LOCUS       NM_012663               2250 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus vesicle-associated membrane protein 2 (Vamp2),
            mRNA.
ACCESSION   NM_012663
VERSION     NM_012663.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2250)
  AUTHORS   Bakr,M., Jullie,D., Krapivkina,J., Paget-Blanc,V., Bouit,L.,
            Petersen,J.D., Retailleau,N., Breillat,C., Herzog,E., Choquet,D.
            and Perrais,D.
  TITLE     The vSNAREs VAMP2 and VAMP4 control recycling and intracellular
            sorting of post-synaptic receptors in neuronal dendrites
  JOURNAL   Cell Rep 36 (10), 109678 (2021)
   PUBMED   34496238
  REMARK    GeneRIF: The vSNAREs VAMP2 and VAMP4 control recycling and
            intracellular sorting of post-synaptic receptors in neuronal
            dendrites.
REFERENCE   2  (bases 1 to 2250)
  AUTHORS   Vilcaes,A.A., Chanaday,N.L. and Kavalali,E.T.
  TITLE     Interneuronal exchange and functional integration of synaptobrevin
            via extracellular vesicles
  JOURNAL   Neuron 109 (6), 971-983 (2021)
   PUBMED   33513363
  REMARK    GeneRIF: Interneuronal exchange and functional integration of
            synaptobrevin via extracellular vesicles.
REFERENCE   3  (bases 1 to 2250)
  AUTHORS   Kondratiuk,I., Jakhanwal,S., Jin,J., Sathyanarayanan,U.,
            Kroppen,B., Pobbati,A.V., Krisko,A., Ashery,U., Meinecke,M.,
            Jahn,R., Fasshauer,D. and Milosevic,I.
  TITLE     PI(4,5)P2-dependent regulation of exocytosis by amisyn, the
            vertebrate-specific competitor of synaptobrevin 2
  JOURNAL   Proc Natl Acad Sci U S A 117 (24), 13468-13479 (2020)
   PUBMED   32467162
  REMARK    GeneRIF: PI(4,5)P2-dependent regulation of exocytosis by amisyn,
            the vertebrate-specific competitor of synaptobrevin 2.
REFERENCE   4  (bases 1 to 2250)
  AUTHORS   Wang,C., Tu,J., Zhang,S., Cai,B., Liu,Z., Hou,S., Zhong,Q., Hu,X.,
            Liu,W., Li,G., Liu,Z., He,L., Diao,J., Zhu,Z.J., Li,D. and Liu,C.
  TITLE     Different regions of synaptic vesicle membrane regulate VAMP2
            conformation for the SNARE assembly
  JOURNAL   Nat Commun 11 (1), 1531 (2020)
   PUBMED   32210233
  REMARK    GeneRIF: By using in-cell NMR spectroscopy study described the
            dynamic membrane association of rat VAMP2 SNARE motif in mammalian
            cells, and the structural change of VAMP2 upon the change of
            intracellular lipis. In contrast to the non-raft region, the
            membrane region of cholesterol-rich lipid raft markedly weakens the
            membrane association of VAMP2 SNARE motif, which releases the SNARE
            motif and facilitates the SNARE assembly.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2250)
  AUTHORS   Salpietro,V., Malintan,N.T., Llano-Rivas,I., Spaeth,C.G.,
            Efthymiou,S., Striano,P., Vandrovcova,J., Cutrupi,M.C., Chimenz,R.,
            David,E., Di Rosa,G., Marce-Grau,A., Raspall-Chaure,M.,
            Martin-Hernandez,E., Zara,F., Minetti,C., Bello,O.D., De Zorzi,R.,
            Fortuna,S., Dauber,A., Alkhawaja,M., Sultan,T., Mankad,K.,
            Vitobello,A., Thomas,Q., Mau-Them,F.T., Faivre,L.,
            Martinez-Azorin,F., Prada,C.E., Macaya,A., Kullmann,D.M.,
            Rothman,J.E., Krishnakumar,S.S. and Houlden,H.
