LOCUS       NM_001106563            5164 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus vav guanine nucleotide exchange factor 2 (Vav2),
            mRNA.
ACCESSION   NM_001106563 XM_001075315 XM_001075347 XM_001075369 XM_001075402
            XM_216030
VERSION     NM_001106563.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5164)
  AUTHORS   Veluthakal,R., Tunduguru,R., Arora,D.K., Sidarala,V., Syeda,K.,
            Vlaar,C.P., Thurmond,D.C. and Kowluru,A.
  TITLE     VAV2, a guanine nucleotide exchange factor for Rac1, regulates
            glucose-stimulated insulin secretion in pancreatic beta cells
  JOURNAL   Diabetologia 58 (11), 2573-2581 (2015)
   PUBMED   26224100
  REMARK    GeneRIF: Our data provide the first evidence to implicate VAV2 in
            glucose-induced Rac1 activation, actin remodelling and
            glucose-stimulated insulin secretion in pancreatic beta cells.
REFERENCE   2  (bases 1 to 5164)
  AUTHORS   Valderrama,F., Thevapala,S. and Ridley,A.J.
  TITLE     Radixin regulates cell migration and cell-cell adhesion through
            Rac1
  JOURNAL   J Cell Sci 125 (Pt 14), 3310-3319 (2012)
   PUBMED   22467863
REFERENCE   3  (bases 1 to 5164)
  AUTHORS   Antoni,G., Oudot-Mellakh,T., Dimitromanolakis,A., Germain,M.,
            Cohen,W., Wells,P., Lathrop,M., Gagnon,F., Morange,P.E. and
            Tregouet,D.A.
  TITLE     Combined analysis of three genome-wide association studies on vWF
            and FVIII plasma levels
  JOURNAL   BMC Med Genet 12, 102 (2011)
   PUBMED   21810271
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5164)
  AUTHORS   Mehlitz,A., Banhart,S., Maurer,A.P., Kaushansky,A., Gordus,A.G.,
            Zielecki,J., Macbeath,G. and Meyer,T.F.
  TITLE     Tarp regulates early Chlamydia-induced host cell survival through
            interactions with the human adaptor protein SHC1
  JOURNAL   J Cell Biol 190 (1), 143-157 (2010)
   PUBMED   20624904
REFERENCE   5  (bases 1 to 5164)
  AUTHORS   Afshari,F.T., Kwok,J.C. and Fawcett,J.W.
  TITLE     Astrocyte-produced ephrins inhibit schwann cell migration via VAV2
            signaling
  JOURNAL   J Neurosci 30 (12), 4246-4255 (2010)
   PUBMED   20335460
  REMARK    GeneRIF: This study suggested that ephrinAs produced by astrocytes
            are involved in inhibition of Schwann cell migration and that this
            effect is mediated through EphA receptors on Schwann cells, leading
            to VAV2 signaling and interception of integrin function.
REFERENCE   6  (bases 1 to 5164)
  AUTHORS   Peng,F., Zhang,B., Ingram,A.J., Gao,B., Zhang,Y. and Krepinsky,J.C.
  TITLE     Mechanical stretch-induced RhoA activation is mediated by the
            RhoGEF Vav2 in mesangial cells
  JOURNAL   Cell Signal 22 (1), 34-40 (2010)
   PUBMED   19755152
  REMARK    GeneRIF: stretch-induced RhoA activation is dependent on
            transactivation of the EGFR and activation of the RhoGEF Vav2.
REFERENCE   7  (bases 1 to 5164)
  AUTHORS   Yi,F., Xia,M., Li,N., Zhang,C., Tang,L. and Li,P.L.
  TITLE     Contribution of guanine nucleotide exchange factor Vav2 to
            hyperhomocysteinemic glomerulosclerosis in rats
  JOURNAL   Hypertension 53 (1), 90-96 (2009)
   PUBMED   19029489
  REMARK    GeneRIF: Vav2-mediated activation of NADPH oxidase is an important
            initiating mechanism resulting in hyperhomocysteinemic glomerular
            injury through enhanced local oxidative stress.
REFERENCE   8  (bases 1 to 5164)
  AUTHORS   Aoki,K., Nakamura,T., Fujikawa,K. and Matsuda,M.
  TITLE     Local phosphatidylinositol 3,4,5-trisphosphate accumulation
            recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite
            outgrowth in nerve growth factor-stimulated PC12 cells
  JOURNAL   Mol Biol Cell 16 (5), 2207-2217 (2005)
   PUBMED   15728722
REFERENCE   9  (bases 1 to 5164)
  AUTHORS   Crespo,P., Schuebel,K.E., Ostrom,A.A., Gutkind,J.S. and
            Bustelo,X.R.
