LOCUS       NM_001135923           12133 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 9, X-linked (Usp9x),
            transcript variant 2, mRNA.
ACCESSION   NM_001135923 XM_343766
VERSION     NM_001135923.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12133)
  AUTHORS   Gong,S., Xiong,H., Lei,Y., Huang,S., Ouyang,Y., Cao,C. and Wang,Y.
  TITLE     Usp9x contributes to the development of sepsis-induced acute kidney
            injury by promoting inflammation and apoptosis in renal tubular
            epithelial cells via activation of the TLR4/nf-kappab pathway
  JOURNAL   Ren Fail 46 (2), 2361089 (2024)
   PUBMED   38874156
  REMARK    GeneRIF: Usp9x contributes to the development of sepsis-induced
            acute kidney injury by promoting inflammation and apoptosis in
            renal tubular epithelial cells via activation of the TLR4/nf-kappab
            pathway.
REFERENCE   2  (bases 1 to 12133)
  AUTHORS   Zhang,Y., Duan,C., Yang,J., Chen,S., Liu,Q., Zhou,L., Huang,Z.,
            Xu,Y. and Xu,G.
  TITLE     Deubiquitinating enzyme USP9X regulates cellular clock function by
            modulating the ubiquitination and degradation of a core circadian
            protein BMAL1
  JOURNAL   Biochem J 475 (8), 1507-1522 (2018)
   PUBMED   29626158
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12133)
  AUTHORS   Zhao,Y., Majid,M.C., Soll,J.M., Brickner,J.R., Dango,S. and
            Mosammaparast,N.
  TITLE     Noncanonical regulation of alkylation damage resistance by the
            OTUD4 deubiquitinase
  JOURNAL   EMBO J 34 (12), 1687-1703 (2015)
   PUBMED   25944111
REFERENCE   4  (bases 1 to 12133)
  AUTHORS   Homan,C.C., Kumar,R., Nguyen,L.S., Haan,E., Raymond,F.L., Abidi,F.,
            Raynaud,M., Schwartz,C.E., Wood,S.A., Gecz,J. and Jolly,L.A.
  TITLE     Mutations in USP9X are associated with X-linked intellectual
            disability and disrupt neuronal cell migration and growth
  JOURNAL   Am J Hum Genet 94 (3), 470-478 (2014)
   PUBMED   24607389
REFERENCE   5  (bases 1 to 12133)
  AUTHORS   Stegeman,S., Jolly,L.A., Premarathne,S., Gecz,J., Richards,L.J.,
            Mackay-Sim,A. and Wood,S.A.
  TITLE     Loss of Usp9x disrupts cortical architecture, hippocampal
            development and TGFbeta-mediated axonogenesis
  JOURNAL   PLoS One 8 (7), e68287 (2013)
   PUBMED   23861879
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12133)
  AUTHORS   Dupont,S., Mamidi,A., Cordenonsi,M., Montagner,M., Zacchigna,L.,
            Adorno,M., Martello,G., Stinchfield,M.J., Soligo,S., Morsut,L.,
            Inui,M., Moro,S., Modena,N., Argenton,F., Newfeld,S.J. and
            Piccolo,S.
  TITLE     FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta
            signaling, controls Smad4 monoubiquitination
  JOURNAL   Cell 136 (1), 123-135 (2009)
   PUBMED   19135894
REFERENCE   7  (bases 1 to 12133)
  AUTHORS   Nathan,J.A., Sengupta,S., Wood,S.A., Admon,A., Markson,G.,
            Sanderson,C. and Lehner,P.J.
  TITLE     The ubiquitin E3 ligase MARCH7 is differentially regulated by the
            deubiquitylating enzymes USP7 and USP9X
  JOURNAL   Traffic 9 (7), 1130-1145 (2008)
   PUBMED   18410486
REFERENCE   8  (bases 1 to 12133)
  AUTHORS   Al-Hakim,A.K., Zagorska,A., Chapman,L., Deak,M., Peggie,M. and
            Alessi,D.R.
  TITLE     Control of AMPK-related kinases by USP9X and atypical
            Lys(29)/Lys(33)-linked polyubiquitin chains
  JOURNAL   Biochem J 411 (2), 249-260 (2008)
   PUBMED   18254724
REFERENCE   9  (bases 1 to 12133)
  AUTHORS   Sato,T., Kanai,Y., Noma,T., Kanai-Azuma,M., Taya,S., Matsui,T.,
            Ishii,M., Kawakami,H., Kurohmaru,M., Kaibuchi,K., Wood,S.A. and
            Hayashi,Y.
