LOCUS       NM_057097               1705 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus vesicle-associated membrane protein 3 (Vamp3),
            mRNA.
ACCESSION   NM_057097
VERSION     NM_057097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Caceres,P.S., Mendez,M., Haque,M.Z. and Ortiz,P.A.
  TITLE     Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive
            Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending
            Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE
  JOURNAL   J Biol Chem 291 (42), 22063-22073 (2016)
   PUBMED   27551042
  REMARK    GeneRIF: VAMP3 is required for normal NKCC2 expression, renal
            function, and blood pressure.
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Beaton,N., Rudigier,C., Moest,H., Muller,S., Mrosek,N., Roder,E.,
            Rudofsky,G., Rulicke,T., Ukropec,J., Ukropcova,B., Augustin,R.,
            Neubauer,H. and Wolfrum,C.
  TITLE     TUSC5 regulates insulin-mediated adipose tissue glucose uptake by
            modulation of GLUT4 recycling
  JOURNAL   Mol Metab 4 (11), 795-810 (2015)
   PUBMED   26629404
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1705)
  AUTHORS   Caceres,P.S., Mendez,M. and Ortiz,P.A.
  TITLE     Vesicle-associated membrane protein 2 (VAMP2) but Not VAMP3
            mediates cAMP-stimulated trafficking of the renal Na+-K+-2Cl-
            co-transporter NKCC2 in thick ascending limbs
  JOURNAL   J Biol Chem 289 (34), 23951-23962 (2014)
   PUBMED   25008321
  REMARK    GeneRIF: In vivo silencing of VAMP2 but not VAMP3 in TALs blunted
            cAMP-stimulated steady-state surface NKCC2 expression and
            completely blocked cAMP-stimulated NKCC2 exocytic delivery
REFERENCE   4  (bases 1 to 1705)
  AUTHORS   Rahman,A., Decourcey,J., Larbi,N.B., Loughran,S.T., Walls,D. and
            Loscher,C.E.
  TITLE     Syntaxin-4 is essential for IgE secretion by plasma cells
  JOURNAL   Biochem Biophys Res Commun 440 (1), 163-167 (2013)
   PUBMED   24055037
REFERENCE   5  (bases 1 to 1705)
  AUTHORS   Peters,C.G., Michelson,A.D. and Flaumenhaft,R.
  TITLE     Granule exocytosis is required for platelet spreading: differential
            sorting of alpha-granules expressing VAMP-7
  JOURNAL   Blood 120 (1), 199-206 (2012)
   PUBMED   22589474
REFERENCE   6  (bases 1 to 1705)
  AUTHORS   St-Denis,J.F., Cabaniols,J.P., Cushman,S.W. and Roche,P.A.
  TITLE     SNAP-23 participates in SNARE complex assembly in rat adipose cells
  JOURNAL   Biochem J 338 (Pt 3) (Pt 3), 709-715 (1999)
   PUBMED   10051443
REFERENCE   7  (bases 1 to 1705)
  AUTHORS   Annaert,W.G., Becker,B., Kistner,U., Reth,M. and Jahn,R.
  TITLE     Export of cellubrevin from the endoplasmic reticulum is controlled
            by BAP31
  JOURNAL   J Cell Biol 139 (6), 1397-1410 (1997)
   PUBMED   9396746
REFERENCE   8  (bases 1 to 1705)
  AUTHORS   Franki,N., Macaluso,F., Schubert,W., Gunther,L. and Hays,R.M.
  TITLE     Water channel-carrying vesicles in the rat IMCD contain cellubrevin
  JOURNAL   Am J Physiol 269 (3 Pt 1), C797-C801 (1995)
   PUBMED   7573412
REFERENCE   9  (bases 1 to 1705)
  AUTHORS   Chilcote,T.J., Galli,T., Mundigl,O., Edelmann,L., McPherson,P.S.,
            Takei,K. and De Camilli,P.
  TITLE     Cellubrevin and synaptobrevins: similar subcellular localization
            and biochemical properties in PC12 cells
  JOURNAL   J Cell Biol 129 (1), 219-231 (1995)
   PUBMED   7698987
REFERENCE   10 (bases 1 to 1705)
  AUTHORS   McMahon,H.T., Ushkaryov,Y.A., Edelmann,L., Link,E., Binz,T.,
            Niemann,H., Jahn,R. and Sudhof,T.C.
