LOCUS       NM_013090               2650 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus vesicle-associated membrane protein 1 (Vamp1),
            mRNA.
ACCESSION   NM_013090
VERSION     NM_013090.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2650)
  AUTHORS   Rodepeter,F.R., Wiegand,S., Luers,H.G., Bonaterra,G.A., Lowe,A.W.,
            Bette,M., Jacob,R. and Mandic,R.
  TITLE     Indication for differential sorting of the rat v-SNARE splice
            isoforms VAMP-1a and -1b
  JOURNAL   Biochem Cell Biol 95 (4), 500-509 (2017)
   PUBMED   28314111
  REMARK    GeneRIF: differential sorting of the rat v-SNARE splice isoforms
            VAMP-1a and -1b
REFERENCE   2  (bases 1 to 2650)
  AUTHORS   Sitarska,E., Xu,J., Park,S., Liu,X., Quade,B., Stepien,K.,
            Sugita,K., Brautigam,C.A., Sugita,S. and Rizo,J.
  TITLE     Autoinhibition of Munc18-1 modulates synaptobrevin binding and
            helps to enable Munc13-dependent regulation of membrane fusion
  JOURNAL   Elife 6, e24278 (2017)
   PUBMED   28477408
  REMARK    GeneRIF: Together with previous studies, these data support a model
            whereby Munc18-1 acts as a template for SNARE complex assembly, and
            autoinhibition of synaptobrevin binding contributes to enabling
            regulation of neurotransmitter release by Munc13-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2650)
  AUTHORS   Gu,Y. and Huganir,R.L.
  TITLE     Identification of the SNARE complex mediating the exocytosis of
            NMDA receptors
  JOURNAL   Proc Natl Acad Sci U S A 113 (43), 12280-12285 (2016)
   PUBMED   27791016
  REMARK    GeneRIF: Our study uncovers the postsynaptic function of the
            SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive
            exocytosis of NMDA receptors, suggesting that this SNARE complex is
            involved in excitatory synaptic transmission
REFERENCE   4  (bases 1 to 2650)
  AUTHORS   Meng,J., Wang,J., Steinhoff,M. and Dolly,J.O.
  TITLE     TNFalpha induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing
            vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated
            fusion
  JOURNAL   Sci Rep 6, 21226 (2016)
   PUBMED   26888187
  REMARK    GeneRIF: TNFalpha induces co-trafficking of TRPV1/TRPA1 in
            VAMP1-containing vesicles to the plasmalemma via
            Munc18-1/syntaxin1/SNAP-25 mediated fusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2650)
  AUTHORS   Peng,L., Adler,M., Demogines,A., Borrell,A., Liu,H., Tao,L.,
            Tepp,W.H., Zhang,S.C., Johnson,E.A., Sawyer,S.L. and Dong,M.
  TITLE     Widespread sequence variations in VAMP1 across vertebrates suggest
            a potential selective pressure from botulinum neurotoxins
  JOURNAL   PLoS Pathog 10 (7), e1004177 (2014)
   PUBMED   25010769
  REMARK    GeneRIF: residue 48 of VAMP1 varies frequently between M and I
            across seventeen closely related primate species, suggesting a
            potential selective pressure from members of BoNTs for resistance
            in vertebrates.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2650)
  AUTHORS   Nabokina,S.M.
  TITLE     Intracellular localization of VAMP-1 protein in human neutrophils
  JOURNAL   Bull Exp Biol Med 131 (2), 130-131 (2001)
   PUBMED   11391393
REFERENCE   7  (bases 1 to 2650)
  AUTHORS   Martincic,I., Peralta,M.E. and Ngsee,J.K.
  TITLE     Isolation and characterization of a dual prenylated Rab and VAMP2
            receptor
  JOURNAL   J Biol Chem 272 (43), 26991-26998 (1997)
   PUBMED   9341137
REFERENCE   8  (bases 1 to 2650)
  AUTHORS   Mandic,R., Trimble,W.S. and Lowe,A.W.
  TITLE     Tissue-specific alternative RNA splicing of rat vesicle-associated
            membrane protein-1 (VAMP-1)
  JOURNAL   Gene 199 (1-2), 173-179 (1997)
   PUBMED   9358054
REFERENCE   9  (bases 1 to 2650)
  AUTHORS   Elferink,L.A., Trimble,W.S. and Scheller,R.H.
  TITLE     Two vesicle-associated membrane protein genes are differentially
            expressed in the rat central nervous system
  JOURNAL   J Biol Chem 264 (19), 11061-11064 (1989)
   PUBMED   2472388
REFERENCE   10 (bases 1 to 2650)
  AUTHORS   Trimble,W.S., Cowan,D.M. and Scheller,R.H.
  TITLE     VAMP-1: a synaptic vesicle-associated integral membrane protein
  JOURNAL   Proc Natl Acad Sci U S A 85 (12), 4538-4542 (1988)
   PUBMED   3380805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB582258.1, CO567426.1, BC092206.1 and AI059682.1.
