LOCUS       NM_001108856            2492 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus vesicle-associated membrane protein 4 (Vamp4),
            mRNA.
ACCESSION   NM_001108856 XM_001070325 XM_344168
VERSION     NM_001108856.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2492)
  AUTHORS   Bakr M, Jullie D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen
            JD, Retailleau N, Breillat C, Herzog E, Choquet D and Perrais D.
  TITLE     The vSNAREs VAMP2 and VAMP4 control recycling and intracellular
            sorting of post-synaptic receptors in neuronal dendrites
  JOURNAL   Cell Rep 36 (10), 109678 (2021)
   PUBMED   34496238
  REMARK    GeneRIF: The vSNAREs VAMP2 and VAMP4 control recycling and
            intracellular sorting of post-synaptic receptors in neuronal
            dendrites.
REFERENCE   2  (bases 1 to 2492)
  AUTHORS   Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM and
            Kavalali ET.
  TITLE     VAMP4 Maintains a Ca2+-Sensitive Pool of Spontaneously Recycling
            Synaptic Vesicles
  JOURNAL   J Neurosci 40 (28), 5389-5401 (2020)
   PUBMED   32532887
  REMARK    GeneRIF: VAMP4 Maintains a Ca(2+)-Sensitive Pool of Spontaneously
            Recycling Synaptic Vesicles.
REFERENCE   3  (bases 1 to 2492)
  AUTHORS   Nicholson-Fish JC, Kokotos AC, Gillingwater TH, Smillie KJ and
            Cousin MA.
  TITLE     VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk
            Endocytosis
  JOURNAL   Neuron 88 (5), 973-984 (2015)
   PUBMED   26607000
  REMARK    GeneRIF: The results of this study suggested that the VAMP4 is the
            first identified Activity-dependent bulk endocytosis cargo and is
            essential for this endocytosis mode to proceed.
REFERENCE   4  (bases 1 to 2492)
  AUTHORS   Shitara A, Shibui T, Okayama M, Arakawa T, Mizoguchi I, Sakakura Y
            and Takuma T.
  TITLE     VAMP4 is required to maintain the ribbon structure of the Golgi
            apparatus
  JOURNAL   Mol Cell Biochem 380 (1-2), 11-21 (2013)
   PUBMED   23677696
  REMARK    Erratum:[Mol Cell Biochem. 2013 Aug;380(1-2):301. Shakakura,
            Yasunori [corrected to Sakakura, Yasunori]]
REFERENCE   5  (bases 1 to 2492)
  AUTHORS   Slater LH, Hett EC, Clatworthy AE, Mark KG and Hung DT.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (bases 1 to 2492)
  AUTHORS   Cocucci E, Racchetti G, Rupnik M and Meldolesi J.
  TITLE     The regulated exocytosis of enlargeosomes is mediated by a SNARE
            machinery that includes VAMP4
  JOURNAL   J Cell Sci 121 (Pt 18), 2983-2991 (2008)
   PUBMED   18713833
  REMARK    GeneRIF: Data show that VAMP4, an R-SNARE that has never been shown
            to participate in regulated exocytoses, appears to be harboured in
            the membrane of enlargeosomes and to be a member of the machinery
            mediating their regulated exocytosis.
REFERENCE   7  (bases 1 to 2492)
  AUTHORS   Best D, Sahlender DA, Walther N, Peden AA and Adams IR.
  TITLE     Sdmg1 is a conserved transmembrane protein associated with germ
            cell sex determination and germline-soma interactions in mice
  JOURNAL   Development 135 (8), 1415-1425 (2008)
   PUBMED   18321981
REFERENCE   8  (bases 1 to 2492)
  AUTHORS   Williams D and Pessin JE.
  TITLE     Mapping of R-SNARE function at distinct intracellular GLUT4
            trafficking steps in adipocytes
  JOURNAL   J Cell Biol 180 (2), 375-387 (2008)
   PUBMED   18227281
REFERENCE   9  (bases 1 to 2492)
  AUTHORS   Rizzoli SO, Bethani I, Zwilling D, Wenzel D, Siddiqui TJ,
            Brandhorst D and Jahn R.
  TITLE     Evidence for early endosome-like fusion of recently endocytosed
            synaptic vesicles
  JOURNAL   Traffic 7 (9), 1163-1176 (2006)
   PUBMED   17004320
REFERENCE   10 (bases 1 to 2492)
  AUTHORS   Zeng Q, Tran TT, Tan HX and Hong W.
