LOCUS       NM_021847               7050 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus VAMP associated protein B and C (Vapb), mRNA.
ACCESSION   NM_021847
VERSION     NM_021847.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7050)
  AUTHORS   Gomez-Suaga,P., Perez-Nievas,B.G., Glennon,E.B., Lau,D.H.W.,
            Paillusson,S., Morotz,G.M., Cali,T., Pizzo,P., Noble,W. and
            Miller,C.C.J.
  TITLE     The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering
            proteins are present in neuronal synapses and regulate synaptic
            activity
  JOURNAL   Acta Neuropathol Commun 7 (1), 35 (2019)
   PUBMED   30841933
  REMARK    GeneRIF: VAPB-PTPIP51 mitochondrial tethering proteins are present
            in synapses and regulate synaptic activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7050)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7050)
  AUTHORS   Alpy,F., Rousseau,A., Schwab,Y., Legueux,F., Stoll,I., Wendling,C.,
            Spiegelhalter,C., Kessler,P., Mathelin,C., Rio,M.C., Levine,T.P.
            and Tomasetto,C.
  TITLE     STARD3 or STARD3NL and VAP form a novel molecular tether between
            late endosomes and the ER
  JOURNAL   J Cell Sci 126 (Pt 23), 5500-5512 (2013)
   PUBMED   24105263
REFERENCE   4  (bases 1 to 7050)
  AUTHORS   Kuijpers,M., Yu,K.L., Teuling,E., Akhmanova,A., Jaarsma,D. and
            Hoogenraad,C.C.
  TITLE     The ALS8 protein VAPB interacts with the ER-Golgi recycling protein
            YIF1A and regulates membrane delivery into dendrites
  JOURNAL   EMBO J 32 (14), 2056-2072 (2013)
   PUBMED   23736259
  REMARK    GeneRIF: YIF1A interacts with VAPB via its transmembrane regions,
            recycles between the ER and Golgi and is mainly localized to the
            ER-Golgi intermediate compartments in hippocampal neurons.
REFERENCE   5  (bases 1 to 7050)
  AUTHORS   De Vos,K.J., Morotz,G.M., Stoica,R., Tudor,E.L., Lau,K.F.,
            Ackerley,S., Warley,A., Shaw,C.E. and Miller,C.C.
  TITLE     VAPB interacts with the mitochondrial protein PTPIP51 to regulate
            calcium homeostasis
  JOURNAL   Hum Mol Genet 21 (6), 1299-1311 (2012)
   PUBMED   22131369
REFERENCE   6  (bases 1 to 7050)
  AUTHORS   Kanekura,K., Nishimoto,I., Aiso,S. and Matsuoka,M.
  TITLE     Characterization of amyotrophic lateral sclerosis-linked P56S
            mutation of vesicle-associated membrane protein-associated protein
            B (VAPB/ALS8)
  JOURNAL   J Biol Chem 281 (40), 30223-30233 (2006)
   PUBMED   16891305
REFERENCE   7  (bases 1 to 7050)
  AUTHORS   Hamamoto,I., Nishimura,Y., Okamoto,T., Aizaki,H., Liu,M., Mori,Y.,
            Abe,T., Suzuki,T., Lai,M.M., Miyamura,T., Moriishi,K. and
            Matsuura,Y.
  TITLE     Human VAP-B is involved in hepatitis C virus replication through
            interaction with NS5A and NS5B
  JOURNAL   J Virol 79 (21), 13473-13482 (2005)
   PUBMED   16227268
REFERENCE   8  (bases 1 to 7050)
  AUTHORS   Nishimura,A.L., Mitne-Neto,M., Silva,H.C., Richieri-Costa,A.,
            Middleton,S., Cascio,D., Kok,F., Oliveira,J.R., Gillingwater,T.,
            Webb,J., Skehel,P. and Zatz,M.
