LOCUS       NM_001389268            5960 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 53 (Usp53), mRNA.
ACCESSION   NM_001389268 XM_006233262
VERSION     NM_001389268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5960)
  AUTHORS   Li,Q., Li,R., Chu,X., An,X., Chen,M., Yu,Y., Zhang,L., Chen,L. and
            Zhu,X.
  TITLE     Ubiquitin-specific peptidase 53 promotes chronic constriction
            injury-induced neuropathic pain through the RhoA/ROCK pathway
  JOURNAL   Acta Neurobiol Exp (Wars) 82 (4), 468-476 (2022)
   PUBMED   36748970
  REMARK    GeneRIF: Ubiquitinspecific peptidase 53 promotes chronic
            constriction injuryinduced neuropathic pain through the RhoA/ROCK
            pathway.
REFERENCE   2  (bases 1 to 5960)
  AUTHORS   Kazmierczak,M., Harris,S.L., Kazmierczak,P., Shah,P.,
            Starovoytov,V., Ohlemiller,K.K. and Schwander,M.
  TITLE     Progressive Hearing Loss in Mice Carrying a Mutation in Usp53
  JOURNAL   J Neurosci 35 (47), 15582-15598 (2015)
   PUBMED   26609154
REFERENCE   3  (bases 1 to 5960)
  AUTHORS   Schwander,M., Sczaniecka,A., Grillet,N., Bailey,J.S., Avenarius,M.,
            Najmabadi,H., Steffy,B.M., Federe,G.C., Lagler,E.A., Banan,R.,
            Hice,R., Grabowski-Boase,L., Keithley,E.M., Ryan,A.F.,
            Housley,G.D., Wiltshire,T., Smith,R.J., Tarantino,L.M. and
            Muller,U.
  TITLE     A forward genetics screen in mice identifies recessive deafness
            traits and reveals that pejvakin is essential for outer hair cell
            function
  JOURNAL   J Neurosci 27 (9), 2163-2175 (2007)
   PUBMED   17329413
REFERENCE   4  (bases 1 to 5960)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 7, 2020 this sequence version replaced XM_006233262.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222386.1, SRR22582419.2264741.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               JAXUCZ010000002.1  213805064-213805308 c
            246-886             JAXUCZ010000002.1  213790202-213790842 c
            887-979             JAXUCZ010000002.1  213783685-213783777 c
            980-1114            JAXUCZ010000002.1  213782506-213782640 c
            1115-1228           JAXUCZ010000002.1  213781347-213781460 c
            1229-1311           JAXUCZ010000002.1  213781185-213781267 c
            1312-1417           JAXUCZ010000002.1  213779284-213779389 c
            1418-1564           JAXUCZ010000002.1  213778040-213778186 c
            1565-1714           JAXUCZ010000002.1  213777201-213777350 c
            1715-1877           JAXUCZ010000002.1  213775217-213775379 c
            1878-2030           JAXUCZ010000002.1  213774608-213774760 c
            2031-2174           JAXUCZ010000002.1  213773561-213773704 c
            2175-2907           JAXUCZ010000002.1  213771428-213772160 c
            2908-2984           JAXUCZ010000002.1  213769403-213769479 c
            2985-3081           JAXUCZ010000002.1  213748365-213748461 c
            3082-5960           JAXUCZ010000002.1  213744106-213746984 c
FEATURES             Location/Qualifiers
     source          1..5960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..5960
                     /gene="Usp53"
                     /note="ubiquitin specific peptidase 53"
                     /db_xref="GeneID:295425"
                     /db_xref="RGD:1306615"
     exon            1..245
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            246..886
