LOCUS       NM_213563               4099 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus valyl-tRNA synthetase 2, mitochondrial (Vars2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_213563 XM_227978
VERSION     NM_213563.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4099)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883047.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by
            NM_001429116.1.
            
            On Aug 30, 2004 this sequence version replaced XM_227978.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4099
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /note="valyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:309596"
                     /db_xref="RGD:1303122"
     exon            1..482
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..3479
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /EC_number="6.1.1.9"
                     /note="valyl-tRNA synthetase, mitochondrial; valRS;
                     valine--tRNA ligase, mitochondrial; valyl-tRNA synthetase
                     2, mitochondrial (putative)"
                     /codon_start=1
                     /product="valine--tRNA ligase, mitochondrial precursor"
                     /protein_id="NP_998728.1"
                     /db_xref="GeneID:309596"
                     /db_xref="RGD:1303122"
                     /translation="MPHLPLASFRPPLWGLRPSWGLARPRALCTQPEPHGSPVSRRNR
                     EAKQKRLREKQAALEAGLAEKSKTPAVPTKAWSHKEVVLYEIPTRPGEKKDVSGPLPP
                     AYSPQYVEAAWYQWWVREGFFKPEYQARLPQATGETFSMCIPPPNVTGSLHIGHALTV
                     AIQDAFVRWHRMRGDRVLWIPGSDHAGIATQAVVEKQLWRERRVRRHELSREDFLRAV
                     WQWKQEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYDLGLLYRNRQL
                     VNWSCTLRSAISDIEVESRPLPGRTVLRLPGCPIPVSFGLLVSIAFPVDGDPGTEIVV
                     GTTRPETLPGDVAVAVHPDDPRYTHLHGRQLRHPLTGQHLPLITDTTVQPHVGTGAVK
                     VTPAHSPADAEMGTRHGLTPLSVIAEDGTMTSLCGDWLQGLHRFVAREKIMCTLRERG
                     LFRGLQEHPMVLPICSRSGDVVEYLLKSQWFVRCQEMGDRAAKAVESGALELWPSFHQ
                     KSWQHWFAHIGDWCVSRQLWWGHQIPAYRVGGEKAEDDREECWVVGRSEAEARAAAAK
                     QTGRPEAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLTLLETGSDLLT
                     FWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSKSLGNVLDPRDIISGQELQVL
                     QAKLRDGNLDQGELAVAAAAQKKDFPYGIPECGTDALRFALCSHGILGGDLHLSVSEV
                     LNYRHFCNKLWNALRFILRALGDDFVPQPAEKVTPSSPMDAWILSRLAFAANECERGF
                     LSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSAPCPPGPPQVLFSCADVGLRLLAP
                     LMPFLAEELWQRLPPRQGGSMAPSICVAPYPSGHSLVSRGQESWRQPELEHCFSRVQE
                     IVQALRALRATYQLTRARPHVLLQSSDPGEQGLVQPFLEPLGVLSHCGAVGFLPPGAA
                     APSGWALAPLGDTIKIYMELQGLVDPQSQLPRLAARRQKLQKQLDDLLNRTVSDGPAE
                     RQQRISSLQLELSKLDQAASHLQQLMEEAPDAREL"
     exon            483..564
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            565..665
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            666..787
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            788..854
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            855..952
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1034
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1154
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1266
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1355
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1446
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1574
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1678
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1760
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1837
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1913
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2019
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2090
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2216
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2321
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2390
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2469
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2597
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2750
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2969
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3084
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3260
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3383
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..4099
                     /gene="Vars2"
                     /gene_synonym="Vars2l; Varsl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttcgctg cggcgttcgc ggtagattcg cgtggcccag gttgagacct gggtgtccct
       61 agtttccgaa ccccaacctt cgtgtcctgg tgaggggcag agctcccgcc tcttccggac
      121 gccctggttt caatgactcc agagtgcggt cccgccgtgc gctccgcccc taggcggaag