  TITLE     Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a
            putative synaptic vesicle fusion protein
  JOURNAL   Nature 364 (6435), 346-349 (1993)
   PUBMED   8332193
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088119.1.
            
            On Oct 24, 2007 this sequence version replaced NM_057097.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088119.1, EV771975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1705
                     /gene="Vamp3"
                     /note="vesicle-associated membrane protein 3"
                     /db_xref="GeneID:29528"
                     /db_xref="RGD:61880"
     exon            1..53
                     /gene="Vamp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..363
                     /gene="Vamp3"
                     /note="CEB; VAMP-3; cellubrevin; synaptobrevin-3"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 3"
                     /protein_id="NP_476438.1"
                     /db_xref="GeneID:29528"
                     /db_xref="RGD:61880"
                     /translation="MSTGVPSGSSAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERD
                     QKLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGISVLVIIVIIIIVWCV
                     S"
     exon            54..135
                     /gene="Vamp3"
                     /inference="alignment:Splign:2.1.0"
     exon            136..294
                     /gene="Vamp3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..346
                     /gene="Vamp3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..1683
                     /gene="Vamp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaagtcca cggaccctcg gccattcgct gccgctgccg ccgccgccaa aatgtctaca
       61 ggggtgcctt cagggtccag tgctgccact ggcagtaatc gaagactcca gcagacacag
      121 aatcaagtag atgaggtggt ggacatcatg agagtcaatg tggataaggt gttagaaaga
      181 gaccagaagc tctcagagct agacgaccgc gcagatgcac tgcaggcagg cgcctcgcag
      241 tttgaaacaa gtgctgccaa gttgaagaga aagtattggt ggaagaactg caagatgtgg
      301 gcgataggga tcagtgtcct ggtgattatt gtcattatca tcattgtgtg gtgtgtctct
      361 taatgaagaa cagaggaaat gaagcctgac ggcaggatct tcttcgagac tttctactta
      421 gaactgcgtg ttgtcgcact tccctgttgt tttttttttt tcccaaatga ttatttgtgt
      481 tagtttacat acagttcagt gcctagaaaa tgtgcctttg tttttcatat acactcgagg
      541 tgtgacctgc cctgcccaca ttttgcacag tgcctttaca gatttatgga ctgggaaaga
      601 ggacttgtgt gtttcagagt gctgagatct aggtggatgt tgtcactgat ggcttgtgga
      661 ttcaaggaag aggattttgt tcaagtcagc tgtccccaca cctaacatgg acttcaaaac
      721 cacagtttaa acctttgggt aattagattc ccaacttgga ccttccaaga agaacactac
      781 tgcctaacaa aaatcagtga caacagcagg gcgtgcctta ttttgataac taggtaactt
      841 ttcattaaga gtacttttgt aagcactacc gaccccgctg tatttaagat gctggtgaag
      901 agctcatgct cttatgttag atacggagat gttcactttc tagttcttgt tgtgtatcac
      961 ttctaaaaca gtattttaat cagaaataac cctttaggaa gtttttatag aactgtgacc
     1021 aaagtttcta ttttgccaaa agttaaatac aaatgaattg tccataagtt tgtcccccag
     1081 tagtaaattc aaataagtgc caagtgtaac tcaaggtgcc ctttaagaaa aaatgttagt
     1141 actgtctgag cccgcagcat cttgacagtc cttcctgtgg aatgctgtag gtacagcttc
     1201 tcatcctgat gtggtttctt tcctagagcg atagaggtga cctcaaatca cacctgtatg
     1261 caagatagta gtttgcagac tgcactagcc tgtggccact agtgtgatga gagcagcatc
     1321 tgaagcctca caaaggcaac agtctgcaca gagttctggg agactgtggc agtgccacca
     1381 ggatgtcctg aaatgtgtgt ctgtgtgcaa agcagcatta gccaaaatgt cataggatct
     1441 ggttctagtt ttttttatct gatcccctaa cattactgaa acaaaacaag tgttgaagac
     1501 atgccttgcc acatagctag ggcctctgtc ctggtctgac cccacaactt tggtgctgtc
     1561 tcctcgtact ctgtcccatg taagtcgttg gctcctgtat taacacagta atacctcgct
     1621 tctctgtgca tttagctggg aatgttcccg ctatggtgac cggaataaag ttattaacat
     1681 gaaaaaaaaa aaaaaaaaaa aaaaa
//
