LOCUS       NM_001401379            3751 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus vasohibin 2 (Vash2), transcript variant 1, mRNA.
ACCESSION   NM_001401379
VERSION     NM_001401379.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Zhou,C., Yan,L., Zhang,W.H. and Liu,Z.
  TITLE     Structural basis of tubulin detyrosination by VASH2/SVBP
            heterodimer
  JOURNAL   Nat Commun 10 (1), 3212 (2019)
   PUBMED   31324789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Wang,N., Bosc,C., Ryul Choi,S., Boulan,B., Peris,L., Olieric,N.,
            Bao,H., Krichen,F., Chen,L., Andrieux,A., Olieric,V., Moutin,M.J.,
            Steinmetz,M.O. and Huang,H.
  TITLE     Structural basis of tubulin detyrosination by the vasohibin-SVBP
            enzyme complex
  JOURNAL   Nat Struct Mol Biol 26 (7), 571-582 (2019)
   PUBMED   31235911
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Liao,S., Rajendraprasad,G., Wang,N., Eibes,S., Gao,J., Yu,H.,
            Wu,G., Tu,X., Huang,H., Barisic,M. and Xu,C.
  TITLE     Molecular basis of vasohibins-mediated detyrosination and its
            impact on spindle function and mitosis
  JOURNAL   Cell Res 29 (7), 533-547 (2019)
   PUBMED   31171830
  REMARK    Erratum:[Cell Res. 2019 Sep;29(9):778. PMID: 31395957]
REFERENCE   4  (bases 1 to 3751)
  AUTHORS   Nieuwenhuis,J., Adamopoulos,A., Bleijerveld,O.B., Mazouzi,A.,
            Stickel,E., Celie,P., Altelaar,M., Knipscheer,P., Perrakis,A.,
            Blomen,V.A. and Brummelkamp,T.R.
  TITLE     Vasohibins encode tubulin detyrosinating activity
  JOURNAL   Science 358 (6369), 1453-1456 (2017)
   PUBMED   29146869
REFERENCE   5  (bases 1 to 3751)
  AUTHORS   Aillaud,C., Bosc,C., Peris,L., Bosson,A., Heemeryck,P., Van
            Dijk,J., Le Friec,J., Boulan,B., Vossier,F., Sanman,L.E., Syed,S.,
            Amara,N., Coute,Y., Lafanechere,L., Denarier,E., Delphin,C.,
            Pelletier,L., Humbert,S., Bogyo,M., Andrieux,A., Rogowski,K. and
            Moutin,M.J.
  TITLE     Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate
            neuron differentiation
  JOURNAL   Science 358 (6369), 1448-1453 (2017)
   PUBMED   29146868
REFERENCE   6  (bases 1 to 3751)
  AUTHORS   Suenaga,K., Kitahara,S., Suzuki,Y., Kobayashi,M., Horie,S.,
            Sugawara,J., Yaegashi,N. and Sato,Y.
  TITLE     Role of the vasohibin family in the regulation of fetoplacental
            vascularization and syncytiotrophoblast formation
  JOURNAL   PLoS One 9 (9), e104728 (2014)
   PUBMED   25184477
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3751)
  AUTHORS   Kimura,H., Miyashita,H., Suzuki,Y., Kobayashi,M., Watanabe,K.,
            Sonoda,H., Ohta,H., Fujiwara,T., Shimosegawa,T. and Sato,Y.
