LOCUS       NM_198133                747 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus urotensin 2B (Uts2b), mRNA.
ACCESSION   NM_198133
VERSION     NM_198133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 747)
  AUTHORS   Bucharles,C., Bizet,P., Arthaud,S., Arabo,A., Leprince,J.,
            Lefranc,B., Cartier,D., Anouar,Y. and Lihrmann,I.
  TITLE     Concordant localization of functional urotensin II and urotensin
            II-related peptide binding sites in the rat brain: Atypical
            occurrence close to the fourth ventricle
  JOURNAL   J Comp Neurol 522 (11), 2634-2649 (2014)
   PUBMED   24478001
  REMARK    GeneRIF: Study demonstrated that UII and URP binding sites are
            totally overlapping and that these sites were functional in regions
            bordering the fourth ventricle; data support a role for UII/URP at
            the interface between brain parenchyma and cerebrospinal fluid
REFERENCE   2  (bases 1 to 747)
  AUTHORS   Doan,N.D., Nguyen,T.T., Letourneau,M., Turcotte,K., Fournier,A. and
            Chatenet,D.
  TITLE     Biochemical and pharmacological characterization of nuclear
            urotensin-II binding sites in rat heart
  JOURNAL   Br J Pharmacol 166 (1), 243-257 (2012)
   PUBMED   22044114
  REMARK    GeneRIF: U-II and URP can differentially modulate nuclear UT
            functions such as gene expression, and both ligands can reach the
            internal cellular space through a receptor-independent mechanism
REFERENCE   3  (bases 1 to 747)
  AUTHORS   Egginger,J.G., Parmentier,C., Garrel,G., Cohen-Tannoudji,J.,
            Camus,A., Calas,A., Hardin-Pouzet,H. and Grange-Messent,V.
  TITLE     Direct evidence for the co-expression of URP and GnRH in a
            sub-population of rat hypothalamic neurones: anatomical and
            functional correlation
  JOURNAL   PLoS One 6 (10), e26611 (2011)
   PUBMED   22039515
  REMARK    GeneRIF: remarkable cellular and subcellular distribution led us to
            test the effect of URP on the GnRH-induced gonadotrophins release
            in the anterior pituitary, and to discuss its putative role at the
            level of the median eminence
REFERENCE   4  (bases 1 to 747)
  AUTHORS   Hirose,T., Takahashi,K., Mori,N., Nakayama,T., Kikuya,M.,
            Ohkubo,T., Kohzuki,M., Totsune,K. and Imai,Y.
  TITLE     Increased expression of urotensin II, urotensin II-related peptide
            and urotensin II receptor mRNAs in the cardiovascular organs of
            hypertensive rats: comparison with endothelin-1
  JOURNAL   Peptides 30 (6), 1124-1129 (2009)
   PUBMED   19463745
  REMARK    GeneRIF: In the aorta, expression levels of urotensin II-related
            peptide mRNA was significantly elevated in 11-12-week-old SHR
            compared with age-matched WKY, similarly to those in the kidney.
REFERENCE   5  (bases 1 to 747)
  AUTHORS   Mori,N., Hirose,T., Nakayama,T., Ito,O., Kanazawa,M., Imai,Y.,
            Kohzuki,M., Takahashi,K. and Totsune,K.
  TITLE     Increased expression of urotensin II-related peptide and its
            receptor in kidney with hypertension or renal failure
  JOURNAL   Peptides 30 (2), 400-408 (2009)
   PUBMED   18955095
  REMARK    GeneRIF: Increased expression of urotensin II-related peptide in
            kidney with hypertension or renal failure
REFERENCE   6  (bases 1 to 747)
  AUTHORS   Sugo,T. and Mori,M.
  TITLE     Another ligand fishing for G protein-coupled receptor 14. Discovery
            of urotensin II-related peptide in the rat brain
  JOURNAL   Peptides 29 (5), 809-812 (2008)
   PUBMED   17628210
  REMARK    GeneRIF: These results suggest that urotensin II-related peptide is
            the endogenous and functional ligand for the urotensin II receptor
            GPR14 in the rat and mouse, and possibly in the human.
REFERENCE   7  (bases 1 to 747)
  AUTHORS   Wang,Y.X., Ding,Y.J., Zhu,Y.Z., Shi,Y., Yao,T. and Zhu,Y.C.
  TITLE     Role of PKC in the novel synergistic action of urotensin II and
            angiotensin II and in urotensin II-induced vasoconstriction
  JOURNAL   Am J Physiol Heart Circ Physiol 292 (1), H348-H359 (2007)
   PUBMED   16951045
  REMARK    GeneRIF: The long-lasting vasoconstriction induced by hU-II alone
            is PKC dependent and associated with PKC-theta phosphorylation.