  TITLE     The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their
            correct subcellular targeting: the N-terminal extenSion of VAMP4
            contains a dominant autonomous targeting signal for the trans-Golgi
            network
  JOURNAL   J Biol Chem 278 (25), 23046-23054 (2003)
   PUBMED   12682051
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            [WARNING] On May 2, 2024 this sequence was replaced by
            NM_001108856.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344168.3, XM_001070325.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2492
                     /gene="Vamp4"
                     /note="vesicle-associated membrane protein 4"
                     /db_xref="GeneID:364033"
                     /db_xref="RGD:1309753"
     exon            1..59
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
     exon            60..181
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..541
                     /gene="Vamp4"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 4"
                     /protein_id="NP_001102326.1"
                     /db_xref="GeneID:364033"
                     /db_xref="RGD:1309753"
                     /translation="MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGP
                     RFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRS
                     KQLRRQMWWRGCKIKAIMALAAAILLLMIITQIILHLKK"
     exon            182..228
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
     exon            229..279
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
     exon            280..380
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..460
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
     exon            461..512
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
     exon            513..2492
                     /gene="Vamp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccctgccta ccgcccccaa cgtccgctgg ggctgggagc tggcctgcgc gagggccggg
       61 tggtggatac ttattctgtt gggaaataca gcaagagtat ttgtgagcag aaagtatgcc
      121 tcccaagttc aagcgccacc taaatgacga tgacgtcact gggtctgtga aaagtgagag
      181 gagaaatctt ttggaagatg attcagatga agaagaggac ttttttctac ggggaccatc
      241 tggaccaaga tttggaccca gaaacgataa aattaagcat gttcagaatc aggtggacga
      301 agttattgat gtaatgcaag agaatattac caaggtaatt gaaagaggag agaggctaga
      361 tgaactacag gacaaatcag aaagcttatc ggataatgca actgctttca gcaacagatc
      421 caaacagctt cgaaggcaaa tgtggtggcg tggatgcaaa ataaaagcca tcatggcttt
      481 ggctgcagct atccttttgc taatgattat cactcagatc atcctgcact tgaaaaaatg
      541 aagttttacc accatcaaaa ctatctttat ttaacaacag tgaagatcaa cagaaaaatc
      601 caagtagctt tgctaatgtt agttgatgcc cagtgaaatc aggtcaccac tgccgtgcct
      661 gacgcgtgcc ctgtggtttg tctgtaacag agcctcttcc cttgcagcag tctgatgagt
      721 gggctccttc tccatcataa cccagtgttg ttgttacctg tggtcctaac aaagctcatt
      781 gggaattgtc ccaaaacttt ataaactggg aaacgtattg atgaaaagaa ggtccagtgt
      841 tgatgatgag cttgttttaa gtggagaaaa ggtaatcaca tcaggtacag aggtgcatga
      901 tggcgtcctg ccgactgtcg tttcagttca ctcccgggtt ctgtgttagg aagtaatgct
      961 ggccttttga aagcagaaac tggcaccttt ctgctctata tggcatgtgg gtgccctgtg
     1021 aatgcaaacg cacacatagg gtgaggctca gatgtgacaa aagcctgacc tctgtccttg
     1081 ccacttaaca cctgttttat gtcctgttgg cactgtagcc caaacagact tgtatttact
     1141 ttatggctag aaaataagca agaagttttt ttcagtgttg aaaacaaatg tcattagatg
     1201 ttcttagttg taccgagtca gagtgttcct aagttaggga ctggactact aatcagattt
     1261 tgtgttttca catagaaagg ttatcggagt cagtttactt ttctgtgagt gatagtaaga
     1321 gcgtgagtca gttgaaacac attgggaggg gttgccaaat atcagcataa agacagtggc
     1381 tcagaagagg cagaaagggc cctcttagtc cataaaatgt gccctcctta aactgatgtg
     1441 gtctgagtct atcttgtgtg tcttgggatt tttggttggt gggtgggttg gttggttggt
     1501 tagttggttg gttttagttt ttttgaaaca cggtctcact gtgtgaccca gactggcctc
     1561 agatgcacag atgcatcggc ctcccaagtg ctgggattgg aggtatgtcc caccacaccc
     1621 tgtagccttt ttctttttgg tcaaagaaag aatccttggg ctcaagtggt ctttgcaact
     1681 tagccccaga agtagctaag actacatgtg ggcaccagca tgtgctgata gaccttcttt
     1741 taaagcctga tgttagtctt acttggatat ttattttcat atgtcaagca gaataaaggg
     1801 tgggacacat ttttattctg gctattgttt catttcacaa gctacttaga acaagttagc
     1861 agggatgaga agaaaaacat tgctagtcca gttggcttca gcttataaag caagggccat
     1921 accatgttgt gtccctcaac tccaagtccc tgtgtgtgtg gctgtgtccc aaagtgacac
     1981 cgtgctggtg gtgtgtaagt gagggctgat ttccagtgtg cgctgagaga tgacatgatt
     2041 gaggtaggtg aacctagaga taaaagggtt cttataattg aatatagaaa acttctggtt
     2101 tgacggtgtt acattaggtt cttttcactt gaaaagattt tgaaataaaa tcacatattt
     2161 taaagctgta aattgtatat gtctgaggat ttagtaaaat gtcagagatc aatctataag
     2221 aaaatttaaa tattgttttt atatcttagt tgtctgtcat tattttagat cccacaatcc
     2281 ctaatttaac catttcggca agtgcctttg acacttaagg agtattgtgg gagatgagca
     2341 aatgtaggtg ccacaccccg tttcctggct tctcaattcc tcgtgacagt atatgtttta
     2401 cagtgctaca aagttcagtc ctttgtgttc atgtgagatt gtactgtagc ctttccatag
     2461 taaacagcaa aataaaccat ttgcagaaaa tg
//