  TITLE     Distinctive localization and opposed roles of vasohibin-1 and
            vasohibin-2 in the regulation of angiogenesis
  JOURNAL   Blood 113 (19), 4810-4818 (2009)
   PUBMED   19204325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1425093.1,
                                           SRR26643293.55328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               JAXUCZ010000013.1  105091225-105091624 c
            401-489             JAXUCZ010000013.1  105083741-105083829 c
            490-546             JAXUCZ010000013.1  105080077-105080133 c
            547-621             JAXUCZ010000013.1  105079381-105079455 c
            622-1003            JAXUCZ010000013.1  105073316-105073697 c
            1004-1119           JAXUCZ010000013.1  105071659-105071774 c
            1120-1176           JAXUCZ010000013.1  105068469-105068525 c
            1177-1245           JAXUCZ010000013.1  105067686-105067754 c
            1246-3751           JAXUCZ010000013.1  105060857-105063362 c
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..3751
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /note="vasohibin 2"
                     /db_xref="GeneID:498309"
                     /db_xref="RGD:1564105"
     exon            1..400
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1318
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /EC_number="3.4.17.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubulinyl-Tyr carboxypeptidase 2"
                     /codon_start=1
                     /product="tubulinyl-Tyr carboxypeptidase 2 isoform 1"
                     /protein_id="NP_001388308.1"
                     /db_xref="GeneID:498309"
                     /db_xref="RGD:1564105"
                     /translation="MTGSAADTHRCPHPKSIKGTRSRSSHARPVSLATSGGSEEEDKD
                     GGVLFHVNKSGFPIDSHTWERMWLHVAKVHPRGGEMVGAIRNAAFLAKPSIPQVPNYR
                     LSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLE
                     AVILGIYLTNGQPSIERFPISFKTYFSGSYFHHVVLGIYCNGYYGSLGMSRRAELMDK
                     PLTFRTLSDLVFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLR
                     ADIRKELEKYARDMRMKILKPASGHSPTQVRIRGKSLSPRRRQASPPRRLGRRDKSTE
                     ENYTIFDNKVEITRSKSQDNRPHQHLHLHPRKTAVRQLQLPALTEKKVADLSTLNEVG
                     YQIRI"
     exon            401..489
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     exon            490..546
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     exon            547..621
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     exon            622..1003
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1119
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1176
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1245
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..3751
                     /gene="Vash2"
                     /gene_synonym="RGD1564105"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggccgg tgagcggggt tctcttcgcg cgtcctgcgg ccgcgagagt taaaggccac
       61 ccccgcgggg ccctgatccc cggcgtgccc gcgtcctccg ccccctcgcc gcgtgcccct
      121 caccatgacc ggctccgccg ccgacactca ccgctgcccc caccccaaaa gcatcaaagg
      181 cacccggtcc cggagcagcc acgcgcggcc ggtgagcctc gccactagcg ggggctcgga
      241 ggaggaggac aaagacggcg gggtgctgtt ccacgtgaac aagagcgggt tccctatcga
      301 cagccacacc tgggagcgga tgtggctgca tgttgccaag gtccacccca gagggggaga
      361 gatggtaggc gccatcagaa acgctgcctt cctggctaag ccttcaattc cccaggtccc
      421 aaactacagg ttgtccatga cgatcccaga ctggctccag gccatccaga attatatgaa
      481 gacactacaa tacaaccata cagggaccca gttctttgaa atcaggaaaa tgcgacctct
      541 gagcgggtta atggagacgg cgaaagagat gacccgagag tccttgccta tcaaatgcct
      601 ggaggcagtc atcctgggca tatatttaac caatgggcag ccttccattg agcggttccc
      661 tatcagcttt aaaacctact tctcaggaag ctactttcac catgtcgtgc tggggattta