  CONSRTM   Deciphering Developmental Disorders Study; SYNAPS Study Group
  TITLE     Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic
            Membrane Fusion and Impair Human Neurodevelopment
  JOURNAL   Am J Hum Genet 104 (4), 721-730 (2019)
   PUBMED   30929742
REFERENCE   6  (bases 1 to 2250)
  AUTHORS   Galli,T., McPherson,P.S. and De Camilli,P.
  TITLE     The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are
            associated on synaptic vesicles in a Triton X-100-resistant,
            freeze-thawing sensitive, complex
  JOURNAL   J Biol Chem 271 (4), 2193-2198 (1996)
   PUBMED   8567678
REFERENCE   7  (bases 1 to 2250)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   8  (bases 1 to 2250)
  AUTHORS   Deng,A.Y. and Rapp,J.P.
  TITLE     Locus for the inducible, but not a constitutive, nitric oxide
            synthase cosegregates with blood pressure in the Dahl
            salt-sensitive rat
  JOURNAL   J Clin Invest 95 (5), 2170-2177 (1995)
   PUBMED   7537756
REFERENCE   9  (bases 1 to 2250)
  AUTHORS   Schiavo,G., Benfenati,F., Poulain,B., Rossetto,O., Polverino de
            Laureto,P., DasGupta,B.R. and Montecucco,C.
  TITLE     Tetanus and botulinum-B neurotoxins block neurotransmitter release
            by proteolytic cleavage of synaptobrevin
  JOURNAL   Nature 359 (6398), 832-835 (1992)
   PUBMED   1331807
REFERENCE   10 (bases 1 to 2250)
  AUTHORS   Elferink,L.A., Trimble,W.S. and Scheller,R.H.
  TITLE     Two vesicle-associated membrane protein genes are differentially
            expressed in the rat central nervous system
  JOURNAL   J Biol Chem 264 (19), 11061-11064 (1989)
   PUBMED   2472388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC074003.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_012663.3.
            
            On Jul 8, 2004 this sequence version replaced NM_012663.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074003.1, M24105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2250
                     /gene="Vamp2"
                     /gene_synonym="RATVAMPB; RATVAMPIR; SYB; Syb2"
                     /note="vesicle-associated membrane protein 2"
                     /db_xref="GeneID:24803"
                     /db_xref="RGD:3949"
     exon            1..84
                     /gene="Vamp2"
                     /gene_synonym="RATVAMPB; RATVAMPIR; SYB; Syb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..433
                     /gene="Vamp2"
                     /gene_synonym="RATVAMPB; RATVAMPIR; SYB; Syb2"
                     /note="VAMP-2; synaptobrevin-2; Synaptobrevin 2
                     (vesicle-associated membrane protein VAMP-2);
                     Vesicle-associated membrane protein (synaptobrevin 2)"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 2"
                     /protein_id="NP_036795.1"
                     /db_xref="GeneID:24803"
                     /db_xref="RGD:3949"
                     /translation="MSATAATVPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVD
                     IMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVI
                     CAIILIIIIVYFST"
     exon            85..205
                     /gene="Vamp2"
                     /gene_synonym="RATVAMPB; RATVAMPIR; SYB; Syb2"
                     /inference="alignment:Splign:2.1.0"
