LOCUS       NM_001198555            3591 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase like 1 (Uspl1),
            transcript variant 1, mRNA.
ACCESSION   NM_001198555
VERSION     NM_001198555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3591)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3591)
  AUTHORS   Hutten,S., Chachami,G., Winter,U., Melchior,F. and Lamond,A.I.
  TITLE     A role for the Cajal-body-associated SUMO isopeptidase USPL1 in
            snRNA transcription mediated by RNA polymerase II
  JOURNAL   J Cell Sci 127 (Pt 5), 1065-1078 (2014)
   PUBMED   24413172
REFERENCE   3  (bases 1 to 3591)
  AUTHORS   Schulz,S., Chachami,G., Kozaczkiewicz,L., Winter,U.,
            Stankovic-Valentin,N., Haas,P., Hofmann,K., Urlaub,H., Ovaa,H.,
            Wittbrodt,J., Meulmeester,E. and Melchior,F.
  TITLE     Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase
            with essential, non-catalytic functions
  JOURNAL   EMBO Rep 13 (10), 930-938 (2012)
   PUBMED   22878415
REFERENCE   4  (bases 1 to 3591)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 3591)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB712845.1, CB787426.1, CB798160.1, DY309833.1, CO396482.1,
            EV774129.1 and JAXUCZ010000012.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.83508.1,
                                           SRR26643429.42234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CB712845.1         1-34
            35-327              CB787426.1         47-339
            328-461             CB712845.1         159-292
            462-506             CB798160.1         296-340
            507-668             CB712845.1         336-497
            669-1087            DY309833.1         90-508
            1088-1192           CO396482.1         1-105
            1193-1861           EV774129.1         1-669
            1862-3591           JAXUCZ010000012.1  10859764-10861493   c
FEATURES             Location/Qualifiers
     source          1..3591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3591
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /note="ubiquitin specific peptidase like 1"
                     /db_xref="GeneID:288447"
                     /db_xref="RGD:1310835"
     exon            1..125
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     exon            126..294
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..3402
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-specific peptidase-like protein 1; SUMO-specific
                     isopeptidase USPL1"
                     /codon_start=1
                     /product="SUMO-specific isopeptidase USPL1 isoform 1"
                     /protein_id="NP_001185484.1"
                     /db_xref="GeneID:288447"
                     /db_xref="RGD:1310835"
                     /translation="MTDDSLKIGNGLPLVGPGTDIGISSLPMLGYLGKNYASAKVPAD
                     GYCPTCRAKGKLNTLKTYRISFQESIFLCEDLQCIYPLGSESLTNLISPDSEDCHTPN
                     KPQKRKRLEDNCKNSSLPVHSKKTRGHLVTDSDQIVNGECNGEVCGDFSASFPGDSAH
                     QDPARTAASVGQNGTLEANDNVVMATTEDPAAVGVTPELEMPSESRCLSLCQPLCVQW
