191714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4642)
  AUTHORS   Zhang,Y., Zhang,Y., Song,Q., Wang,Y. and Pan,J.
  TITLE     The role of Vav3 expression for inflammation and cell death during
            experimental myocardial infarction
  JOURNAL   Clinics (Sao Paulo) 78, 100273 (2023)
   PUBMED   37591108
  REMARK    GeneRIF: The role of Vav3 expression for inflammation and cell
            death during experimental myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4642)
  AUTHORS   Valderrama,F., Thevapala,S. and Ridley,A.J.
  TITLE     Radixin regulates cell migration and cell-cell adhesion through
            Rac1
  JOURNAL   J Cell Sci 125 (Pt 14), 3310-3319 (2012)
   PUBMED   22467863
REFERENCE   3  (bases 1 to 4642)
  AUTHORS   Lawson,C.D., Donald,S., Anderson,K.E., Patton,D.T. and Welch,H.C.
  TITLE     P-Rex1 and Vav1 cooperate in the regulation of
            formyl-methionyl-leucyl-phenylalanine-dependent neutrophil
            responses
  JOURNAL   J Immunol 186 (3), 1467-1476 (2011)
   PUBMED   21178006
REFERENCE   4  (bases 1 to 4642)
  AUTHORS   Toumaniantz,G., Ferland-McCollough,D., Cario-Toumaniantz,C.,
            Pacaud,P. and Loirand,G.
  TITLE     The Rho protein exchange factor Vav3 regulates vascular smooth
            muscle cell proliferation and migration
  JOURNAL   Cardiovasc Res 86 (1), 131-140 (2010)
   PUBMED   19969623
  REMARK    GeneRIF: The Rho GEF Vav3 controls vascular smooth muscle cell
            proliferation and migration through activation of Rac1/PAK
            signalling
REFERENCE   5  (bases 1 to 4642)
  AUTHORS   Joshi,A.D., Hegde,G.V., Dickinson,J.D., Mittal,A.K., Lynch,J.C.,
            Eudy,J.D., Armitage,J.O., Bierman,P.J., Bociek,R.G., Devetten,M.P.,
            Vose,J.M. and Joshi,S.S.
  TITLE     ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing
            B-cell chronic lymphocytic leukemia
  JOURNAL   Clin Cancer Res 13 (18 Pt 1), 5295-5304 (2007)
   PUBMED   17875758
REFERENCE   6  (bases 1 to 4642)
  AUTHORS   Aoki,K., Nakamura,T., Fujikawa,K. and Matsuda,M.
  TITLE     Local phosphatidylinositol 3,4,5-trisphosphate accumulation
            recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite
            outgrowth in nerve growth factor-stimulated PC12 cells
  JOURNAL   Mol Biol Cell 16 (5), 2207-2217 (2005)
   PUBMED   15728722
REFERENCE   7  (bases 1 to 4642)
  AUTHORS   Charvet,C., Canonigo,A.J., Billadeau,D.D. and Altman,A.
  TITLE     Membrane localization and function of Vav3 in T cells depend on its
            association with the adapter SLP-76
  JOURNAL   J Biol Chem 280 (15), 15289-15299 (2005)
   PUBMED   15708849
REFERENCE   8  (bases 1 to 4642)
  AUTHORS   Gakidis,M.A., Cullere,X., Olson,T., Wilsbacher,J.L., Zhang,B.,
            Moores,S.L., Ley,K., Swat,W., Mayadas,T. and Brugge,J.S.
  TITLE     Vav GEFs are required for beta2 integrin-dependent functions of
            neutrophils
  JOURNAL   J Cell Biol 166 (2), 273-282 (2004)
   PUBMED   15249579
REFERENCE   9  (bases 1 to 4642)
  AUTHORS   Crespo,P., Schuebel,K.E., Ostrom,A.A., Gutkind,J.S. and
            Bustelo,X.R.
