LOCUS       NM_001108458            1722 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus uronyl-2-sulfotransferase (Ust), mRNA.
ACCESSION   NM_001108458 XM_001068892 XM_341728
VERSION     NM_001108458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1722)
  AUTHORS   Liu Y, Qu HQ, Chang X, Qu J, Mentch FD, Nguyen K, Tian L, Glessner
            J, Sleiman PMA and Hakonarson H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 1722)
  AUTHORS   Nishimura K, Ishii M, Kuraoka M, Kamimura K and Maeda N.
  TITLE     Opposing functions of chondroitin sulfate and heparan sulfate
            during early neuronal polarization
  JOURNAL   Neuroscience 169 (4), 1535-1547 (2010)
   PUBMED   20600662
REFERENCE   3  (bases 1 to 1722)
  AUTHORS   Properzi F, Lin R, Kwok J, Naidu M, van Kuppevelt TH, Ten Dam GB,
            Camargo LM, Raha-Chowdhury R, Furukawa Y, Mikami T, Sugahara K and
            Fawcett JW.
  TITLE     Heparan sulphate proteoglycans in glia and in the normal and
            injured CNS: expression of sulphotransferases and changes in
            sulphation
  JOURNAL   Eur J Neurosci 27 (3), 593-604 (2008)
   PUBMED   18279312
  REMARK    GeneRIF: The major injury-related change, seen in injured brain and
            cultured glia, was an increase in 2-O-sulphated HS and increased
            syndecan-1, suggesting novel approaches to modulating scar
            formation.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473994.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341728.3, XM_001068892.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..1722
                     /gene="Ust"
                     /note="uronyl-2-sulfotransferase"
                     /db_xref="GeneID:361450"
                     /db_xref="RGD:1304743"
     exon            1..624
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1601
                     /gene="Ust"
                     /codon_start=1
                     /product="uronyl 2-sulfotransferase"
                     /protein_id="NP_001101928.1"
                     /db_xref="GeneID:361450"
                     /db_xref="RGD:1304743"
                     /translation="MKKKQQQHPGGGADPWPHGAPVGGAPPCLGSCKRRIPLLPFLRF
                     SLRDYGFCMATLLVFCLGSLFYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPF
                     PSQVVYNRVGKCGSRTVVLLLRILSEKHGFKLVTSDIHNKTRLTKNEQMELIKNISTV
                     EQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVSRFLSNYFFRRFGDWRGEQNHMIRT
                     PSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVN
                     ENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEA
                     VQILYQRMRYEYEFYHYVKEQFHLLKRKLGLKSRASRPPLRPQFFIPTPLETEEPIDD
                     EEQDDDEKWLEDIYKR"
     exon            625..668
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
     exon            669..824
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
     exon            825..904
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1058
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1156
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1314
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1722
                     /gene="Ust"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaagcccg gggggtccac gctggcgctg gaggcgagcc gggagcgagc ccggggcgcg
       61 gcgggacttg gggcgcaggg ctgccacggg acacggggct gctagtggga cgcgcgaccg
      121 ggagtgggtt gcaatcgcta ccctctacgg cggggcccgg aacatcttgg gccctttggg
      181 gccgcagcga gcggtgggga ccaagatgag cagagtaccc tgagcccggc aacttcggcc
      241 cctccccgcc cccactcggc tgcccacagt gcgtccctct ccatgtgcag acggccggcc
      301 aggcgctccg gctggcggcg gatgggtgac ctcttcctgg cccgggcggg ctgtgcgagg
      361 cggcggagcg ggcgatgaag aagaagcagc agcagcatcc cggcggcggc gcggatccct
      421 ggccccatgg ggcccctgtg gggggcgccc ctccgtgcct gggcagctgc aagcgccgga
      481 tcccgctgct gcctttcctg cgcttctccc tccgggacta cggtttctgc atggctacgc
      541 tgctggtctt ctgcctgggc tcccttttct accagctcag cgggggaccc cctcgttttc
      601 tactcgacct gcggcagtat ttgggaaatt ctacttactt ggatgaccat ggaccacctc
      661 ctagtaaggt ccttcccttc cccagccagg tggtgtacaa cagagtcggc aagtgtggca
      721 gtcgcaccgt ggtcctgctt ctgagaatct tgtcagaaaa gcacggcttc aaattggtca
      781 cgtcagacat tcacaacaaa accaggctta ctaaaaatga acaaatggaa ctgattaaga
      841 atataagtac cgtcgaacag ccctatttat tcacgagaca cgtccacttc ctcaacttct
      901 ccaggtttgg aggagaccag cccgtctaca tcaacatcat cagagacccc gtcagtagat
      961 ttctatccaa ctattttttc cgtcgcttcg gagactggag aggggaacag aatcacatga
     1021 tccgcacccc cagcatgagg caggaggagc gctacctgga catcaatgag tgcattctgg
     1081 aaaactaccc cgagtgttcc aaccccaggc tattttacat catcccgtat ttctgtggac
     1141 agcaccccag atgtagggag cctggcgaat gggcactgga gcgggccaag ctgaacgtga
     1201 atgaaaactt cctgcttgtg gggattctgg aggagctgga agatgtgctg cttctactgg
     1261 agagattttt acctcattac ttcaagggcg tgctcagcat ctacaaggac ccagagcata
     1321 ggaaacttgg caacatgact gtgaccgtga agaagactgt cccctctccc gaggcggtgc
     1381 agattctcta ccagaggatg agatacgagt acgagttcta ccactacgtc aaagaacagt
     1441 tccacctgct taagcgcaag ctcggactga agtctcgcgc gagcagacct cccctgagac
     1501 cacagttctt cattcccacc cctctggaga ctgaggagcc aatcgatgac gaggagcaag
     1561 acgacgatga gaaatggcta gaagatattt ataagaggtg atgccagcac cagattgcct
     1621 ctgtggcttc gtccccctct ttacgaagtt ctctggggaa gaaaaaaaaa tctgaagggg
     1681 actttcatta atgctcgggt gcattaaaaa gaacaaaaca tt
//
