LOCUS       NP_001009640             686 aa            linear   ROD 23-MAR-2023
DEFINITION  U3 small nucleolar RNA-associated protein 4 homolog [Rattus
            norvegicus].
ACCESSION   NP_001009640 XP_214663
VERSION     NP_001009640.1
DBSOURCE    REFSEQ: accession NM_001009640.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 686)
  AUTHORS   Sato M, Araki N, Kumeta M, Takeyasu K, Taguchi Y, Asai T, Furukawa
            K and Horigome T.
  TITLE     Interaction, mobility, and phosphorylation of human orthologues of
            WD repeat-containing components of the yeast SSU processome t-UTP
            sub-complex
  JOURNAL   Biochem Cell Biol 91 (6), 466-475 (2013)
   PUBMED   24219289
REFERENCE   2  (residues 1 to 686)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (residues 1 to 686)
  AUTHORS   Freed EF, Prieto JL, McCann KL, McStay B and Baserga SJ.
  TITLE     NOL11, implicated in the pathogenesis of North American Indian
            childhood cirrhosis, is required for pre-rRNA transcription and
            processing
  JOURNAL   PLoS Genet 8 (8), e1002892 (2012)
   PUBMED   22916032
REFERENCE   4  (residues 1 to 686)
  AUTHORS   Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L,
            Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T,
            Earnshaw WC and Rappsilber J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
REFERENCE   5  (residues 1 to 686)
  AUTHORS   Yu B, Mitchell GA and Richter A.
  TITLE     Cirhin up-regulates a canonical NF-kappaB element through strong
            interaction with Cirip/HIVEP1
  JOURNAL   Exp Cell Res 315 (18), 3086-3098 (2009)
   PUBMED   19732766
REFERENCE   6  (residues 1 to 686)
  AUTHORS   Prieto JL and McStay B.
  TITLE     Recruitment of factors linking transcription and processing of
            pre-rRNA to NOR chromatin is UBF-dependent and occurs independent
            of transcription in human cells
  JOURNAL   Genes Dev 21 (16), 2041-2054 (2007)
   PUBMED   17699751
REFERENCE   7  (residues 1 to 686)
  AUTHORS   Yu B, Mitchell GA and Richter A.
  TITLE     Nucleolar localization of cirhin, the protein mutated in North
            American Indian childhood cirrhosis
  JOURNAL   Exp Cell Res 311 (2), 218-228 (2005)
   PUBMED   16225863
REFERENCE   8  (residues 1 to 686)
  AUTHORS   Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E,
            Rasquin-Weber A, Hudson TJ and Richter A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088461.1.
            
            On Jan 13, 2005 this sequence version replaced XP_214663.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088461.1, SRR8487226.74973.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..686
                     /product="U3 small nucleolar RNA-associated protein 4
                     homolog"
                     /note="testis-expressed gene 292; cirrhosis, autosomal
                     recessive 1A (cirhin); UTP4 small subunit (SSU) processome
                     component"
                     /calculated_mol_wt=76732
     Region          <7..306
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          21..57
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          63..99
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          104..142
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          149..189
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          198..229
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          239..284
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          334..374
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <442..547
                     /region_name="YncE"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; COG3391"
                     /db_xref="CDD:442618"
     Region          445..476
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          487..521
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          529..576
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..686
                     /gene="Utp4"
                     /gene_synonym="Cirh1a; Cirhin; Naic; Teg-292; Tex292"
                     /coded_by="NM_001009640.1:35..2095"
                     /db_xref="GeneID:291987"
                     /db_xref="RGD:1311341"
ORIGIN      
        1 mgefkvhrvr ffnyvpsgir cvaynnqsnr lavsrtdgtv eiynlsanyf qekffpghes
       61 rgtealcwae gqrlfsagln geileydlqa lnikytldaf ggpiwsmtas psgsqllvgc
      121 edgsvklfev tpdkiqfarn fdrqksrils lswhpagthv aagsidyisv fdvksgsitr
      181 kmvldrqhlg vtksrcivwg vaflsdgtvi svdsvgkvql wdsatgtlvk shlianadvq
      241 siavadqeds fvvgtaegtv fhfqlvsvts nssekqwvrt kpfqhhthdv rtvahsptal
      301 isggtdthlv irplmekvev knydaalrki tfphrrlisc skrrqlllfq fahhlelwrl
      361 gstaatgkng dtlplsknad hllhlktkgp eniicscvsp cgswiaysta srfflyrlky
      421 erdnislqrv sklpaflrsa lhilfsedst klfvasnqgs lhvihlsegs fkhlhtfqpq
      481 sgtveamcll avspdgnwla asgtsagvhi ydlhhlklhc tvpaynfpvt alaiapntnn
      541 lviahsdqqv fefsipdkqy tewsrsvqkq gfhqlwlqrd tpithisihp krpmhillhd
      601 aymfciidks lplpndktvl ynplppknes dvflrrtthg fkmskiykpl lfmdlldert
      661 lvaverpldd iiaqlpppik kkkfgt
//
