LOCUS       NM_001135893           10475 bp    mRNA    linear   ROD 01-FEB-2021
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 9, X-linked (Usp9x),
            transcript variant 1, mRNA.
ACCESSION   NM_001135893 XM_001056701
VERSION     NM_001135893.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10475)
  AUTHORS   Zhang Y, Duan C, Yang J, Chen S, Liu Q, Zhou L, Huang Z, Xu Y and
            Xu G.
  TITLE     Deubiquitinating enzyme USP9X regulates cellular clock function by
            modulating the ubiquitination and degradation of a core circadian
            protein BMAL1
  JOURNAL   Biochem. J. 475 (8), 1507-1522 (2018)
   PUBMED   29626158
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10475)
  AUTHORS   Zhao Y, Majid MC, Soll JM, Brickner JR, Dango S and Mosammaparast
            N.
  TITLE     Noncanonical regulation of alkylation damage resistance by the
            OTUD4 deubiquitinase
  JOURNAL   EMBO J. 34 (12), 1687-1703 (2015)
   PUBMED   25944111
REFERENCE   3  (bases 1 to 10475)
  AUTHORS   Homan CC, Kumar R, Nguyen LS, Haan E, Raymond FL, Abidi F, Raynaud
            M, Schwartz CE, Wood SA, Gecz J and Jolly LA.
  TITLE     Mutations in USP9X are associated with X-linked intellectual
            disability and disrupt neuronal cell migration and growth
  JOURNAL   Am. J. Hum. Genet. 94 (3), 470-478 (2014)
   PUBMED   24607389
REFERENCE   4  (bases 1 to 10475)
  AUTHORS   Stegeman S, Jolly LA, Premarathne S, Gecz J, Richards LJ,
            Mackay-Sim A and Wood SA.
  TITLE     Loss of Usp9x disrupts cortical architecture, hippocampal
            development and TGFbeta-mediated axonogenesis
  JOURNAL   PLoS ONE 8 (7), e68287 (2013)
   PUBMED   23861879
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10475)
  AUTHORS   Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho
            AF, Domingues P, Wood SA, Rodriguez-Borges JE, Sa-Miranda C,
            Fransen M and Azevedo JE.
  TITLE     Identification of ubiquitin-specific protease 9X (USP9X) as a
            deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester
            conjugate
  JOURNAL   J. Biol. Chem. 287 (16), 12815-12827 (2012)
   PUBMED   22371489
  REMARK    GeneRIF: Our results suggest that ubiquitin-specific protease 9X
            (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5,
            both in female rat liver and HeLa cells.
REFERENCE   6  (bases 1 to 10475)
  AUTHORS   Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno
            M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S,
            Modena N, Argenton F, Newfeld SJ and Piccolo S.
  TITLE     FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta
            signaling, controls Smad4 monoubiquitination
  JOURNAL   Cell 136 (1), 123-135 (2009)
   PUBMED   19135894
REFERENCE   7  (bases 1 to 10475)
  AUTHORS   Nathan JA, Sengupta S, Wood SA, Admon A, Markson G, Sanderson C and
            Lehner PJ.
  TITLE     The ubiquitin E3 ligase MARCH7 is differentially regulated by the
            deubiquitylating enzymes USP7 and USP9X
  JOURNAL   Traffic 9 (7), 1130-1145 (2008)
   PUBMED   18410486
REFERENCE   8  (bases 1 to 10475)
  AUTHORS   Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M and Alessi DR.
  TITLE     Control of AMPK-related kinases by USP9X and atypical
            Lys(29)/Lys(33)-linked polyubiquitin chains
  JOURNAL   Biochem. J. 411 (2), 249-260 (2008)
   PUBMED   18254724
REFERENCE   9  (bases 1 to 10475)
  AUTHORS   Sato T, Kanai Y, Noma T, Kanai-Azuma M, Taya S, Matsui T, Ishii M,
            Kawakami H, Kurohmaru M, Kaibuchi K, Wood SA and Hayashi Y.
