LOCUS       NM_020537               1161 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus urotensin 2 receptor (Uts2r), mRNA.
ACCESSION   NM_020537
VERSION     NM_020537.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Ajiboye,B.O., Oyinloye,B.E., Onikanni,S.A., Osukoya,O.A.,
            Lawal,O.E. and Bamisaye,F.A.
  TITLE     Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate
            Cardiomyopathy in Streptozotocin-induced Diabetic Rats via
            Urotensin II and FABP3 Expressions
  JOURNAL   J Oleo Sci 70 (12), 1805-1814 (2021)
   PUBMED   34866110
  REMARK    GeneRIF: Sterculia tragacantha Lindl Aqueous Leaf Extract
            Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats
            via Urotensin II and FABP3 Expressions.
REFERENCE   2  (bases 1 to 1161)
  AUTHORS   Cadirci,E., Halici,Z., Yayla,M., Toktay,E., Bayir,Y., Karakus,E.,
            Topcu,A., Buyuk,B. and Albayrak,A.
  TITLE     Blocking of urotensin receptors as new target for treatment of
            carrageenan induced inflammation in rats
  JOURNAL   Peptides 82, 35-43 (2016)
   PUBMED   27208703
  REMARK    GeneRIF: This study investigated possible role of U-II and its
            receptor expression in inflammation by using UTR agonist and
            antagonist in carrageenan induced acute inflammation
REFERENCE   3  (bases 1 to 1161)
  AUTHORS   Liu,L.M., Liang,D.Y., Ye,C.G., Tu,W.J. and Zhu,T.
  TITLE     The UII/UT system mediates upregulation of proinflammatory
            cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated
            Kupffer cells
  JOURNAL   PLoS One 10 (3), e0121383 (2015)
   PUBMED   25803040
  REMARK    GeneRIF: The UII/UT system mediates upregulation of proinflammatory
            cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated
            Kupffer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1161)
  AUTHORS   Sainsily,X., Cabana,J., Holleran,B.J., Escher,E., Lavigne,P. and
            Leduc,R.
  TITLE     Identification of transmembrane domain 1 & 2 residues that
            contribute to the formation of the ligand-binding pocket of the
            urotensin-II receptor
  JOURNAL   Biochem Pharmacol 92 (2), 280-288 (2014)
   PUBMED   25175740
  REMARK    GeneRIF: Key transmembrane domain 1 and 2 residues were identified
            in urotensin-II receptor (UT) that participate in the formation of
            the UT receptor binding pocket.
REFERENCE   5  (bases 1 to 1161)
  AUTHORS   Tian,L., Li,Y., Hua,W., Jia,Y., Zhou,M., Gu,Y. and Qi,J.
  TITLE     Expression of Urotensin II During Focal Cerebral Ischemic in
            Diabetic Rats
  JOURNAL   Can J Neurol Sci 41 (4), 498-503 (2014)
   PUBMED   24878476
  REMARK    GeneRIF: Expression of GPR14 was increased at mRNA and protein
            levels in brain from cerebral ischemia rats.
REFERENCE   6  (bases 1 to 1161)
  AUTHORS   Sugo,T., Murakami,Y., Shimomura,Y., Harada,M., Abe,M.,
            Ishibashi,Y., Kitada,C., Miyajima,N., Suzuki,N., Mori,M. and
            Fujino,M.
  TITLE     Identification of urotensin II-related peptide as the urotensin
            II-immunoreactive molecule in the rat brain
  JOURNAL   Biochem Biophys Res Commun 310 (3), 860-868 (2003)
   PUBMED   14550283
REFERENCE   7  (bases 1 to 1161)
  AUTHORS   Boucard,A.A., Sauve,S.S., Guillemette,G., Escher,E. and Leduc,R.
  TITLE     Photolabelling the rat urotensin II/GPR14 receptor identifies a
            ligand-binding site in the fourth transmembrane domain
  JOURNAL   Biochem J 370 (Pt 3), 829-838 (2003)
   PUBMED   12495432
  REMARK    GeneRIF: Results indicate that position 6 of urotensin-II normally
            occupied by phenylalanine would interact with Met(184) and/or
            Met(185) of the fourth transmembrane domain of the urotensin-II
            receptor (GPR14).
REFERENCE   8  (bases 1 to 1161)
  AUTHORS   Liu,Q., Pong,S.S., Zeng,Z., Zhang,Q., Howard,A.D., Williams,D.L.
