LOCUS       NM_001024790            4487 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 7 (Usp7), mRNA.
ACCESSION   NM_001024790 XM_340747
VERSION     NM_001024790.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4487)
  AUTHORS   Wang,C., Zhu,Y., Zhu,X., Chen,R., Zhang,X. and Lian,N.
  TITLE     USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis
            and ameliorate spinal cord injury in rats
  JOURNAL   Neurochem Int 168, 105554 (2023)
   PUBMED   37257587
  REMARK    GeneRIF: USP7 regulates HMOX-1 via deubiquitination to suppress
            ferroptosis and ameliorate spinal cord injury in rats.
REFERENCE   2  (bases 1 to 4487)
  AUTHORS   Li,X., Wang,T., Tao,Y., Wang,X., Li,L. and Liu,J.
  TITLE     Inhibition of USP7 suppresses advanced glycation end-induced cell
            cycle arrest and senescence of human umbilical vein endothelial
            cells through ubiquitination of p53
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (3), 311-320 (2022)
   PUBMED   35538032
  REMARK    GeneRIF: Inhibition of USP7 suppresses advanced glycation
            end-induced cell cycle arrest and senescence of human umbilical
            vein endothelial cells through ubiquitination of p53.
REFERENCE   3  (bases 1 to 4487)
  AUTHORS   Xue,Q., Yang,D., Zhang,J., Gan,P., Lin,C., Lu,Y., Zhang,W.,
            Zhang,L. and Guang,X.
  TITLE     USP7, negatively regulated by miR-409-5p, aggravates
            hypoxia-induced cardiomyocyte injury
  JOURNAL   APMIS 129 (3), 152-162 (2021)
   PUBMED   33241864
  REMARK    GeneRIF: USP7, negatively regulated by miR-409-5p, aggravates
            hypoxia-induced cardiomyocyte injury.
REFERENCE   4  (bases 1 to 4487)
  AUTHORS   Pluciennik,A., Liu,Y., Molotsky,E., Marsh,G.B., Ranxhi,B.,
            Arnold,F.J., St-Cyr,S., Davidson,B., Pourshafie,N., Lieberman,A.P.,
            Gu,W., Todi,S.V. and Merry,D.E.
  TITLE     Deubiquitinase USP7 contributes to the pathogenicity of spinal and
            bulbar muscular atrophy
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   33170804
  REMARK    GeneRIF: Deubiquitinase USP7 contributes to the pathogenicity of
            spinal and bulbar muscular atrophy.
REFERENCE   5  (bases 1 to 4487)
  AUTHORS   Tang,L.J., Zhou,Y.J., Xiong,X.M., Li,N.S., Zhang,J.J., Luo,X.J. and
            Peng,J.
  TITLE     Ubiquitin-specific protease 7 promotes ferroptosis via activation
            of the p53/TfR1 pathway in the rat hearts after
            ischemia/reperfusion
  JOURNAL   Free Radic Biol Med 162, 339-352 (2021)
   PUBMED   33157209
  REMARK    GeneRIF: Ubiquitin-specific protease 7 promotes ferroptosis via
            activation of the p53/TfR1 pathway in the rat hearts after
            ischemia/reperfusion.
REFERENCE   6  (bases 1 to 4487)
  AUTHORS   Baek,K.H., Lee,H.J., Kim,M.S., Kim,Y.S., Seong,M., Lee,E.J. and
            Lee,M.Y.
  TITLE     Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in
            rat testis
  JOURNAL   Oncol Rep 15 (1), 173-177 (2006)
   PUBMED   16328052
  REMARK    GeneRIF: A rat HAUSP from testis was identified and cloned.
REFERENCE   7  (bases 1 to 4487)
  AUTHORS   Lee,H.J., Kim,M.S., Kim,Y.K., Oh,Y.K. and Baek,K.H.
  TITLE     HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated,
            polyneddylated, and dimerized
  JOURNAL   FEBS Lett 579 (21), 4867-4872 (2005)
   PUBMED   16111684
  REMARK    GeneRIF: Data show that rat HAUSP (rHAUSP, Usp7_predicted) is
            polyubiquitinated, polyneddylated, and dimerized, and suggest that
            rHAUSP may function as a dimer or multimer and is also degraded
            through the proteasome-mediated degradation.
REFERENCE   8  (bases 1 to 4487)
  AUTHORS   Hong,S., Kim,S.J., Ka,S., Choi,I. and Kang,S.