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     CDS             743..3991
                     /gene="Usp53"
                     /note="ubiquitin specific protease 53"
                     /codon_start=1
                     /product="inactive ubiquitin carboxyl-terminal hydrolase
                     53"
                     /protein_id="NP_001376197.1"
                     /db_xref="GeneID:295425"
                     /db_xref="RGD:1306615"
                     /translation="MAWVKFLRKPSGNLGKAYPAGSLLSLAPTVGLLNEPGQNSCFLN
                     SAVQVLWQLDIFRRSLRVLTGHICQGDACIFCALKTIFAQFQHSREKALPSDNIRHAL
                     AESFKDEQRFQLGLMDDAAECFENILARIHFHLAPNRDADMCTSKSCVTHQKFAMTLY
                     EQCVCRSCGASSDPLPFTEFVRYISTTALCNEVERMMERHERFKPEMFADLLQAANTA
                     DDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSEHSDLTEDVVRSLATHLYLPGLF
                     YRVTDENAVDSELHLVGMICYTSRHYCAFAFHTKSSKWVFFDDALVKEIGTRWKDVVS
                     KCIRCHLQPLLLFYANPDGTAVSTEDALKQVVHWSHYKSVEENMGCEKPIIYKPDNLK
                     ENGFGGQIKQKENHKFQGDNISSFNRSQVQTSGRRAPVKLSHDQREKIKDISRECALK
                     AMEQKNALSSQRKELEKGQRKDTGRHRDVVDEDLSSFKSASPPASDGFRQQGNPHLYH
                     SQGKGPCKHDRAASESSSSGKVMSSSRSQNPLVPGEKTTGKAKSDSGTGYDTDSSQDS
                     RDKGGSYGSRTKSRHRGWKPMRETLNVDSVFSESEKRQHSPRRKSDIGNRPKCSKDQS
                     CNNWPKANPKRKGLMTIYEDEMKQEAGSRSSHETNGKGAEKNTGAAESRGPGSSWQMQ
                     RTESGYESSDHVSNGSASLDSPGIDGSGAVMDVGGGKAFSEQIKMNSPNTDSVECVSH
                     QSKDLPEGFRKDLQDLEADDKSYELHPESHVQIKNHLIKRSQIGETNDKLFPSASSQT
                     PAREYVYQTNEQKGEKPDRTKCSEWRNTEISEGMGLPFHVDESSVAGKRVNSNETVSP
                     SSLSSSVRTAGLKAETGPVIFWPQQNITEQGYSENSLSRELTRQSACNADSCQMPKLH
                     CHRSPPPLPPKKYSTTSVPRLERAGFIPDVRLPEAFNTNFSSLPKHSLSTASGPSSEG
                     SAYMTQEKDKETIQVKHQAANSCPSSCSTGGFQANSKALVNMFCEPDQDSRSMCPSET
                     VSLTTYFSVDSCMTDTYRLKYHQRPKLCFPESSGHCSDKSLSQTEQVEGSIT"
     exon            887..979
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1114
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1228
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1311
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1417
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1564
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1714
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1877
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2030
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2174
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2907
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..2984
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3081
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..5960
                     /gene="Usp53"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcggga gccccggctg ggcggaggac tcgcgtcccc acggcctggc ggcgctcggg
       61 cgcgctgacc cgggtggccg caggctgaag gcgggatccg gccgggtcgg gatgcgctgg
      121 ccaggctcct gcggctcacg gttcaaccct acagccgtcc gagcactcag ccttctccag
      181 ggctccagca tgattggcgt ccctctttgg gagagcagac tggattggat gtgatagaat
      241 cttggatttg agtcatgctg atgaagtatg gagtcctttg ctaacttcac ccagatcaga
      301 gaaaagctgc ttcactaaag acgcataaag aaaacaatga ccagaggagc cctgcagacg
      361 ccaactgtgc agcttggatc ttctgttctc agcccagcag gactaatgac ttacacgtta
      421 aagaacatga tctattcatc atatattttt agcagttaat ttttatcagt gtgtccaact