            
            On Sep 28, 2005 this sequence version replaced NM_013090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM030153.1, BC092206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CB582258.1         1-15
            16-279              CO567426.1         45-308
            280-2629            BC092206.1         178-2527
            2630-2650           AI059682.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2650
                     /gene="Vamp1"
                     /gene_synonym="Syb1"
                     /note="vesicle-associated membrane protein 1"
                     /db_xref="GeneID:25624"
                     /db_xref="RGD:3948"
     exon            1..136
                     /gene="Vamp1"
                     /gene_synonym="Syb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..491
                     /gene="Vamp1"
                     /gene_synonym="Syb1"
                     /note="VAMP-1; synaptobrevin-1"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 1"
                     /protein_id="NP_037222.2"
                     /db_xref="GeneID:25624"
                     /db_xref="RGD:3948"
                     /translation="MSAPAQPPAEGTEGAAPGGGPPGPPPNTTSNRRLQQTQAQVEEV
                     VDIMRVNVDKVLERDQKLSELDDRADALQAGASVFESSAAKLKRKYWWKNCKMMIMLG
                     AICAIIVVVIVIYIFT"
     exon            137..263
                     /gene="Vamp1"
                     /gene_synonym="Syb1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..422
                     /gene="Vamp1"
                     /gene_synonym="Syb1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..474
                     /gene="Vamp1"
                     /gene_synonym="Syb1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..2634
                     /gene="Vamp1"
                     /gene_synonym="Syb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagttag agttccgggt ggctcgcgtg aggcggagct cggcagttcc gtctacttca
       61 gccgcagcgt ctccctgcct gtctcattgc attctctaga gaggggacgg acctccactt
      121 cctctttcag aaaaatgtct gctccagctc agccacctgc tgaagggaca gaaggggctg
      181 ccccaggtgg gggtcctcct ggtcctcctc ccaatacgac cagtaacaga cgattacagc
      241 aaacccaggc acaagtggag gaggtggtgg acatcatgcg cgtgaatgtg gacaaggtct
      301 tggagaggga ccagaagttg tcagagttgg atgaccgagc tgacgccttg caggcaggag
      361 cgtcagtgtt tgagagcagt gctgccaagc taaaaaggaa gtattggtgg aaaaactgca
      421 agatgatgat catgctggga gctatctgtg ccatcatcgt ggtagtaatt gtaatctaca
      481 tttttacttg agaatgtgcc atcccttccc tgttctccat tgccatccaa gctcatgttt
      541 cccctctgtt tgctctctca acaaagtcct ccatcttccg ttctccatcc tggcccaggc
      601 ttctctgtga tccgaccttc cctttttgtt gcattcattc gcactcttcc tcaaaactag
      661 aaatgctgct cgtggcacag tcctgaaagt cactgcccga agagaacacc cagcacctcc
      721 tctttaccca tttatcatgt gccctggagc ttaaaagagt tgtggccaat ggcagaggtg
      781 aagtgtctga gaagttagca tggctgaggg gaagagaaag gcatttgtgt ccaagaaagg
      841 ctggcctttg gcaggaggga agcaagaata gttgggaagt agtagcttgc tgccagtgta
      901 tatgtatatg tatatgtata tgtatatgta tatgtatatg tatatgtata tgtatatgta
      961 tatgtatatg tatatgtata tgtatatgta tatgtatatg tatatgtata tattagttgg
     1021 gaactatgac ctgctgtcct catttggaac tttcctccca taccaggcct gtcttgggtc
     1081 ccagaggtct gtttaaagac caacttcaaa tcccttttag aaaaacatca aacttgcatt
     1141 ttgtagctac tgttatctgt cagtacaaga ttttctgtgt ctttggggga actttacaac
     1201 ttttcgcttt gtctctatag ccccaggaga gaagtacctt ctgattttaa aaacagcagg
     1261 acactcttac cttcttctag aaggcgtccc acatgcttct gactagaagg agctaccacc
     1321 tcttcatgtc atctgaagca tttgatgttg ttcatgaagg caccaaataa tttcagggaa
     1381 tgaggggctt tgaggataac aggctctcag gaacacgctc catgccatcc cactctccaa
     1441 tgaaagccct gtacctccct tgttgattaa gagaaatgag agttatatgg tgagactccc
     1501 agggtcccac agaacacttc cccctgcact acccacttac tgtgtgtaag acaaggatga
     1561 ggcaggaggg cctttccaga ttcagctcag acttggatag cggggtctag gctgtgtcag
     1621 gtgtaccgtg cactgctgtg tggcatgggc ctcgcatccg cagctgcctg ccgtgcttcc
     1681 ttcagttctt tctctgcagc tgccgtgtcc atccatcctg catcacctcc ttcctttccc
     1741 tccctttgca tgctctgtgc gcagactctg gaaccgagga caggagctgc tcagtctgtt
     1801 ttgggagctt ctgctgagcc tcagatagga tgctgcatgg ggtaaagcca ggtgctgggg
     1861 tgggagcagg gtgggagcag gaggggtgtt ctcagacctc tattcctgct gtcctctggt
     1921 gcacaagcag gagaggtggc catgctaggc tgggtgccca cttcccgtga agcagcattt
     1981 cattctgcag aaccatcctt cctttccctt gcccatttcc cacgtttcct tcgtgctgcc
     2041 tcagggcagg actgaagagc tggaaggaag cagtcagtgt accctcccaa cgttccctga
     2101 aggtctccac tagactctgg gcttcccttt gcctagtgca ggggtcaccg ctggagaaga
     2161 accaacactg tccttggtgt gctccaagcc tggagccaat ttaccctgtt ggcccaccca
     2221 gccccagcgg gggattattt cctgggtttc tgtccctcca aggcttacca ggtgtagttg
     2281 gctttgttct tctggggctg ttagtccttc tactttcttt ctcacttcac cctggacccc
     2341 cttctgtgtc tctgcagtct tctgtccctc ccacccatgt gcatgagcaa atatgcaact
     2401 taccttggga tctgcagtca gttgaagcca agcttcccac atcctctttg tttgccatga
     2461 ggtgatgtgg ggtttccatt gtgtctgtca ttaccaccgt gtctttccta acccagtctc
     2521 acagtttatg tatagtagta agagttgtcc ttccaccaaa ggcatgtgac agatttacca
     2581 atctcatgta ttctcaacaa aggcgaaaaa tacaaattcc taccacaaca tggaaaaaaa
     2641 aaaaaaaaaa
//