  TITLE     A mutation in the vesicle-trafficking protein VAPB causes
            late-onset spinal muscular atrophy and amyotrophic lateral
            sclerosis
  JOURNAL   Am J Hum Genet 75 (5), 822-831 (2004)
   PUBMED   15372378
REFERENCE   9  (bases 1 to 7050)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   10 (bases 1 to 7050)
  AUTHORS   Nishimura,Y., Hayashi,M., Inada,H. and Tanaka,T.
  TITLE     Molecular cloning and characterization of mammalian homologues of
            vesicle-associated membrane protein-associated (VAMP-associated)
            proteins
  JOURNAL   Biochem Biophys Res Commun 254 (1), 21-26 (1999)
   PUBMED   9920726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 25, 2022 this sequence version replaced NM_021847.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.9977.1,
                                           SRR26643298.20567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000003.1  182954247-182954420
            175-327             JAXUCZ010000003.1  182975829-182975981
            328-431             JAXUCZ010000003.1  182984060-182984163
            432-512             JAXUCZ010000003.1  182986882-182986962
            513-689             JAXUCZ010000003.1  182988455-182988631
            690-7050            JAXUCZ010000003.1  182990658-182997018
FEATURES             Location/Qualifiers
     source          1..7050
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..7050
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /note="VAMP associated protein B and C"
                     /db_xref="GeneID:60431"
                     /db_xref="RGD:68326"
     exon            1..174
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..848
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /note="vesicle-associated membrane protein, associated
                     protein B and C; VAMP-associated protein B; VAMP
                     (vesicle-associated membrane protein)-associated protein B
                     and C"
                     /codon_start=1
                     /product="vesicle-associated membrane protein-associated
                     protein B"
                     /protein_id="NP_068619.1"
                     /db_xref="GeneID:60431"
                     /db_xref="RGD:68326"
                     /translation="MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKV
                     KTTAPRRYCVRPNSGVIDAGASLNVSVMLQPFDYDPNEKSKHKFMVQSMFAPPDTSDM
                     EAVWKEAKPEDLMDSKLRCVFELPAENAKPHDVEINKIMPTSASKTEAPVAAKPLTSP
                     LDDAEVKKVMEECRRLQGEVQRLREESRQLKEEDGLRARKALPSNSPMAALAASGKEE
                     GLSARLLALVVLFFIVGVIIGKIAL"
     exon            175..327
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            328..431
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            432..512
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            513..689
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            690..7050