  TITLE     A close correlation in the expression patterns of Af-6 and Usp9x in
            Sertoli and granulosa cells of mouse testis and ovary
  JOURNAL   Reproduction 128 (5), 583-594 (2004)
   PUBMED   15509704
REFERENCE   10 (bases 1 to 10475)
  AUTHORS   Kanai-Azuma M, Mattick JS, Kaibuchi K and Wood SA.
  TITLE     Co-localization of FAM and AF-6, the mammalian homologues of
            Drosophila faf and canoe, in mouse eye development
  JOURNAL   Mech. Dev. 91 (1-2), 383-386 (2000)
   PUBMED   10704870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474009.2.
            
            On Oct 21, 2008 this sequence version replaced XM_001056701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..10475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..10475
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /note="ubiquitin specific peptidase 9, X-linked"
                     /db_xref="GeneID:363445"
                     /db_xref="RGD:1560056"
     exon            1..230
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            231..341
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            342..595
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     CDS             500..8143
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable ubiquitin carboxyl-terminal hydrolase FAF-X;
                     ubiquitin specific peptidase 9, X chromosome"
                     /codon_start=1
                     /product="probable ubiquitin carboxyl-terminal hydrolase
                     FAF-X isoform 1"
                     /protein_id="NP_001129365.1"
                     /db_xref="GeneID:363445"
                     /db_xref="RGD:1560056"
                     /translation="MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSP
                     ATPPDEQGQGDAPPQIEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAI
                     DLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCV
                     AKLAQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPK
                     GWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFL
                     PIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKSLASRVPGQEETVKNLEIF
                     RLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGSSEEEEWLTAERMAEWIQQ
                     NNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVH
                     DLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVL
                     NLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWV
                     IPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYM
                     ESMRLYGRDNEDYDPQTVRVGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWK
                     CLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCF
                     ERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYT
                     NLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSINCARQEAVRMVRVLTV
                     LREYINECDSDYHEERTILPMSRAFRGKHLSFIVRFPNQGRQVDDLEVWSHTNDTIGS
                     VRRCILNRIKANVAHTKIELFVGGELIDPGDDRKLIGQLNLKDKSLITAKLTQISSNM
                     PSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSS
                     LNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQV
                     LYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRG
                     AYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTSVNQVTHDQAVVLQSALQS
                     IPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWTSGCGGLQLVFSPNE
                     EVTKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLL
