LOCUS       NP_446007                102 aa            linear   ROD 31-MAR-2024
DEFINITION  vesicle-associated membrane protein 5 [Rattus norvegicus].
ACCESSION   NP_446007
VERSION     NP_446007.1
DBSOURCE    REFSEQ: accession NM_053555.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 102)
  AUTHORS   Takahashi,M., Tajika,Y., Khairani,A.F., Ueno,H., Murakami,T. and
            Yorifuji,H.
  TITLE     The localization of VAMP5 in skeletal and cardiac muscle
  JOURNAL   Histochem Cell Biol 139 (4), 573-582 (2013)
   PUBMED   23180306
REFERENCE   2  (residues 1 to 102)
  AUTHORS   Hasan,N., Corbin,D. and Hu,C.
  TITLE     Fusogenic pairings of vesicle-associated membrane proteins (VAMPs)
            and plasma membrane t-SNAREs--VAMP5 as the exception
  JOURNAL   PLoS One 5 (12), e14238 (2010)
   PUBMED   21151919
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 102)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (residues 1 to 102)
  AUTHORS   Schwenk,R.W., Dirkx,E., Coumans,W.A., Bonen,A., Klip,A., Glatz,J.F.
            and Luiken,J.J.
  TITLE     Requirement for distinct vesicle-associated membrane proteins in
            insulin- and AMP-activated protein kinase (AMPK)-induced
            translocation of GLUT4 and CD36 in cultured cardiomyocytes
  JOURNAL   Diabetologia 53 (10), 2209-2219 (2010)
   PUBMED   20582536
REFERENCE   5  (residues 1 to 102)
  AUTHORS   Rose,A.J., Jeppesen,J., Kiens,B. and Richter,E.A.
  TITLE     Effects of contraction on localization of GLUT4 and v-SNARE
            isoforms in rat skeletal muscle
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 297 (5), R1228-R1237 (2009)
   PUBMED   19675279
  REMARK    GeneRIF: VAMP2, VAMP5, and VAMP7 may be involved in translocation
            of GLUT4 during muscle contractions.
REFERENCE   6  (residues 1 to 102)
  AUTHORS   Zeng,Q., Tran,T.T., Tan,H.X. and Hong,W.
  TITLE     The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their
            correct subcellular targeting: the N-terminal extenSion of VAMP4
            contains a dominant autonomous targeting signal for the trans-Golgi
            network
  JOURNAL   J Biol Chem 278 (25), 23046-23054 (2003)
   PUBMED   12682051
REFERENCE   7  (residues 1 to 102)
  AUTHORS   Zeng,Q., Subramaniam,V.N., Wong,S.H., Tang,B.L., Parton,R.G.,
            Rea,S., James,D.E. and Hong,W.
  TITLE     A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased
            during in vitro myogenesis and present in the plasma membrane
  JOURNAL   Mol Biol Cell 9 (9), 2423-2437 (1998)
   PUBMED   9725904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ127573.1, FQ217123.1 and JAXUCZ010000004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217123.1, FQ127573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840121, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..102
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     Protein         1..102
                     /product="vesicle-associated membrane protein 5"
                     /note="VAMP-5; myobrevin"
                     /calculated_mol_wt=11364
     Region          5..70
                     /region_name="R-SNARE_VAMP5"
                     /note="SNARE motif of VAMP5; cd15872"
                     /db_xref="CDD:277225"
     Site            order(5..7,9..10,12..17,19..21,23,26..27,29..31,33..38,
                     40..45,47..52,54..59,61..63)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277225"
     Site            30
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277225"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z2P8; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2J5.1)"
     Site            48
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95183; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2J5.1)"
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95183; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2J5.1)"
     Site            73..93
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2J5.1)"
     CDS             1..102
                     /gene="Vamp5"
                     /coded_by="NM_053555.2:114..422"
                     /db_xref="GeneID:89818"
                     /db_xref="RGD:620419"
ORIGIN      
        1 magkelercq rqadqvteim lnnfdkvler dgklselqqr sdqlldmssa fskttktlaq
       61 qkrwenircr vylglavagg lllilvvllv iflpsgedss kp
//