  TITLE     A close correlation in the expression patterns of Af-6 and Usp9x in
            Sertoli and granulosa cells of mouse testis and ovary
  JOURNAL   Reproduction 128 (5), 583-594 (2004)
   PUBMED   15509704
REFERENCE   10 (bases 1 to 12133)
  AUTHORS   Kanai-Azuma,M., Mattick,J.S., Kaibuchi,K. and Wood,S.A.
  TITLE     Co-localization of FAM and AF-6, the mammalian homologues of
            Drosophila faf and canoe, in mouse eye development
  JOURNAL   Mech Dev 91 (1-2), 383-386 (2000)
   PUBMED   10704870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Feb 4, 2021 this sequence version replaced NM_001135923.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000021.1  12369278-12369491   c
            215-468             JAXUCZ010000021.1  12346641-12346894   c
            469-614             JAXUCZ010000021.1  12344101-12344246   c
            615-694             JAXUCZ010000021.1  12341928-12342007   c
            695-807             JAXUCZ010000021.1  12336535-12336647   c
            808-1026            JAXUCZ010000021.1  12335203-12335421   c
            1027-1142           JAXUCZ010000021.1  12331203-12331318   c
            1143-1394           JAXUCZ010000021.1  12330601-12330852   c
            1395-1533           JAXUCZ010000021.1  12330388-12330526   c
            1534-1686           JAXUCZ010000021.1  12328295-12328447   c
            1687-1791           JAXUCZ010000021.1  12326712-12326816   c
            1792-1998           JAXUCZ010000021.1  12324712-12324918   c
            1999-2135           JAXUCZ010000021.1  12323842-12323978   c
            2136-2269           JAXUCZ010000021.1  12322089-12322222   c
            2270-2357           JAXUCZ010000021.1  12311352-12311439   c
            2358-2700           JAXUCZ010000021.1  12309613-12309955   c
            2701-2796           JAXUCZ010000021.1  12308266-12308361   c
            2797-3008           JAXUCZ010000021.1  12307517-12307728   c
            3009-3249           JAXUCZ010000021.1  12304816-12305056   c
            3250-3399           JAXUCZ010000021.1  12304188-12304337   c
            3400-3520           JAXUCZ010000021.1  12303289-12303409   c
            3521-3651           JAXUCZ010000021.1  12300309-12300439   c
            3652-3930           JAXUCZ010000021.1  12299854-12300132   c
            3931-4056           JAXUCZ010000021.1  12297479-12297604   c
            4057-4182           JAXUCZ010000021.1  12296122-12296247   c
            4183-4349           JAXUCZ010000021.1  12293957-12294123   c
            4350-4458           JAXUCZ010000021.1  12291784-12291892   c
            4459-4605           JAXUCZ010000021.1  12291441-12291587   c
            4606-4752           JAXUCZ010000021.1  12290520-12290666   c
            4753-4975           JAXUCZ010000021.1  12289469-12289691   c
            4976-5196           JAXUCZ010000021.1  12287099-12287319   c
            5197-5387           JAXUCZ010000021.1  12284017-12284207   c
            5388-5561           JAXUCZ010000021.1  12280844-12281017   c
            5562-5703           JAXUCZ010000021.1  12278809-12278950   c
            5704-6457           JAXUCZ010000021.1  12277241-12277994   c
            6458-6581           JAXUCZ010000021.1  12276372-12276495   c
            6582-6807           JAXUCZ010000021.1  12275150-12275375   c
            6808-6937           JAXUCZ010000021.1  12274288-12274417   c
            6938-7123           JAXUCZ010000021.1  12272230-12272415   c
            7124-7344           JAXUCZ010000021.1  12271655-12271875   c
            7345-7433           JAXUCZ010000021.1  12271479-12271567   c
            7434-7590           JAXUCZ010000021.1  12268575-12268731   c
            7591-7803           JAXUCZ010000021.1  12267969-12268181   c
            7804-7899           JAXUCZ010000021.1  12267114-12267209   c