                     /gene="Vapb"
                     /gene_synonym="VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacgtgcgt gcgtgccgtg agctcgcccg gcaccgcggc ctcgccctcc gcccctgtgc
       61 cccgccaccc aggccgccgc cccccgcccg cgccgccgcc cccgacgggg aggaccatgg
      121 cgaaggtgga gcaggtcctg agtctcgagc cacagcacga gctcaagttc cgaggtccct
      181 tcactgatgt tgtcactacc aacctaaagc tgggcaaccc gacagaccgg aacgtgtgtt
      241 tcaaagtgaa gaccacagcg ccgcgcaggt actgcgtgcg gcccaacagt ggggtcattg
      301 atgccggggc ctctctcaat gtgtctgtga tgttacagcc tttcgattat gaccccaatg
      361 agaaaagtaa acacaagttt atggttcagt ctatgtttgc tccgcccgac acttccgata
      421 tggaggcagt atggaaggag gcaaaaccgg aagaccttat ggattcaaaa cttagatgtg
      481 tgtttgaatt gccagcagaa aacgctaaac cacatgatgt agaaataaat aaaattatgc
      541 ctacaagtgc atccaagaca gaagcaccgg tggccgccaa gcccctcaca tcgccccttg
      601 atgacgcgga agtaaagaag gtgatggaag agtgcaggcg gctgcagggg gaggtgcaga
      661 ggcttcggga ggagagcagg cagctcaagg aagaagacgg gcttcgggcg aggaaggcac
      721 tgccgagcaa cagccccatg gcggctctgg ctgccagcgg gaaggaggag ggcctcagcg
      781 cgcggctgct ggctctggtg gtgctgttct ttattgttgg ggtcattata gggaagatcg
      841 ccttgtagag gccgcatgca gaggacggca gactggatgg acggatctac cacaccatgg
      901 gatttaaatt tatcataacc atgcgtaaac agaaattaat gtatgacggc atctcacagg
      961 tcttgccttt aaatatccct ccccatgcac acacaaatgc acacaaatat agcataatat
     1021 aacgatcttt tagagagttg aagatgtgta ggaaatggat ggggaaggac ggtctattgc
     1081 tgaaggacgg acagacggat ggacgccatg attagcctta gtggcatctt gtagcttgtc
     1141 acgtcattcg ggtaggcctg ggcacatgtt gctagatcac ctctcttaaa gcaagaagct
     1201 cttcctcaca tgctggggct ggcccatggg agcggggtcc ttcaaggtgg ggtgtgctgt
     1261 cttttcttac ccaggtagct tccccaggcc tgctctttgt ccaggcaccg agatctcctc
     1321 aggcctacag agctgcaaga gccaaagtgc attgcacagc ggccacgtct gtaccctgta
     1381 ggtcgtgtgg gagagacatg agtagagcga tggatccagc atggggaaat caaagtctgt
     1441 gctctgttct cttgaaggga ccaagctaaa ttactgttgg ttcgagtcgt gagaccaagc
     1501 tgttatcagt gatgggtgat gcgtatttag cctatttcat gaatttcatc tcgtgtttct
     1561 gctgccacca gagcacaggc agtgagtgct gcagcctgtc agtcacctgt gctacagacc
     1621 accagtgagg agccactgct gccatgggct ctgtggctct caggtctgga gctctgaggg
     1681 gtggggaggt tctgagtcag gaagtgtcct gttgtaggtc agtagcagct gtcctgagga
     1741 gggacggaca ttctttgtga tgacagtcag ctctggacta cccagccttc taggctgttt
     1801 ttcccctctc tcccctgtca ctcatccttc tagaacacag gccaggtctg acctgcctgc
     1861 ctcaggatga atgagtcagg cagcggaggg tgaagggcat agagggggta gggtgggggt
     1921 gggggaaccc ctcagcaaat ccatctgctg gtgatgaaga gtcttgactg tgaattaatt
     1981 tcatgccata aaagaccgat ccagttctgc tcaactatgt agcatcttaa aggaagagat
     2041 taaaataaag ccccaaatta agagtccctt tgtcgttttg tcgaatttgc cgtgtgtggg
     2101 gttactatca gtcatcatta gcgcgcaatg gaaggctgat ttcaaaatga gctctatcag
     2161 cggcaaacac atgtgtaatg atttgactct gcacacatct gtgtgcacgc gcacacacac
     2221 atatattact attactttta tcattatatt tttggttggc ctccgcttaa cagcaggagc