  TITLE     Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by
            the vav proto-oncogene product
  JOURNAL   Nature 385 (6612), 169-172 (1997)
   PUBMED   8990121
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_227600.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.10588.1,
                                           SRR26643294.11075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000002.1  199700778-199700981
            205-321             JAXUCZ010000002.1  199780087-199780203
            322-380             JAXUCZ010000002.1  199852663-199852721
            381-446             JAXUCZ010000002.1  199854838-199854903
            447-555             JAXUCZ010000002.1  199859595-199859703
            556-648             JAXUCZ010000002.1  199861574-199861666
            649-717             JAXUCZ010000002.1  199864624-199864692
            718-821             JAXUCZ010000002.1  199866625-199866728
            822-921             JAXUCZ010000002.1  199868873-199868972
            922-1017            JAXUCZ010000002.1  199873338-199873433
            1018-1086           JAXUCZ010000002.1  199877181-199877249
            1087-1173           JAXUCZ010000002.1  199878916-199879002
            1174-1259           JAXUCZ010000002.1  199883280-199883365
            1260-1392           JAXUCZ010000002.1  199884807-199884939
            1393-1502           JAXUCZ010000002.1  199885585-199885694
            1503-1604           JAXUCZ010000002.1  199928098-199928199
            1605-1705           JAXUCZ010000002.1  199928451-199928551
            1706-1731           JAXUCZ010000002.1  199939508-199939533
            1732-1777           JAXUCZ010000002.1  199944042-199944087
            1778-1914           JAXUCZ010000002.1  199986852-199986988
            1915-1980           JAXUCZ010000002.1  200003899-200003964
            1981-2015           JAXUCZ010000002.1  200008525-200008559
            2016-2132           JAXUCZ010000002.1  200014471-200014587
            2133-2220           JAXUCZ010000002.1  200015137-200015224
            2221-2350           JAXUCZ010000002.1  200021145-200021274
            2351-2502           JAXUCZ010000002.1  200039452-200039603
            2503-4642           JAXUCZ010000002.1  200040205-200042344
FEATURES             Location/Qualifiers
     source          1..4642
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q41"
     gene            1..4642
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /note="vav guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:295378"
                     /db_xref="RGD:1565941"
     CDS             1..2544
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /note="vav 3 oncogene; vav 3 guanine nucleotide exchange
                     factor"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor VAV3"
                     /protein_id="NP_001178643.1"
                     /db_xref="GeneID:295378"
                     /db_xref="RGD:1565941"
                     /translation="MEPWKQCAQWLIHCKVLPANHRVTWDSAQVFDLAQTLRDGVLLC
                     QLLNNLRPHSINLKEINLRPQMSQFLCLKNIRTFLAACCDTFGMKKSELFEAFDLFDV
                     RDFGKVIETLSRLSRTPIALATGIRPFPTEESVNDEDIYKGLPDLIDETRVEDEEDLY
                     DCVYGEDEGGEVYEDLMKAEEAHQAKSQENDIRSCCLAEIRQTEEKYTETLESIEKYF
                     MAPLKRFLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDHNLYQVFINYKERLV
                     IYGQYCSGVESAISSLDYISKTKEDVRLKLEECSKRANNGKFTLRDLLVVPMQRVLKY
                     HLLLQELVKHTHDPMEKSNLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLN
                     QPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQY
                     KIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDY
                     ADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAKAHKECLGRVDNCGRVN
                     SVEQGPFKPPEKRTNGLRRASRQVDPGLPKMRVIRNYTGTPPPALHEGPPLHIQAGDT
                     VELLRGEAHTVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERLQA
                     ETELINRVNSTYLVRLRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLM
                     ELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHASGQRGNRTGNSLLSPKVLGIAIARYD
                     FCARDMRELSLLKGDMVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE"
     exon            1..204
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            205..321
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            322..380
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            381..446
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            447..555
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            556..648
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            649..717
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            718..821
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            822..921
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1017
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1086
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1173
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1259
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1392
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1502
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1604
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1705
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1731
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1777
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1914
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1980
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2015
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2132
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2220
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2350
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2502
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..4642
                     /gene="Vav3"
                     /gene_synonym="RGD1565941"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagccgt ggaagcagtg cgctcagtgg ctcatccact gcaaagtgct gcccgccaac
       61 caccgggtga cctgggactc ggcgcaggtg ttcgacctgg cgcagaccct ccgcgatgga
      121 gtcctgctct gccagctgct caacaacctg cggccacact ccatcaatct gaaggagatc
      181 aacctgagac cccagatgtc ccagtttctc tgtctgaaga atatccggac atttctggcc
      241 gcctgctgtg acacgttcgg aatgaagaaa agtgagcttt ttgaggcatt tgacctattc
      301 gatgttcgtg actttggaaa ggttatagaa acattatctc gcctatcccg aacaccaata
      361 gcattggcca caggaatcag gccattcccc acggaagaaa gtgtaaatga tgaagacatc
      421 tacaaaggcc ttcctgacct gatagatgaa acccgtgtgg aggacgaaga agacctctat
      481 gactgtgtgt acggggagga tgaaggcgga gaagtctatg aagatttgat gaaggcggag
      541 gaggctcacc aagctaaatc acaagaaaat gatatacgga gttgttgcct agcagaaatt
      601 aggcagacag aagaaaaata cacagaaact ttggagtcaa tagaaaaata tttcatggca
      661 ccattgaaaa gatttctgac agcggcggaa tttgattcag tatttatcaa cattcctgac
      721 cttgtaaaag ttcatcggag cttaatgcaa gagattcacg attccattgt aaataaagat
      781 gaccataact tgtatcaagt ttttattaac tacaaggaaa gattggttat ttatggacag
      841 tactgcagtg gagtggagtc agccatctct agcctagact acatctctaa gacaaaagaa
      901 gatgtcagac tgaaactaga ggaatgttca aagagagcca ataatgggaa atttactctg
      961 cgtgatttgc tggtagttcc catgcagcgg gtgctgaaat atcacctcct ccttcaggag
     1021 ctggttaaac acacccatga tcccatggag aagtcgaacc tgaagctggc tctggatgca
     1081 atgaaggact tggcacaata tgtgaatgaa gtaaaaagag ataatgagac ccttcgtgaa
     1141 attaagcagt ttcagctatc tatagaaaat ttgaaccagc ccgttttgct ctttgggcga
     1201 ccgcagggag acggtgaaat ccgaataacc acactggaca agcatacgaa acaagaaagg
     1261 catatcttct tattcgatct ggcagtgatt gtctgtaaaa ggaaagggga taactacgag
     1321 atgaaggaaa taatagatct ccagcagtac aagatcgcca acaaccctac cacggataaa
     1381 gagaataaaa agtggtctta tggcttctac ctcatccata cccaaggaca aaatgggctg
     1441 gaattttatt gcaaaacaaa agatttaaag aaaaaatggc tggaacagtt tgaaatggct