            7900-12133          JAXUCZ010000021.1  12261633-12265866   c
FEATURES             Location/Qualifiers
     source          1..12133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..12133
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /note="ubiquitin specific peptidase 9, X-linked"
                     /db_xref="GeneID:363445"
                     /db_xref="RGD:1560056"
     exon            1..214
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            215..468
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..8037
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /EC_number="3.1.2.15"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable ubiquitin carboxyl-terminal hydrolase FAF-X;
                     ubiquitin specific peptidase 9, X chromosome"
                     /codon_start=1
                     /product="probable ubiquitin carboxyl-terminal hydrolase
                     FAF-X isoform 2"
                     /protein_id="NP_001129395.1"
                     /db_xref="GeneID:363445"
                     /db_xref="RGD:1560056"
                     /translation="MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSP
                     ATPPDEQGQGDAPPQIEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAI
                     DLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCV
                     AKLAQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPK
                     GWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFL
                     PIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKSLASRVPGQEETVKNLEIF
                     RLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGSSEEEEWLTAERMAEWIQQ
                     NNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVH
                     DLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVL
                     NLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWV
                     IPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYM
                     ESMRLYGRDNEDYDPQTVRVGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWK
                     CLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCF
                     ERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYT
                     NLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSINCARQEAVRMVRVLTV
                     LREYINECDSDYHEERTILPMSRAFRGKHLSFIVRFPNQGRQVDDLEVWSHTNDTIGS
                     VRRCILNRIKANVAHTKIELFVGGELIDPGDDRKLIGQLNLKDKSLITAKLTQISSNM
                     PSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSS
                     LNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQV
                     LYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRG
                     AYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTSVNQVTHDQAVVLQSALQS
                     IPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWTSGCGGLQLVFSPNE
                     EVTKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLL
                     LHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTL
                     LRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGVEETILEGHLGVTKE
                     LLAFQTPEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGS
                     PATINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRP
                     PKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESN
                     VDPRDDVFGYPQQFEDKPPLSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFW
                     KQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQG
                     CPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRL
                     LIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNP
                     ESQLIQQNEQSESEKAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGEKNRWYKF
                     DDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDT
                     IDHDDEVIRYISEIAITTRPHQIVMPSAIERSVRKQNVQFMHNRMQYSLEYFQFMKKL
                     LTCNGVYLNPPPGQDHLSPEAEEITMISIQLAARFLFTTGFHTKKIVRGSASDWYDAL
                     CILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGP
                     CPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGV
                     AEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSS
                     INGNPSLPNPFGDPNLSQPIMPIQQNVVDILFVRTSYVKKIIEDCSNSDETVKLLRFC
                     CWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPD
                     DRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWL
                     GDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPD
                     DQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQE
                     NYEGSEEVSPPQTKDQ"
     exon            469..614
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            615..694
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            695..807
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1026
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1142
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1394
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1533
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1686
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1791
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1998
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2135
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2269
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2357
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2700
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2796
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..3008
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3249
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3399
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3520
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3651
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3930
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4056
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4182
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4349
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            4350..4458
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4605
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4752
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            4753..4975
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            4976..5196
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5387
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            5388..5561
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5703
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            5704..6457
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            6458..6581
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            6582..6807
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            6808..6937
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            6938..7123
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            7124..7344
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            7345..7433
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            7434..7590
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            7591..7803
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            7804..7899
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
     exon            7900..12133
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggagtc tgcgctgctg ccgctgctgc cgctgctgtc gctgtcgctg ctgccgctgc