      721 ctgcaatggt tactacggtt cactgggcat gagccgaagg gcggagctga tggacaagcc
      781 gctgaccttt aggactctga gtgaccttgt ctttgacttt gaagactcct ataagaaata
      841 ccttcacacg gtcaagaagg tcaagattgg gctgtacgtc ccccatgagc ctcacagctt
      901 ccagcccatc gagtggaagc aacttgtcct caatgtctca aagatgctga gggctgacat
      961 caggaaggag ctggagaagt acgccaggga catgcggatg aagatcttga aacctgcaag
     1021 tggccactct ccaacccaag tgagaatccg gggaaagtcc ctgtctccac ggaggagaca
     1081 agcaagccct ccgaggaggc tcggcaggcg agacaaatca actgaagaga actacaccat
     1141 ctttgacaac aaggtggaaa taaccaggag caagagccaa gacaatcggc cacaccagca
     1201 ccttcatctg catccgagga agacagctgt tagacagcta cagttgcctg ctctgaccga
     1261 gaagaaggtg gctgacctca gtactctgaa cgaagtgggc tatcagatcc ggatctagcc
     1321 aggcaaggcc agcaaggctt ctatggtgct cttctctgcg ctttacccag cagcttcagg
     1381 aggaactgca acttgtggag ttttgatttt gaaggattta cctggagata gaatctgagt
     1441 gggtttttga aaaactcact ggtcagcagg catgactggg ctgaagtgac ggacaaaccc
     1501 ctgggttgac tgactccctc actcaggatc tcaagaacaa tgttactgca gttttctatt
     1561 tttccatttg ccgactttcc gcttgctttg gacattacgc ctcggctata gtaaccgttt
     1621 gtggagtccc ctcccacttt tggtacagca ggcagctcag ccagtaccgc cgtcttctca
     1681 gcaataacaa gcgaggatgg gtggcttctt taaacagttg atattacctc agcgtttggc
     1741 atcagatatg cagtcttaat gagttttata ttctatttgt attgttttcc tacagggatc
     1801 tcgatggtct ggagggtttt tgttgttttt tctggttcac acgtgagatg agatttaagt
     1861 tatatgcaga tgctttagaa gcactgaagt tctggcaata agggaaacag tggggtcttg
     1921 gagtctcttt ccttaaagca tctgctgaca ggttttctcc taacaagcat gttaagaagc
     1981 tctagcccat gctgttgcca acagttaagc cttttctgag tcaggcaaaa agcacaagag
     2041 accatgtgtt cctgaaaaca cagcagtgct gagacttctc agacaggagg gcagacgtct
     2101 ggtcagcctt ggctcttagt ggctcctggt agttagtgtt ctgctgtctt tcatgagggt
     2161 agacatgttt tccaggagct tgtcttaggc gccacttcat ggccttagga ggcactgggg
     2221 gaagccagga ccttaagcct gtcttaaggg aggagtttca gcacagtgct ctgcctcagt
     2281 gttacccagg cctagagcac agtgagcctg cctgtggcca ctccagcaca gcttctgctc
     2341 gcaccacgag gaggaagcac agcttcaagt cattcatctt agtggtcacc atgccaactc
     2401 aggagagcag aggcccagct gcagctgagt ggctggcccc cagagttcag catgctccct
     2461 tttggctgtg actggggagc tctaagaagt caacgtctgc tcactaagtc tttgccagga
     2521 aaaccctagg gccacaagga gggcaaaggt gtgtgcagaa aaaaaaaaaa caaaaaaaaa
     2581 aaacaaaaaa acaacccact ccccactcca gccagcatta ttaatgaaaa gttgtttgct
     2641 tggaaagctt agtgtccttt ataggacagg accaggaaac taaatcagtg tgagcttcaa
     2701 attctcaact caatggcttt cttcaagaat cctgttactg cagttcaagg tgagttatgg
     2761 ggcccaggcg tgtgctcaga gcctctggtt tgacgcccag cacccgagga agccccaccc
     2821 ccctccacat gtcctcacga tccctgttgt cagggccatg tgcactgaaa tgttccaaga
     2881 agcaatctgg tgagtgcagc caccaggcct gtgttcaagg tcagctcaca gagacacagc
     2941 actgaacatc aggacaacct tgatgtgtgg caacagcagg cagctgtgac actgtcatct
     3001 aatctcttcc acaaccacct gattcttagg ctcttctttc aaggcagggt tggtcagaaa
     3061 catttaaaag gctctttatc actcaatttt actgcctgta gtcacactaa gacagaagca
     3121 agccccaaac acctacattc taatgcaatc gtttacagta agacagcaaa agtgaaccca
     3181 gcttgtctta cctcagactg accttctgtc tggcagtgat gtagatgaag aggaaaactg
     3241 agctgacaga agcgagttta tcctgtgcac cacggcaaga cgcacagagc tggataagga
     3301 cgtgagccga ctgctactga ctgtgaaagt ggcctgggtg ctttctgaca tgcggggggt
     3361 ggggggggac gggaccgtga gcacgccgcc cctttccatg agtcagctgt ttcctagggt
     3421 gtcctcagca gagcgaggtc atcaaagggc agcctttgta acccctcagc tcactgcaag
     3481 cctttcgtac actagacttt tatgtacaac cttgtacaat gtttttgacg tacaactcag
     3541 attcttgttt attcttagac tttgatctgg ccaatacatt tttaaaaaaa tctttcagat
     3601 gaaccgtgat tgctttagtg ggtatttttc taagtacatg aagacttgat ggtattccac
     3661 agaacaccac aagtgcatgc ttcaggctca aatctctctc atgtgtccac acacagcatg
     3721 gaactgtaat aaaactgatc tggaaactga g
//