     exon            206..364
                     /gene="Vamp2"
                     /gene_synonym="RATVAMPB; RATVAMPIR; SYB; Syb2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..416
                     /gene="Vamp2"
                     /gene_synonym="RATVAMPB; RATVAMPIR; SYB; Syb2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..2170
                     /gene="Vamp2"
                     /gene_synonym="RATVAMPB; RATVAMPIR; SYB; Syb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagccagc gccagtcgga gccagcgcga gccgccgccg ctgtcactgc ctctgccaag
       61 tcctctgccc gctacccccg ccatgtcggc taccgctgcc accgtcccgc ctgccgcccc
      121 ggccggcgag ggtggccccc ctgcacctcc tccaaatctt accagtaaca ggagactgca
      181 gcagacccag gcccaggtgg atgaggtggt ggacatcatg agggtgaatg tggacaaggt
      241 cctggagcgg gaccagaagc tatcggaact ggatgatcgc gcagatgccc tccaggcagg
      301 ggcctcccag tttgaaacaa gtgcagccaa gctcaagcgc aaatactggt ggaaaaacct
      361 caagatgatg atcatcttgg gagtgatttg cgccatcatc ctcatcatca tcatcgttta
      421 cttcagcact taagtccctg aggagtctgc cctgcctaag aagggcctct cccccaccct
      481 cagcccgtcc tccacctctc agccatatct ttcagccccc tcccttggat ccgtgtgtgt
      541 gtgtgtccgt gtgtgtgccc cctgtaaata gccagctgtt atttatacat atataatatt
      601 atatatattt ggtctgtttg tagttttatt actagaagat tttttccggt tgtccttaac
      661 accccttcct gaggttccca tcacctctct ctctcaccct ctgccccctt tcctctttcc
      721 tgttcagccc caagtccctt catttgcatc tgctatgcaa tagcccctct cctccttccc
      781 ttggatttaa ccaatccttc ccctatcttc cctgtacaat tccagaccct ccccaaacag
      841 agcaaacccc acagaaacaa acaaaacacc ccacctgtct aggcttccat aggttgcatc
      901 tttgtatccc ttgggagcct ctaagactgg tcctacttgg tcctaagaat cccaaggttt
      961 tctgggagct tccaacatgt tgattagcat atcatttgca tacactgtct tttttttttc
     1021 cctgggtttc ttcctttctg ttccattact cttcactctt ctgtgttttt tttttttctt
     1081 tctttctttt cggaagagtt agtttccatt ggtcctctta tcacactttt atttgcacga
     1141 cattatctgc aggtggtggg gagcctgggc ttttggggaa ctaggacccc aaagttgcct
     1201 cctcccagcc cctctagtct agtttgcttc ccttacccca ttttccacac ctcttgtacc
     1261 ctcctctccc tcccccagct ggtgtgtaag tgtcttggag ttcagtgtgt tatgatggac
     1321 caataattct gccacttggg gtctctccct acattcctgc tccccagttt tcgtgtgggg
     1381 cattcagctg acattcccgg gggtctccct ccctcccatc tgcctgatct gctgcctcct
     1441 cccaccagga gaactggagg ctgaccacaa tctggttctt tgaggagggg tggctctagt
     1501 gtgtgtgggg gtcatcactg ccttggggag gagtgggaca aaacagaacc ccccctaatt
     1561 cctgcctgaa atctctggcc tcatccttgc tagaggttgg actgaaaact ttcctcccca
     1621 atcctggggg ggggtattac cccccatcac tgcccagctc ctctgactgc ccccctgtat
     1681 tcagggtggg ggtactagtc actgccaata tgtgtatggg acttgctgga ggatggggat
     1741 ccttgtcctt ctctagggct gctgagccct gagagagaga gagagagaga gagagagaga
     1801 gagagagaga gagagagaga gagggaagca agctatttcc ctgttgggta caatgataga
     1861 gaaaggatct aatctttaaa aatggcacag ttttaggggt ctgagggtac agccccttaa
     1921 cctgcctctt ggggggggtg ttccccaaac tcttccccca cacacaccag gttttctgtg
     1981 tggaggggaa ccaaggagat ctaaactgtg gtgtgaaagg gtaggagaga tgctgggggt
     2041 gggggtgctt gtgttttaga cccccaatat tatcccagtg tcccctgcct tccttcttcc
     2101 cctgccccat gcccccaatt ctgtggcgca tccagattgt gaaaatgtac aataaacgtg
     2161 taatgagtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
