LOCUS       NM_012759               2917 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus vav guanine nucleotide exchange factor 1 (Vav1),
            mRNA.
ACCESSION   NM_012759
VERSION     NM_012759.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Wang,Q., Gong,L., Mao,S., Yao,C., Liu,M., Wang,Y., Yang,J., Yu,B.,
            Chen,G. and Gu,X.
  TITLE     Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral
            nerve injury
  JOURNAL   Exp Neurol 343, 113788 (2021)
   PUBMED   34147481
  REMARK    GeneRIF: Klf2-Vav1-Rac1 axis promotes axon regeneration after
            peripheral nerve injury.
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Pedros,C., Gaud,G., Bernard,I., Kassem,S., Chabod,M., Lagrange,D.,
            Andreoletti,O., Dejean,A.S., Lesourne,R., Fournie,G.J. and
            Saoudi,A.
  TITLE     An Epistatic Interaction between Themis1 and Vav1 Modulates
            Regulatory T Cell Function and Inflammatory Bowel Disease
            Development
  JOURNAL   J Immunol 195 (4), 1608-1616 (2015)
   PUBMED   26163585
  REMARK    GeneRIF: these results highlight the importance of the signaling
            pathway involving epistasis between Themis1 and Vav1 in the control
            of Treg suppressive function and susceptibility to IBD development.
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   4  (bases 1 to 2917)
  AUTHORS   Valderrama,F., Thevapala,S. and Ridley,A.J.
  TITLE     Radixin regulates cell migration and cell-cell adhesion through
            Rac1
  JOURNAL   J Cell Sci 125 (Pt 14), 3310-3319 (2012)
   PUBMED   22467863
REFERENCE   5  (bases 1 to 2917)
  AUTHORS   Lawson,C.D., Donald,S., Anderson,K.E., Patton,D.T. and Welch,H.C.
  TITLE     P-Rex1 and Vav1 cooperate in the regulation of
            formyl-methionyl-leucyl-phenylalanine-dependent neutrophil
            responses
  JOURNAL   J Immunol 186 (3), 1467-1476 (2011)
   PUBMED   21178006
REFERENCE   6  (bases 1 to 2917)
  AUTHORS   Song,J.S., Haleem-Smith,H., Arudchandran,R., Gomez,J., Scott,P.M.,
            Mill,J.F., Tan,T.H. and Rivera,J.
  TITLE     Tyrosine phosphorylation of Vav stimulates IL-6 production in mast
            cells by a Rac/c-Jun N-terminal kinase-dependent pathway
  JOURNAL   J Immunol 163 (2), 802-810 (1999)
   PUBMED   10395673
REFERENCE   7  (bases 1 to 2917)
  AUTHORS   Bieg,S.
  TITLE     Differential expression of p95vav in primary lymphoid tissue of BB
            rats congenic for the lymphopenia gene
  JOURNAL   Autoimmunity 30 (1), 37-42 (1999)
   PUBMED   10433093
REFERENCE   8  (bases 1 to 2917)
  AUTHORS   Crespo,P., Schuebel,K.E., Ostrom,A.A., Gutkind,J.S. and
            Bustelo,X.R.
  TITLE     Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by
            the vav proto-oncogene product
  JOURNAL   Nature 385 (6612), 169-172 (1997)
   PUBMED   8990121
REFERENCE   9  (bases 1 to 2917)
  AUTHORS   Margolis,B., Hu,P., Katzav,S., Li,W., Oliver,J.M., Ullrich,A.,
            Weiss,A. and Schlessinger,J.
  TITLE     Tyrosine phosphorylation of vav proto-oncogene product containing
            SH2 domain and transcription factor motifs
  JOURNAL   Nature 356 (6364), 71-74 (1992)
   PUBMED   1531699
REFERENCE   10 (bases 1 to 2917)
  AUTHORS   Hernandez,L., Petropoulos,C.J., Hughes,S.H. and Lijinsky,W.
  TITLE     DNA methylation and oncogene expression in methapyrilene-induced
            rat liver tumors and in treated hepatocytes in culture
  JOURNAL   Mol Carcinog 4 (3), 203-209 (1991)
   PUBMED   2064726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC091160.1.
