LOCUS       NP_001388471             698 aa            linear   ROD 31-MAR-2024
DEFINITION  UV radiation resistance-associated gene protein isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001388471 XP_006229825
VERSION     NP_001388471.1
DBSOURCE    REFSEQ: accession NM_001401542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 698)
  AUTHORS   Cheng,X., Ma,X., Ding,X., Li,L., Jiang,X., Shen,Z., Chen,S.,
            Liu,W., Gong,W. and Sun,Q.
  TITLE     Pacer Mediates the Function of Class III PI3K and HOPS Complexes in
            Autophagosome Maturation by Engaging Stx17
  JOURNAL   Mol Cell 65 (6), 1029-1043 (2017)
   PUBMED   28306502
REFERENCE   2  (residues 1 to 698)
  AUTHORS   Pirooz,S.D., He,S., Zhang,T., Zhang,X., Zhao,Z., Oh,S.,
            O'Connell,D., Khalilzadeh,P., Amini-Bavil-Olyaee,S., Farzan,M. and
            Liang,C.
  TITLE     UVRAG is required for virus entry through combinatorial interaction
            with the class C-Vps complex and SNAREs
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2716-2721 (2014)
   PUBMED   24550300
REFERENCE   3  (residues 1 to 698)
  AUTHORS   He,S., Ni,D., Ma,B., Lee,J.H., Zhang,T., Ghozalli,I., Pirooz,S.D.,
            Zhao,Z., Bharatham,N., Li,B., Oh,S., Lee,W.H., Takahashi,Y.,
            Wang,H.G., Minassian,A., Feng,P., Deretic,V., Pepperkok,R.,
            Tagaya,M., Yoon,H.S. and Liang,C.
  TITLE     PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9
            transport by differential interactions with the ER tether and the
            beclin 1 complex
  JOURNAL   Nat Cell Biol 15 (10), 1206-1219 (2013)
   PUBMED   24056303
REFERENCE   4  (residues 1 to 698)
  AUTHORS   Ma,C., Wang,N., Detre,C., Wang,G., O'Keeffe,M. and Terhorst,C.
  TITLE     Receptor signaling lymphocyte-activation molecule family 1 (Slamf1)
            regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by
            recruiting a Beclin-1/Vps34/ultraviolet radiation
            resistance-associated gene (UVRAG) complex
  JOURNAL   J Biol Chem 287 (22), 18359-18365 (2012)
   PUBMED   22493499
REFERENCE   5  (residues 1 to 698)
  AUTHORS   Zhao,Z., Oh,S., Li,D., Ni,D., Pirooz,S.D., Lee,J.H., Yang,S.,
            Lee,J.Y., Ghozalli,I., Costanzo,V., Stark,J.M. and Liang,C.
  TITLE     A dual role for UVRAG in maintaining chromosomal stability
            independent of autophagy
  JOURNAL   Dev Cell 22 (5), 1001-1016 (2012)
   PUBMED   22542840
REFERENCE   6  (residues 1 to 698)
  AUTHORS   Thoresen,S.B., Pedersen,N.M., Liestol,K. and Stenmark,H.
  TITLE     A phosphatidylinositol 3-kinase class III sub-complex containing
            VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and
            degradative endocytic traffic
  JOURNAL   Exp Cell Res 316 (20), 3368-3378 (2010)
   PUBMED   20643123
REFERENCE   7  (residues 1 to 698)
  AUTHORS   Yang,Z. and Klionsky,D.J.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   8  (residues 1 to 698)
  AUTHORS   Matsunaga,K., Saitoh,T., Tabata,K., Omori,H., Satoh,T.,
            Kurotori,N., Maejima,I., Shirahama-Noda,K., Ichimura,T., Isobe,T.,
            Akira,S., Noda,T. and Yoshimori,T.
  TITLE     Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally
            regulate autophagy at different stages
  JOURNAL   Nat Cell Biol 11 (4), 385-396 (2009)
   PUBMED   19270696
REFERENCE   9  (residues 1 to 698)
  AUTHORS   Takahashi,Y., Coppola,D., Matsushita,N., Cualing,H.D., Sun,M.,
            Sato,Y., Liang,C., Jung,J.U., Cheng,J.Q., Mule,J.J., Pledger,W.J.
            and Wang,H.G.
  TITLE     Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy
            and tumorigenesis
  JOURNAL   Nat Cell Biol 9 (10), 1142-1151 (2007)
   PUBMED   17891140
REFERENCE   10 (residues 1 to 698)
  AUTHORS   Farah,C.A., Liazoghli,D., Perreault,S., Desjardins,M., Guimont,A.,
            Anton,A., Lauzon,M., Kreibich,G., Paiement,J. and Leclerc,N.
  TITLE     Interaction of microtubule-associated protein-2 and p63: a new link
            between microtubules and rough endoplasmic reticulum membranes in
            neurons
  JOURNAL   J Biol Chem 280 (10), 9439-9449 (2005)
   PUBMED   15623521
  REMARK    GeneRIF: In cultured hippocampal neurons, MAP2 and p63 were found
            to concomitantly compartmentalize to the dendritic processes during
            neuronal differentiation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 15, 2022 this sequence version replaced XP_006229825.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.2215.1,
                                           SRR26643286.2169.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     Protein         1..698
                     /product="UV radiation resistance-associated gene protein
                     isoform 1"
                     /note="UV radiation resistance-associated gene protein"
                     /calculated_mol_wt=77984
     Region          39..436
                     /region_name="VPS38"
                     /note="Vacuolar protein sorting 38; pfam17649"
                     /db_xref="CDD:435943"
     CDS             1..698
                     /gene="Uvrag"
                     /coded_by="NM_001401542.1:183..2279"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:308846"
                     /db_xref="RGD:1589754"
ORIGIN      
        1 msscaslggp vplpppgpsa altpgaptra lhvelpsqqr rlrhlrniaa rnivnrnghq
       61 lldtyftlhl cdnekickef yrseviknsl nptwrsldfg impdrldtsv scfvvkiwgg
      121 keeayqllie wkvyldglky lgqqiharnq neiifglndg yygapfehka hpnaqknllq
      181 vdqncvrnsy dvfsllrlhr aqcaikqtqv tvqrigkeie eklrltstsn elkkeseclr
      241 lkilvlrnel erqkkalgre vaflhkqqma lqdkgsafaa ehaklqlqke slrelrkect
      301 akrelflktn aqltircrql lselsyiypi dlnehkdyfv cgvklpnsed fqakddgsia
      361 valgytahlv smisfflqvp lrypiihkgs rstikdnind kltekerefp lypkggeklq
      421 fdygvyllnk niaqlryqhg lgtpdlrqtl pnlknfmehg lmvrcdrhhi ssaipvpkrq
      481 sstfrgadvg lstgvpspdn vhrkrassen erlqyktppp synsaltqhg vamptlgdse
      541 rkvtplsssl dtsldfskes kktgvdlgns vsgdhrnvds sqeqgealpg hlatingtal
      601 pseqpgpagt llpglchpap saelccaveq aeeiigleat gftsgdqlea lscipvdsav
      661 avecdeqvlg efeefsrriy alsenvssfr rprrssdk
//
