LOCUS       NM_001009640            2230 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus UTP4 small subunit processome component (Utp4),
            mRNA.
ACCESSION   NM_001009640 XM_214663
VERSION     NM_001009640.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2230)
  AUTHORS   Sato M, Araki N, Kumeta M, Takeyasu K, Taguchi Y, Asai T, Furukawa
            K and Horigome T.
  TITLE     Interaction, mobility, and phosphorylation of human orthologues of
            WD repeat-containing components of the yeast SSU processome t-UTP
            sub-complex
  JOURNAL   Biochem Cell Biol 91 (6), 466-475 (2013)
   PUBMED   24219289
REFERENCE   2  (bases 1 to 2230)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 2230)
  AUTHORS   Freed EF, Prieto JL, McCann KL, McStay B and Baserga SJ.
  TITLE     NOL11, implicated in the pathogenesis of North American Indian
            childhood cirrhosis, is required for pre-rRNA transcription and
            processing
  JOURNAL   PLoS Genet 8 (8), e1002892 (2012)
   PUBMED   22916032
REFERENCE   4  (bases 1 to 2230)
  AUTHORS   Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L,
            Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T,
            Earnshaw WC and Rappsilber J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
REFERENCE   5  (bases 1 to 2230)
  AUTHORS   Yu B, Mitchell GA and Richter A.
  TITLE     Cirhin up-regulates a canonical NF-kappaB element through strong
            interaction with Cirip/HIVEP1
  JOURNAL   Exp Cell Res 315 (18), 3086-3098 (2009)
   PUBMED   19732766
REFERENCE   6  (bases 1 to 2230)
  AUTHORS   Prieto JL and McStay B.
  TITLE     Recruitment of factors linking transcription and processing of
            pre-rRNA to NOR chromatin is UBF-dependent and occurs independent
            of transcription in human cells
  JOURNAL   Genes Dev 21 (16), 2041-2054 (2007)
   PUBMED   17699751
REFERENCE   7  (bases 1 to 2230)
  AUTHORS   Yu B, Mitchell GA and Richter A.
  TITLE     Nucleolar localization of cirhin, the protein mutated in North
            American Indian childhood cirrhosis
  JOURNAL   Exp Cell Res 311 (2), 218-228 (2005)
   PUBMED   16225863
REFERENCE   8  (bases 1 to 2230)
  AUTHORS   Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E,
            Rasquin-Weber A, Hudson TJ and Richter A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088461.1.
            
            On Jan 13, 2005 this sequence version replaced XM_214663.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088461.1, SRR8487226.74973.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2230
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /note="UTP4 small subunit processome component"
                     /db_xref="GeneID:291987"
                     /db_xref="RGD:1311341"
     exon            1..32
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            33..193
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2095
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /note="testis-expressed gene 292; cirrhosis, autosomal
                     recessive 1A (cirhin); UTP4 small subunit (SSU) processome
                     component"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein 4
                     homolog"
                     /protein_id="NP_001009640.1"
                     /db_xref="GeneID:291987"
                     /db_xref="RGD:1311341"
                     /translation="MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYN
                     LSANYFQEKFFPGHESRGTEALCWAEGQRLFSAGLNGEILEYDLQALNIKYTLDAFGG
                     PIWSMTASPSGSQLLVGCEDGSVKLFEVTPDKIQFARNFDRQKSRILSLSWHPAGTHV
                     AAGSIDYISVFDVKSGSITRKMVLDRQHLGVTKSRCIVWGVAFLSDGTVISVDSVGKV
                     QLWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVSVTSNSSEKQ
                     WVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVIRPLMEKVEVKNYDAALRKITFPH
                     RRLISCSKRRQLLLFQFAHHLELWRLGSTAATGKNGDTLPLSKNADHLLHLKTKGPEN
                     IICSCVSPCGSWIAYSTASRFFLYRLKYERDNISLQRVSKLPAFLRSALHILFSEDST
