LOCUS       NM_053531               2969 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus vesicle-associated membrane protein 7 (Vamp7),
            mRNA.
ACCESSION   NM_053531 XM_006249016
VERSION     NM_053531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2969)
  AUTHORS   Pirooz,S.D., He,S., Zhang,T., Zhang,X., Zhao,Z., Oh,S.,
            O'Connell,D., Khalilzadeh,P., Amini-Bavil-Olyaee,S., Farzan,M. and
            Liang,C.
  TITLE     UVRAG is required for virus entry through combinatorial interaction
            with the class C-Vps complex and SNAREs
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2716-2721 (2014)
   PUBMED   24550300
REFERENCE   2  (bases 1 to 2969)
  AUTHORS   Bal,M., Leitz,J., Reese,A.L., Ramirez,D.M., Durakoglugil,M.,
            Herz,J., Monteggia,L.M. and Kavalali,E.T.
  TITLE     Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and
            selectively augments spontaneous neurotransmission
  JOURNAL   Neuron 80 (4), 934-946 (2013)
   PUBMED   24210904
  REMARK    GeneRIF: The specificity of Reelin action on spontaneous
            neurotransmitter release requires VAMP7
REFERENCE   3  (bases 1 to 2969)
  AUTHORS   Itakura,E., Kishi-Itakura,C. and Mizushima,N.
  TITLE     The hairpin-type tail-anchored SNARE syntaxin 17 targets to
            autophagosomes for fusion with endosomes/lysosomes
  JOURNAL   Cell 151 (6), 1256-1269 (2012)
   PUBMED   23217709
REFERENCE   4  (bases 1 to 2969)
  AUTHORS   Burgo,A., Proux-Gillardeaux,V., Sotirakis,E., Bun,P., Casano,A.,
            Verraes,A., Liem,R.K., Formstecher,E., Coppey-Moisan,M. and
            Galli,T.
  TITLE     A molecular network for the transport of the TI-VAMP/VAMP7 vesicles
            from cell center to periphery
  JOURNAL   Dev Cell 23 (1), 166-180 (2012)
   PUBMED   22705394
REFERENCE   5  (bases 1 to 2969)
  AUTHORS   Peters,C.G., Michelson,A.D. and Flaumenhaft,R.
  TITLE     Granule exocytosis is required for platelet spreading: differential
            sorting of alpha-granules expressing VAMP-7
  JOURNAL   Blood 120 (1), 199-206 (2012)
   PUBMED   22589474
REFERENCE   6  (bases 1 to 2969)
  AUTHORS   Chae,T.H., Kim,S., Marz,K.E., Hanson,P.I. and Walsh,C.A.
  TITLE     The hyh mutation uncovers roles for alpha Snap in apical protein
            localization and control of neural cell fate
  JOURNAL   Nat Genet 36 (3), 264-270 (2004)
   PUBMED   14758363
  REMARK    Erratum:[Nat Genet. 2004 Apr;36(4):427]
REFERENCE   7  (bases 1 to 2969)
  AUTHORS   Muzerelle,A., Alberts,P., Martinez-Arca,S., Jeannequin,O.,
            Lafaye,P., Mazie,J.C., Galli,T. and Gaspar,P.
  TITLE     Tetanus neurotoxin-insensitive vesicle-associated membrane protein
            localizes to a presynaptic membrane compartment in selected
            terminal subsets of the rat brain
  JOURNAL   Neuroscience 122 (1), 59-75 (2003)
   PUBMED   14596849
REFERENCE   8  (bases 1 to 2969)
  AUTHORS   Ward,D.M., Pevsner,J., Scullion,M.A., Vaughn,M. and Kaplan,J.
  TITLE     Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor
            attachment protein receptors required for late endosome-lysosome
            and homotypic lysosome fusion in alveolar macrophages
  JOURNAL   Mol Biol Cell 11 (7), 2327-2333 (2000)
   PUBMED   10888671
REFERENCE   9  (bases 1 to 2969)
  AUTHORS   Hibi,T., Hirashima,N. and Nakanishi,M.
