LOCUS       NM_019160                527 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus urotensin 2 (Uts2), mRNA.
ACCESSION   NM_019160
VERSION     NM_019160.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Tillinger,A., Padova,A., Mravec,B. and Tomova,A.
  TITLE     Stressors affect urocortin 1 and urocortin 2 gene expression in rat
            spleen: The role of glucocorticoids
  JOURNAL   J Neuroimmunol 336, 577030 (2019)
   PUBMED   31473519
  REMARK    GeneRIF: There is an increase of Ucn2 mRNA levels in the adrenal
            medulla and spleen induced by immobilization stress.
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Li,J., Zhang,Y.G., Luo,L.M., Dong,X., Ding,W.H. and Dang,S.Y.
  TITLE     Urotensin II promotes aldosterone expression in rat aortic
            adventitial fibroblasts
  JOURNAL   Mol Med Rep 17 (2), 2921-2928 (2018)
   PUBMED   29257277
  REMARK    GeneRIF: Aldosterone and its receptors were expressed on tunica
            adventitia. Urotensin II promoted ALD protein secretion from cells
            in a dose and timedependent manner.
REFERENCE   3  (bases 1 to 527)
  AUTHORS   Xu,J., Han,Q., Shi,H., Liu,W., Chu,T. and Li,H.
  TITLE     Role of PKA in the process of neonatal cardiomyocyte hypertrophy
            induced by urotensin II
  JOURNAL   Int J Mol Med 40 (2), 499-504 (2017)
   PUBMED   28656205
  REMARK    GeneRIF: These results suggest that urotensin II induces
            cardiomyocyte hypertrophy through the cAMP-dependent protein kinase
            A -mediated upregulation of phospholamban phosphorylation at Ser16,
            which provides a new experimental foundation for the prevention
            and/or treatment of cardiac hypertrophy.
REFERENCE   4  (bases 1 to 527)
  AUTHORS   Park,C.H., Lee,J.H., Lee,M.Y., Lee,J.H., Lee,B.H. and Oh,K.S.
  TITLE     A novel role of G protein-coupled receptor kinase 5 in urotensin
            II-stimulated cellular hypertrophy in H9c2UT cells
  JOURNAL   Mol Cell Biochem 422 (1-2), 151-160 (2016)
   PUBMED   27613164
  REMARK    GeneRIF: results suggest that GRK5 may be involved in a
            UII-mediated hypertrophic response via activation of NF-kappaB and
            HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent
            pathways.
REFERENCE   5  (bases 1 to 527)
  AUTHORS   Liu,L.M., Tu,W.J., Zhu,T., Wang,X.T., Tan,Z.L., Zhong,H., Gao,D.Y.
            and Liang,D.Y.
  TITLE     IRF3 is an important molecule in the UII/UT system and mediates
            immune inflammatory injury in acute liver failure
  JOURNAL   Oncotarget 7 (31), 49027-49041 (2016)
   PUBMED   27448985
  REMARK    GeneRIF: IRF3 expression and activation depend on the signal
            transduction of the the urotensin II/urotensin receptor (UII/UT)
            system, and play important roles in UII/UT-mediated immune
            inflammatory injury in the liver
REFERENCE   6  (bases 1 to 527)
  AUTHORS   Lin,Y., Tsuchihashi,T., Matsumura,K., Fukuhara,M., Ohya,Y.,
            Fujii,K. and Iida,M.
  TITLE     Central cardiovascular action of urotensin II in spontaneously
            hypertensive rats
  JOURNAL   Hypertens Res 26 (10), 839-845 (2003)
   PUBMED   14621188
REFERENCE   7  (bases 1 to 527)
  AUTHORS   Russell,F.D., Meyers,D., Galbraith,A.J., Bett,N., Toth,I.,
            Kearns,P. and Molenaar,P.
  TITLE     Elevated plasma levels of human urotensin-II immunoreactivity in
            congestive heart failure
  JOURNAL   Am J Physiol Heart Circ Physiol 285 (4), H1576-H1581 (2003)
   PUBMED   12791592
REFERENCE   8  (bases 1 to 527)
  AUTHORS   Lu,Y., Zou,C.J., Huang,D.W. and Tang,C.S.
  TITLE     Cardiovascular effects of urotensin II in different brain areas
  JOURNAL   Peptides 23 (9), 1631-1635 (2002)
   PUBMED   12217424
REFERENCE   9  (bases 1 to 527)
  AUTHORS   Pelletier,G., Lihrmann,I. and Vaudry,H.
  TITLE     Role of androgens in the regulation of urotensin II precursor mRNA
            expression in the rat brainstem and spinal cord
  JOURNAL   Neuroscience 115 (2), 525-532 (2002)
   PUBMED   12421619
REFERENCE   10 (bases 1 to 527)
  AUTHORS   Coulouarn,Y., Jegou,S., Tostivint,H., Vaudry,H. and Lihrmann,I.
  TITLE     Cloning, sequence analysis and tissue distribution of the mouse and
            rat urotensin II precursors
  JOURNAL   FEBS Lett 457 (1), 28-32 (1999)
   PUBMED   10486557
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF172174.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_019160.3.
            
            On Feb 21, 2013 this sequence version replaced NM_019160.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AF172174.1         1-527
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..527
                     /gene="Uts2"
                     /gene_synonym="Ucn2"
                     /note="urotensin 2"
                     /db_xref="GeneID:29180"
                     /db_xref="RGD:3930"
     exon            1..139
                     /gene="Uts2"
                     /gene_synonym="Ucn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..408
                     /gene="Uts2"
                     /gene_synonym="Ucn2"
                     /note="UII; U-II; urotensin II; urocortin 2"
                     /codon_start=1
                     /product="urotensin-2 precursor"
                     /protein_id="NP_062033.1"
                     /db_xref="GeneID:29180"
                     /db_xref="RGD:3930"
                     /translation="MDRVPFCCLLFVGLLNPLLSFPVTDTGEMSLQLPVLEENALRAL
                     EELERTALLQTLRQTVGTEAEGSLGQADPSAETPTPRGSLRKALTGQDSNTVLSRLLA
                     RTRKQRKQHGTAPECFWKYCI"
     exon            140..250
                     /gene="Uts2"
                     /gene_synonym="Ucn2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..294
                     /gene="Uts2"
                     /gene_synonym="Ucn2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..527
                     /gene="Uts2"
                     /gene_synonym="Ucn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagcagac acccagccag acttcttccc gtcgtcatgg acagggtgcc cttctgctgc
       61 ctgctcttcg taggactcct gaatccactc ctgtcttttc ccgtcacgga cactggtgaa
      121 atgtctcttc agcttccagt gcttgaggaa aatgctcttc gggctctgga ggagctggag
      181 aggactgccc tcctgcagac gctgcgccag accgtgggca cagaagcaga gggaagccta
      241 ggccaggcag atcccagtgc cgagactccc actccaaggg gaagcttgag gaaggctctc
      301 actgggcaag attctaacac tgtactgagc cgtcttttgg cgagaaccag gaaacaacgt
      361 aagcaacacg ggactgcccc agaatgcttc tggaagtact gcatttgaag agagacgtct
      421 cctcagaacc atcacttcag gaaactaaag agcagatgct tgaagaaaaa tcgtgccaac
      481 aacgccccgt tctccactat gagaaataaa ccctctatgt ttctcaa
//