       61 cgccgccgac actgccactg gccgtgcggg ttttcttttt ctttttcttt ttctcttttc
      121 ttttttgatt tgttggatcc gccatattga cgaggctgtg gtactcaaag ctgcggaagc
      181 tagactccgc cggtggcgga gccgcaacct ctcggttatg caatggtctc tgcaagatgt
      241 tttattcttg aattggaacc ttttaagact gacaaatgct ggtacttcgt cttctataag
      301 tggactataa tttcttttct taagacaact acataagcag acaaaattgc aaagatctgc
      361 cctgtgtcga gtatgacagc cacgactcgt ggctctccag ttggagggaa tgacaaccag
      421 ggccaagctc ctgatggaca gtctcagccc cccctccaac agaatcagac ttcatcgcct
      481 gattcatcca atgaaaattc ccctgcaact cctcctgatg agcaaggcca aggtgatgct
      541 cctccccaga ttgaagatga ggaacctgca tttccacaca ctgacctggc aaagttagat
      601 gatatgatca acaggcctcg ctgggtcgtt ccagttttgc cgaaagggga attagaagtg
      661 cttttagaag ctgctattga tcttagtaag aaaggccttg atgtcaaaag tgaagcatgt
      721 cagagatttt tccgagatgg gctaacaatc tcattcacaa aaatccttac agatgaagca
      781 gtgagtggct ggaagtttga aattcataga tgtattatta acaatactca tcgcctggtg
      841 gagctgtgtg tggctaagtt agcccaagac tggtttccac ttctagaact tcttgccatg
      901 gccttaaatc ctcattgcaa attccatatc tacaatggta cacgtccctg cgagtcagtg
      961 tcctcaagtg ttcagttgcc tgaagatgaa ctctttgctc gttctccaga ccctcgatca
     1021 ccaaaaggtt ggctagtgga tctcctcaac aaatttggca ctttaaatgg attccagata
     1081 ctgcatgatc gttttattaa tggatcagca ttaaatgttc agataattgc agcccttatt
     1141 aaaccatttg gacagtgcta tgagtttctt actcttcaca cggtgaaaaa atactttctt
     1201 ccaataatag aaatggttcc acagttttta gaaaacttaa ctgatgaaga gctgaagaaa
     1261 gaagcaaaga atgaagccaa aaatgatgct ctctcaatga ttattaaatc attgaagagt
     1321 ttagcttcac gagttcctgg acaggaagaa actgtaaaga acttagaaat atttaggtta
     1381 aaaatgatac ttagattatt gcaaatttct tccttcaatg gaaagatgaa tgcactgaat
     1441 gaggttaata aggtgatttc cagtgtgtca tactataccc atcggcatgg cagttctgag
     1501 gaagaagagt ggctcacagc agagaggatg gctgaatgga tacagcagaa caatatttta
     1561 tcaatagttt tacgagatag tcttcatcaa ccacagtatg tagagaaact agaaaagatt
     1621 cttcgctttg tcataaaaga aaaagctctg accttgcaag atcttgataa tatctgggca
     1681 gcacaggcag ggaaacatga agccatcgta aagaatgtcc atgatctact ggccaaattg
     1741 gcatgggatt tttctcctga acaacttgat catctttttg attgctttaa ggccagttgg
     1801 acaaatgcaa gtaaaaagca acgtgaaaag ctccttgagc tgattcgtcg tcttgcagaa
     1861 gatgataaag atggtgtgat ggcacataaa gtgttgaacc ttctgtggaa tctagctcac
     1921 agtgatgatg tgcctgtgga tatcatggac ttggctctca gtgctcacat caaaatacta
     1981 gattatagtt gctcccagga ccgggacaca caaaagatcc agtggataga tcgcttcata
     2041 gaagaacttc gcacaaatga caagtgggtc attcctgcac tgaaacaaat tagagaaatt
     2101 tgcagtttgt ttggtgaagc acctcaaaat ttgagtcaaa ctcagagaag tccccatgta
     2161 ttttatcgcc atgatttaat caatcaactt cagcacaatc atgccctagt tactttggta
     2221 gcagaaaacc ttgcaactta catggaaagc atgagactgt atggcagaga caatgaagac
     2281 tatgacccac aaactgtgag agtgggaagt agatatagtc atgttcaaga agtccaagaa
     2341 cgtcttaact ttcttagatt tttattgaag gatggccagc tatggctgtg tgctcctcag
     2401 gcaaaacaaa tatggaagtg cttagcagag aatgcggttt atctttgtga ccgtgaagcc
     2461 tgctttaagt ggtattccaa attaatggga gatgaaccag acttagatcc tgatatcaat
     2521 aaggacttct ttgaaagtaa tgtgcttcag cttgatcctt cactattaac tgaaaatgga
     2581 atgaaatgtt ttgagagatt cttcaaagct gtgaattgtc gagaaggaaa actagtagca
     2641 aaaagaagag cctatatgat ggatgatttg gaattgatag gattagacta tctttggagg
     2701 gttgtaattc agagtaatga tgatattgcc agccgagcta ttgatctcct caaagagata
     2761 tacacaaacc ttggtccaag actgcaggtc aatcaggtgg tgatccatga agacttcatt
     2821 cagtcttgct ttgatcgttt gaaagcctct tatgacacgt tgtgtgtttt ggatggtgac
     2881 aaagacagta ttaattgtgc aagacaggaa gctgttcgaa tggtccgagt attaactgtt
     2941 ttaagagaat atataaatga atgtgacagt gattatcatg aagaaagaac aattttgcct
     3001 atgtcaagag ctttccgtgg taaacacctc tcttttatag ttcggtttcc aaaccagggc