  TITLE     Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in
            granule membranes
  JOURNAL   Biochem Biophys Res Commun 271 (1), 36-41 (2000)
   PUBMED   10777677
REFERENCE   10 (bases 1 to 2969)
  AUTHORS   Advani,R.J., Yang,B., Prekeris,R., Lee,K.C., Klumperman,J. and
            Scheller,R.H.
  TITLE     VAMP-7 mediates vesicular transport from endosomes to lysosomes
  JOURNAL   J Cell Biol 146 (4), 765-776 (1999)
   PUBMED   10459012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000225.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_053531.3.
            
            On or before Oct 5, 2022 this sequence version replaced
            XM_006249016.4, NM_053531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228923.1, CO575017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JACYVU010000225.1  3427838-3427986
            150-304             JACYVU010000225.1  3434660-3434814
            305-362             JACYVU010000225.1  3438656-3438713
            363-500             JACYVU010000225.1  3439942-3440079
            501-591             JACYVU010000225.1  3447616-3447706
            592-659             JACYVU010000225.1  3458086-3458153
            660-752             JACYVU010000225.1  3460309-3460401
            753-2969            JACYVU010000225.1  3461397-3463613
FEATURES             Location/Qualifiers
     source          1..2969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2969
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /note="vesicle-associated membrane protein 7"
                     /db_xref="GeneID:85491"
                     /db_xref="RGD:621558"
     exon            1..149
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            150..304
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..821
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /note="VAMP-7; synaptobrevin-like protein 1;
                     synaptobrevin-like 1"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 7"
                     /protein_id="NP_445983.1"
                     /db_xref="GeneID:85491"
                     /db_xref="RGD:621558"
                     /translation="MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLT
                     YSHGNYLFHYICQDRIVYLCITDDDFERSRAFGFLNEVKKRFQTTYGSRAQTALPYAM
                     NSEFSSVLAAQLKHHSENQSLDRVTETQAQVDELKGIMVRNIDLVAQRGERLELLIDK
                     TENLVDSSVTFKTTSRNLARAMCVKNVKLTAIIVVVSIVFIYIIVSPLCGGFTWPSCV
                     KK"
     exon            305..362
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..500
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..591
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..659
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..752
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..2969
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggaggcc acgcgtaggc ggggcgcttt acccggaagc ttgcagcctc gggtcccgtc
       61 catctcttgt ttcaggcagt ggacgaccct ggggggaccc gcgcccatca gtccggagcg
      121 cgagtgcccg ctagggggta cccggccaga ttgaagtcat ggccattctt tttgccgttg
      181 ttgccagggg aaccactatt cttgccaaac atgcttggtg tggaggaaac ttcctggagg
      241 tgacagagca gattctggct aagatacctt ctgaaaataa taaactaact tactctcatg
      301 gcaattattt gtttcactac atctgccagg acaggattgt gtatctttgc atcacggatg