                     RNTQALCWLDCILSALVHLEVLRDAVLEVCSREECVFGKLFETYHQADKLLYTHHLHG
                     VTGEDCKKMTTEIFTEIDTSLNKIRDEIFAKLQPKLRCTLGDMESPVFALPVLLKLEP
                     HVENLFTYSFSWNFECSHCGHQYQNRCVKSLVTFTNVVPEWHPLNAAHFGPCNSCNSK
                     SQIRKMVLERASPIIMLHFVEGLPRKDLQHYAFHFEGSLYQVTSVIQYRAKNHFITWT
                     VDADGSWLECDDLKGPCAKRHEACEVPASETHIVIWERKSQVPVEGAACLPHMKLHVQ
                     SVSGEEQPSSLAGTATSEPSVAHPTPMAVAPQILPATQAVAHGDSVLSGTGGLLDSVS
                     PSALEETIQETASVSQIDSKDCLLEDKPVVGSAGPVRTLTFQPQDSLGSSLVLNLCEG
                     MLVAPCVDSRFPSQAVSTGLQAVPSQAGDTVVPKPVTDAPVPVLVQELKSMATEDSQT
                     QLLPLKTDRLNPGQPPGKTQASNLRKRENAASSKPVAARSAQNQPRKDEQKKAFVGSW
                     VKGLLSRGGAFMPPCVSAQSRAVTDLQPSVKGANNFDGFKTKSINRRSKRMSRKAKHV
                     EEASPGSSPPLSGSTAALPQAAGNASSAQLKEQEGSRSAPLSHRPPSDESAMSPAGRA
                     EAAEDQVHKLRLRLLKKLKAKKKKLAALMSSPRREPSVSDHSEPASHCGSPNDCDAVE
                     DLLRELQYQIDLADNKSGCTSAPDGTSCNSQSHEEILAELLSPTALSEPSESGEPELR
                     YLEMGDNSTPTPAPSEFSAVSQNTCLNQEHNYCSPEKSQCEVDLHSVIDSACVRALNL
                     GSPMKTDIFDDFFPTSALNSLTNDTLDIPHFDDSLFENC"
     exon            295..423
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1027
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1141
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1271
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1397
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1555
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..3591
                     /gene="Uspl1"
                     /gene_synonym="RGD1310835"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacggctg tgggggagga gccgtccgag ggaacgtggg ttgaacgtta cgggtagatg
       61 gtgtggatct caagctggaa caggagttcg gactcattgt atacaaagaa gtgtgcttcg
      121 ggcagggttc attgaaaaat ccttagtgat tttgacatgt tccaagtgac ataaattagc
      181 caatgactcg gaatgacgga tgactctctg aagattggaa atggtttgcc actggttgga
      241 ccagggactg atatagggat atcttcactc cccatgctgg ggtacttggg aaaaaattat
      301 gcttcagcta aagttccagc agacgggtat tgccctactt gtagagcgaa aggaaagcta
      361 aacaccttaa aaacttaccg catcagcttc caagaatcta tctttttgtg tgaggatctt
      421 cagtgcattt atcctttggg ctctgagtca cttactaact taatttctcc tgattcggaa
      481 gattgtcaca ctccaaataa gcctcagaaa agaaagagat tggaagacaa ctgtaagaat
      541 tcatctcttc cagtacattc taaaaagact agaggtcacc ttgtcactga cagtgaccag
      601 attgtgaacg gtgagtgtaa tggagaagtg tgtggtgact tctcagccag cttcccaggt
      661 gacagtgctc accaggatcc cgccaggaca gctgcttctg tggggcagaa tgggactttg
      721 gaagccaatg ataacgtggt catggctact acagaagatc ctgctgcagt tggtgtcaca
      781 ccggagctgg aaatgccgtc tgagagcaga tgtttatcac tttgccagcc tctctgtgtc
      841 cagtggagaa acactcaggc gctgtgctgg ttagactgta tcctctcggc cctggtgcac
      901 ctggaggtgt tgagggacgc cgtgctggag gtgtgctcca gagaggagtg tgtgtttggg
      961 aagctgttcg aaacctacca ccaagcagat aagcttctgt acacccatca cctgcatggc
     1021 gtcacaggtg aagattgtaa aaaaatgacg acagaaatat ttacagagat agatacctct
     1081 ttgaataaaa ttagagatga aatttttgct aaacttcagc ctaagcttag atgcacacta