  TITLE     USP7, a ubiquitin-specific protease, interacts with ataxin-1, the
            SCA1 gene product
  JOURNAL   Mol Cell Neurosci 20 (2), 298-306 (2002)
   PUBMED   12093161
REFERENCE   9  (bases 1 to 4487)
  AUTHORS   Li,M., Chen,D., Shiloh,A., Luo,J., Nikolaev,A.Y., Qin,J. and Gu,W.
  TITLE     Deubiquitination of p53 by HAUSP is an important pathway for p53
            stabilization
  JOURNAL   Nature 416 (6881), 648-653 (2002)
   PUBMED   11923872
REFERENCE   10 (bases 1 to 4487)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 29, 2022 this sequence version replaced NM_001024790.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY641530.1, SRR26643429.35445.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000010.1  7387353-7387434
            83-187              JAXUCZ010000010.1  7403745-7403849
            188-386             JAXUCZ010000010.1  7408405-7408603
            387-525             JAXUCZ010000010.1  7410518-7410656
            526-614             JAXUCZ010000010.1  7411706-7411794
            615-723             JAXUCZ010000010.1  7412894-7413002
            724-854             JAXUCZ010000010.1  7413951-7414081
            855-909             JAXUCZ010000010.1  7414537-7414591
            910-990             JAXUCZ010000010.1  7415494-7415574
            991-1081            JAXUCZ010000010.1  7415677-7415767
            1082-1164           JAXUCZ010000010.1  7417167-7417249
            1165-1274           JAXUCZ010000010.1  7419329-7419438
            1275-1431           JAXUCZ010000010.1  7421316-7421472
            1432-1576           JAXUCZ010000010.1  7422184-7422328
            1577-1707           JAXUCZ010000010.1  7422616-7422746
            1708-1842           JAXUCZ010000010.1  7422940-7423074
            1843-1944           JAXUCZ010000010.1  7423549-7423650
            1945-2050           JAXUCZ010000010.1  7423831-7423936
            2051-2143           JAXUCZ010000010.1  7424666-7424758
            2144-2211           JAXUCZ010000010.1  7424842-7424909
            2212-2312           JAXUCZ010000010.1  7425544-7425644
            2313-2466           JAXUCZ010000010.1  7426447-7426600
            2467-2534           JAXUCZ010000010.1  7427021-7427088
            2535-2643           JAXUCZ010000010.1  7427696-7427804
            2644-2721           JAXUCZ010000010.1  7427899-7427976
            2722-2822           JAXUCZ010000010.1  7428590-7428690
            2823-2922           JAXUCZ010000010.1  7429168-7429267
            2923-3042           JAXUCZ010000010.1  7429970-7430089
            3043-3114           JAXUCZ010000010.1  7430199-7430270
            3115-3205           JAXUCZ010000010.1  7430389-7430479
            3206-4487           JAXUCZ010000010.1  7430737-7432018
FEATURES             Location/Qualifiers
     source          1..4487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..4487
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /note="ubiquitin specific peptidase 7"
                     /db_xref="GeneID:360471"
                     /db_xref="RGD:1306915"
     CDS             1..3312
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /EC_number="3.4.19.12"
                     /note="herpes-virus-associated ubiquitin-specific
                     protease; rHAUSP; ubiquitin thioesterase 7;
                     deubiquitinating enzyme 7; ubiquitin-specific-processing
                     protease 7; herpesvirus-associated ubiquitin-specific
                     protease; ubiquitin specific peptidase 7 (herpes
                     virus-associated); ubiquitin specific protease 7 (herpes
                     virus-associated)"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 7"
                     /protein_id="NP_001019961.2"
                     /db_xref="GeneID:360471"
                     /db_xref="RGD:1306915"
                     /translation="MNHQQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVIN
                     GNVALSDGHSNAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMV
                     MPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDDKSFSRRISHLFF
                     HKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLK
                     NQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVG
                     TKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQ
                     CKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEK
                     GVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYI
                     LHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSV
                     RHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYM
                     QVQIVAEDQFCGHQGNDMYDEEKVRYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLW
                     PMQARSNGTKRPAMLDNEADGSKTMIELSDNENPWTIFLETVDPELAASGATLPKFDK
                     DHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVK
                     PNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVI
                     FCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRH
                     NYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPD
                     KHGCVRDLLEECKKAVELGDKASGRLRLLEIVSYKIIGVHQEDELLECLSPATSRTFR
                     IEEIPLDQVDIDKENEMLITVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLD
                     IQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPK
                     RSRYTYLEKAIKIHN"
     exon            1..82
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            83..187
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            188..386
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            387..525
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            526..614
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            615..723
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            724..854
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            855..909
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            910..990
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1081
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1164
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1274
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1431
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1576
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1707
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1842
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1944
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2050
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2143
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2211
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2312
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2466
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2534
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2643
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2721
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2822
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2922
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3042
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3114
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3205
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..4487
                     /gene="Usp7"
                     /gene_synonym="Hausp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaccacc aacagcagca gcagcagcag cagaaagcgg gcgagcagca gctgagcgag
       61 cccgaggaca tggagatgga agctggagat acagatgacc caccaagaat tactcagaac
      121 cccgtcatca atggaaatgt agccctgagt gatgggcaca gcaacgcaga ggaggacatg
      181 gaggacgaca ccagttggcg ctccgaggca acctttcagt tcactgtcga gcgcttcagc
      241 agactgagtg agtcggtcct tagccctccg tgttttgtgc gaaatctgcc atggaagatt
      301 atggtgatgc cacgctttta tccagacaga ccacaccaaa aaagcgtagg attctttctc
      361 cagtgcaatg ctgaatctga ctccacgtcg tggtcctgcc atgcacaagc agtgctgaag
      421 ataataaatt acagggatga cgacaagtca ttcagccggc gaatcagcca cttgttcttc
      481 cacaaggaaa acgactgggg attctctaat ttcatggcct ggagtgaagt gactgatcct
      541 gagaaaggat ttatagatga tgacaaagtc acctttgaag tttttgtaca ggcggatgct
      601 ccccatggag ttgcgtggga ctcaaagaag catactggct atgtcggctt aaagaatcag
      661 ggagcgacgt gttacatgaa tagcttgctg cagaccttgt ttttcacaaa tcagttacga
      721 aaggctgtgt acatgatgcc aacagagggt gatgattcat ctaaaagcgt ccctttagca
      781 ttgcagagag tgttctatga gttacagcac agcgataagc ctgtaggaac aaaaaagctc
      841 acaaagtcat ttgggtggga aactttagat agcttcatgc aacacgatgt tcaagaactt
      901 tgtcgagtgt tgcttgataa tgtggaaaat aaaatgaaag gcacatgtgt agaaggcacc
      961 attcccaagt tattccgagg caaaatggtg tcttatattc agtgcaaaga agtagactac
