LOCUS       NM_001108475            2124 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            mRNA.
ACCESSION   NM_001108475 XM_001075571 XM_341799
VERSION     NM_001108475.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2124)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 2124)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 2124)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 2124)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 2124)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168841.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001108475.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680424, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2124
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..183
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1309
                     /gene="Vasp"
                     /codon_start=1
                     /product="vasodilator-stimulated phosphoprotein"
                     /protein_id="NP_001101945.2"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
                     /translation="MSNETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPT
                     ANSFRVVGRKLQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAAQ
                     FAIGMANALEALEGGGPPPAPAPPAWSTQNGPSPEELEQQKRQPEHLERRVSNAGGPP
                     APPAGGPPPPPGPPPPPGPPPPPGLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGS
                     GAPGLAAAIAGAKLRKVSKEEASGGPLAPKAENSRGTGGGLMEEMNAMLARRRKATQV
                     GEKPPKDESASQEESEARIPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSVPSS
                     SDDSDLERVKQELVEEVRKELQKMKEEIIEVFVQELRKRGSP"
     exon            184..358
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            359..524
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            525..609
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            610..647
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            648..889
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            890..987
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1039
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1076
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1122
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1213
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1271
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..2099
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcctgag cacccgcccg ggcccggtcc acgttctccc caggaagctg gactctatgg
       61 ggcgggaccc cgagagagac tgagcagaac ctggagccag ccccgcaccc ctgcacttcc
      121 aatcaggggc gccccgggag cactccccgt gggcgcgccg cctgccctct gcgcagccat
      181 gagcaacgag acggtcattt gttccagccg ggctactgtg atgctttacg atgacagcaa
      241 caaacgatgg cttcctgctg gcaccggtcc ccaggccttt agccgcgtcc agatctacca
      301 caaccccact gctaactctt tccgagttgt tggccgcaag ctgcagcctg accagcaggt
      361 ggttatcaac tgtgccatca ttcgaggtgt caagtacaat caggccactc ccatattcca
      421 ccagtggcgt gatgcccgcc aggtctgggg cctcaacttc ggcagcaagg aggacgctgc
      481 gcagtttgcg atcggcatgg ccaatgccct ggaggccttg gaaggaggtg ggcctccccc
      541 tgccccagca ccccctgcct ggtctaccca gaatggcccc tccccagagg agctggaaca
      601 acagaaaagg cagcctgaac atttggagcg ccgggtctcc aatgcaggag gcccacctgc
      661 tcccccagct gggggcccac ctccacctcc aggacctccc cctcctccgg gtcccccccc
      721 acccccaggt ctgcccccct caggggtatc tggggcaggt catggaacag gtgtagcccc
      781 accccctgca cccccactcc ctacagcaca gggccccagt agtgggggtt ccggggcccc
      841 aggcctggcc gctgccattg ctggagccaa actcaggaaa gtgagcaagg aggaggcctc
      901 tggggggccc ctggccccca aagctgagaa tagtcgaggc actggtgggg ggcttatgga
      961 agagatgaac gccatgctgg cccggagaag gaaagccaca caggttgggg agaagccccc
     1021 caaagacgag tcagccagtc aggaggagtc agaggcccga atccctgccc aaagtgaacc
     1081 tgtgcgaaga ccctgggaga agaacagcac aaccttgcca aggatgaagt catcctcttc
     1141 tgtgactacc tccgaggccc acccctctgt gcccagctcc agtgatgact ccgacttgga
     1201 gagggtgaag caggagcttg tggaagaggt gcggaaggag ctacagaaaa tgaaagagga
     1261 aataatcgaa gtctttgtcc aggagctgag gaagcggggt tctccttgac tacagggacc
     1321 cagaagaccc atttcttctt tttgtacttc ctgcctggca cctgctttcc ctgcctcaac
     1381 ttgaccaaga gttacacaag aatgcgttct cccctaccag ctcccacttg gaagattcca
     1441 caggggtgtg gcttcctggt gccgtggtca cacccacgct ggctgctgat tggataagga
     1501 ggtcccaccc ctttgttccc tttggtcctt ccccttcacc atccccttgg agctggttcc
     1561 tctgctgggg atgtaagagt aaccccacag taagggaagg aaggagggga tctcaccttc
     1621 tcttgttctg gattcacttt aacgctttaa tgccttggaa tttttttttt taagaaaaag
     1681 tatatatata tatttgggtt ttgtgggggg aagggaaatt ttttgttctc tttggttttg
     1741 ataaaatggg gtgtgggagt ttttaaatgc tataccccaa gctttgtccc atcagaggca
     1801 gctatgtaag aggaggggta tcccaccaag tagggggcat ttcccccacc cctgggatac
     1861 ctccccattt gccttggctc ctctctcttt tctataagga attaagattc tttaactttt
     1921 ttggaacctc agttttgtgg ttttttttat ttgggttagg atttcagggt ccagaccatt
     1981 tttgccctcc aggaagacga agtgaggggg aggagaagag gaaaaatagg tcctccgact
     2041 tctacaccat agcttcttgg acacgggccc tcgctgaata aatctgcagt ttttataaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaa
//