      361 acgatttcga gcgttctcgg gccttcggtt ttttgaatga agtgaagaag aggttccaga
      421 ccacatatgg ctcgagagca cagaccgcac ttccctatgc catgaacagt gagttttcga
      481 gcgttctggc tgcacaactg aagcatcact ccgagaatca gagcctggac agagtgacgg
      541 agactcaagc ccaagtggac gaactgaaag gcatcatggt cagaaacata gatctagttg
      601 ctcagcgtgg agaaaggcta gaattgctga tagataaaac agaaaacctc gtagattcgt
      661 ccgtcacctt caagacgacc agcaggaacc ttgcccgggc catgtgcgtg aagaacgtca
      721 agctcactgc catcatcgtc gttgtatcga ttgtgttcat ctacatcatc gtgtctccac
      781 tgtgcggtgg cttcacgtgg ccaagctgtg tgaagaaata aaggaaaaaa atcactgttc
      841 accaaggatg tgagcatgga aggaggaaaa gccaatgcgt gtggccctgg ctttcacttc
      901 tctcagcaaa cgccatttct ttcatcctct ttcctttttc tctttgccca tcacacggtt
      961 tgtgttaacg aatttcacat cgagtcgttg tgcacaggag aaaggacatc gtttgttcct
     1021 ccgatttgtt aagtagaagc ttctagaaag acatctttgc ttctaacatg caaagctttt
     1081 gccaaagtgg aaacggctgc gctcacgacc tgtctgtgaa ctcacgacct gtctgctaaa
     1141 cctgtctgtg acgttgtgtg ttgacacaaa gcactgggaa acgggttgca ccgctgacat
     1201 ctcactttag tctctttcgt tgtgggagaa ttttgagtgc ttcacaataa tggagaaatt
     1261 tgggaattat aataaattac aataaatggt cggtgctgct tatgtccagg agcccatccg
     1321 ggtaacggtt aacgttgaat tttatctcag tgaggtggga aatgccttca atacctcaag
     1381 gaccatgggt tagctggatc ctatggtcca atgggtagag cagcctgacg gcagcccaga
     1441 cctgttgaag agccgtgggt tccaggcccc acacaagcga gcattttgat tgacagacca
     1501 ttagaagcac aaggatgacc cttccttctc ccagctttgg ctttctgaaa tgaagtcccg
     1561 gacattattt attcactctg cacatagttt aacactttct gtttatccat taccaattcg
     1621 aactgagatt aagtaaagga ttggggttgg ggatttagct cagtggtaga gcgcttgcct
     1681 aggaagcgca aggccctggg ttcggtcccc agctccgaaa taaaagaacc aaaaaaaaaa
     1741 aaaaaaagaa aaaaagtaaa ggattgtggg ttttacatat tttccttcca tacatatttg
     1801 gggcaaacgt ggtaataaaa ttcgtaatgg aagagagggg aggccaatgc ctctgtgtca
     1861 ccaaagacaa agaatggagc catactagaa gtgcatgcat ttaacctcac aacatacaat
     1921 aatgtgggat tttttttttt tcccattctg ggaaaagccc aaactgaaca cggtcagaag
     1981 tcaactcctc gattcagatt tgactttttt gaataatggt ttgatctttc tttgtgattt
     2041 acctaatcct tcaatctgcc tacttttgaa taattaaatt tgaattcaaa ttacttttga
     2101 attaaaacat gaaagagttt taatacatag tataataata tagaaacaat atataatatc
     2161 ttaacatata tttattgtca taagaaaatc ggagtgtgat gttgctccct ctcctttggc
     2221 atcattcagt agtcggtgat tatctgagaa gaagaaaatt tttttcctgc ctattattga
     2281 atttatttat gaaaaggtga aactgaacag aagtgatgtc tcattttact ctcttcccag
     2341 tgaaacaata aattagtatc ttgaactcag cccactgtta gcctagtcat gtgccttgaa
     2401 tatctgtgtc ctataaacag gaaccttcca cgttcacaat aactgcttga tttgtttagt
     2461 aatcgaatgc acacaggaac tcttttggtc atagggtata atgctgttgt tctttctaga
     2521 catttttatg agcgctgttc attgtaatta tataattatt tcctattagg aaatacattc
     2581 actctcaaaa gaaaaaaata gacattccca aataatgatt tcaaataaag gcttaaaatt
     2641 tatttctctt tcttataaaa actgaataag atttttgtgc atgctttagg gtttaattac
     2701 ttaagagttt cttgttctat ttatgagtag gaatgctttc aaaggcacaa gtatccatgt
     2761 aaatgataca caaattaaag acattaataa aatttaagaa tactacatcg agtttcttct
     2821 tggccaagta cattcaaatc atgatgcctc acttcacatc aaaccacaga taatttgtac
     2881 ttgaagaaag aggttgagct caatgttctg atatttctaa gtcaattatt atatttctat
     2941 aatagtagta aaaattttat gtaaaataa
//