     1021 cgttctgata ggagagaaga ttattatgat atccagctaa gtataaaagg aaagaaaaac
     1081 atatttgaat catttgtgga ttatgtggca gtagaacaac tagacggtga caataaatac
     1141 gacgctgggg agcatggcct gcaggaagca gagaagggcg tgaagttcct gaccttgccc
     1201 ccagtcttac acctgcagct catgcggttc atgtacgacc ctcagacgga ccaaaacatc
     1261 aagatcaatg acaggtttga gtttccagaa cagttaccac ttgatgaatt tttgcaaaaa
     1321 acggacccta aggaccctgc aaattatatt ctccatgcag tcttggttca cagtggagat
     1381 aatcatggtg gacattacgt ggtttaccta aaccccaaag gggatggcaa atggtgtaaa
     1441 tttgatgatg acgtggtatc caggtgtact aaagaagaag caatcgagca caattatggg
     1501 ggtcatgatg acgatctatc tgttcgacac tgcacaaatg cctatatgtt agtgtacatc
     1561 agggaatcaa agctgagtga ggtgttgcaa gctgtcaccg accatgatat tcctcagcag
     1621 ttggtggaac gtttgcaaga agagaaaagg atcgaggctc agaagcggaa ggagcggcag
     1681 gaagcccatc tctacatgca agtgcagata gttgcagagg accagttttg tggccaccaa
     1741 ggaaatgaca tgtacgacga ggagaaagtg aggtacaccg tgttcaaggt tctgaagaac
     1801 tcctccctgg ccgagtttgt tcagagcctc tcgcagacca tggggtttcc acaagatcag
     1861 attcgattat ggcctatgca agcaaggagt aacgggacaa agcggcctgc aatgttagat
     1921 aatgaagccg acggcagcaa aacaatgatt gaactgagtg ataatgaaaa cccttggaca
     1981 atattcctgg aaacagttga ccctgagctg gctgctagtg gagcaacact gcccaagttt
     2041 gataaagatc atgatgtaat gttatttttg aagatgtatg atcctaaaac acggagcttg
     2101 aattactgtg gacacatcta cacacccata tcctgtaaaa tacgtgactt gctcccggtt
     2161 atgtgtgaca gagcaggatt tatccaggat actagcctta tcctctatga ggaagttaag
     2221 ccgaatttaa cagagagaat tcaggactat gatgtgtctc ttgataaagc cctcgatgag
     2281 ctgatggatg gtgacatcat cgtgtttcag aaggatgacc cggaaaacga taacagtgag
     2341 ctacccactg ctaaggagta cttcagagac ctctaccatc gcgtcgacgt catcttctgt
     2401 gacaaaacga tccctaatga ccctgggttt gtggtcacct tatcaaatag gatgaattat
     2461 tttcaggttg caaagacagt tgcacagagg ctcaacacag accccatgtt gcttcagttt
     2521 ttcaagtctc aaggttatag ggacggcccc ggtaatcccc ttaggcataa ttacgaaggt
     2581 actttaagag atcttctaca attcttcaag ccaagacaac ctaagaaact ttactatcag
     2641 cagcttaaga tgaaaatcac ggactttgag aacaggagaa gttttaagtg tatatggtta
     2701 aacagccaat ttagggaaga ggaaataaca ctatacccag acaagcatgg ctgtgtccgg
     2761 gacctgttag aagaatgtaa aaaagccgtg gagcttggtg acaaagcatc agggagactt
     2821 aggctgctag aaattgtgag ctacaaaatt attggtgtgc accaagaaga tgaactatta
     2881 gagtgcttat ctcctgcaac gagtcggact tttagaatag aggaaatacc tttggaccag
     2941 gtagacatcg ataaggaaaa cgagatgcta atcacggtgg cgcatttcca caaagaagtg
     3001 tttgggacat tcggaattcc gtttttgctg aggatacacc agggtgagca tttcagagaa
     3061 gtgatgaagc ggattcagag cctgctggat atccaggaaa aggagtttga aaagtttaaa
     3121 ttcgcaattg tcatgatggg ccggcaccag tacatcaatg aagatgagta tgaagtgaat
     3181 ttgaaggact ttgagccaca acctggtaac atgtctcatc ctcggccttg gctagggctt
     3241 gaccacttca acaaagcccc aaagaggagt cgctacactt acctagaaaa ggcaattaaa
     3301 atccacaact gacttccttc ccgtgtccaa ggcgagggac agtgcgtggg tgtgtgccct
     3361 ttttaacagc cgtagaactc tggtgcacgt gcactctacc cgaagtctcc agcaagaggg
     3421 tttgctgccg atgttatttt attttgttga ggctgttcag tttggcttct ctgtatctat
     3481 tgactgccct ttttgagcaa aatgaaggtg tttttataaa gcttggatgc caatgagagt
     3541 tattttatgg taaccacaat gcaaggcaac catcagcatc atgggaggag gagaggttcc
     3601 taggatgtga gtccccggca ggaggttatc tggttggcac aggcagcttg gccacctgcc
     3661 cgggtcctgc caccagccct gcagctagtc agctgatgaa tataggctcg tccgatttct
     3721 tcttcagtta gactttgtga cctgtgtgcc tgtaaaggca aaccagagaa acagccctaa
     3781 tcagtagcac tctccttcac catgtgcgtt gcaggccctc ctggggttcc tctcctcagc
     3841 tgcctggagt ctttaataac tgtctcttct tcagctagtt ctgttgggca gcccattcac
     3901 aaagtggatg cactgaacac ggtcagtcct gacagttaga ggtcttttta tacactgaga
     3961 acattgtcag atacaattaa ggtttactct gttgcccatt ggcaaacata atgatctgag
     4021 caggtgaaaa gtcactctag gcttgtgagg acagagtgtg caagcgaccg aggaggagag
     4081 cctttcagca agagcgcatg ctcgctagtg gttagtaagc tgttgacttt gtaaaaaaga
     4141 taaaataaaa aaggaaaatg gaaaatgaaa ttgtatattt aatgaatgaa acctgtacaa
     4201 tttgccctgg gaggaggttg ttttctgttg ggtgagtgca agtgaacttg gccgacttgg
     4261 actctgcgta gctttacggg ccctctcctt gtttcccttt ctgttggagc tatgccagct
     4321 gcgtgtctag tttggagtgc gagtagaacg agcaagccac tcttctcccc ccccacccca
     4381 cccccagtgc ttctgtttgt ttctgtagca gcagtgtaca ccaatcctcc tgtatattgc
     4441 ctttttgctg gaaaatgttg tatgttgaat aaaattttct ataaaaa
//
