LOCUS       NM_001105969            2813 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus VANGL planar cell polarity protein 2 (Vangl2),
            mRNA.
ACCESSION   NM_001105969 XM_001056450 XM_222896
VERSION     NM_001105969.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2813)
  AUTHORS   Zhang,P., Hu,C., Li,Y., Wang,Y., Gao,L., Lu,K., Chang,G., Li,Y.,
            Qin,S. and Zhang,D.
  TITLE     Vangl2 is essential for myocardial remodeling activated by Wnt/JNK
            signaling
  JOURNAL   Exp Cell Res 365 (1), 33-45 (2018)
   PUBMED   29454802
  REMARK    GeneRIF: Wnt/JNK activation induced cytoskeleton rearrangement but
            failed to activate these effects in cells lacking Vangl2.
REFERENCE   2  (bases 1 to 2813)
  AUTHORS   Chen,H., Xiao,X., Lui,W.Y., Lee,W.M. and Cheng,C.Y.
  TITLE     Vangl2 regulates spermatid planar cell polarity through microtubule
            (MT)-based cytoskeleton in the rat testis
  JOURNAL   Cell Death Dis 9 (3), 340 (2018)
   PUBMED   29497043
  REMARK    GeneRIF: Spermatid planar cell polarity was regulated by Vangl2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2813)
  AUTHORS   Chen,H., Mruk,D.D., Lee,W.M. and Cheng,C.Y.
  TITLE     Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic
            Specialization Dynamics via Its Effects on Actin Microfilaments in
            the Testes of Male Rats
  JOURNAL   Endocrinology 157 (5), 2140-2159 (2016)
   PUBMED   26990065
  REMARK    GeneRIF: In summary, the PCP protein Vangl2 is an ectoplasmic
            specialisation regulator through its effects on actin
            microfilaments in the testis.
REFERENCE   4  (bases 1 to 2813)
  AUTHORS   Nagaoka,T. and Kishi,M.
  TITLE     The planar cell polarity protein Vangl2 is involved in postsynaptic
            compartmentalization
  JOURNAL   Neurosci Lett 612, 251-255 (2016)
   PUBMED   26683906
  REMARK    GeneRIF: Vangl2 plays a role in the establishment and/or
            maintenance of the postsynaptic compartments.
REFERENCE   5  (bases 1 to 2813)
  AUTHORS   Nagaoka,T., Tabuchi,K. and Kishi,M.
  TITLE     PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only
            a limited role in the synaptic localisation of Vangl2
  JOURNAL   Sci Rep 5, 12916 (2015)
   PUBMED   26257100
  REMARK    GeneRIF: The synaptic localisation of Vangl2 was categorised into
            two types: overlapping co-localisation with postsynaptic density
            (PSD)-95 or highly correlated but complementary pattern of
            association with PSD-95.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2813)
  AUTHORS   Montcouquiol,M., Rachel,R.A., Lanford,P.J., Copeland,N.G.,
            Jenkins,N.A. and Kelley,M.W.
  TITLE     Identification of Vangl2 and Scrb1 as planar polarity genes in
            mammals
  JOURNAL   Nature 423 (6936), 173-177 (2003)
   PUBMED   12724779
REFERENCE   7  (bases 1 to 2813)
  AUTHORS   Murdoch,J.N., Henderson,D.J., Doudney,K., Gaston-Massuet,C.,
            Phillips,H.M., Paternotte,C., Arkell,R., Stanier,P. and Copp,A.J.
  TITLE     Disruption of scribble (Scrb1) causes severe neural tube defects in
            the circletail mouse
  JOURNAL   Hum Mol Genet 12 (2), 87-98 (2003)
   PUBMED   12499390
REFERENCE   8  (bases 1 to 2813)
  AUTHORS   Katoh,M.
  TITLE     Structure and expression of Strabismus 1 gene on human chromosome
            1q21-q23
  JOURNAL   Int J Oncol 20 (6), 1197-1203 (2002)
   PUBMED   12011999
REFERENCE   9  (bases 1 to 2813)
  AUTHORS   Murdoch,J.N., Doudney,K., Paternotte,C., Copp,A.J. and Stanier,P.
  TITLE     Severe neural tube defects in the loop-tail mouse result from
            mutation of Lpp1, a novel gene involved in floor plate
            specification
  JOURNAL   Hum Mol Genet 10 (22), 2593-2601 (2001)
   PUBMED   11709546
REFERENCE   10 (bases 1 to 2813)
  AUTHORS   Henderson,D.J., Conway,S.J., Greene,N.D., Gerrelli,D.,
            Murdoch,J.N., Anderson,R.H. and Copp,A.J.
