LOCUS       NM_001401542            3358 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus UV radiation resistance associated (Uvrag),
            transcript variant 1, mRNA.
ACCESSION   NM_001401542 XM_006229763
VERSION     NM_001401542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3358)
  AUTHORS   Cheng,X., Ma,X., Ding,X., Li,L., Jiang,X., Shen,Z., Chen,S.,
            Liu,W., Gong,W. and Sun,Q.
  TITLE     Pacer Mediates the Function of Class III PI3K and HOPS Complexes in
            Autophagosome Maturation by Engaging Stx17
  JOURNAL   Mol Cell 65 (6), 1029-1043 (2017)
   PUBMED   28306502
REFERENCE   2  (bases 1 to 3358)
  AUTHORS   Pirooz,S.D., He,S., Zhang,T., Zhang,X., Zhao,Z., Oh,S.,
            O'Connell,D., Khalilzadeh,P., Amini-Bavil-Olyaee,S., Farzan,M. and
            Liang,C.
  TITLE     UVRAG is required for virus entry through combinatorial interaction
            with the class C-Vps complex and SNAREs
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2716-2721 (2014)
   PUBMED   24550300
REFERENCE   3  (bases 1 to 3358)
  AUTHORS   He,S., Ni,D., Ma,B., Lee,J.H., Zhang,T., Ghozalli,I., Pirooz,S.D.,
            Zhao,Z., Bharatham,N., Li,B., Oh,S., Lee,W.H., Takahashi,Y.,
            Wang,H.G., Minassian,A., Feng,P., Deretic,V., Pepperkok,R.,
            Tagaya,M., Yoon,H.S. and Liang,C.
  TITLE     PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9
            transport by differential interactions with the ER tether and the
            beclin 1 complex
  JOURNAL   Nat Cell Biol 15 (10), 1206-1219 (2013)
   PUBMED   24056303
REFERENCE   4  (bases 1 to 3358)
  AUTHORS   Ma,C., Wang,N., Detre,C., Wang,G., O'Keeffe,M. and Terhorst,C.
  TITLE     Receptor signaling lymphocyte-activation molecule family 1 (Slamf1)
            regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by
            recruiting a Beclin-1/Vps34/ultraviolet radiation
            resistance-associated gene (UVRAG) complex
  JOURNAL   J Biol Chem 287 (22), 18359-18365 (2012)
   PUBMED   22493499
REFERENCE   5  (bases 1 to 3358)
  AUTHORS   Zhao,Z., Oh,S., Li,D., Ni,D., Pirooz,S.D., Lee,J.H., Yang,S.,
            Lee,J.Y., Ghozalli,I., Costanzo,V., Stark,J.M. and Liang,C.
  TITLE     A dual role for UVRAG in maintaining chromosomal stability
            independent of autophagy
  JOURNAL   Dev Cell 22 (5), 1001-1016 (2012)
   PUBMED   22542840
REFERENCE   6  (bases 1 to 3358)
  AUTHORS   Thoresen,S.B., Pedersen,N.M., Liestol,K. and Stenmark,H.
  TITLE     A phosphatidylinositol 3-kinase class III sub-complex containing
            VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and
            degradative endocytic traffic
  JOURNAL   Exp Cell Res 316 (20), 3368-3378 (2010)
   PUBMED   20643123
REFERENCE   7  (bases 1 to 3358)
  AUTHORS   Yang,Z. and Klionsky,D.J.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   8  (bases 1 to 3358)
  AUTHORS   Matsunaga,K., Saitoh,T., Tabata,K., Omori,H., Satoh,T.,
            Kurotori,N., Maejima,I., Shirahama-Noda,K., Ichimura,T., Isobe,T.,
            Akira,S., Noda,T. and Yoshimori,T.
  TITLE     Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally
            regulate autophagy at different stages
  JOURNAL   Nat Cell Biol 11 (4), 385-396 (2009)
   PUBMED   19270696
REFERENCE   9  (bases 1 to 3358)
  AUTHORS   Takahashi,Y., Coppola,D., Matsushita,N., Cualing,H.D., Sun,M.,
            Sato,Y., Liang,C., Jung,J.U., Cheng,J.Q., Mule,J.J., Pledger,W.J.
            and Wang,H.G.
  TITLE     Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy
            and tumorigenesis
  JOURNAL   Nat Cell Biol 9 (10), 1142-1151 (2007)
   PUBMED   17891140
REFERENCE   10 (bases 1 to 3358)
  AUTHORS   Farah,C.A., Liazoghli,D., Perreault,S., Desjardins,M., Guimont,A.,
            Anton,A., Lauzon,M., Kreibich,G., Paiement,J. and Leclerc,N.