      481 tataaaattt aaatgttatc aaacctggaa ggccttgttt aaaataggtt gcttttttta
      541 gctctcagaa attcaccatt tactttgttt ttacatatga aagtcctcag aaatgtagcc
      601 catcaggaac aatatgggct tggaagcata cagtcttatt gtggattgcc gtggaattca
      661 gtggacagcg caacatcacc cattttcttg tccagaatac cacatcaaca cactacttta
      721 atgcaaaaga agtggcttga aaatggcctg ggtgaaattt ttacggaagc ctagtggtaa
      781 ccttggcaaa gcctatccag ctggaagctt gctgtccctg gcccctactg taggcctgtt
      841 aaatgagcca ggacagaaca gctgctttct taacagtgct gtacaggttt tatggcaatt
      901 agatatattc cgaagaagct tgagagttct gactggacat atatgtcagg gagatgcctg
      961 tatattttgt gcattgaaga caatatttgc acaatttcaa cacagtcgag agaaagcact
     1021 tccgtcagat aacataaggc atgctcttgc agagagcttc aaagatgagc agagatttca
     1081 gcttggcctc atggacgatg ctgccgagtg ctttgaaaat atactggcaa gaattcattt
     1141 tcacctggcg ccaaacaggg atgcagacat gtgcacctct aaatcgtgtg tgactcatca
     1201 gaagtttgcc atgactctgt atgaacagtg tgtgtgccgc agctgtggag cgtcctcaga
     1261 ccctctgccc ttcacggaat tcgtgcggta catttctaca acagccctgt gcaatgaagt
     1321 tgaaagaatg atggaaaggc atgaacgatt taaaccagag atgttcgcag acttgctgca
     1381 agctgcaaat acagcagatg actaccggaa gtgccctagt aactgtggcc aaaaaataaa
     1441 aatccgccgt gttttaatga attgcccaga gattgttaca attggattag tctgggactc
     1501 tgagcactcg gacttgactg aagatgttgt tcgaagtcta gccacgcatc tctaccttcc
     1561 tgggcttttt tacagggtta ctgatgaaaa tgccgtagac agtgaactgc accttgttgg
     1621 tatgatctgt tacaccagcc gacactactg tgcctttgcg tttcacacca agagctccaa
     1681 gtgggtgttt tttgatgatg cacttgtgaa ggagatcgga accagatgga aagatgtggt
     1741 ctccaagtgc atccgatgcc acttacagcc acttttgctg ttttatgcaa acccagatgg
     1801 tacagcagtc tctactgagg acgcactcaa gcaggttgtc cactggtcac attacaaatc
     1861 tgttgaagaa aatatgggat gtgaaaagcc tatcatttat aaaccagata atttgaagga
     1921 aaatggattt ggtggtcaga taaagcagaa agaaaatcac aaatttcaag gtgataacat
     1981 ttcctccttt aatcggagcc aagtgcagac aagtggaagg agagcaccag ttaagttaag
     2041 ccatgatcaa agagaaaaga taaaagacat ttccagagaa tgtgctctga aagccatgga
     2101 acagaaaaat gcactttctt ctcaacgaaa agagttagaa aagggacaga ggaaagacac
     2161 aggccggcac agagatgtgg ttgatgaaga cctgtcgtct ttcaagtctg cttcacctcc
     2221 tgcttcagat ggctttagac aacaagggaa cccccatctg taccacagcc aaggcaaagg
     2281 accttgtaaa catgaccgag ctgcctctga gagctcctcc tcaggaaaag tgatgagttc
     2341 aagcagatcc cagaatcctc ttgttcctgg agagaagaca acaggcaaag ctaagagtga
     2401 cagtggcact ggttatgata cagacagcag ccaagattca agggacaaag gaggcagcta
     2461 cggtagtagg accaaaagcc gccaccgagg ctggaaaccc atgagagaaa cattaaacgt
     2521 cgatagtgtt tttagtgaaa gtgagaaaag gcagcatagt ccaaggcgga agtcagatat
     2581 tgggaacaga cctaagtgta gcaaggacca gagttgtaat aactggccaa aagcaaaccc
     2641 aaagcgaaaa ggcttaatga ccatatatga agatgaaatg aaacaagagg caggaagcag
     2701 aagttcccat gaaactaatg ggaaaggagc agagaaaaac acaggcgctg ccgagagcag
     2761 aggtcctgga agcagctggc agatgcagag gacagagtct gggtatgaga gcagcgatca
     2821 tgtcagtaat ggatctgcta gcttggactc tcctggtatt gatggaagtg gggcagtcat
     2881 ggatgtcggt ggtggtaaag ccttcagtga gcagattaag atgaacagcc caaacacgga
     2941 cagtgtggag tgtgtatctc atcagagcaa agacctccca gaaggcttta gaaaagacct
     3001 ccaggacttg gaagcagatg ataaatctta tgagctccac ccagaatcac atgtgcaaat
     3061 aaaaaaccat ttgataaaaa ggtcacagat tggtgaaacc aatgacaagc tgtttccttc
     3121 agccagctca caaacacctg caagagagta tgtctaccag acaaatgaac agaaaggaga
     3181 aaaaccagat aggaccaaat gttctgagtg gcgtaataca gaaatttctg aaggaatggg