     3061 agacaagtag atgacttgga agtttggtct catacaaatg ataccattgg ttcagttcga
     3121 cgatgtatac taaatcgcat taaagccaat gtagctcata caaaaattga actctttgtg
     3181 ggtggtgagc ttattgatcc tggagatgac agaaagttga ttggacaatt aaacctaaaa
     3241 gataaatcac taattacagc caaacttaca caaatcagct ccaatatgcc gtcaagtcct
     3301 gatagctcct ctgattcctc aactggatct cctggaaacc atggtaatca ttacagtgat
     3361 ggtcccaacc cagaggtaga aagctgtttg cctggagtga taatgtcact tcatcccaga
     3421 tacatctctt tcctttggca agttgcagac ttagggagca gcctaaatat gccccctctt
     3481 agagatggag caagagttct tatgaaactt atgccgccag atagtacaac aatagaaaaa
     3541 ttaagagcta tttgtttaga tcatgccaaa cttggagaaa gcagccttag tccatctctt
     3601 gactcacttt tctttggtcc ttcagcctca caagtgctat acctaacaga ggtagtctat
     3661 gccctgttaa tgcctgctgg tgcacccctg gctgatgact cctctgattt tcagtttcac
     3721 ttcttgaaaa gtggtggttt gccccttgtt ctgagtatgc taaccagaaa taacttccta
     3781 ccaaatgctg atatggaaac tcgaaggggt gcctacctca atgctcttaa aatagccaaa
     3841 ctgttactaa ctgccattgg ctatggccat gttcgggctg tggcagaagc atgtcagcca
     3901 ggtgtagaag gcgtgaatcc tatgacatcg gtcaaccaag taactcatga tcaagcagtg
     3961 gtgctacaaa gtgcccttca gagcattcct aacccatcat ctgaatgcat gcttagaaac
     4021 gtgtctgttc gtcttgctca gcagatttct gatgaggctt caagatatat gcctgatatt
     4081 tgtgtaatta gagctataca aaagattatt tggacatcag gatgtggggg attacaactg
     4141 gtattcagcc caaatgagga agtcacaaaa atttatgaga agaccaatgc aggcaatgag
     4201 ccagaccttg aagatgaaca ggtttgctgt gaggcattgg aagtgatgac actgtgtttc
     4261 gccctgattc caacagcctt agatgctcta agtaaagaaa aggcttggca gacatttatt
     4321 attgacttac tgttacactg tcacagcaaa actgtccgtc aagtagcaca ggaacaattc
     4381 ttcttaatgt gcaccagatg ttgcatggga cacaggcctc tacttttctt cattactcta
     4441 ctctttactg ttttggggag cacagccaga gagagggcta aacattcagg cgactacttt
     4501 actcttttaa ggcatcttct taattacgct tacaacagta acattaatgt acccaatgct
     4561 gaagttcttc taaataatga aattgattgg cttaaaagaa ttagggatga tgttaaaaga
     4621 acaggtgaaa caggcgttga agagacaatc ttagaaggac accttggggt tacaaaggag
     4681 ctactggctt ttcagacccc tgagaaaaag tttcatattg gttgtgaaaa ggggggtgct
     4741 aatctcatta aagaattaat cgacgatttc atctttcctg catccaatgt ttacctccag
     4801 tatatgagaa atggagaact ccctgctgag caggccattc ctgtctgtgg ttcaccagcc
     4861 acaattaatg ctggttttga gttacttgta gcattagctg ttggctgtgt aaggaacctc
     4921 aaacagatag tagattcttt gactgaaatg tattacattg gtacagcaat aactacttgt
     4981 gaggcactta ctgagtggga atacctgcca cctgttggac cccgtccacc aaaaggattt
     5041 gtggggctga aaaatgctgg tgctacttgt tacatgaatt ctgtgattca gcaactctat
     5101 atgattccct ctatcaggaa cggtattctt gcaattgaag gcacaggtag tgatgtagat
     5161 gatgatatgt ctggggatga gaagcaggac aatgagagca atgttgatcc cagggatgat
     5221 gtgtttggat atcctcaaca atttgaagac aaaccaccac tgagtaaaac agaagataga
     5281 aaagagtaca atattggtgt tctaagacac cttcaagtta tctttggcca tttagctgct
     5341 tctcgactac agtactatgt gcccagagga ttttggaaac agttcaggct ttggggtgag
     5401 cctgttaatc ttcgtgaaca acatgatgct ttagagttct ttaattcatt ggtggatagt
     5461 ttagatgaag ctttaaaagc cttagggcat ccagctatgc taagtaaagt cttgggaggt
     5521 tccttcgctg atcagaaaat ttgtcaaggc tgcccacata ggtatgaatg tgaagaatct
     5581 tttacgactc tgaatgtaga cattagaaac caccaaaatc ttcttgattc tttggaacag
     5641 tatgtcaaag gagatttact agaaggggca aatgcttatc attgtgaaaa atgcaataaa
     5701 aaggttgata ctgtaaagcg cttgctaatt aaaaagttgc ctcctgttct tgctatccaa
     5761 ctaaaacgat tcgattatga ctgggaaaga gaatgtgcaa tcaagttcaa tgattacttt
     5821 gagtttcctc gagagttaga catggagccg tacacagttg caggtgttgc taaactagag
     5881 ggagataatg tcaacccaga aagtcagctg atacaacaga atgagcagtc tgaaagcgaa
     5941 aaagccggaa gcacaaaata cagacttgtg ggtgtgcttg tacacagtgg tcaagcaagt
     6001 gggggacatt actattctta catcattcag aggaatggag gagatggtga aaaaaatcgt