      181 gacgtagagt gagagggtcc tgcgggccgg agtgaagggt cgtgacctcc tgcaccccat
      241 gatctagtga gcagacctcc accccttcct aaacactccc gatgcctcat ttacctctgg
      301 cctctttccg gccacctctc tgggggctga ggccctcatg gggtctcgcc aggccccggg
      361 cactttgtac acaaccggag ccccacggct ccccagtctc tcggaggaac cgtgaagcca
      421 aacagaagcg cctgcgggag aagcaggcgg ccctggaggc tgggctggct gagaagagca
      481 agacacctgc agtgcccact aaggcctgga gtcacaagga agtagtattg tatgaaatcc
      541 ccacccggcc aggtgaaaag aaagatgttt ccgggcccct gcctcctgct tacagccccc
      601 aatatgttga agcagcctgg taccagtggt gggtgcgaga gggcttcttc aaaccagagt
      661 atcaggcaag gctgccccaa gctacagggg agaccttttc catgtgtatc ccacctccca
      721 atgtcacggg ctccctgcac attggccatg cgctcacagt ggcgatacag gatgcttttg
      781 tgcgctggca ccggatgcgt ggggatcgtg tgctgtggat ccccgggtca gatcatgcag
      841 gaattgctac acaggctgtg gtggagaaac agctgtggag ggagcggaga gtgcggagac
      901 acgagctgag ccgggaggac ttcctcaggg ctgtgtggca gtggaaacag gagaaaggag
      961 gggagatcta cgagcagctg tgcgccctgg gcgcctctct ggactgggat cgagagtgtt
     1021 tcaccatgga tgccggctcc tcagcagctg tgacggaagc ttttgtgcga ctctatgacc
     1081 tgggattgtt gtaccggaac cgccagcttg tcaactggtc atgtactctg agatcggcca
     1141 tctcagacat tgaggtagaa agccggcccc tacctggccg cacggtgttg cggctgcccg
     1201 gctgcccaat ccccgtgtct tttgggctcc tggtttccat tgctttccct gtggatggag
     1261 accctggcac agagattgtg gtgggaacca ccaggccaga gaccctgcct ggagatgtgg
     1321 ctgtggccgt tcacccagat gacccaagat acacgcattt acatgggcgc cagctccgtc
     1381 accctttgac aggacagcat ctccccctca tcacagacac cactgttcag ccacatgtgg
     1441 gtacaggggc ggtgaaggtg actcctgctc acagtcccgc agacgctgag atggggaccc
     1501 ggcatggctt gaccccactg agtgtcattg cagaggatgg gaccatgacg tccctctgtg
     1561 gagactggct gcagggcctt caccgattcg tagcccggga aaagatcatg tgcacactga
     1621 gggagcgggg cctgttccgg ggcctacagg agcaccccat ggtgctgccc atctgcagcc
     1681 gttccgggga tgtcgtggag tacctgctga agagccagtg gtttgtgcgc tgccaggaaa
     1741 tgggagaccg agctgccaag gctgtggagt cgggggctct ggagctctgg ccctccttcc
     1801 accagaagag ctggcaacac tggtttgccc acattgggga ctggtgtgtc tcccggcagc
     1861 tgtggtgggg ccatcagatt ccagcctacc gggtcggcgg ggagaaagca gaggatgaca
     1921 gggaggaatg ctgggtggtt ggacggtcag aggctgaggc cagagcagca gcagcaaaac
     1981 agacaggaag accagaggca gagctgaccc tggagaggga ccctgatgtc ctggacactt
     2041 ggttctcttc agctcttttc cccttctctg ccttgggttg gccccaagag acgccagacc
     2101 ttgctcgctt ctaccccctc acacttctgg aaacgggcag tgacctcctg acgttctggg
     2161 tgggccgcat ggtcatgctg gggacccagc tcactggaca gctccccttc agcaaggtgc
     2221 tccttcactc catggttcgg gacaggcagg gccggaagat gagcaagtcc ctggggaacg
     2281 tgctagaccc gcgggacatc atcagtgggc aggagctgca ggtgctccag gccaagctga
     2341 gagatggcaa cttggaccag ggagagctcg ctgttgcagc cgcagcacag aaaaaggact
     2401 ttccttacgg gatccccgag tgtgggacgg atgccctgag atttgcactg tgctcccatg
     2461 gaatcctggg tggcgacctg cacctgtcgg tctcagaggt cctgaactac cgccatttct
     2521 gcaacaagct ctggaatgcc ctgcgcttta tcctccgtgc cctgggggat gatttcgtgc
     2581 cccagcccgc agagaaggta acgccctcct cccccatgga cgcctggatt ctgagccgct
     2641 tggcctttgc ggccaacgag tgtgagaggg gcttcctcag ccgggagctt tcgcttgtca
     2701 cccacaccct gtatcatttc tggctccaca atctctgtga tgtctacctg gaagcggtga
     2761 agccagtgtt gtcgagtgcg ccctgtcccc caggaccccc tcaggtcctg ttctcctgtg
     2821 cagatgtcgg tctgcgcctc ctcgccccgc tgatgccctt cctggcagaa gaactttggc
     2881 agaggctgcc ccccaggcaa ggtggctcca tggctcccag catctgtgtg gccccctacc
     2941 ccagtggtca cagcctggtg agtcgtgggc aggagtcctg gcgccagcca gagttggagc
     3001 actgcttctc ccgagtccaa gagattgtac aggcactgcg ggcgcttcga gccacctacc
     3061 agctcacaag agcccgaccc catgtgctgc tacagagctc agacccagga gaacaaggcc
     3121 tagtccagcc cttcctggaa cctctgggcg tcctgagcca ctgtggggct gtaggattcc
     3181 tgcccccagg agcagcagct ccctcagggt gggccctggc cccactgggt gacaccataa
     3241 agatctacat ggagctgcag ggcctggtgg acccccagag ccagctacct cggctagctg
     3301 cccggaggca gaagttacag aagcagcttg atgacctctt gaaccggacc gtgtccgatg
     3361 gtcctgcaga gaggcagcag aggatttcct ccctccagct ggaattgtca aagctggacc
     3421 aggcagcctc tcacctacag caactgatgg aggaggctcc agacgccagg gagctctgag
     3481 ctccactcac atccagccat ggttcctcct cagacctgct ttcaaggaca gatctgcctg
     3541 ctgctggtgc aatgggacct cagaggtgac atggaccacc ttcctcattc tgtaggaggg
     3601 agcagactga agaatgagga gatggagata aaaggataaa ctccaagccc cccaacccca
     3661 acttcccacc agtgtggtcc tttccccctc ctgtgcctct cccttgctcc aggaagagga
     3721 ggctgcctaa caacacacct tttaccttca ttttggacac gagttgccag agagtgggaa
     3781 gtaatttccc taccttatca aaaggagttt aacctagctg atcgacataa ctgggcacag
     3841 ctcctttctg tgacaggagc agagttccaa acgtgctaac ttcaacgggc aggcgctcct
     3901 gttgtgggca gcagtgccgg gtttgggctc cacgtctctg ctccttctgc ctttttttcc
     3961 tgacacacta accacatcca agatctacct cagctgcccc catgtgtctg cattcttcct
     4021 gaagggaaag ccttcttgat ctccctccct ctgggtcagt gggtgaggca gtgagtctaa
     4081 aagtcaccaa atggagggg
//
