LOCUS       NP_445983                220 aa            linear   ROD 03-APR-2024
DEFINITION  vesicle-associated membrane protein 7 [Rattus norvegicus].
ACCESSION   NP_445983 XP_006249078
VERSION     NP_445983.1
DBSOURCE    REFSEQ: accession NM_053531.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 220)
  AUTHORS   Pirooz,S.D., He,S., Zhang,T., Zhang,X., Zhao,Z., Oh,S.,
            O'Connell,D., Khalilzadeh,P., Amini-Bavil-Olyaee,S., Farzan,M. and
            Liang,C.
  TITLE     UVRAG is required for virus entry through combinatorial interaction
            with the class C-Vps complex and SNAREs
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2716-2721 (2014)
   PUBMED   24550300
REFERENCE   2  (residues 1 to 220)
  AUTHORS   Bal,M., Leitz,J., Reese,A.L., Ramirez,D.M., Durakoglugil,M.,
            Herz,J., Monteggia,L.M. and Kavalali,E.T.
  TITLE     Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and
            selectively augments spontaneous neurotransmission
  JOURNAL   Neuron 80 (4), 934-946 (2013)
   PUBMED   24210904
  REMARK    GeneRIF: The specificity of Reelin action on spontaneous
            neurotransmitter release requires VAMP7
REFERENCE   3  (residues 1 to 220)
  AUTHORS   Itakura,E., Kishi-Itakura,C. and Mizushima,N.
  TITLE     The hairpin-type tail-anchored SNARE syntaxin 17 targets to
            autophagosomes for fusion with endosomes/lysosomes
  JOURNAL   Cell 151 (6), 1256-1269 (2012)
   PUBMED   23217709
REFERENCE   4  (residues 1 to 220)
  AUTHORS   Burgo,A., Proux-Gillardeaux,V., Sotirakis,E., Bun,P., Casano,A.,
            Verraes,A., Liem,R.K., Formstecher,E., Coppey-Moisan,M. and
            Galli,T.
  TITLE     A molecular network for the transport of the TI-VAMP/VAMP7 vesicles
            from cell center to periphery
  JOURNAL   Dev Cell 23 (1), 166-180 (2012)
   PUBMED   22705394
REFERENCE   5  (residues 1 to 220)
  AUTHORS   Peters,C.G., Michelson,A.D. and Flaumenhaft,R.
  TITLE     Granule exocytosis is required for platelet spreading: differential
            sorting of alpha-granules expressing VAMP-7
  JOURNAL   Blood 120 (1), 199-206 (2012)
   PUBMED   22589474
REFERENCE   6  (residues 1 to 220)
  AUTHORS   Chae,T.H., Kim,S., Marz,K.E., Hanson,P.I. and Walsh,C.A.
  TITLE     The hyh mutation uncovers roles for alpha Snap in apical protein
            localization and control of neural cell fate
  JOURNAL   Nat Genet 36 (3), 264-270 (2004)
   PUBMED   14758363
  REMARK    Erratum:[Nat Genet. 2004 Apr;36(4):427]
REFERENCE   7  (residues 1 to 220)
  AUTHORS   Muzerelle,A., Alberts,P., Martinez-Arca,S., Jeannequin,O.,
            Lafaye,P., Mazie,J.C., Galli,T. and Gaspar,P.
  TITLE     Tetanus neurotoxin-insensitive vesicle-associated membrane protein
            localizes to a presynaptic membrane compartment in selected
            terminal subsets of the rat brain
  JOURNAL   Neuroscience 122 (1), 59-75 (2003)
   PUBMED   14596849
REFERENCE   8  (residues 1 to 220)
  AUTHORS   Ward,D.M., Pevsner,J., Scullion,M.A., Vaughn,M. and Kaplan,J.
  TITLE     Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor
            attachment protein receptors required for late endosome-lysosome
            and homotypic lysosome fusion in alveolar macrophages
  JOURNAL   Mol Biol Cell 11 (7), 2327-2333 (2000)
   PUBMED   10888671
REFERENCE   9  (residues 1 to 220)
  AUTHORS   Hibi,T., Hirashima,N. and Nakanishi,M.
  TITLE     Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in
            granule membranes
  JOURNAL   Biochem Biophys Res Commun 271 (1), 36-41 (2000)
   PUBMED   10777677
REFERENCE   10 (residues 1 to 220)
  AUTHORS   Advani,R.J., Yang,B., Prekeris,R., Lee,K.C., Klumperman,J. and
            Scheller,R.H.
  TITLE     VAMP-7 mediates vesicular transport from endosomes to lysosomes
  JOURNAL   J Cell Biol 146 (4), 765-776 (1999)
   PUBMED   10459012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Oct 5, 2022 this sequence version replaced XP_006249078.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228923.1, SRR26360186.624744.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..220
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     Protein         1..220
                     /product="vesicle-associated membrane protein 7"
                     /note="VAMP-7; synaptobrevin-like protein 1;
                     synaptobrevin-like 1"
                     /calculated_mol_wt=24645
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P51809; propagated from
                     UniProtKB/Swiss-Prot (Q9JHW5.1)"
     Region          4..116
                     /region_name="Longin"
                     /note="longin domain; cd14824"
                     /db_xref="CDD:341428"
     Site            order(4,25,28,47,50,52)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:341428"
     Site            order(14,17,19,26,30,108,112,115)
                     /site_type="other"
                     /note="Sec22 interface [polypeptide binding]"
                     /db_xref="CDD:341428"
     Site            order(46,49,69,73)
                     /site_type="other"
                     /note="VARP interface [polypeptide binding]"
                     /db_xref="CDD:341428"
     Region          124..188
                     /region_name="R-SNARE_VAMP7"
                     /note="SNARE motif of VAMP7; cd15871"
                     /db_xref="CDD:277224"
     Site            order(124..125,128..129,131..133,135..140,142..144,
                     146..147,149..150,153..154,156..161,163..165,167..168,
                     170..175,177..178)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277224"
     Site            150
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277224"
     Site            167
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51809; propagated from
                     UniProtKB/Swiss-Prot (Q9JHW5.1)"
     Site            168
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70280; propagated from
                     UniProtKB/Swiss-Prot (Q9JHW5.1)"
     Site            189..209
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHW5.1)"
     CDS             1..220
                     /gene="Vamp7"
                     /gene_synonym="Sybl1"
                     /coded_by="NM_053531.3:159..821"
                     /db_xref="GeneID:85491"
                     /db_xref="RGD:621558"
ORIGIN      
        1 mailfavvar gttilakhaw cggnflevte qilakipsen nkltyshgny lfhyicqdri
       61 vylcitdddf ersrafgfln evkkrfqtty gsraqtalpy amnsefssvl aaqlkhhsen
      121 qsldrvtetq aqvdelkgim vrnidlvaqr gerlellidk tenlvdssvt fkttsrnlar
      181 amcvknvklt aiivvvsivf iyiivsplcg gftwpscvkk
//
