LOCUS       NM_139336               2006 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus UDP-glucuronate decarboxylase 1 (Uxs1), mRNA.
ACCESSION   NM_139336
VERSION     NM_139336.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2006)
  AUTHORS   Polizzi,S.J., Walsh,R.M. Jr., Le Magueres,P., Criswell,A.R. and
            Wood,Z.A.
  TITLE     Human UDP-alpha-d-xylose synthase forms a catalytically important
            tetramer that has not been observed in crystal structures
  JOURNAL   Biochemistry 52 (22), 3888-3898 (2013)
   PUBMED   23656592
REFERENCE   2  (bases 1 to 2006)
  AUTHORS   Polizzi,S.J., Walsh,R.M. Jr., Peeples,W.B., Lim,J.M., Wells,L. and
            Wood,Z.A.
  TITLE     Human UDP-alpha-D-xylose synthase and Escherichia coli ArnA
            conserve a conformational shunt that controls whether xylose or
            4-keto-xylose is produced
  JOURNAL   Biochemistry 51 (44), 8844-8855 (2012)
   PUBMED   23072385
REFERENCE   3  (bases 1 to 2006)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 2006)
  AUTHORS   Moriarity,J.L., Hurt,K.J., Resnick,A.C., Storm,P.B., Laroy,W.,
            Schnaar,R.L. and Snyder,S.H.
  TITLE     UDP-glucuronate decarboxylase, a key enzyme in proteoglycan
            synthesis: cloning, characterization, and localization
  JOURNAL   J Biol Chem 277 (19), 16968-16975 (2002)
   PUBMED   11877387
  REMARK    GeneRIF: UDP-glucuronate decarboxylase, a key enzyme in
            proteoglycan synthesis: cloning, characterization, and
            localization.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139336.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF482705.1, BC086988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000009.1  740980-741118
            140-167             JAXUCZ010000009.1  763850-763877
            168-216             JAXUCZ010000009.1  765700-765748
            217-260             JAXUCZ010000009.1  766002-766045
            261-321             JAXUCZ010000009.1  774205-774265
            322-502             JAXUCZ010000009.1  780452-780632
            503-607             JAXUCZ010000009.1  789087-789191
            608-667             JAXUCZ010000009.1  792943-793002
            668-789             JAXUCZ010000009.1  795512-795633
            790-909             JAXUCZ010000009.1  803093-803212
            910-953             JAXUCZ010000009.1  808423-808466
            954-1014            JAXUCZ010000009.1  811711-811771
            1015-1072           JAXUCZ010000009.1  813002-813059
            1073-1176           JAXUCZ010000009.1  815103-815206
            1177-2006           JAXUCZ010000009.1  817481-818310
FEATURES             Location/Qualifiers
     source          1..2006
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2006
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /note="UDP-glucuronate decarboxylase 1"
                     /db_xref="GeneID:246232"
                     /db_xref="RGD:628680"
     exon            1..139
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1308
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /EC_number="4.1.1.35"
                     /note="UXS-1"
                     /codon_start=1
                     /product="UDP-glucuronic acid decarboxylase 1"
                     /protein_id="NP_647552.2"
                     /db_xref="GeneID:246232"
                     /db_xref="RGD:628680"
                     /translation="MVSKGLLRLVSSVNRRKMKLLLGIALFAYAASVWGNFVNMRSIQ
                     ENGELKIESKIEEIIEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGS
                     HLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLA
                     SPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDY
                     WGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSN
                     FILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEF
                     AQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFR
                     KELEYQANNQYIPKPKPARVKKGRTRHS"
     exon            140..167
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            168..216
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            217..260
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            261..321
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            322..502
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            503..607
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            608..667
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            668..789
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            790..909
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            910..953
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1014
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1072
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1176
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..2006
                     /gene="Uxs1"
                     /gene_synonym="UGD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctggccg gcggggcagg ccccggaccc gtgcggttcc tgggcatggt gagcaagggg
       61 ctgctgcgcc ttgtctcttc agtcaaccgc aggaagatga agcttctgct gggcatcgcg
      121 ctgttcgcct acgccgcctc tgtttggggc aactttgtta acatgaggtc tatccaggaa
      181 aatggtgaac taaagattga aagcaagatt gaagagatta ttgaaccatt aagagagaaa
      241 atcagagatt tggaaaaaag tttcacccag aaatacccac cagtaaagtt tttgtcagaa
      301 aaggaccgga agaggatttt gatcactgga ggtgcgggct ttgtgggctc ccatctaact
      361 gacaaactca tgatggatgg ccatgaggtg accgtggtgg acaacttctt cacaggcagg
      421 aagagaaatg tggaacactg gattggccat gagaacttcg agctgattaa ccatgatgtg
      481 gtagagccac tctacatcga agttgaccag atctaccatc tggcttctcc agcctcccct
      541 ccaaactaca tgtacaaccc catcaagacc ctgaagacaa atacaattgg aacactaaac
      601 atgttgggac tggcaaagcg tgtgggtgcc cgtctgctcc tagcctccac atctgaggta
      661 tatggagatc ctgaggtcca ccctcaaagt gaggactact ggggccacgt gaatcccata
      721 ggaccccgag cctgctatga cgagggcaaa cgtgttgcgg aaaccatgtg ctatgcctac
      781 atgaagcagg aaggtgtgga ggtgcgggtg gccaggatct tcaacacctt tgggccacga
      841 atgcacatga atgatgggag ggtggtcagc aacttcatct tacaagcgct acaaggggag
      901 ccgctcacag tatatggatc tgggtctcag acacgggcat tccagtatgt tagcgatcta
      961 gtgaatggcc tggtagcact gatgaacagc aatgtcagca gccctgtcaa cctgggaaat
     1021 ccagaagaac acacaatcct ggaatttgct cagttaatta aaaaccttgt tggtagtgga
     1081 agtgaaattc agtttctctc tgaagctcag gatgatccac agaaaagaaa accagacatc
     1141 aaaaaagcaa aactgatgct ggggtgggag cctgtggttc cattggagga aggattgaac
     1201 aaagccatcc actatttccg gaaggaacta gagtaccagg ctaataacca gtacatccct
     1261 aaacccaagc ctgccagagt gaagaagggc cggacgcgcc acagctgagt tagccttggg
     1321 atgcgagact ctattttact ttataaggtg gacttttgtg ggattttttt ttttttttta
     1381 agacttaaac aggtgtcatg aagaacaaac tggaatttta ttctgaagct tgctttaaag
     1441 acactgatgt gcctaaaagc tcccttgaac tctgcagact ttgccttgca ctttttaact
     1501 ctgtcttttt tatgcacaac agcctagatg cattctctgc tattttcagg tttttttatc
     1561 ttgctgttag agtgtatgct gtaactgtca ctgacagttt tatttactgg tttctttgtg
     1621 aagctgaaaa gaaacattaa atggggtgga aaatgccaat tttatttata aaagtgagta
     1681 ctttataaat gagatgttac actatgcata aagaatacaa acctagaggt atggccagct
     1741 gggcagtgca ccagtgttta tttggggaca gatgaaagaa ctccattgga aagctttgca
     1801 tttctttttt aattctgaat tttctgaagg tctagttttc agttacagac ttgactttga
     1861 aacatccctg ttggttcttg atcaaagata tttgaaatca ctactgtgtt gtgctgcata
     1921 ttggggtggg ggtggggaca atgttaacat attcttggtt aaccatggtt aaatatgcta
     1981 ttttaataaa atattgaaac tcgtca
//
