LOCUS       NP_001102326             141 aa            linear   ROD 03-MAY-2024
DEFINITION  vesicle-associated membrane protein 4 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001102326 XP_001070325 XP_006250248 XP_344169
VERSION     NP_001102326.1
DBSOURCE    REFSEQ: accession NM_001108856.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 141)
  AUTHORS   Bakr,M., Jullie,D., Krapivkina,J., Paget-Blanc,V., Bouit,L.,
            Petersen,J.D., Retailleau,N., Breillat,C., Herzog,E., Choquet,D.
            and Perrais,D.
  TITLE     The vSNAREs VAMP2 and VAMP4 control recycling and intracellular
            sorting of post-synaptic receptors in neuronal dendrites
  JOURNAL   Cell Rep 36 (10), 109678 (2021)
   PUBMED   34496238
  REMARK    GeneRIF: The vSNAREs VAMP2 and VAMP4 control recycling and
            intracellular sorting of post-synaptic receptors in neuronal
            dendrites.
REFERENCE   2  (residues 1 to 141)
  AUTHORS   Lin,P.Y., Chanaday,N.L., Horvath,P.M., Ramirez,D.M.O.,
            Monteggia,L.M. and Kavalali,E.T.
  TITLE     VAMP4 Maintains a Ca2+-Sensitive Pool of Spontaneously Recycling
            Synaptic Vesicles
  JOURNAL   J Neurosci 40 (28), 5389-5401 (2020)
   PUBMED   32532887
  REMARK    GeneRIF: VAMP4 Maintains a Ca(2+)-Sensitive Pool of Spontaneously
            Recycling Synaptic Vesicles.
REFERENCE   3  (residues 1 to 141)
  AUTHORS   Nicholson-Fish,J.C., Kokotos,A.C., Gillingwater,T.H., Smillie,K.J.
            and Cousin,M.A.
  TITLE     VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk
            Endocytosis
  JOURNAL   Neuron 88 (5), 973-984 (2015)
   PUBMED   26607000
  REMARK    GeneRIF: The results of this study suggested that the VAMP4 is the
            first identified Activity-dependent bulk endocytosis cargo and is
            essential for this endocytosis mode to proceed.
REFERENCE   4  (residues 1 to 141)
  AUTHORS   Shitara,A., Shibui,T., Okayama,M., Arakawa,T., Mizoguchi,I.,
            Sakakura,Y. and Takuma,T.
  TITLE     VAMP4 is required to maintain the ribbon structure of the Golgi
            apparatus
  JOURNAL   Mol Cell Biochem 380 (1-2), 11-21 (2013)
   PUBMED   23677696
  REMARK    Erratum:[Mol Cell Biochem. 2013 Aug;380(1-2):301. Shakakura,
            Yasunori [corrected to Sakakura, Yasunori]]
REFERENCE   5  (residues 1 to 141)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (residues 1 to 141)
  AUTHORS   Cocucci,E., Racchetti,G., Rupnik,M. and Meldolesi,J.
  TITLE     The regulated exocytosis of enlargeosomes is mediated by a SNARE
            machinery that includes VAMP4
  JOURNAL   J Cell Sci 121 (Pt 18), 2983-2991 (2008)
   PUBMED   18713833
  REMARK    GeneRIF: Data show that VAMP4, an R-SNARE that has never been shown
            to participate in regulated exocytoses, appears to be harboured in
            the membrane of enlargeosomes and to be a member of the machinery
            mediating their regulated exocytosis.
REFERENCE   7  (residues 1 to 141)
  AUTHORS   Best,D., Sahlender,D.A., Walther,N., Peden,A.A. and Adams,I.R.
  TITLE     Sdmg1 is a conserved transmembrane protein associated with germ
            cell sex determination and germline-soma interactions in mice
  JOURNAL   Development 135 (8), 1415-1425 (2008)
   PUBMED   18321981
REFERENCE   8  (residues 1 to 141)
  AUTHORS   Williams,D. and Pessin,J.E.
  TITLE     Mapping of R-SNARE function at distinct intracellular GLUT4
            trafficking steps in adipocytes
  JOURNAL   J Cell Biol 180 (2), 375-387 (2008)
   PUBMED   18227281
REFERENCE   9  (residues 1 to 141)
  AUTHORS   Rizzoli,S.O., Bethani,I., Zwilling,D., Wenzel,D., Siddiqui,T.J.,
            Brandhorst,D. and Jahn,R.
  TITLE     Evidence for early endosome-like fusion of recently endocytosed
            synaptic vesicles
  JOURNAL   Traffic 7 (9), 1163-1176 (2006)
   PUBMED   17004320
REFERENCE   10 (residues 1 to 141)
  AUTHORS   Zeng,Q., Tran,T.T., Tan,H.X. and Hong,W.
  TITLE     The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their
            correct subcellular targeting: the N-terminal extenSion of VAMP4
            contains a dominant autonomous targeting signal for the trans-Golgi
            network
  JOURNAL   J Biol Chem 278 (25), 23046-23054 (2003)
   PUBMED   12682051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before May 2, 2024 this sequence version replaced
            XP_006250248.1, XP_344169.2, XP_001070325.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.44930.1,
                                           SRR26643293.54110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     Protein         1..141
                     /product="vesicle-associated membrane protein 4 isoform 1"
                     /calculated_mol_wt=16227
     Region          50..116
                     /region_name="R-SNARE_VAMP4"
                     /note="SNARE motif of VAMP4; cd15869"
                     /db_xref="CDD:277222"
     Site            order(52..53,56..57,59..64,66..67,70..71,73..74,77..78,
                     81..82,84..85,87..88,90..92,94..96,98..99,101..103,
                     105..106,108..110)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277222"
     Site            77
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277222"
     CDS             1..141
                     /gene="Vamp4"
                     /coded_by="NM_001108856.2:211..636"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:364033"
                     /db_xref="RGD:1309753"
ORIGIN      
        1 mppkfkrhln dddvtgsvks errnlledds deeedfflrg psgprfgprn dkikhvqnqv
       61 devidvmqen itkvierger ldelqdkses lsdnatafsn rskqlrrqmw wrgckikaim
      121 alaaailllm iitqiilhlk k
//