                     LHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTL
                     LRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGVEETILEGHLGVTKE
                     LLAFQTPEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGS
                     PATINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRP
                     PKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESN
                     VDPRDDVFGYPQQFEDKPPLSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFW
                     KQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQG
                     CPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRL
                     LIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNP
                     ESQLIQQNEQSESEKAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGEKNRWYKF
                     DDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDT
                     IDHDDEVIRYISEIAITTRPHQIVMPSAIERSVRKQNVQFMHNRMQYSLEYFQFMKKL
                     LTCNGVYLNPPPGQDHLSPEAEEITMISIQLAARFLFTTGFHTKKIVRGSASDWYDAL
                     CILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGP
                     CPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGV
                     AEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSS
                     INGNPSLPNPFGDPNLSQPIMPIQQNVVDILFVRTSYVKKIIEDCSNSDETVKLLRFC
                     CWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPD
                     DRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWL
                     GDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPD
                     DQDAPDEHESPPPEDAPLYPHSPGSQYQQPYTGPAAHHMNNPQRTGQRAQENYEGSEE
                     VSPPQTKDQ"
     exon            596..741
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            742..821
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            822..934
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            935..1153
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            1154..1269
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            1270..1521
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            1522..1660
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            1661..1813
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            1814..1918
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            1919..2125
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            2126..2262
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            2263..2396
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            2397..2484
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            2485..2827
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            2828..2923
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            2924..3135
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            3136..3376
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            3377..3526
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            3527..3647
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            3648..3778
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            3779..4057
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            4058..4183
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            4184..4309
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            4310..4476
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            4477..4585
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            4586..4732
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            4733..4879