     1501 ttatccaaca taaggccgga ctatgcagac tccaatttcc atgacttcaa gatgcacaca
     1561 ttcactcggg tgacatcctg tagggtctgc caaatgctcc tgagggggac attttatcaa
     1621 ggctacttat gttttaagtg tggagcaaaa gcgcataaag aatgtttggg aagagtagac
     1681 aattgtggca gagttaattc cgttgaacaa gggccattca aaccaccgga gaagcggacc
     1741 aatggacttc ggagagcttc cagacaggtg gatccaggct tgccgaagat gcgggtcatt
     1801 aggaactaca ctggcacccc gcccccagct cttcacgaag gaccaccgtt gcatatccag
     1861 gcaggggaca ctgttgaact tctgagagga gaggcacaca ctgttttctg gcagggacga
     1921 aacttagctt caggagaggt tggatttttc ccaagcgatg ctgtcaagcc atctccatgt
     1981 gtacctaaac cagtagatta ttcttgccaa ccctggtatg ctggcccaat ggaaagattg
     2041 caggcagaaa ctgaacttat taacagggtg aatagcactt accttgtaag gctcaggacc
     2101 aaagagtctg gagaatatgc aattagcatt aagtacaata atgaagcaaa acacatcaag
     2161 attttaacaa gagatggctt ttttcacatt gcagaaaata gaaaatttaa aagcttaatg
     2221 gaacttgtgg agtactacaa gcaccattct cttaaagaag ggttcaggac cttagatacg
     2281 acgctacagt ttccatacaa ggagcctgaa cacgcatctg gacagagggg taatagaaca
     2341 ggcaacagct tgctaagtcc caaagttctg ggcattgcca tcgctcggta tgacttctgt
     2401 gcaagagata tgcgggagct ctccctattg aaaggagaca tggtgaagat ttacacaaag
     2461 atgagtgcaa atggctggtg gagaggagaa gtaaatggca gggtgggctg gtttccatcc
     2521 acgtatgtgg aagaagacga gtaaagtcca atccagagtt gatcctgcac caaaatctca
     2581 ggcaacacag acagaaacct gcacgccatt atgagttaac tcaagtgttt agaaagcagc
     2641 gttcttggct gttcaacacc ctcttttctc tcttcctaag tcttaacgct gggatttcta
     2701 aagattctgg tactgacaga ttaatagctt gcctagagca gtgcaagaaa caacctgcct
     2761 gcctaccatt gtcaggaacc agggcaaagc caaccgcttt ccttccccaa aagagtcctg
     2821 caaacacatc aggtttctct tcattgggcc agacaccatg gatccaactg ttaggaaatg
     2881 cttcctgcat atttactttg ttcttacagt ttttgatgat acaaagaaat acaagtttaa
     2941 ttttgctttt tcccagcatg aagaaaaagt agagtctgcc atctgggaaa gatccagctt
     3001 gctggagaga tccagcattt ctcgtcttaa attgttcaac aggtgactca ctgcctggca
     3061 aacactttta tccccagatg ttactcatga taaaataaaa gagcctcatg ctcaggtttg
     3121 catcataagt gataaattac agagagggtt ttaattattc atttgatgtc ctgattatat
     3181 ttccacactt ctttataaag aagaaaaaga gaagcacttg aaaggaagtg tctttgtatg
     3241 aaagcctcgc agtttttgtg gtttcagagg gtgttttgga aatgtcatgc ctgacaagga
     3301 atcgtggccg ggcagatcat gcttggttgc caggaatccc agaggtagag gtgtttacag
     3361 agacagatca agtgctgtaa tcaatccata ggatatcact atatagctgc aatagctatg
     3421 aacacaagcc ttccttctct ctagagaccc gaggcatagt tgctgatttc cactgttttt
     3481 tatttttttt taatggtagc acaaaagagc tttattgagg atttgggaag aaaggcacac
     3541 cgagtccttc atttctttct gagacagaag gaacctgatt tctgtgttct catggctcct
     3601 ctgttttccc ttctgaagcc tttcttgcta tgtcttaatc agtaggaaga tccactttgc
     3661 agcatgtttc tttctccaag ctttcactgt gttccacgag gagtctaagt atcttcctcc
     3721 tgagatgcgt ggagtcccta gttgaggctg acaagttaag atactaactt gcccttccat
     3781 ggtagagtat ttctttggta gcagtagcta tgttctgtca agattcagaa aatgtttctg
     3841 cttggataaa agatagaggt atttttatct tagaagtgat ctctaagtgt ctctgatacc
     3901 agatttttgg ggtcacctct aacatgaaag ggctgaggca acctgtcctc tcctgtctca
     3961 caggagtgcc agagcctgtt tcgtggacac atctccctgg aggagacccc atcggggcta
     4021 ggacttttca tttaaataga ctcaagacct ttacctcaga attatgtaaa ctgtgattgt
     4081 gttttagaac aattgagctt ttgtatatgt gtaaatggtg atgaaaatgt attttataaa
     4141 atgtctgtat agtgaacttg tgctgacaag gtctactctt ggaatggatt cctaccttta
     4201 aggtcttatc tgtgtcttgg ggatgttttg tatgttagtg ttggcaagtg ttgctatgga
     4261 gagtacagct tcccacaggt tgaaacactc ctgtgtacag tattgtagca cgtattgttt
     4321 atttcagtca atagactccc tgcctcacga gtgcaatgtg gtcttcctgt tgcatttcat
     4381 tggcctcagc gtttcatagc ggaggacaca agagcctctc ttcatgacat taccaatgat
     4441 gactttgtct acatttaata ctttgtattg gagattttaa atgccatgac ctgtgtagat
     4501 ttctaatacc aaagacagac ataaatgttt tccatagact ttgtcttgcc tgtctgtagc
     4561 ccctgtgtaa tatggtgagt tagaatggca ttttactttg taatattttg taaatatgtc
     4621 aataaaatag ttactacttg ca
//