  TITLE     Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by
            the vav proto-oncogene product
  JOURNAL   Nature 385 (6612), 169-172 (1997)
   PUBMED   8990121
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 12, 2008 this sequence version replaced NM_001106563.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-679               JAXUCZ010000003.1  31151438-31152116   c
            680-796             JAXUCZ010000003.1  31110735-31110851   c
            797-855             JAXUCZ010000003.1  31056925-31056983   c
            856-924             JAXUCZ010000003.1  31036918-31036986   c
            925-1027            JAXUCZ010000003.1  31020538-31020640   c
            1028-1126           JAXUCZ010000003.1  31017847-31017945   c
            1127-1195           JAXUCZ010000003.1  31016174-31016242   c
            1196-1296           JAXUCZ010000003.1  31014735-31014835   c
            1297-1396           JAXUCZ010000003.1  31011556-31011655   c
            1397-1492           JAXUCZ010000003.1  31010740-31010835   c
            1493-1561           JAXUCZ010000003.1  31010266-31010334   c
            1562-1648           JAXUCZ010000003.1  31007547-31007633   c
            1649-1734           JAXUCZ010000003.1  31005391-31005476   c
            1735-1867           JAXUCZ010000003.1  31004598-31004730   c
            1868-1977           JAXUCZ010000003.1  31002070-31002179   c
            1978-2079           JAXUCZ010000003.1  31000566-31000667   c
            2080-2168           JAXUCZ010000003.1  31000254-31000342   c
            2169-2185           JAXUCZ010000003.1  30998219-30998235   c
            2186-2207           JAXUCZ010000003.1  30997655-30997676   c
            2208-2335           JAXUCZ010000003.1  30996743-30996870   c
            2336-2410           JAXUCZ010000003.1  30995428-30995502   c
            2411-2463           JAXUCZ010000003.1  30994113-30994165   c
            2464-2580           JAXUCZ010000003.1  30991721-30991837   c
            2581-2668           JAXUCZ010000003.1  30989826-30989913   c
            2669-2792           JAXUCZ010000003.1  30988708-30988831   c
            2793-2879           JAXUCZ010000003.1  30988009-30988095   c
            2880-3034           JAXUCZ010000003.1  30987138-30987292   c
            3035-5164           JAXUCZ010000003.1  30982754-30984883   c
FEATURES             Location/Qualifiers
     source          1..5164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..5164
                     /gene="Vav2"
                     /note="vav guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:296603"
                     /db_xref="RGD:1306285"
     exon            1..679
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..3082
                     /gene="Vav2"
                     /note="Vav2 oncogene; vav 2 guanine nucleotide exchange
                     factor"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor VAV2"
                     /protein_id="NP_001100033.2"
                     /db_xref="GeneID:296603"
                     /db_xref="RGD:1306285"
                     /translation="MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLC
                     QLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDV
                     RDFGKVISAVSRLSLHSIAQSKGIRPFPSEETAENDDDVYRSLEELADEHDLGEDIYD
                     CVPCEDEGDDIYEDIIKVEVQQPMKMGLTEDDKRSCCLLEIQETEAKYYRTLEDIEKN
                     YMGPLRQVLSPVDMATIFINLEDLIKVHHSFLRAIDVSMMAGGSTLAKVFLEFKERLL
                     IYGEYCSHMEHAQSALNQLLASRDDFRQKVEECTLKVQEGKFKLQDLLVVPMQRVLKY
                     HLLLKELLSHSADRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQCSIENLQ
                     VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEVIELLFH
                     KMTDDPMHNKDIKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK
                     ANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTRCGVGAHKECLEVIPPCKMSS
                     PADADAPGAGLGPKMVAVQNYHGNPAPPGKPVLTFQTGDVIELLRGDPDSPWWEGRLV
                     QTRKSGYFPSSSVKPCPVDGRPPVGRPPSREIDYTAYPWFAGNMERQQTDNLLKSHAS
                     GTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWIHITEAKKFESLLELVEYYQCH