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            4880..5102
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            5103..5323
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            5324..5514
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            5515..5688
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            5689..5830
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            5831..6584
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            6585..6708
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            6709..6934
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            6935..7064
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            7065..7250
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            7251..7471
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            7472..7560
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            7561..7717
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            7718..7930
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            7931..8026
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            8027..8440
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
     exon            8441..10475
                     /gene="Usp9x"
                     /gene_synonym="RGD1560056"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      
        1 gggcggcgct gagactagtg ggagtctgcg ctgctgccgc tgctgccgct gctgtcgctg
       61 tcgctgctgc cgctgccgcc gccgacactg ccactggccg tgcgggtttt ctttttcttt
      121 ttctttttct cttttctttt ttgatttgtt ggatccgcca tattgacgag gctgtggtac
      181 tcaaagctgc ggaagctaga ctccgccggt ggcggagccg caacctctcg cccctggctt
      241 gggatgctcc caggttaggc ctcgtcccag gatcgagctt ttgcatttcg tctcccgcct
      301 ccgcgtgtcc tgcttcttag aagactcctg tgttgtgttt ggttatgcaa tggtctctgc
      361 aagatgtttt attcttgaat tggaaccttt taagactgac aaatgctggt acttcgtctt
      421 ctataagtgg actataattt cttttcttaa gacaactaca taagcagaca aaattgcaaa
      481 gatctgccct gtgtcgagta tgacagccac gactcgtggc tctccagttg gagggaatga
      541 caaccagggc caagctcctg atggacagtc tcagcccccc ctccaacaga atcagacttc
      601 atcgcctgat tcatccaatg aaaattcccc tgcaactcct cctgatgagc aaggccaagg
      661 tgatgctcct ccccagattg aagatgagga acctgcattt ccacacactg acctggcaaa
      721 gttagatgat atgatcaaca ggcctcgctg ggtcgttcca gttttgccga aaggggaatt
      781 agaagtgctt ttagaagctg ctattgatct tagtaagaaa ggccttgatg tcaaaagtga
      841 agcatgtcag agatttttcc gagatgggct aacaatctca ttcacaaaaa tccttacaga
      901 tgaagcagtg agtggctgga agtttgaaat tcatagatgt attattaaca atactcatcg
      961 cctggtggag ctgtgtgtgg ctaagttagc ccaagactgg tttccacttc tagaacttct
     1021 tgccatggcc ttaaatcctc attgcaaatt ccatatctac aatggtacac gtccctgcga
     1081 gtcagtgtcc tcaagtgttc agttgcctga agatgaactc tttgctcgtt ctccagaccc
     1141 tcgatcacca aaaggttggc tagtggatct cctcaacaaa tttggcactt taaatggatt
     1201 ccagatactg catgatcgtt ttattaatgg atcagcatta aatgttcaga taattgcagc
     1261 ccttattaaa ccatttggac agtgctatga gtttcttact cttcacacgg tgaaaaaata
     1321 ctttcttcca ataatagaaa tggttccaca gtttttagaa aacttaactg atgaagagct
     1381 gaagaaagaa gcaaagaatg aagccaaaaa tgatgctctc tcaatgatta ttaaatcatt
     1441 gaagagttta gcttcacgag ttcctggaca ggaagaaact gtaaagaact tagaaatatt
     1501 taggttaaaa atgatactta gattattgca aatttcttcc ttcaatggaa agatgaatgc
     1561 actgaatgag gttaataagg tgatttccag tgtgtcatac tatacccatc ggcatggcag
     1621 ttctgaggaa gaagagtggc tcacagcaga gaggatggct gaatggatac agcagaacaa
     1681 tattttatca atagttttac gagatagtct tcatcaacca cagtatgtag agaaactaga