                     KLFVASNQGSLHVIHLSEGSFKHLHTFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGV
                     HIYDLHHLKLHCTVPAYNFPVTALAIAPNTNNLVIAHSDQQVFEFSIPDKQYTEWSRS
                     VQKQGFHQLWLQRDTPITHISIHPKRPMHILLHDAYMFCIIDKSLPLPNDKTVLYNPL
                     PPKNESDVFLRRTTHGFKMSKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKK
                     KFGT"
     exon            194..385
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            386..470
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            471..560
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            561..772
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            773..944
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1036
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1133
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1198
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1321
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1478
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1585
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1681
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1867
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1978
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2205
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggtcccg ggtagcgagt gcctggcggt aggaatgggt gaatttaaag tccatcgagt
       61 tcgtttcttt aattacgttc catcaggcat ccgatgtgtg gcttacaata accagtcaaa
      121 cagattggct gtttcacgaa cagatggcac ggtggaaatt tataatttgt ctgcaaacta
      181 ttttcaggag aaatttttcc caggtcatga gtctcggggt accgaagccc tgtgttgggc
      241 agaaggacag cggctcttta gtgccggact gaatggagaa attcttgagt atgacctaca
      301 ggcactaaac atcaagtaca ctttggatgc ctttggagga ccgatttgga gtatgaccgc
      361 cagccccagt ggctctcaac ttttggttgg ctgtgaagat ggctccgtga aattatttga
      421 agtcacccca gacaaaatcc aatttgcaag aaatttcgat cgtcaaaaaa gtcggatcct
      481 gagtctcagc tggcatcctg ctggtaccca cgttgcagct ggttccatag actacattag
      541 tgtgttcgat gtcaaatcag ggagcataac ccggaagatg gttttagaca ggcagcacct
      601 gggagtgacc aagtcaaggt gcatagtgtg gggtgttgcc ttcctgtccg acggcactgt
      661 cataagcgtg gactcagttg gaaaggtgca gttatgggac tcagctactg ggacacttgt
      721 caagagccat ctcatcgcaa acgctgacgt gcagtctatt gctgttgctg atcaagaaga
      781 cagttttgtg gtgggcacag ccgagggcac agtgttccat ttccagctgg tgtcggtgac
      841 ttccaacagc agcgagaagc agtgggtgcg gacgaaacca ttccagcacc acacacacga
      901 cgtgcgcact gtggcccaca gcccaacagc cctgatatca ggaggcaccg acacccacct
      961 agttattcgg cctctcatgg agaaagtgga ggtaaagaac tacgatgccg ctctccgaaa
     1021 gatcactttc ccccatcggc gtctcatttc ctgttcaaag cgaaggcagc ttctcctttt
     1081 ccagtttgct caccacttgg aactctggag actaggatcc acagccgcaa caggcaagaa
     1141 tggagatact cttccgctct ctaaaaatgc agaccatctc ctgcacctca agacaaaggg
     1201 ccctgagaac attatctgca gctgcgtctc cccgtgtgga agttggatag cctattctac
     1261 agcgtctcgg ttttttctct atcgattgaa atatgaacgt gataacatta gcctccaaag
     1321 agtttccaaa ttaccagcat tccttcgctc tgcccttcat attttgtttt ctgaagattc
     1381 aacaaagctc tttgtggcat caaatcaagg gtctctacat gtcatccatc tttcggaagg
     1441 aagcttcaag cacttgcata ctttccagcc acaatcaggg acagtggagg ccatgtgtct
     1501 tttggcagtc agtcccgatg ggaattggct agctgcatca ggtaccagtg ctggagtcca
     1561 catatatgat ctgcatcatc taaagcttca ctgcacagtg cctgcttaca atttcccagt
     1621 gactgctctg gccatcgccc ccaataccaa caacctggtc attgctcatt ctgaccagca
     1681 ggtatttgag ttcagcatcc cagacaagca gtatacagag tggagccgct ctgtccagaa
     1741 gcaaggattt caccagctgt ggctccaaag ggatactccc atcacacaca tcagcatcca
     1801 tcccaagaga cccatgcaca tcctcctcca tgacgcctac atgttctgca tcattgacaa
     1861 gtccttgcca cttccaaatg acaaaactgt gctctataat ccgcttcctc cgaaaaacga
     1921 atcagatgtc ttcctgaggc gcacgaccca tggatttaaa atgtctaaga tatataagcc
     1981 cttactcttt atggatcttt tggatgaaag gacacttgtg gcagtagaac gacctctgga
     2041 tgacatcatt gctcagctcc caccacccat caaaaagaag aaatttggaa cttaaaacgg
     2101 gacactgact gtgtcctttc ttgaactgtc tgtcctgttc tttgtttgtt cgtttctttg
     2161 tttgtttttt ctgaaatcat gataataaaa caaagttatt ctttaaaaaa aaaaaaaaaa
     2221 aaaaaaaaaa
//