     1141 ggtgacatgg aaagtcctgt gtttgcactt cctgtactgt taaagcttga accccatgtt
     1201 gaaaacctct ttacatattc tttttcttgg aattttgaat gttcccattg tgggcaccag
     1261 taccaaaaca ggtgtgtgaa gagtctggtc acctttacaa atgttgttcc tgagtggcat
     1321 ccactcaatg ctgcccattt cggtccgtgt aacagttgca acagtaaatc acaaatcaga
     1381 aaaatggtgt tggaaagagc gtcgcccata atcatgctgc acttcgtgga aggtttgccc
     1441 aggaaggacc tgcaacacta tgccttccac tttgaaggca gtctttacca agtcacctcc
     1501 gtcatacagt accgggcaaa gaaccatttt ataacgtgga ctgtagatgc tgatgggagt
     1561 tggctggagt gtgatgacct gaagggtccg tgtgctaaaa ggcatgaggc ctgtgaagtg
     1621 ccagcatcag agacacatat cgttatttgg gaaagaaaat cccaggtgcc agttgaagga
     1681 gctgcctgcc ttccacacat gaagctgcac gtgcagtccg tgtcaggtga ggagcagccg
     1741 agttctctgg ctgggaccgc cacctcagaa ccctcagtcg cccatcctac acctatggca
     1801 gttgctcctc agattcttcc agcaacccaa gctgtagctc atggagatag tgtcctttca
     1861 ggaacaggag gcttgctgga cagcgtttca ccctctgcac ttgaagagac tatccaggaa
     1921 actgcctctg tttctcagat tgactccaaa gattgcctct tagaagacaa acctgtggta
     1981 ggaagtgcag gacctgtgag aacactgact tttcagccgc aggactccct ggggtcttcc
     2041 ttggtgttga acctgtgtga aggaatgcta gttgcccctt gtgtggattc caggttccca
     2101 tcccaagctg tgagcacagg tctgcaggca gtaccgtctc aggcagggga cacagtggtt
     2161 cctaaacctg tgactgatgc ccctgttcct gttcttgttc aggaattgaa gtccatggca
     2221 actgaggact ctcagacaca gttgctgcca ctgaaaactg acaggttaaa ccctggacaa
     2281 ccaccaggta aaactcaggc atctaatttg agaaaaagag aaaatgcagc gtcttctaaa
     2341 ccggtagcag ccaggtcagc acagaatcag cctcggaagg atgagcagaa gaaggccttc
     2401 gtgggaagtt gggtgaaagg gctgctgagc aggggcggtg cgtttatgcc accctgtgtt
     2461 tcagctcaga gtagagcagt aactgacctg cagccctccg tgaaaggagc caataatttt
     2521 gatggcttta aaacgaaaag tataaaccgc aggtctaaaa ggatgtccag gaaagctaag
     2581 catgtggagg aggcatctcc aggtagcagc cctccactgt cgggtagcac ggctgctctg
     2641 ccgcaggccg ctgggaatgc ctcctcagcc cagttgaagg agcaggaagg ctcacgttca
     2701 gctcccctca gccacagacc tcccagtgat gaaagcgcca tgtctccagc aggccgtgca
     2761 gaggcagctg aagatcaggt tcataagctt cggctcagac ttcttaaaaa gctaaaggca
     2821 aaaaagaaga aactagcggc cctcatgtct tccccacgcc gtgaaccgtc tgtaagcgac
     2881 cattcagagc ctgcgtccca ctgtgggtct ccgaatgact gtgacgcagt agaagatctg
     2941 ctcagagagc tacagtacca gattgacctt gcagacaaca agtctgggtg cacctctgct
     3001 cccgacggca cctcatgcaa cagccagagt catgaggaga ttttagcaga gctgttgtcg
     3061 cctacagccc tgtcagagcc ctcagaaagt ggagagcctg agttgaggta cttggaaatg
     3121 ggggacaaca gcaccccaac accagcacct agcgaattca gtgctgtttc ccagaacaca
     3181 tgtctgaacc aggagcataa ttactgcagc cctgagaaaa gccagtgtga ggttgatctg
     3241 cattcagtca tcgacagtgc ctgtgtaaga gccttgaact tggggagtcc catgaagact
     3301 gacatttttg atgatttttt tcctacttca gcattgaatt cgttaacaaa tgacacattg
     3361 gacatacctc atttcgatga ctctctgttt gagaattgct gagtgcatgc tagtgtcgtc
     3421 gtttagtcct gaccgctgct gctaggaggc tgagctgtgg gtagtgctgg ctgaagtgca
     3481 cagccttgtg ctccagccat ggggaaactg tgaactactg gggtcttcct ctggttctgc
     3541 ctgtgagaca tgagatctct gcaaattaaa gtcctcagac aagtttctgt c
//