     6061 tggtataaat ttgatgatgg agatgtaaca gagtgtaaaa tggatgatga tgaagaaatg
     6121 aaaaaccagt gttttggtgg cgagtacatg ggagaagtgt ttgatcacat gatgaagcgc
     6181 atgtcgtaca ggcggcagaa aaggtggtgg aatgcatata tactttttta tgaaagaatg
     6241 gatacgatag atcatgatga tgaggtgata agatacatat cagagattgc tatcaccaca
     6301 aggccccatc agattgttat gccatcggcc attgaaagaa gtgtgcggaa gcagaatgtc
     6361 caattcatgc ataaccgaat gcagtacagt ttggaatatt ttcagtttat gaaaaagcta
     6421 cttacatgta atggtgttta tttaaaccct ccaccagggc aagatcacct gtctcctgaa
     6481 gcagaagaaa tcactatgat tagtattcag cttgctgcta ggttcctttt tactacagga
     6541 tttcacacaa agaaaatagt ccgaggatcc gccagtgatt ggtatgatgc attgtgtatt
     6601 ctcctccgtc acagcaagaa tgtgcggttt tggtttgctc acaatgtgct ttttaatgtt
     6661 tcaaatcgat tctctgagta ccttttggaa tgccctagtg cagaagtgag aggtgcattt
     6721 gctaaactta tagttttcat tgcacacttt tccttacaag atgggccttg tccttcacct
     6781 tttgcatctc ctggaccttc tagtcaggct tatgataact taagtttgag tgaccaccta
     6841 ctaagagcag tactaaatct cttgaggagg gaggtttcag agcatggacg tcatttacag
     6901 cagtatttca acttgtttgt aatgtatgcc aatttaggag tggcagagaa aacacagctg
     6961 ctcaaactga gtgtacctgc tacctttatg cttgtgtcct tagatgaagg tcctggtcct
     7021 ccaattaaat atcagtatgc tgaattaggc aaattatact ccgtagtgtc acagttaatc
     7081 cgctgttgca atgtctcttc aagaatgcag tcttcaatca atggtaatcc ttctcttcca
     7141 aatccttttg gtgatcctaa tttatcacaa cctataatgc caattcaaca aaatgtggta
     7201 gacattttat ttgtgagaac aagttatgtg aagaaaatta ttgaagactg cagtaactct
     7261 gatgagaccg tcaaattgct tcgcttttgc tgctgggaga atcctcagtt ctcatctact
     7321 gtcctgagtg aacttctttg gcaggttgcg tattcctata cttacgaact ccggccctat
     7381 ttggatctgc ttttacaaat cttactgatt gaagactcct ggcagactca cagaattcat
     7441 aatgccctta aaggaattcc agatgaccga gatgggctgt ttgacacaat tcagcgttct
     7501 aagaatcact atcaaaaaag agcataccaa tgtataaaat gtatggtagc cctctttagc
     7561 agttgtcctg tggcttacca aatcctgcag ggcaatggag atcttaaaag gaaatggacc
     7621 tgggcagtag agtggcttgg agatgaactc gaaagaagac catacactgg caatcctcag
     7681 tacacttaca acaactggtc tcctccagtg caaagcaatg aaacatcaaa tggctacttc
     7741 ttggagagat cacatagcgc taggatgaca cttgcaaaag cttgtgaact ctgtcctgag
     7801 gaggaaccag atgaccaaga tgccccagat gagcatgaat cacctccacc tgaagatgcc
     7861 ccattatacc cccattcccc tggatctcaa tatcagcaga ataaccatgt gcatggacag
     7921 ccctatacag gcccagccgc acatcacatg aacaaccctc agagaactgg ccaacgagca
     7981 caagaaaatt atgaaggcag tgaagaagtg tccccacctc agaccaagga tcagtgaaat
     8041 gcacatatta actggttcca tcaagactgt gcacccaggc cttacagtcc aacttttttc
     8101 tgtgtctggc taatatttca aactagaaaa ctattcctaa tcaacatgga gtggagagtt
     8161 tattcactgt cttatctgca gaaatttgct gtcaatatat aacccgcctg cagtggaaag
     8221 tgtatagtgt tttgtaataa atggcctgat gctaatgtgt aaatggcaaa ggtgtatata
     8281 gtatattaat gtttgactgt taattcttaa gcaagagact tttttttttc ttgatgagac
     8341 tcacagatct acaaaactac attaattttc ttgttactcc ctctgcactc tgcagccagt
     8401 gttgcctacc ttgtggcagt tggatcacct cctttacaaa aacaaaaagt aaaccaacat
     8461 caacaaaaca gcccattcat tcatgtcaca ccaatagttt cgtgttcatt gtttgccact
     8521 ggagtcaatt ttactatgag caatgtaagg ctggttacct tttaattatt tggttgatgt
     8581 ggaaaattgg tgatgtacta tgtttctagg tctttttcat tgccttttta ttctgatgtt
     8641 aggttaatca ctttgaagct atagatatgc tgtaacattt agcatggctt cacacaagtt
     8701 agtgtagcca gtgaagaaat attaccataa tgactgcagt tgtcctgaca tggcatctgc
     8761 attgctcgga gctttccttc ttaaacccta ggttataaac tacagactga gggagaactg
     8821 ttgcaagcag gcggttctca attacacaca tgttcttctc atgtttgaca gtgtgatctc
     8881 tgggtggaat aaagaacact taaacttaac aacttggtaa tgggaatttt gaaagattta
     8941 aaacaaaata agcaaaaatt tgctacacca ggatgctggc tggagcctag tagactgtat
     9001 ttggtgtgct tatttcgttc tttgctagag cttactaagt gactcttttc aaactgtcct
     9061 tctgtgcgat cccagtgatg cggaagtcct cagaatccca caatctttgg agtacctttg
