LOCUS       NP_001102852             673 aa            linear   ROD 26-FEB-2024
DEFINITION  vasorin precursor [Rattus norvegicus].
ACCESSION   NP_001102852 XP_001055204
VERSION     NP_001102852.1
DBSOURCE    REFSEQ: accession NM_001109382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 673)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 673)
  AUTHORS   Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, Li T,
            Jitkaew S, Cao X, Kim YS, Kim HS, Levitt P, Shih G, Birre M, Deng
            CX and Liu ZG.
  TITLE     A HIF-1 target, ATIA, protects cells from apoptosis by modulating
            the mitochondrial thioredoxin, TRX2
  JOURNAL   Mol Cell 42 (5), 597-609 (2011)
   PUBMED   21658601
REFERENCE   3  (residues 1 to 673)
  AUTHORS   Malapeira J, Esselens C, Bech-Serra JJ, Canals F and Arribas J.
  TITLE     ADAM17 (TACE) regulates TGFbeta signaling through the cleavage of
            vasorin
  JOURNAL   Oncogene 30 (16), 1912-1922 (2011)
   PUBMED   21170088
REFERENCE   4  (residues 1 to 673)
  AUTHORS   Zhang Y, Li Y, Qiu F and Qiu Z.
  TITLE     Comprehensive analysis of low-abundance proteins in human urinary
            exosomes using peptide ligand library technology, peptide OFFGEL
            fractionation and nanoHPLC-chip-MS/MS
  JOURNAL   Electrophoresis 31 (23-24), 3797-3807 (2010)
   PUBMED   21082674
REFERENCE   5  (residues 1 to 673)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (residues 1 to 673)
  AUTHORS   Schroder B, Wrocklage C, Pan C, Jager R, Kosters B, Schafer H,
            Elsasser HP, Mann M and Hasilik A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (residues 1 to 673)
  AUTHORS   Ikeda Y, Imai Y, Kumagai H, Nosaka T, Morikawa Y, Hisaoka T, Manabe
            I, Maemura K, Nakaoka T, Imamura T, Miyazono K, Komuro I, Nagai R
            and Kitamura T.
  TITLE     Vasorin, a transforming growth factor beta-binding protein
            expressed in vascular smooth muscle cells, modulates the arterial
            response to injury in vivo
  JOURNAL   Proc Natl Acad Sci U S A 101 (29), 10732-10737 (2004)
   PUBMED   15247411
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474017.1.
            
            On Oct 4, 2007 this sequence version replaced XP_001055204.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB614933.1, FQ151950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     Protein         1..673
                     /product="vasorin precursor"
                     /calculated_mol_wt=69792
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2547
     Region          25..55
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          35..57
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          58..78
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <64..>345
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          79..102
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          103..126
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          127..150
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..194
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          195..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          219..241
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          242..266
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          267..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          410..441
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          469..546
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(543..544,546..547)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..673
                     /gene="Vasn"
                     /coded_by="NM_001109382.1:156..2177"
                     /db_xref="GeneID:679921"
                     /db_xref="RGD:1598149"
ORIGIN      
        1 mhsrsclppl lllllvllgs gvqscpsgcq cnqpqtvfct arqgttvprd vppdtvglyi
       61 fengittldv gcfagfpglq lldlsqnqit slpggifqpl vnlsnldlta nklheisnet
      121 frglrrlerl ylgknrirhi qpgafdaldh llelklpdne lrvlpplhlp rlllldlshn
      181 sipaleagil dtanvealrl aglglrqlde glfgrlrnlh dldvsdnqlg hmpsviqglr
      241 gltrlrlagn triaqirped lagltalqel dvsnlslqal psdlsslfpr lrllaaarnp
      301 fnclcplswf gpwvreshvv laspeetrch fppknagrll leldyadfgc pvttttatvp
      361 tirptvrept pstssqaptw psptepttqa pivlstappt mrpapqpqdc pasiclnggs
      421 crvgakhhle clcpegfigl ycespveqrt kpssipdtpr pprllplrie pvsptslrve
      481 lqrylqgntv qlrslrltyr nlsgpdkrlv tlrlpaslae ytvtqlrpna tysicvtalg
      541 agrtpegeea cgeantpqav rsnhapvtqa regnlpllia palaavllav laasgavycv
      601 rrarasstaq dkgqvgpgtg plelegvkvp lepgskaseg ggealsggpe cevplmgypg
      661 pslqgvlpaq pyi
//