     1741 aaagattctt cgctttgtca taaaagaaaa agctctgacc ttgcaagatc ttgataatat
     1801 ctgggcagca caggcaggga aacatgaagc catcgtaaag aatgtccatg atctactggc
     1861 caaattggca tgggattttt ctcctgaaca acttgatcat ctttttgatt gctttaaggc
     1921 cagttggaca aatgcaagta aaaagcaacg tgaaaagctc cttgagctga ttcgtcgtct
     1981 tgcagaagat gataaagatg gtgtgatggc acataaagtg ttgaaccttc tgtggaatct
     2041 agctcacagt gatgatgtgc ctgtggatat catggacttg gctctcagtg ctcacatcaa
     2101 aatactagat tatagttgct cccaggaccg ggacacacaa aagatccagt ggatagatcg
     2161 cttcatagaa gaacttcgca caaatgacaa gtgggtcatt cctgcactga aacaaattag
     2221 agaaatttgc agtttgtttg gtgaagcacc tcaaaatttg agtcaaactc agagaagtcc
     2281 ccatgtattt tatcgccatg atttaatcaa tcaacttcag cacaatcatg ccctagttac
     2341 tttggtagca gaaaaccttg caacttacat ggaaagcatg agactgtatg gcagagacaa
     2401 tgaagactat gacccacaaa ctgtgagagt gggaagtaga tatagtcatg ttcaagaagt
     2461 ccaagaacgt cttaactttc ttagattttt attgaaggat ggccagctat ggctgtgtgc
     2521 tcctcaggca aaacaaatat ggaagtgctt agcagagaat gcggtttatc tttgtgaccg
     2581 tgaagcctgc tttaagtggt attccaaatt aatgggagat gaaccagact tagatcctga
     2641 tatcaataag gacttctttg aaagtaatgt gcttcagctt gatccttcac tattaactga
     2701 aaatggaatg aaatgttttg agagattctt caaagctgtg aattgtcgag aaggaaaact
     2761 agtagcaaaa agaagagcct atatgatgga tgatttggaa ttgataggat tagactatct
     2821 ttggagggtt gtaattcaga gtaatgatga tattgccagc cgagctattg atctcctcaa
     2881 agagatatac acaaaccttg gtccaagact gcaggtcaat caggtggtga tccatgaaga
     2941 cttcattcag tcttgctttg atcgtttgaa agcctcttat gacacgttgt gtgttttgga
     3001 tggtgacaaa gacagtatta attgtgcaag acaggaagct gttcgaatgg tccgagtatt
     3061 aactgtttta agagaatata taaatgaatg tgacagtgat tatcatgaag aaagaacaat
     3121 tttgcctatg tcaagagctt tccgtggtaa acacctctct tttatagttc ggtttccaaa
     3181 ccagggcaga caagtagatg acttggaagt ttggtctcat acaaatgata ccattggttc
     3241 agttcgacga tgtatactaa atcgcattaa agccaatgta gctcatacaa aaattgaact
     3301 ctttgtgggt ggtgagctta ttgatcctgg agatgacaga aagttgattg gacaattaaa
     3361 cctaaaagat aaatcactaa ttacagccaa acttacacaa atcagctcca atatgccgtc
     3421 aagtcctgat agctcctctg attcctcaac tggatctcct ggaaaccatg gtaatcatta
     3481 cagtgatggt cccaacccag aggtagaaag ctgtttgcct ggagtgataa tgtcacttca
     3541 tcccagatac atctctttcc tttggcaagt tgcagactta gggagcagcc taaatatgcc
     3601 ccctcttaga gatggagcaa gagttcttat gaaacttatg ccgccagata gtacaacaat
     3661 agaaaaatta agagctattt gtttagatca tgccaaactt ggagaaagca gccttagtcc
     3721 atctcttgac tcacttttct ttggtccttc agcctcacaa gtgctatacc taacagaggt
     3781 agtctatgcc ctgttaatgc ctgctggtgc acccctggct gatgactcct ctgattttca
     3841 gtttcacttc ttgaaaagtg gtggtttgcc ccttgttctg agtatgctaa ccagaaataa
     3901 cttcctacca aatgctgata tggaaactcg aaggggtgcc tacctcaatg ctcttaaaat
     3961 agccaaactg ttactaactg ccattggcta tggccatgtt cgggctgtgg cagaagcatg
     4021 tcagccaggt gtagaaggcg tgaatcctat gacatcggtc aaccaagtaa ctcatgatca
     4081 agcagtggtg ctacaaagtg cccttcagag cattcctaac ccatcatctg aatgcatgct
     4141 tagaaacgtg tctgttcgtc ttgctcagca gatttctgat gaggcttcaa gatatatgcc
     4201 tgatatttgt gtaattagag ctatacaaaa gattatttgg acatcaggat gtgggggatt
     4261 acaactggta ttcagcccaa atgaggaagt cacaaaaatt tatgagaaga ccaatgcagg
     4321 caatgagcca gaccttgaag atgaacaggt ttgctgtgag gcattggaag tgatgacact
     4381 gtgtttcgcc ctgattccaa cagccttaga tgctctaagt aaagaaaagg cttggcagac
     4441 atttattatt gacttactgt tacactgtca cagcaaaact gtccgtcaag tagcacagga
     4501 acaattcttc ttaatgtgca ccagatgttg catgggacac aggcctctac ttttcttcat
     4561 tactctactc tttactgttt tggggagcac agccagagag agggctaaac attcaggcga
     4621 ctactttact cttttaaggc atcttcttaa ttacgcttac aacagtaaca ttaatgtacc