                     SLKESFKQLDTTLKFPYKSRERAATRASSRSPASCASYSFSFLSPQGLSFAPQGPSAP
                     FWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKGETNGRIGW
                     FPSTYVEEEGIQ"
     exon            680..796
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..855
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..924
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1027
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1126
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1195
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1296
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1396
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1492
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1561
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1648
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1734
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1867
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1977
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2079
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2168
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2185
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2207
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2335
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2410
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2463
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2580
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2668
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2792
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2879
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3034
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..5164
                     /gene="Vav2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtggggcg agtagctcag gcgccggacg cagggaccga gcgacccgct gcgcctttgt
       61 ctcgggtggg gcaggagcgg cggccggagc ggggcgcccc gaacgcagaa tgcggcgccc
      121 agaggggcgg atcgaagagc gctgcggcgg caggaggtgt ggagcccggg ccggagcccg
      181 agcgcacttg tgtgtgtgaa ggggggaccc ggcacactgc cccgagagcg cctagtggcc
      241 gcacgtgggc gggagccgcg gcccgctagt agcccgagga ggaggaggag gaagaggagg
      301 gccgtgtggc cgcgcagcgg ggacccgggg ccgcctgcgc gaagccccgc cccggcggcc
      361 gagccccgcg cgggcggtcg ggatgctccg cggtcaccgc actttggccg gagcgctgcc
      421 ctgagccagc tggcccagcg gccgcggcgg cgagcgcacg ggcgccgcgg gcgccatgga
      481 gcagtggcgg caatgcggcc gctggctcat tgactgcaag gtcctgccgc ccaaccaccg
      541 cgtcgtgtgg ccctcggcgg tggtcttcga cctggcgcag gcgctgcgcg acggcgtcct
      601 tctgtgccag ctgctgcaca acctctcccc cggctccatc gaccttaagg acatcaactt
      661 ccggccgcag atgtcccagt tcctgtgtct gaagaatatt cgcaccttcc tcaaagtctg
      721 ccacgacaaa tttggactaa ggaacagtga gctgtttgac cctttcgacc tctttgatgt
      781 ccgagacttc gggaaggtca tctctgccgt gtcccgtctg tccctgcaca gcatcgcgca
      841 gagcaaaggg atcaggcctt ttccatcaga ggagacggct gaaaacgatg acgatgtcta
      901 ccggagtctg gaagagctgg ctgacgagca tgacctgggt gaggacatct acgactgtgt
      961 cccgtgtgaa gatgaaggag atgacattta tgaggacatc atcaaggtgg aggtgcagca
     1021 gcccatgaaa atgggactaa ccgaggacga caagaggagc tgctgcttgt tagagattca
     1081 ggagaccgag gccaagtact accgcaccct ggaggacatt gagaagaact acatgggtcc
     1141 cttgcggcag gtgctgagcc ccgtggacat ggccaccatc ttcatcaacc tggaggacct
     1201 catcaaggtg caccacagct ttctgcgagc catcgatgtg tccatgatgg ctggtggcag
     1261 taccctggct aaggtcttcc tggagtttaa ggaacggctc ctgatctacg gagagtactg
     1321 tagccacatg gagcatgcgc agagcgcact gaaccagctc ctcgccagcc gagacgactt
     1381 caggcagaaa gtggaggagt gcacactcaa ggtccaggag ggcaagttca agctgcagga
     1441 tctgctggtg gtgcccatgc agcgggtgct caagtaccac ctgttgctca aggagctcct
     1501 gagccattcc gcagaccggc ctgaaagaca acagctcaaa gaagcactgg aagccatgca
     1561 ggacttggcc atgtatatta atgaagtgaa acgggacaag gagaccttga agaagattag
     1621 tgagttccag tgctccatag aaaacctgca agtgaagctg gaggaatttg ggaggccgaa
     1681 gattgacggg gagctgaaag ttcggtccat agtcaaccac accaagcaag acaggtacct
     1741 gttcctgttt gacaaggtgg tcatcgtgtg taagaggaag ggctacagct atgagctgaa
     1801 ggaggttatt gaactgctct tccacaagat gactgatgac cccatgcaca acaaagacat