  TITLE     Cardiovascular defects associated with abnormalities in midline
            development in the Loop-tail mouse mutant
  JOURNAL   Circ Res 89 (1), 6-12 (2001)
   PUBMED   11440971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_222896.4, XM_001056450.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2813
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2813
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /note="VANGL planar cell polarity protein 2"
                     /db_xref="GeneID:289229"
                     /db_xref="RGD:1309442"
     exon            1..288
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     exon            289..398
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     exon            399..661
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..2156
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /note="vang-like 2 (van gogh, Drosophila); van Gogh-like
                     protein 2; loop tail associated protein"
                     /codon_start=1
                     /product="vang-like protein 2"
                     /protein_id="NP_001099439.1"
                     /db_xref="GeneID:289229"
                     /db_xref="RGD:1309442"
                     /translation="MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGSRGDKSV
                     TIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLD
                     CSRHLGVAAGAILALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILL
                     LGSWALFFRRPKASLPRVFVLRALLMVLVFLLVISYWLFYGVRILDARERSYQGVVQF
                     AVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWIL
                     EKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRR
                     DNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQ
                     AIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQY
                     HKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKS
                     HKFVMRLQSETSV"
     exon            662..782
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1390
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1527
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1663
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1895
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2813
                     /gene="Vangl2"
                     /gene_synonym="Ltap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagatctgat tcctgatccc cgattgcttg gtcctgggtc ccgccatggg agcctgagcg
       61 ccctgcagtt cccccggccc cctgtccccg gggcctcgag ggggaaacag ccgagtggtc
      121 tgggacggag ccggggtgag ccacctcagg agccccctcg tcaaccccca tcgcccgcgc
      181 tgccggttct ggagcgcgga gttcggaacg acccggtgcg ctgcggatac aaaggcgcgg
      241 agcggagcgg ggcgtgcgcc cagtccaccc ggcttttcgc agcggcggct cccacctggg
      301 tgcttctact ctgatccctg tgcgattcat cttcctgctt tgcctctggt caacctcctc
      361 tctctctgag ttgacccgaa acctctcata ctctacaggg agctgtcgat tgaatttctc
      421 cgagataagc ccactcgtcc agcaaaatag agtccctcag ggtgacagtt gacttcctaa
      481 aggtgcctct tggcctgaag aagcctgtgc tgaaggaggt ggctgtgggg ccccccaaga
      541 ggccccagcc cgcggccctg gagcgctaca aggcacggcg ttcagacgcc atggacaccg
      601 agtcccagta ctcgggctat tcctacaagt cgggccactc ccgcagctcc agaaagcaca
      661 gggaccgccg ggaccgacac cgctctaaga gccgggatgg gagtcgtgga gataaatcag
      721 tgacgatcca ggctccggga gagcccctgc tggacaatga gtccacgagg ggggatgagc
      781 gggatgacaa ctggggagaa acaacaacgg tggtcacagg cacttctgag cacagtatct
      841 cccatgatga cctcacacgc atcgccaagg acatggagga cagtgtcccg ttggattgtt
      901 cccgccacct gggcgtggcg gcaggggcca ttttggcact gctctctttt ctcaccccgc
      961 tggctttcct gttgctgcct ccactgctgt ggcgggagga gctggagccg tgtgggaccg
     1021 cctgtgaggg cctcttcatc tccgtggcct tcaagctgct catcctgctg ctgggcagct
     1081 gggctctgtt cttccggcgg cccaaggctt cactgccccg agtcttcgtg ttacgagctc
     1141 tgctcatggt gcttgtcttc ctgctcgtta tctcctactg gctcttctac ggcgtgcgca
     1201 tcttggacgc ccgggagcgc agctaccagg gcgtggttca gtttgccgtt tcgctagtgg
     1261 atgctttact cttcgtgcac tatctggccg tagttctgct ggagctgcgt cagcttcagc
     1321 cccagttcac gctcaaggtc gtgcgatcca cagatggagc gagccgcttc tataatgtcg
     1381 gccacctcag catccagcga gtggcagtgt ggatcctgga gaagtattac catgacttcc
     1441 ctgtctacaa ccccgccctc ctcaacctgc ccaagtccgt cctggccaag aaagtgtctg
     1501 gcttcaaggt gtattctctc ggagaggaaa acagcaccaa taactccacg ggccagtcaa
     1561 gggccgtgat tgcggcagcg gcacggaggc gcgacaacag ccacaatgag tactactacg
     1621 aggaagccga acatgagcgc agagtgcgca agcgcagggc caggctggtg gtggctgtgg
     1681 aggaggcctt cacacacatt aagcggctgc aggaagagga gcagaagaac cccagggagg
     1741 tgatggaccc ccgggaagca gcccaagcca tctttgcatc catggcccga gccatgcaga
     1801 agtaccttcg caccacgaaa cagcagcctt accacaccat ggagagcatc cttcagcacc
     1861 tggagttctg catcacccac gacatgacac ccaaggcctt cctggagcgg tatctggccg
     1921 ctggacccac catccagtac cacaaggaac gttggctggc caagcagtgg acattggtga
     1981 gcgaggagcc ggtgaccaat gggcttaagg acggcattgt tttcctctta aagcgccagg
     2041 acttcagctt ggtggtgagc accaagaagg tgcccttctt caaactttcc gaggaattcg
     2101 tggatcccaa gtcacataag tttgtcatgc ggctgcagtc ggagacctct gtgtgacttt
     2161 gcagcagccc agagggaggg atgtgggggt tcctgcggag tgggaggggc ttggttctca
     2221 ggccctgaca catttctgcc atcctacttc ctcttgctct tgctttgttt tgtgtttttt
     2281 ttgttttttt tgtttttttg ttttttactt gaattaactt atcctgtacc cagtctcctc
     2341 ccctatccct cagtttcccc atctggaaat ctggagagaa caccttgctt taacaatacc
     2401 tgggaaccat cctgccccct aattttgtat cactccaggc cctgcaggaa acagtgccta
     2461 ataactaccc ccaaacccct gttcttcccc ccagaatgtt ccctggatgg aagccccttc
     2521 caaacgtgtt cagggccttc ctgattgtac ccttgcctcc tgagctccaa cttataaacg
     2581 tatgttctta gagccatgct ctctagtggc ccctgatagg gtttctcttg aaggcacagc
     2641 tctgacccca gagaaccatg gtgccaaatt cctgtgggac agcagctaac gctgtccccc
     2701 atcctcaccc ttagccccaa gtctctgggc acaatgtacc tgtgacatag tcccagagtt
     2761 aggattctcc ttgtagtctt gctctccagt gttacagctg tagttcctgg tat
//