     4681 caatgctgaa gttcttctaa ataatgaaat tgattggctt aaaagaatta gggatgatgt
     4741 taaaagaaca ggtgaaacag gcgttgaaga gacaatctta gaaggacacc ttggggttac
     4801 aaaggagcta ctggcttttc agacccctga gaaaaagttt catattggtt gtgaaaaggg
     4861 gggtgctaat ctcattaaag aattaatcga cgatttcatc tttcctgcat ccaatgttta
     4921 cctccagtat atgagaaatg gagaactccc tgctgagcag gccattcctg tctgtggttc
     4981 accagccaca attaatgctg gttttgagtt acttgtagca ttagctgttg gctgtgtaag
     5041 gaacctcaaa cagatagtag attctttgac tgaaatgtat tacattggta cagcaataac
     5101 tacttgtgag gcacttactg agtgggaata cctgccacct gttggacccc gtccaccaaa
     5161 aggatttgtg gggctgaaaa atgctggtgc tacttgttac atgaattctg tgattcagca
     5221 actctatatg attccctcta tcaggaacgg tattcttgca attgaaggca caggtagtga
     5281 tgtagatgat gatatgtctg gggatgagaa gcaggacaat gagagcaatg ttgatcccag
     5341 ggatgatgtg tttggatatc ctcaacaatt tgaagacaaa ccaccactga gtaaaacaga
     5401 agatagaaaa gagtacaata ttggtgttct aagacacctt caagttatct ttggccattt
     5461 agctgcttct cgactacagt actatgtgcc cagaggattt tggaaacagt tcaggctttg
     5521 gggtgagcct gttaatcttc gtgaacaaca tgatgcttta gagttcttta attcattggt
     5581 ggatagttta gatgaagctt taaaagcctt agggcatcca gctatgctaa gtaaagtctt
     5641 gggaggttcc ttcgctgatc agaaaatttg tcaaggctgc ccacataggt atgaatgtga
     5701 agaatctttt acgactctga atgtagacat tagaaaccac caaaatcttc ttgattcttt
     5761 ggaacagtat gtcaaaggag atttactaga aggggcaaat gcttatcatt gtgaaaaatg
     5821 caataaaaag gttgatactg taaagcgctt gctaattaaa aagttgcctc ctgttcttgc
     5881 tatccaacta aaacgattcg attatgactg ggaaagagaa tgtgcaatca agttcaatga
     5941 ttactttgag tttcctcgag agttagacat ggagccgtac acagttgcag gtgttgctaa
     6001 actagaggga gataatgtca acccagaaag tcagctgata caacagaatg agcagtctga
     6061 aagcgaaaaa gccggaagca caaaatacag acttgtgggt gtgcttgtac acagtggtca
     6121 agcaagtggg ggacattact attcttacat cattcagagg aatggaggag atggtgaaaa
     6181 aaatcgttgg tataaatttg atgatggaga tgtaacagag tgtaaaatgg atgatgatga
     6241 agaaatgaaa aaccagtgtt ttggtggcga gtacatggga gaagtgtttg atcacatgat
     6301 gaagcgcatg tcgtacaggc ggcagaaaag gtggtggaat gcatatatac ttttttatga
     6361 aagaatggat acgatagatc atgatgatga ggtgataaga tacatatcag agattgctat
     6421 caccacaagg ccccatcaga ttgttatgcc atcggccatt gaaagaagtg tgcggaagca
     6481 gaatgtccaa ttcatgcata accgaatgca gtacagtttg gaatattttc agtttatgaa
     6541 aaagctactt acatgtaatg gtgtttattt aaaccctcca ccagggcaag atcacctgtc
     6601 tcctgaagca gaagaaatca ctatgattag tattcagctt gctgctaggt tcctttttac
     6661 tacaggattt cacacaaaga aaatagtccg aggatccgcc agtgattggt atgatgcatt
     6721 gtgtattctc ctccgtcaca gcaagaatgt gcggttttgg tttgctcaca atgtgctttt
     6781 taatgtttca aatcgattct ctgagtacct tttggaatgc cctagtgcag aagtgagagg
     6841 tgcatttgct aaacttatag ttttcattgc acacttttcc ttacaagatg ggccttgtcc
     6901 ttcacctttt gcatctcctg gaccttctag tcaggcttat gataacttaa gtttgagtga
     6961 ccacctacta agagcagtac taaatctctt gaggagggag gtttcagagc atggacgtca
     7021 tttacagcag tatttcaact tgtttgtaat gtatgccaat ttaggagtgg cagagaaaac
     7081 acagctgctc aaactgagtg tacctgctac ctttatgctt gtgtccttag atgaaggtcc
     7141 tggtcctcca attaaatatc agtatgctga attaggcaaa ttatactccg tagtgtcaca
     7201 gttaatccgc tgttgcaatg tctcttcaag aatgcagtct tcaatcaatg gtaatccttc
     7261 tcttccaaat ccttttggtg atcctaattt atcacaacct ataatgccaa ttcaacaaaa
     7321 tgtggtagac attttatttg tgagaacaag ttatgtgaag aaaattattg aagactgcag
     7381 taactctgat gagaccgtca aattgcttcg cttttgctgc tgggagaatc ctcagttctc
     7441 atctactgtc ctgagtgaac ttctttggca ggttgcgtat tcctatactt acgaactccg
     7501 gccctatttg gatctgcttt tacaaatctt actgattgaa gactcctggc agactcacag