     3241 tttgccattt catgttgatg agagttctgt ggctgggaag agagtcaaca gtaacgaaac
     3301 agtctcgcca tcttcattgt cttcgtctgt gagaactgct gggctaaagg ccgaaactgg
     3361 acccgtcata ttttggccac agcaaaacat cacagaacag ggttactctg agaattcgct
     3421 gtccagagaa ctcacacgtc agtctgcttg caatgctgat agttgccaga tgccaaaact
     3481 ccactgccac cgttcaccac cccctttgcc accaaagaaa tactctacaa ccagtgtgcc
     3541 caggttagag agagctggat ttatacctga cgtcaggctt cccgaggcat ttaacactaa
     3601 tttctccagt cttccaaaac acagcttgag tacagcctca ggaccaagtt cagaagggag
     3661 tgcgtacatg acccaggaaa aagataaaga aaccattcaa gtgaagcacc aggctgccaa
     3721 cagctgccca tctagttgtt caactggtgg ttttcaggca aactcaaaag cactcgtcaa
     3781 tatgttttgc gagccagatc aagactctag gtctatgtgt cccagtgaaa cagtttcgtt
     3841 aactacctat ttctcagttg atagttgcat gactgatacg tacagattga agtaccatca
     3901 aagacccaag ctctgttttc cggagagcag tggccattgt agtgataagt cactgtctca
     3961 gactgagcag gtagagggat ctattacata atggtccttt cttcaacctg tcctccgagc
     4021 aaagattaaa aaccctggca tgcattgttt gataaatgaa ccagccatta aaaataccaa
     4081 ctgataaaac ctaatgatat ataaaataaa acctgttatt ttgaaaatta ttaatcaggt
     4141 taacatatat tttatgatca atttactgaa tattttagaa atttcctttg gtcttggcgt
     4201 gccttgaaaa ataaggaagt gtctaattaa tttgctgtat gtaacagttg agcaagcgcc
     4261 gtgcctccta ctgttaggta gcaggtgttt aactactata cttcagtgta ggctggtgaa
     4321 ttctgctaaa taagaagtac agcgtgtcta ggaaagcagt atccgctttc gcagagcact
     4381 ttctggtggg taaccaaaag atggctatac ccacatgctt ttgacttcta tgatagtcta
     4441 atacaagtga tctttcaagt gtcttaaaaa tgcccatgga tttgctatgt tatcatctgg
     4501 aaagcatttg cttaatgatg aacaattttt aataaaaata tcaaggtcat ataaaattta
     4561 ctttgttcct agaacttttc agagtgtcta tcataattag ccattataac ttgtacccaa
     4621 aaatatttca gtcatgtaag ttaaaaataa aaatatggta gtatatttat cttatttaat
     4681 tgtcttctag ctttatatga aatgtgaaag atcttccctt tggtttgatt tactttaggc
     4741 tgctattaac caatgttaca agttaacttt gggcttcttc tcgggatggt cactgctgct
     4801 ttgatcacta aaagattgct agatggtctg tgcttttact attgaggctt ccaggttaaa
     4861 tttctgcctt tatataaggt ttaatcttaa tgaaatgttt tctttctttc tttctttttt
     4921 tttacttaaa caaataatgg ctttagctcc actaccatca cggagtggag tttatttata
     4981 ttaatttttt tcattatttt gaaagtaagc tgaattgcct tattagtttt tattttattt
     5041 tgtaacaggc tgaaaactag ttttagcata gtttcataat aactattcca gagaattaag
     5101 aactacaaaa ttagttgtct ttattacctc tctaaatggg aaggctcata atcatgactt
     5161 taaaactcat agctcgctga gccctacaaa ctactaaaac tcaaaaccca acacttgttt
     5221 aagaaaaggt acttttaact caaaattgct tataaaagtg ttgtcaattc ttagccaaac
     5281 cctgtttttg ttcatttcta gcataattgg tgaccatttc tttgtattct cttaaggaac
     5341 acttgaatat aaaattaaaa tttatcctta aagattattt tttaacagct tttagtacgg
     5401 agcgtttgta aataatgtaa actttgtaaa attgtatttg aaatgtcagt gtttataatt
     5461 cttgctttta taacactgta aaatactaga aaagatcttg ttatttttaa tagtttttaa
     5521 aagattttaa agtttaaaaa aaatcccatt tggtctctat tccctgttgg gaatgcatta
     5581 tctgaagcac taactaattt ctgtgcatta cagcagtttc ctagatgaac ctttcgactc
     5641 cgtcgagttt gcaaacagaa gtgtcatttc tcctctcggt tgatgcacag cttagttaca
     5701 cactctgcat tatctaagac tgaaatagag aacctgctcg tttgtcaatt caacacagaa
     5761 tagatccagt acgtttgcct aattaattgt atgtatttct tctctggtgc ctattgttaa
     5821 ccaatgtttc cgtgtcgata agcttgtaac ttcttaaatg atgtaatcat gtttcacata
     5881 gttatcttca gagtattata ttttcatgtg aaatcaactt cttttggctc aaaaaaaatg
     5941 aagcttaatt ttaagcagta
//