REFERENCE   8  (bases 1 to 747)
  AUTHORS   Mori,M. and Fujino,M.
  TITLE     Urotensin II-related peptide, the endogenous ligand for the
            urotensin II receptor in the rat brain
  JOURNAL   Peptides 25 (10), 1815-1818 (2004)
   PUBMED   15476951
  REMARK    GeneRIF: URP is the endogenous and functional ligand for urotensin
            II receptor in the rat. (REVIEW)
            Review article
REFERENCE   9  (bases 1 to 747)
  AUTHORS   Sugo,T., Murakami,Y., Shimomura,Y., Harada,M., Abe,M.,
            Ishibashi,Y., Kitada,C., Miyajima,N., Suzuki,N., Mori,M. and
            Fujino,M.
  TITLE     Identification of urotensin II-related peptide as the urotensin
            II-immunoreactive molecule in the rat brain
  JOURNAL   Biochem Biophys Res Commun 310 (3), 860-868 (2003)
   PUBMED   14550283
  REMARK    GeneRIF: URP is the endogenous and functional ligand for UII
            receptor in the rat
REFERENCE   10 (bases 1 to 747)
  AUTHORS   Lin,Y., Tsuchihashi,T., Matsumura,K., Fukuhara,M., Ohya,Y.,
            Fujii,K. and Iida,M.
  TITLE     Central cardiovascular action of urotensin II in spontaneously
            hypertensive rats
  JOURNAL   Hypertens Res 26 (10), 839-845 (2003)
   PUBMED   14621188
  REMARK    GeneRIF: central urotensin II may play a role in the pathogenesis
            of hypertension in SHR rats
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY321314.1.
            
            On Oct 17, 2004 this sequence version replaced NM_198133.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY321314.1, AB116019.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN09345330 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..747
                     /gene="Uts2b"
                     /gene_synonym="U2B; Urp; Uts2d"
                     /note="urotensin 2B"
                     /db_xref="GeneID:378939"
                     /db_xref="RGD:727977"
     exon            1..162
                     /gene="Uts2b"
                     /gene_synonym="U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..419
                     /gene="Uts2b"
                     /gene_synonym="U2B; Urp; Uts2d"
                     /note="urotensin IIB; UIIB; U-IIB; urotensin-2
                     domain-containing protein; urotensin II-related peptide;
                     urotensin 2 domain containing"
                     /codon_start=1
                     /product="urotensin-2B precursor"
                     /protein_id="NP_937766.1"
                     /db_xref="GeneID:378939"
                     /db_xref="RGD:727977"
                     /translation="MKFFSTSLCFGLLALLSVTTLLHSVRGRPHLSSGHELFPAEEHT
                     TQEKLPLGLLIRNPGFQRPAHAGVDLPSKVEELRQLKKLREWFMEAKSAEPSNALDKL
                     SSSHPIKRACFWKYCV"
     exon            163..261
                     /gene="Uts2b"
                     /gene_synonym="U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     exon            262..299
                     /gene="Uts2b"
                     /gene_synonym="U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     exon            300..393
                     /gene="Uts2b"
                     /gene_synonym="U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
     exon            394..747
                     /gene="Uts2b"
                     /gene_synonym="U2B; Urp; Uts2d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaactatct gccttgactt gaaaatttgg tttctctgtt agaactggaa gagattttta
       61 acatgaagtt cttctcaact tctctctgct ttggactcct ggctttgttg tctgtgacga
      121 cccttttaca ttctgtacgt ggacggccgc atctgagctc aggacatgag ttatttccag
      181 ctgaagaaca cacgactcag gagaaactac cgctgggtct gctgatccga aaccctggtt
      241 tccagaggcc cgcccatgct ggtgtagatt tgcccagcaa agtggaagaa cttagacagc
      301 taaagaagct gagagaatgg tttatggagg caaagagtgc tgagccgtcc aatgctttag
      361 acaagctatc ctcttcccac cctattaaac gagcttgctt ttggaaatac tgtgtctgag
      421 acttttctga atataccgaa gaaagggaca ccaaaaaatt acatgtgtat acacgtatat
      481 tatgcacaat atatgtatac atatatacat attgaagttt acgtttgctt caagtgttaa
      541 gaaactggcc tttgttctgc acatcacttt ctcatgctgt gagcctgcgc ccgcctgctt
      601 ctggcttgct gtatgcttgt atggtgaaca gtgacactgg ctgaactctg gaatggaact
      661 gagaactgcg tatcaaaatg gctttggtgc cgaaactggg tggtttgatc tgttgtatgc
      721 tcgcctgaag tctgccatcc tctctca
//