     2281 catctcaggc tggctaccct tccccttccg tgaccttggc gtgaccttcg gtgacaggcc
     2341 tgggtctgtg aggacaaaca catcttaagg aagaccggcc tcgacaccag ggcccacatt
     2401 gctgctgtgc ctgagtagcc agctgggacc ggagaccgct gaggtggcgc tgggcggtaa
     2461 gcagccctgg tctgccctgg ttagtgagtt tccagatcct tcccatgcac ctgaggaaga
     2521 cgatgcacgg ctgaacagag agctccgagc tgttaccttg cttgccttgg tggccgaggt
     2581 tcagcagtct aaggtgctga caatgatccc tgctgctctc gagaacagag tcactcaggg
     2641 cctctaacag gacctgaggt gtcaaccagc tctatgaccc aggagccagg gtctgcaagt
     2701 gttcttaagg gatggctctg tgtgccagga aagctcttga gaagcatagc cagctgccga
     2761 gattaaagcg tgtctggaag ctgccgtggc tagggccatg gaaggtgatt gtgtgtccga
     2821 cgtcagaatg ctctccgtgg gccagaggtt gtagacatac ctgctgtagc agcaacaaca
     2881 aaacctcgag atacaaaggt accttccttt ggccctcagg agcccttcct cggagggatg
     2941 atggtccaag tgtggtagtt gttggggctt cttgaccaag gggacagtgg gaactctagg
     3001 gagattagca aggcagagtg ggtaattctc cgagttaccc cgtcactaaa gaatgctgga
     3061 agagaggtgt cggcaagaag agtatttaca cgtgggcctc tcaagagagc cgtgcatatt
     3121 tggggggtcc tttctgaaaa tttcagagca gaaaaacctg agtaaggtac agagaaggtg
     3181 aacgttactc tttgccccac aagtctgctg tctccagaga ggacagagtc aggagttctg
     3241 gaaggcatga agctaagagc tagcaggaca gcagccacga agcagccggg caggtccttc
     3301 atggtcacag ggcctgctgc tgctcctccc cgttgggtgt cctggtgttg gaagcccctg
     3361 ctacagtgct cacagggaca cagtggcaga gtcccaccaa ctattgattc aatttccaag
     3421 ccgatagttt aagcccggaa agagacagag cgcctctgag agcgagtgag cactattatc
     3481 cgttcgcgcg aggcccggct ttaattttct tctcctccta ctttgcatgt tttccctctc
     3541 tggtctttta aactgctggc accagcagta ataaatactg ataaaatcaa aattgatttt
     3601 taccagtgga cagtttatgc ctagagagat ggcttatacc tacataacac agacgggggg
     3661 tgggggggat gaggagcctc cagtgagccg tgaaaagcta actgctttca aacagatcct
     3721 gggaacagca tggctgtgtg aagatagcag gacccagcct gcaggctgtg ttgagtcaga
     3781 cagaactgag tgcagccaga gctaaaagcc cttcagatta atttgaaaac aaagccctgt
     3841 gtgtgcatgt gtgtgtttgt gtgtagcata tgtgccgtgt gtaggcagct tgacagttcc
     3901 cgaacggtgc ctgtatcttt tctttgcaca cagatcttgg tgttttcaaa ctcaagagtc
     3961 catgccaaaa tgcagtgtca tttgtcattt ttttatgctc ctcaagatga actggcctga
     4021 gtgcaagttt ctagttacgg tttgcaaaac cctttttcta agggagagac ggggacacgg
     4081 gacagttggt tctgtgacct ggtcattctg tatacctggg tggcaccccc aggccttccg
     4141 cagtgtagag gttcatgatc cccttgtggc agctgtgtct ccttggaccc tgcctactgt
     4201 gacgggggtg ggggtgggtg gtgtgatcaa aaacgttgtg agtaaccgga aggcaggcac
     4261 cagacttgtc ctgattacac ttggccttgt ttgctgttct gagaatgaat gcttctcaga
     4321 gccaagcaga aatgcaattg tgtttaaaat ccctctgcag agcgtagatg gatgggtgcc
     4381 atttgcagca tggggaggtc ctgctatcac tctctgggat cacgacccaa tggctccctt
     4441 ggggttccct ggcctgattg tacagggaga aggccttttc cctttgtcag caccaccctg
     4501 gctgcagagc acctcacaga aacctcacag tagactctgc gctgtacatg gggataaaaa
     4561 aggccccact gcgttaaggt gcgcaacctt ttagtcgtga actaaatcag ccctagcctg
     4621 tgtgtacacg ctaaagcact gcttgttgga gatctgcaaa tcaatggagg gaacaaggtg