            Jr., Davidoff,M., Wang,R., Austin,C.P., McDonald,T.P., Bai,C.,
            George,S.R., Evans,J.F. and Caskey,C.T.
  TITLE     Identification of urotensin II as the endogenous ligand for the
            orphan G-protein-coupled receptor GPR14
  JOURNAL   Biochem Biophys Res Commun 266 (1), 174-178 (1999)
   PUBMED   10581185
REFERENCE   9  (bases 1 to 1161)
  AUTHORS   Marchese,A., Heiber,M., Nguyen,T., Heng,H.H., Saldivia,V.R.,
            Cheng,R., Murphy,P.M., Tsui,L.C., Shi,X., Gregor,P. et al.
  TITLE     Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
            and GPR14, encoding receptors related to interleukin 8,
            neuropeptide Y, and somatostatin receptors
  JOURNAL   Genomics 29 (2), 335-344 (1995)
   PUBMED   8666380
REFERENCE   10 (bases 1 to 1161)
  AUTHORS   Tal,M., Ammar,D.A., Karpuj,M., Krizhanovsky,V., Naim,M. and
            Thompson,D.A.
  TITLE     A novel putative neuropeptide receptor expressed in neural tissue,
            including sensory epithelia
  JOURNAL   Biochem Biophys Res Commun 209 (2), 752-759 (1995)
   PUBMED   7733947
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB012210.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB029611.1, AB012210.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1161
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="urotensin 2 receptor"
                     /db_xref="GeneID:57305"
                     /db_xref="RGD:621884"
     CDS             1..1161
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="urotensin II receptor; UR-II-R; G-protein coupled
                     receptor 14; G-protein coupled sensory epithelial
                     neuropeptide-like receptor; putative G protein-coupled
                     receptor (SENR)"
                     /codon_start=1
                     /product="urotensin-2 receptor"
                     /protein_id="NP_065412.1"
                     /db_xref="GeneID:57305"
                     /db_xref="RGD:621884"
                     /translation="MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSS
                     LKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLL
                     SIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQ
                     RSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGT
                     SIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFW
                     LWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRS
                     LGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL"
     exon            1..1161
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctctga gcctggagtc tacaacaagc tttcatatgc tcaccgtgtc cggaagcact
       61 gtgactgagc tgcctggtga ctccaacgtg tccctcaaca gttcctggtc cggcccaaca
      121 gatcccagct ccctgaaaga ccttgtggcc acgggtgtca tcggggcagt gctctcagcc
      181 atgggtgtgg tgggcatggt gggaaatgta tacactttgg tggtcatgtg ccggtttctg
      241 cgtgcctcgg cctccatgta cgtctatgtg gtcaacctag cgctggctga tctgctgtac
      301 ctgctgagca ttcccttcat catagccacc tacgtcacta aggactggca ctttggagat
      361 gtgggctgca gagtcctctt tagcctggac ttcctgacaa tgcacgccag catcttcacc
      421 ctgaccataa tgagcagcga acgctatgca gccgtactga ggcctctgga cacagtccag
      481 cgctccaagg gttaccgtaa gctgctggtg ctgggcacct ggttgctggc actgctgctg
      541 accctaccca tgatgcttgc catccagctg gtccgcaggg gctctaagag cctctgcctg
      601 ccagcctggg gccctcgtgc ccaccgtact tacctaacgt tgctctttgg gaccagcatt
      661 gtggggcctg gcttggtcat tgggctgctc tatgtccgtc tggccagggc ctactggcta
      721 tctcagcaag cttctttcaa gcagacacgg cggctgccca accccagggt gctctacctc
      781 atccttggta tcgtccttct cttctgggcc tgctttctac ccttctggct gtggcagctg
      841 ctggcccagt accacgaggc catgccactg actcccgaga ctgcacgcat tgtcaactac
      901 ctgaccacct gcctcactta tggcaacagt tgcatcaatc ccttcctcta cactctgctc
      961 accaagaact atcgagagta cctacgtggc cgccagcggt cactgggtag tagttgccac
     1021 agcccaggga gtcctggcag cttcctgccc agccgagtcc acctccagca ggactcgggc
     1081 cgctcgctgt cctccagcag ccaacaggcc acagagaccc tcatgctgtc tccagtcccc
     1141 cgtaacgggg cccttctctg a
//