     1861 caagaagtgg tcctatggct tctacctgat tcacctccaa gggaagcaag gctttcagtt
     1921 cttctgcaag acggaagaca tgaaacggaa gtggatggag cagttcgaga tggccatgtc
     1981 aaacatcaag ccagacaagg ccaatgccaa ccatcatagt ttccagatgt acacgtttga
     2041 caagaccacc aactgcaaag cctgcaagat gttcctcagg ggtaccttct accagggata
     2101 cctgtgtacc agatgtggtg tcggggcaca caaggagtgc ctggaggtga tacccccctg
     2161 caagatgagt tcgcctgcag atgcggacgc tcccggagca ggactaggtc ccaagatggt
     2221 tgccgtgcag aattaccatg gtaacccagc ccctcccggg aagcccgtgt tgaccttcca
     2281 gacaggggat gtgatagagc tgctccgggg tgaccccgat tctccttggt gggaggggag
     2341 gctggttcaa actcggaagt cagggtattt ccccagctca tctgtgaagc cctgcccggt
     2401 ggacggaagg ccgcctgttg gccgcccgcc atcccgggag atcgattaca ctgcataccc
     2461 gtggttcgct ggcaacatgg aacggcagca gacggacaat ctactcaagt ctcatgccag
     2521 cgggacctac ctcatcagag agcgcccagc agaggcagag cgtttcgcca tcagcatcaa
     2581 gttcaatgat gaagtgaaac acatcaaggt ggtggaaaaa gacagctgga tccacatcac
     2641 ggaagctaag aagtttgaga gcctcctgga gctggtggag tactaccagt gccactcact
     2701 taaggagagc ttcaagcagt tagacactac actcaagttc ccctacaagt ctcgggagcg
     2761 cgccgccacc agggcctcaa gccgatctcc agcttcgtgt gcttcctaca gcttttcttt
     2821 tctcagtcct cagggcctca gctttgcccc ccagggcccc tctgctccct tctggtcagt
     2881 gttcacaccg cgggtcatcg gcacagccgt ggccaggtac aactttgctg cacgagacat
     2941 gcgggagctg tcgctgcggg aaggtgatgt ggtgaagatc tacagccgga tcggtgggga
     3001 ccagggctgg tggaagggcg agacgaacgg gcggatcggt tggtttcctt cgacgtacgt
     3061 ggaagaggaa ggcatccagt gagggcgaga cctggacaga acccacagat gctcttggga
     3121 gtctccccag ctctgaagtc cgcctctggc ttctccgtag ctctgggaac tgcctgctaa
     3181 gcctgcagct gttatggccc ctagggatgg ggagggtgtc ccaccatcac ctgccctagg
     3241 tggcctgtgc ctgggtacat tccttgtaca tagaggagat ccgtgctggc cacacccaga
     3301 gcaccaagga tggggagctc aggccatatg gccaagcatg tgtggatgac agcaaaggtc
     3361 agaagctact gcctgcccct ctggtttaga tggttgctca ggagcccaga cttcgactca
     3421 tggtgtgcca gggagggctg gggacaacag ggggtccctt cccaggccca tctgctgccc
     3481 cacactgatc tgcctgtctt ttctgctgct ctctagagtg tgtgtcaggt tttgggaggc
     3541 aggcaggacc agagccaagc tgtgctgtag cacactccag gcccagctgg gagagagctt
     3601 gcacaggggc cgctggatca cgctagctct ggagatttcc ctggctgcct cccttcctga
     3661 cacagcaggg tcctgctgcg tgctaactgg gcaggcccct ccctcatgag ggaccttcgg
     3721 accgatgaca ttgctgaccc atccccagcc cacccagtca gtggtactgc tctttgcttg
     3781 ttgaagcccc tttcctgagc caggaaacag gtcttttctg ccctgctgcc aggggggaca
     3841 catctgtgaa cctcgaagag cagggtagaa aaccaggttc ccctccctgc tcgctgtctc
     3901 ttttctctcc gggaggcact cttgggtctt ctgcactcta aaccatgctc actaggagtc
     3961 tgctggcctt tgcactagat gttagtttga gcccttgtct ggtatcccac aaggattcct
     4021 gcaacccaca cactgggctt atggccagct caaaataagt gctcttgggg gtctctgccc
     4081 tttcacttct tctcctggtg cttcctggcc tttgacctct gcttgcttgg ccaaccctct
     4141 tttcacccgg tggagttctg agtggaagct tatgtgaaga cacacacaca gactcttggg
     4201 ccctttctcc cctcatccag ctgcccattc ctggatgagt aggagccaag gttagggaca
     4261 ctgtcccact gtcccactgt ccccaacgga gtggataatg cactacttgc tcctggggac
     4321 actttccaga gttggcttat gtcctccagc ttggtgtcca catataacat gctaggatgt
     4381 taggggaggc agagagggat tcggagaagg ggagcagcag gaagagagag accttggaaa
     4441 gcctcagcta tgagaaactg ggagtgaagg gtttggagag ggccggggcg cgggccacct
     4501 acactgctcc ttggcccagc ctgcccagtg caagtgcaga ccttggggag ggctctgtcg
     4561 gcaggagcca tacgaacgcc ctcacgtcag tcacgacacc ctgtgcttta ggttttgttt
     4621 cgtttgtttg tttttctgtt gtagcttttt ttcctttttt gtcctgttac attttgtttt
     4681 gcctgttcgt atcttagaag gggggaaagt tgtaattatt tcatctaaat ctcccattat
     4741 atatctgtga ataagagatt ctatgatagc agaaggatgt atattttagc ttgtcatgac
     4801 gtgtcatgat aacgaaggac actgagaaag aggatagtcc agagccccgt tcttgtgaat
     4861 gttttgtgtt tgttttgaca tgtgtgtttg gtttgggttt ttttgttttt gttgtttttg
     4921 agctgcactg agcagggtgc tgggcaggct ggggcatggg cacctctgca ggagactgga
     4981 caccgactaa ggactggggg cctgagatca gctgtgaaca tttgcagcac aatgcatgca
     5041 agtcagggat gtgggggtcc cacagccagc agcaccccct gatggaacaa ctgtacattt
     5101 gccaatgggt tttccccaca agactacggt ttttactaca aataaactta cgttctattc
     5161 tgca
//