     7561 aattcataat gcccttaaag gaattccaga tgaccgagat gggctgtttg acacaattca
     7621 gcgttctaag aatcactatc aaaaaagagc ataccaatgt ataaaatgta tggtagccct
     7681 ctttagcagt tgtcctgtgg cttaccaaat cctgcagggc aatggagatc ttaaaaggaa
     7741 atggacctgg gcagtagagt ggcttggaga tgaactcgaa agaagaccat acactggcaa
     7801 tcctcagtac acttacaaca actggtctcc tccagtgcaa agcaatgaaa catcaaatgg
     7861 ctacttcttg gagagatcac atagcgctag gatgacactt gcaaaagctt gtgaactctg
     7921 tcctgaggag gaaccagatg accaagatgc cccagatgag catgaatcac ctccacctga
     7981 agatgcccca ttataccccc attcccctgg atctcaatat cagcagccct atacaggccc
     8041 agccgcacat cacatgaaca accctcagag aactggccaa cgagcacaag aaaattatga
     8101 aggcagtgaa gaagtgtccc cacctcagac caaggatcag tgaaatgcac atattaactg
     8161 gttccatcaa gactgtgcac ccaggcctta cagtccaact tttttctgtg tctggctaat
     8221 atttcaaact agaaaactat tcctaatcaa catggagtgg agagtttatt cactgtctta
     8281 tctgcagaaa tttgctgtca atatataacc cgcctgcagt ggaaagtgta tagtgttttg
     8341 taataaatgg cctgatgcta atgtgtaaat ggcaaaggtg tatatagtat attaatgttt
     8401 gactgttaat tcttaagcaa gagacttttt tttttcttga tgagactcac agatctacaa
     8461 aactacatta attttcttgt tactccctct gcactctgca gccagtgttg cctaccttgt
     8521 ggcagttgga tcacctcctt tacaaaaaca aaaagtaaac caacatcaac aaaacagccc
     8581 attcattcat gtcacaccaa tagtttcgtg ttcattgttt gccactggag tcaattttac
     8641 tatgagcaat gtaaggctgg ttacctttta attatttggt tgatgtggaa aattggtgat
     8701 gtactatgtt tctaggtctt tttcattgcc tttttattct gatgttaggt taatcacttt
     8761 gaagctatag atatgctgta acatttagca tggcttcaca caagttagtg tagccagtga
     8821 agaaatatta ccataatgac tgcagttgtc ctgacatggc atctgcattg ctcggagctt
     8881 tccttcttaa accctaggtt ataaactaca gactgaggga gaactgttgc aagcaggcgg
     8941 ttctcaatta cacacatgtt cttctcatgt ttgacagtgt gatctctggg tggaataaag
     9001 aacacttaaa cttaacaact tggtaatggg aattttgaaa gatttaaaac aaaataagca
     9061 aaaatttgct acaccaggat gctggctgga gcctagtaga ctgtatttgg tgtgcttatt
     9121 tcgttctttg ctagagctta ctaagtgact cttttcaaac tgtccttctg tgcgatccca
     9181 gtgatgcgga agtcctcaga atcccacaat ctttggagta cctttgcacc aaggtctctg
     9241 gctgatttct ctgctcagtc ataattttac ttgaaagcaa aatggtccta gctccttttc
     9301 cattattcca aaaaatttaa cattcaaagc agggtctaat ttaaaacgtt actggtagtt
     9361 aatataattg actgattaaa ttttagagta aacaatttga ataaagataa aggaatcagt
     9421 taaaactgta tttcaaagaa aattggtgac ttgaatatgt gtaatttttt ggaacctgtc
     9481 taaaaccaaa tacccctgca aacagataca acctacccta tttaaatatt ttgctgtttt
     9541 attttataga aattattttg ctgaatttgc aaatagaatt tgatttaaga agaacttttt
     9601 gtcctgtggt gtgtttgggg gttttggtac cttctctgtc tgcctgtgtg tgtgtgtgtg
     9661 tctgcctgcc ccccacccct ctctgaggac tgcatatttc tggaaagcta attctgtgca
     9721 tagcatgttt acacaaccta cagtgaagat tttaagtctc attaagtttt tgtgcacaga
     9781 aagatggggt ctttggctct ttactaaaga cttggagaac aggatgttga cgctgtaaaa
     9841 gttccctagc aatcaatctt acactttttg tatgttttta tatacatgtg tatttaatga
     9901 gcacaagctt ggttgtattt ttatgattca gttgatagga aaatgttgaa aggctatagt
     9961 tggcattgat caaagcagaa gcaaaattga gcattatgtt attttgtgat ttaaaagggg
    10021 cagtatttaa gataaaggtt taggtgtctt atttgcagta ttccacagtt ctgcttctag
    10081 gctgcctgta attttagcaa cttttgacac cagctagagt ctgtttacat cagaatttgc
    10141 ttttgttttg gtttttggag cctggggatc cagggcctga agtcccccca ggcaagtgct
    10201 ctacaactca ggctgagcct ccagcccgag ttgaagtttg agcaaagatt gtacagtgtt
    10261 tgcagttcca actggaagtt ttttaaagtt cttcaagtag tgaagtaggt tggctttgtt
    10321 tggaccagta actggtacta gttacagtat cttaccatct gacatgcgag tttgggattt
    10381 tctgcttctt aaggaaatta tgaaatactt aaaacttagt gacttcctag ataagagaaa
    10441 acttgacatt ttcaaaggct gtgaattttt cttgg
//