     4681 gagggaagca tttgctctag gcacctcagc tcaccagctg aactgtctgc caccccgatc
     4741 cagctggtgt ctctaggctg agccagtaga gttgggactc tggtgtggcc ctgaacacat
     4801 cccacatgat gagtgcatat ggccgtttcc atttcgctca ctgcccatgt gcctggggaa
     4861 ttatgggagc tttagaaaga aaattaccac tgcgtctcaa tgaggtgagg ctgctgtgtc
     4921 tggaggctcc tcataacttg taaattaaat gtgaatgaga gaagttcatt aaaattggca
     4981 ttatagaagt ggcctattga ggtttgaaag cagctgagct catggtgtct gggctctctc
     5041 taaacctgtg gagaaatgca tgaacaaatg acaggcagtg gtcacaggag cgtagggttc
     5101 aggcagcttg agtgctgtga gtggattgct gcccggctcc cagccctccg ggggcataga
     5161 ggggagtcac tgctcaatgc atgaggctca gccactgaga atatttgtta tttggggtat
     5221 acaagggagc caaaccccta agggaaggga ctagtgccat ttccacagca tcgtggatgt
     5281 tgttttcatt tattcccggt atacaggtat gtgtaaaaat ctcaaaggca cagcacacac
     5341 aaacatctgt gtattatggt tcagagagat accgggaagg tggaggagag gtggtttcag
     5401 tgaatacaat aattaccttc atttttttcc ttaatggaat taatgtatta gaagatgtat
     5461 gcatctcctc tacagagaag gaaggaaaac taacagtaaa aacatagcta ttatccacct
     5521 caccacaaat atttgcagtt acggaatgtt gccacagtgt gaattccact gatgaaaaga
     5581 tgttgctggg gaggagagag gctgctggcg ctgagccctg ccactgccgc ataaatgctg
     5641 ctgtttattt tgaaccagga aacgttgatc ctgtaacaat gccccattac agttgctgta
     5701 ttgcagtgag gggctgatgc aggtttaatc atctcgctaa tggatgtggg tgcaggatgg
     5761 atgctctgcc ctgctttccc cacctgcatc ctgatgagcc tcagtagccg gcagggccat
     5821 tgcacagtgg agcagctgca gctgcagttc catctccctg atgctcaaaa gccatgtctg
     5881 gccaaagtaa aacagattat ctgttctttt ctgtctccct tcagaagaca ccaactatgg
     5941 gagacaaatc agatctttta acacaatctc attaaggctc catgctaaca agagtgcaga
     6001 gcttacctga cttacagacg tgatgaatta gcatgcacac tgcacacatc aactcaccag
     6061 ctctccctgt aacatggaaa ggcctccatc tttttaatgg atgagctgcc tgcattccca
     6121 tctgtttgct tcttagaagt aaactaaatt cagcggccag ccatctagtg cagcatttat
     6181 ttaaaagata cagaaatact gtttcccact gggtctctta catggcctca aaggtcagaa
     6241 tttattgtct gtgatagtga aaccatgtat acaaaactcc cttctgttca tgatccatgt
     6301 agcagacgtt cctaaagcac agtctctaag cattttcctt acgggcgggg tgctcaaaga
     6361 ataatcagca ggagtcattt agcgattgtg tgtttcactg gtaagtggtc taagttgaat
     6421 gcaaaatgca ttgggcctct tttttttttg tggctggtgt tgcttttgtt tattctgttt
     6481 tggtttttaa ataaaatata tgaactgctg gcatttggaa catcccataa taattgcaag
     6541 ataatgttcc tgtcactgcc ccctcttcat tggaggagag acactagctc agtaattcat
     6601 gtcgtcctgt ccggttttac atcctttctc atctccaacc tgtgactgtg catgtcaatt
     6661 ctgacctcag tctccatcaa cattataggg actgggtatt ttaaaggatg ttttagaatg
     6721 ccgttctttc ctgatctctc ctttatgctt ttaagctata tttcctgttc tgatgtggga
     6781 ctcgttcaca gaatcagggc aggaaaggac tcttcctcat tgtgtacttc ggtttctgat
     6841 gtgtgataaa tccatggttt tatggctgac cttacacttc ccagagggaa ggagacagat
     6901 ttctagtgtc cagaccaaga gagctattca cccagagttc tcacatgctg tgtactggtc
     6961 tgatgaaacc tgccctgtgg cgtaaacttt cgtatgagct gtctccatgt aatattcaat
     7021 aaattgtgtg ctctgaatat atataaatga
//