            
            On Dec 11, 2007 this sequence version replaced NM_012759.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091160.1, U39476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2917
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /note="vav guanine nucleotide exchange factor 1"
                     /db_xref="GeneID:25156"
                     /db_xref="RGD:3951"
     exon            1..261
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2589
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /note="p95; vav 1 oncogene; vav 1 guanine nucleotide
                     exchange factor"
                     /codon_start=1
                     /product="proto-oncogene vav"
                     /protein_id="NP_036891.2"
                     /db_xref="GeneID:25156"
                     /db_xref="RGD:3951"
                     /translation="MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLC
                     QLLNNLLPHAINLREVNLWPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDV
                     QDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLY
                     DCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQ
                     HFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKER
                     FLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVL
                     KYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIEN
                     LDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLH
                     SFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYP
                     ENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGR
                     QDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVE
                     LTKAEAEHNWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGI
                     LTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELV
                     EFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSE
                     LSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC"
     exon            262..378
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            379..437
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            438..506
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            507..615
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            616..711
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            712..780
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            781..884
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            885..984
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1080
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1149
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1236
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1322
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1455
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1565
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1667
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1759
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1782
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1828
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1965
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2031
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2063
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2180
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2268
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2383
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2535
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2824
                     /gene="Vav1"
                     /gene_synonym="Vav"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaacgagg gtgcacgggg cctccccgag gggccaaggg agaggcaggc agccactatg
       61 gagctctggc gacagtgcac ccactggctg atccagtgtc gggtgctgcc tcccagccac
      121 cgtgtgacct gggagggggc ccaggtgtgt gagctggcac aggcactgcg ggatggtgtc
      181 ctcctgtgtc aactgcttaa caacctgctc ccccacgcca tcaatctgcg ggaagttaac
      241 ttgtggcccc agatgtccca gttcctttgt cttaagaaca tccgaacctt cctgtctact
      301 tgctgtgaga aattcggcct caagcgcagc gaactctttg aggcttttga cctctttgat
      361 gtgcaggact ttggaaaggt catctacacc ctgtctgccc tgtcatggac acccattgcc
      421 cagaacaaag ggatcatgcc cttcccaaca gaggacagcg ccctgggtga tgaagatatt
      481 tacagtggcc tttcagacca gattgatgac accgcagagg aagatgagga cctttatgac
      541 tgcgtggaga atgaggaggc agagggggac gagatctacg aggacctaat gcgctcggag
      601 tcggtgccca cacctcccaa gatgacagag tacgataagc gctgctgctg cctgcgggag
      661 atccagcaga ctgaggagaa gtacacagac acactgggct ccatccagca gcacttcatg
      721 aagcccctcc agcgattcct caagcctcaa gacatggaga ccatctttgt caacattgag
      781 gagctgctct ctgtgcacac ccacttctta aaggaactga aggatgccct gtctggcccg
      841 ggagcaacga tgctgtatca ggtcttcatc aagtataagg agaggttcct tgtttatggc
      901 cgttattgca gtcaggtgga gtcagccagc aagcacttgg atcaagtggc cacagcacgg
      961 gaggatgtgc agatgaagct ggaggaatgc tctcaaagag ccaacaatgg ccgcttcacc
     1021 ctgcgggatc tgctgatggt gcctatgcag cgggtgctga agtatcacct cctcctccag
     1081 gagctagtga aacacacaca ggatactaca gaaaaggaga acctgcggtt ggccctggac
     1141 gccatgaggg acctggcgca gtgtgtgaat gaggtcaaga gggacaatga aaccttacgg
     1201 cagatcacaa actttcagct gtccattgag aacctggacc agtctctggc caactatggc
     1261 cggcctaaga ttgacggtga gctcaagatt acctcagtgg aacggcgctc caagacagac
     1321 aggtatgcct tcctgctgga caaagcactg ctcatctgta agcgccgcgg ggactcttat
     1381 gacctcaagg cctcagtgaa cctgcacagc ttccaagttc gggatgactc ttccggggag
     1441 cgggacaaca agaagtggag ccacatgttc cttctgattg aggatcaagg tgcccagggg
     1501 tatgagctgt tcttcaagac tcgggagcta aaaaagaagt ggatggaaca gtttgaaatg
     1561 gccatctcca acatctaccc agaaaatgct acagccaatg gacatgattt tcagatgttc
     1621 tcctttgagg agaccacttc ctgcaaggcc tgccagatgt tactcagggg cacattctac
     1681 cagggatatc gctgttacag gtgccgtgca cccgcacaca aggagtgtct gggaagggtg
     1741 cctccatgtg gccgtcaaga tttctcagga accatgaaga aggacaagct acatcgaagg
     1801 gcccaggaca agaaaaggaa tgaattgggc cttcctaaga tggaggtgtg tcaggaatac
     1861 tacgggatcc ctcctcctcc cggagccttt gggccatttc tgcggctcaa ccctggggac
     1921 attgtggaac tcactaaggc agaggctgaa cacaactggt gggagggaag aaatacagct
     1981 acgaatgaag tcggctggtt tccctgtaac agagttcgtc cctacgtcca cggccctccc
     2041 caggacctgt ctgtgcacct ctggtatgcg ggccccatgg agcgagcagg cgccgagggc
     2101 atcctcacca accgctctga tgggacctac ctggtgcggc aaagggtgaa agatacagcg
     2161 gaattcgcca tcagcattaa gtataatgtg gaggtcaagc atattaaaat catgacgtca
     2221 gaggggttgt accgcatcac agagaagaag gctttccggg gcctcccgga actggtagag
     2281 ttttatcagc agaattccct aaaagattgc ttcaagtcgt tggacaccac cttgcagttt
     2341 ccttacaagg aacctgagag gagagccatc aacaagccgc cggttggaag caccaagtat
     2401 tttggcactg ccaaagcccg ctacgacttc tgtgcccggg accgatcgga actgtccctt
     2461 aaggagggtg acatcatcaa gatcctcaac aagaagggac agcaaggctg gtggcgtggg
     2521 gagatctatg gccggattgg ctggtttccc tctaactatg tggaggaaga ctattctgaa
     2581 tactgctgag cccgatgccc tgcaggacac agagagaggc agatgatggc tgagcccagg
     2641 atgccagcag ggttgagggg ctgtgagctg ttctcattgg cagaggatct ggatggagct
     2701 cagatggcta gtggccagct agcagggttc ccaggatgaa gcccagagat ggttaattta
     2761 tagcacactg attttttcga gtcctccaag aaagctgatt ctaataaagt gaggacagca
     2821 ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