  TITLE     Interaction of microtubule-associated protein-2 and p63: a new link
            between microtubules and rough endoplasmic reticulum membranes in
            neurons
  JOURNAL   J Biol Chem 280 (10), 9439-9449 (2005)
   PUBMED   15623521
  REMARK    GeneRIF: In cultured hippocampal neurons, MAP2 and p63 were found
            to concomitantly compartmentalize to the dendritic processes during
            neuronal differentiation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 15, 2022 this sequence version replaced XM_006229763.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.2215.1,
                                           SRR26643286.2169.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000001.1  162854050-162854348 c
            300-417             JAXUCZ010000001.1  162828397-162828514 c
            418-452             JAXUCZ010000001.1  162817040-162817074 c
            453-614             JAXUCZ010000001.1  162806794-162806955 c
            615-689             JAXUCZ010000001.1  162797602-162797676 c
            690-772             JAXUCZ010000001.1  162777018-162777100 c
            773-878             JAXUCZ010000001.1  162728637-162728742 c
            879-1005            JAXUCZ010000001.1  162716897-162717023 c
            1006-1090           JAXUCZ010000001.1  162702765-162702849 c
            1091-1178           JAXUCZ010000001.1  162700557-162700644 c
            1179-1239           JAXUCZ010000001.1  162698949-162699009 c
            1240-1405           JAXUCZ010000001.1  162690865-162691030 c
            1406-1484           JAXUCZ010000001.1  162653477-162653555 c
            1485-1576           JAXUCZ010000001.1  162618032-162618123 c
            1577-3358           JAXUCZ010000001.1  162596515-162598296 c
FEATURES             Location/Qualifiers
     source          1..3358
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3358
                     /gene="Uvrag"
                     /note="UV radiation resistance associated"
                     /db_xref="GeneID:308846"
                     /db_xref="RGD:1589754"
     exon            1..299
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2279
                     /gene="Uvrag"
                     /note="isoform 1 is encoded by transcript variant 1; UV
                     radiation resistance-associated gene protein"
                     /codon_start=1
                     /product="UV radiation resistance-associated gene protein
                     isoform 1"
                     /protein_id="NP_001388471.1"
                     /db_xref="GeneID:308846"
                     /db_xref="RGD:1589754"
                     /translation="MSSCASLGGPVPLPPPGPSAALTPGAPTRALHVELPSQQRRLRH
                     LRNIAARNIVNRNGHQLLDTYFTLHLCDNEKICKEFYRSEVIKNSLNPTWRSLDFGIM
                     PDRLDTSVSCFVVKIWGGKEEAYQLLIEWKVYLDGLKYLGQQIHARNQNEIIFGLNDG
                     YYGAPFEHKAHPNAQKNLLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQRIGKE
                     IEEKLRLTSTSNELKKESECLRLKILVLRNELERQKKALGREVAFLHKQQMALQDKGS
                     AFAAEHAKLQLQKESLRELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNE
                     HKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRS
                     TIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
                     PNLKNFMEHGLMVRCDRHHISSAIPVPKRQSSTFRGADVGLSTGVPSPDNVHRKRASS
                     ENERLQYKTPPPSYNSALTQHGVAMPTLGDSERKVTPLSSSLDTSLDFSKESKKTGVD
                     LGNSVSGDHRNVDSSQEQGEALPGHLATINGTALPSEQPGPAGTLLPGLCHPAPSAEL
                     CCAVEQAEEIIGLEATGFTSGDQLEALSCIPVDSAVAVECDEQVLGEFEEFSRRIYAL
                     SENVSSFRRPRRSSDK"
     exon            300..417
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            418..452
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            453..614
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            615..689
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            690..772
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            773..878
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1005
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1090
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1178
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1239
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1405
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1484