     9121 caccaaggtc tctggctgat ttctctgctc agtcataatt ttacttgaaa gcaaaatggt
     9181 cctagctcct tttccattat tccaaaaaat ttaacattca aagcagggtc taatttaaaa
     9241 cgttactggt agttaatata attgactgat taaattttag agtaaacaat ttgaataaag
     9301 ataaaggaat cagttaaaac tgtatttcaa agaaaattgg tgacttgaat atgtgtaatt
     9361 ttttggaacc tgtctaaaac caaatacccc tgcaaacaga tacaacctac cctatttaaa
     9421 tattttgctg ttttatttta tagaaattat tttgctgaat ttgcaaatag aatttgattt
     9481 aagaagaact ttttgtcctg tggtgtgttt gggggttttg gtaccttctc tgtctgcctg
     9541 tgtgtgtgtg tgtgtctgcc tgccccccac ccctctctga ggactgcata tttctggaaa
     9601 gctaattctg tgcatagcat gtttacacaa cctacagtga agattttaag tctcattaag
     9661 tttttgtgca cagaaagatg gggtctttgg ctctttacta aagacttgga gaacaggatg
     9721 ttgacgctgt aaaagttccc tagcaatcaa tcttacactt tttgtatgtt tttatataca
     9781 tgtgtattta atgagcacaa gcttggttgt atttttatga ttcagttgat aggaaaatgt
     9841 tgaaaggcta tagttggcat tgatcaaagc agaagcaaaa ttgagcatta tgttattttg
     9901 tgatttaaaa ggggcagtat ttaagataaa ggtttaggtg tcttatttgc agtattccac
     9961 agttctgctt ctaggctgcc tgtaatttta gcaacttttg acaccagcta gagtctgttt
    10021 acatcagaat ttgcttttgt tttggttttt ggagcctggg gatccagggc ctgaagtccc
    10081 cccaggcaag tgctctacaa ctcaggctga gcctccagcc cgagttgaag tttgagcaaa
    10141 gattgtacag tgtttgcagt tccaactgga agttttttaa agttcttcaa gtagtgaagt
    10201 aggttggctt tgtttggacc agtaactggt actagttaca gtatcttacc atctgacatg
    10261 cgagtttggg attttctgct tcttaaggaa attatgaaat acttaaaact tagtgacttc
    10321 ctagataaga gaaaacttga cattttcaaa ggctgtgaat ttttcttgga ggaattctac
    10381 cccctacccc ctttagttgc tttgagtgtg taagcccacc agttccagat gatgagggct
    10441 tatgagtcat ggttcccttt catttgagga agagtaggcc tatgtcgtga acaggagtga
    10501 gggaaggtga acagagttat ttttgtttgt ttgtgcaaat tattttctat attaactctt
    10561 taagcattaa tgtataaccg gaaattttaa gatgcatgtt attgtaagag caacatagtg
    10621 gtgattttga ggtctttctc taaaacataa gtggcacatt ttaaaattca agtcttaaag
    10681 tgcctcaaag ttattttatt ctctcaactg atttcttttg agccatatgt tttctccttt
    10741 aaatgtttgt tatagaatca ctagtcttcg tttgaagtac tcccacgttt ctaaatggca
    10801 tgattactct attgaagaca gtagaatctg ttaacgtaag actgaagaga ttttggggtt
    10861 ggggatttag ctcagtggta gagcgcttgc ctaggaagcg caaggccctg ggttcggtcc
    10921 ccagctccga aaaatagaac caaaaaaaaa aaaaaaaaaa aaagactgaa gagattttag
    10981 ttgtgcaact gtgtaaactg gggctctgcc cagtcggatc taagtatttt tgtgtacaac
    11041 ttggtaaaca ccatattgct gctgtttcta agccctccac cttactgact tctcgtgttt
    11101 agcatcgcag aggcagaaat acaagcataa acatatatgg gctttgtttc tttttgttga
    11161 tttttctcag tgatgatttc ccagcttttt ttttttgtct cttagctatg attatacaga
    11221 cctagaatta ttcaaatgtt ttctattttc atgattaact tttattaggg gacaataaca
    11281 acttaagtct ttaatcctca tattggttaa aagatgagga gcctttttta tttgaattac
    11341 ttttgtaaaa gaaagcaaca gtctgaatat tcaggtgact actttggcat agttcttcag
    11401 gtttttatta gtgtttttcc aggttatgtt tttcccatga actttttact ttgttaattt
    11461 tgtggttaat ttggtggcta tatcctgcct tatttaggat tttaggaaat tgcctttttg
    11521 tgataagtgc ccagttttta tttctagttt gaaggtacga ggacataccg actgctgata
    11581 aaggaaaaca gcaccccttt gccccagctt ttgtgttacc aatagaacca ttcgcagtac
    11641 tggtttcatt gtagggccca accagaattg gtcctgcacc tacatgagtg ttgcatattt
    11701 ggaaagggtt tgggtgtgat aaatcactac ggaagtgctg aatgtattaa gaactcgctg
    11761 ccgattgtat ttctaacgat tattttgtgt ttgcacttgt cctccaagct tccaggtgta
    11821 agggggaaag gtgaaccaca ttttaaagtc actaatgagt gcaatttttt ttggaattgg
    11881 ggttcccaag aggaaatttc accacccaaa tcttacatac ttcttagcct tttacaagcc
    11941 aacagactga cataaagatt gtctgcaatt cgtaagatct agcacatata caaaaataaa
    12001 actttataaa ttaaatttgg gtttttcttt catttattaa cataaggttt ccccctatat
    12061 tgctaggggt ggcatgcagg gcatcaaatg tatataggca agtgccatat cactcagcca
    12121 catttggccc ttg
//