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1576
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..3358
                     /gene="Uvrag"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgcactgc ggtaatatgg ctcttcctta gctagcggcg gtggccagag cgggtgcgga
       61 gctgccgggg ctcccgggtg cctcgtttct aggctgtagg ggctcggcga atcacagctc
      121 gggaggcggc ggccgatgcg tgaggactgc ccacccggcc gctcggcggc ccaggggtcc
      181 agatgagctc ctgcgcctcg ctcgggggcc cggtgcccct gccacccccg ggcccgtccg
      241 ccgcgctgac accgggtgcc cccacgcggg ccctgcatgt ggagctgccg tctcagcagc
      301 ggcgtctgcg tcatctccgg aacattgctg ctcggaacat tgttaacaga aatggccatc
      361 agcttctgga tacctacttc actcttcatt tgtgtgataa cgagaagatc tgtaaagaat
      421 tttataggag tgaagtgatt aagaattcct tgaatccaac gtggaggagt cttgactttg
      481 gaataatgcc ggaccgtctg gatacatctg tgtcctgctt tgtggtgaag atttggggtg
      541 gaaaggaaga ggcctatcag ctgttgatag agtggaaagt ctacttggat gggctgaagt
      601 acttgggtca gcagatccat gcccgcaacc agaatgaaat catttttggg ctgaacgatg
      661 gctactacgg tgctccattt gaacacaagg ctcatccaaa tgcacagaag aacctccttc
      721 aggtggacca gaactgtgtt cgcaattcct atgatgtgtt ttctttgctg cggcttcata
      781 gagcccagtg tgcaattaaa cagactcagg taactgttca gagaattgga aaggaaattg
      841 aagaaaaact aagactcaca tcgacaagca atgagctgaa aaaagaaagt gaatgtctgc
      901 gattaaaaat tttggtgctt cgaaatgaac tggaaagaca gaagaaagct ctgggacggg
      961 aggtggcctt cctgcataag caacaaatgg ctctacaaga caaaggaagt gcatttgccg
     1021 cggagcacgc gaagcttcag ctgcagaagg aatcgctgag ggagctgagg aaggagtgca
     1081 ccgccaaaag agaactcttt ctgaagacaa acgctcagct gaccatccgc tgcaggcagt
     1141 tactctcgga gctgtcctac atttacccta ttgatctgaa tgagcataag gattattttg
     1201 tatgtggtgt caagttgcct aattccgagg acttccaagc aaaagatgat ggaagcattg
     1261 ccgtcgccct tggttacact gcacatttgg tctccatgat ctccttcttc ctacaagtac
     1321 ccctcagata tcccataatt cataaggggt ccagatcaac catcaaagat aacatcaacg
     1381 acaagctgac agaaaaggag agagagtttc cactgtatcc aaagggaggg gagaagctgc
     1441 agtttgatta tggtgtctac cttctgaaca agaacatagc acagctgaga taccagcacg
     1501 gcctggggac tccagacttg aggcaaactc ttcctaacct gaaaaacttc atggagcacg
     1561 gactgatggt cagatgtgac agacatcaca tctccagtgc catccctgtt ccgaagagac
     1621 agagctccac gtttcggggt gcagatgtag gcctctctac gggtgtccct tcaccagata
     1681 acgtacatcg aaaacgggcc agctcagaga atgagagact ccagtacaaa acccctcctc
     1741 ccagctacaa ctcagcattg acacagcacg gggtggccat gcccaccttg ggagactctg
     1801 agaggaaggt caccccactg tcctcctccc tggacacctc cttggacttc tccaaagaaa
     1861 gtaagaaaac aggagtagac ctgggcaaca gtgtaagtgg agaccacaga aatgtggact
     1921 ccagccaaga acaaggggaa gccctgcctg ggcacctggc caccataaat ggcactgcgc
     1981 ttcccagcga gcagcctggc cctgccggca ccctgctgcc aggcctgtgc cacccggccc
     2041 cctcagccga gctctgctgt gcagtggagc aagcagaaga aattatcggg ctggaagcca
     2101 caggcttcac gtcaggcgac cagctcgaag cactcagctg catcccggtg gacagcgcgg
     2161 tggcggtgga gtgtgacgag caggtgctgg gggagtttga ggagttctct cggaggatct
     2221 acgccctcag cgaaaacgtg tccagcttcc gccggcctcg caggagttct gacaagtgag
     2281 gcgagcagtc agacagtagc accaggacag agccgccctg caccaggcca agagctgcac
     2341 ttaacctttt taataattcc aacacaaacg agtgtcagtg gagcagactc ctcagaaagg
     2401 ctgactttgg gaacagaggg gactcagggt cactggggac ccatggggcc agtccgtgag
     2461 atttgttcac tttccagtca aaggtcgccc tcttgcttac agctcaagtc ctgtcgtagg
     2521 catctgtctg cactctattt acacttctgg gttctcctca gagagaggat gataatagtg
     2581 taacagaacg agctcacctt taatttctca taagcatcca ccctctccat catttgtaaa
     2641 gcagaaacaa ctttgcacca ctgagaagcc tgtgttcacc ctttaggcag gtgagtaaga
     2701 gcagagtgtg gtctctgttc caggccctcg gcccgagtac cacagtctgc ctgcagaccc
     2761 cgctgtcgtc ctgctttctc aagatgggcg tgcatcctgg aagctggggc ggtaaatccg
     2821 ctagtccaaa gcctgcagaa acgatgttct gtctctgcct agtgtgccat acccggatga
     2881 aaaattatcc tgtgggggct cccaggggac cctcggaaac ctcacggtta ccacagccag
     2941 atggcagcca gcttcctttg gggccaaagt ttttatgtgg tccaaaattg ggcacacttc
     3001 tggcaataca caccccagat aaagacccct tagatacaaa tcctgttaac ttattacatt
     3061 tcagtcagaa ggaagccatt atatatgaca aaagtgtacg tagagtcagg atgtctagtg
     3121 tgcgagatgg ctgagagata gctgggttaa gagaccagag aaagcataga ctgcaatttc
     3181 acgatgttca attatgtttt ccaagtccat gtccttacca cattcagatt ccattcactg
     3241 ttgctttatc cattatgtgc ccacagcatt gcctcagggt tgcaagctct taaaagaaaa
     3301 atttatccac atatccatgt attgtaaaga agaataaaaa ttgaatttac ttcacttg
//
