LOCUS       NM_001394369            3091 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 5 (Usp5), transcript
            variant 2, mRNA.
ACCESSION   NM_001394369 XM_006237338
VERSION     NM_001394369.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3091)
  AUTHORS   Liu,Y., Soetandyo,N., Lee,J.G., Liu,L., Xu,Y., Clemons,W.M. Jr. and
            Ye,Y.
  TITLE     USP13 antagonizes gp78 to maintain functionality of a chaperone in
            ER-associated degradation
  JOURNAL   Elife 3, e01369 (2014)
   PUBMED   24424410
REFERENCE   2  (bases 1 to 3091)
  AUTHORS   Tsihlis,N.D., Kapadia,M.R., Vavra,A.K., Flannery,W.D.,
            Oustwani,C.S., Jiang,Q. and Kibbe,M.R.
  TITLE     Nitric oxide may inhibit neointimal hyperplasia by decreasing
            isopeptidase T levels and activity in the vasculature
  JOURNAL   J Vasc Surg 58 (1), 179-186 (2013)
   PUBMED   23375434
  REMARK    GeneRIF: Local administration of NO may prevent neointimal
            hyperplasia by inhibiting isopeptidase T levels and activity in the
            vasculature, thereby inhibiting the 26S proteasome in vascular
            smooth muscle cells.
REFERENCE   3  (bases 1 to 3091)
  AUTHORS   Dayal,S., Sparks,A., Jacob,J., Allende-Vega,N., Lane,D.P. and
            Saville,M.K.
  TITLE     Suppression of the deubiquitinating enzyme USP5 causes the
            accumulation of unanchored polyubiquitin and the activation of p53
  JOURNAL   J Biol Chem 284 (8), 5030-5041 (2009)
   PUBMED   19098288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Aug 31, 2021 this sequence version replaced XM_006237338.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.727707.1,
                                           SRR26643297.17425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000004.1  159320800-159320956 c
            158-283             JAXUCZ010000004.1  159318012-159318137 c
            284-350             JAXUCZ010000004.1  159316534-159316600 c
            351-484             JAXUCZ010000004.1  159316275-159316408 c
            485-630             JAXUCZ010000004.1  159315991-159316136 c
            631-815             JAXUCZ010000004.1  159315554-159315738 c
            816-910             JAXUCZ010000004.1  159314780-159314874 c
            911-1104            JAXUCZ010000004.1  159313654-159313847 c
            1105-1176           JAXUCZ010000004.1  159313070-159313141 c
            1177-1264           JAXUCZ010000004.1  159312690-159312777 c
            1265-1390           JAXUCZ010000004.1  159312456-159312581 c
            1391-1544           JAXUCZ010000004.1  159311603-159311756 c
            1545-1719           JAXUCZ010000004.1  159311160-159311334 c
            1720-1808           JAXUCZ010000004.1  159310541-159310629 c
            1809-1931           JAXUCZ010000004.1  159309550-159309672 c
            1932-2075           JAXUCZ010000004.1  159308875-159309018 c
            2076-2221           JAXUCZ010000004.1  159308651-159308796 c
            2222-2375           JAXUCZ010000004.1  159308320-159308473 c
            2376-2460           JAXUCZ010000004.1  159307980-159308064 c
            2461-3091           JAXUCZ010000004.1  159305938-159306568 c
FEATURES             Location/Qualifiers
     source          1..3091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3091
                     /gene="Usp5"
                     /note="ubiquitin specific peptidase 5"
                     /db_xref="GeneID:297593"
                     /db_xref="RGD:1308438"
     exon            1..157
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2554
                     /gene="Usp5"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 5 (isopeptidase T); ubiquitin
                     carboxyl-terminal hydrolase 5; ubiquitin specific
                     peptidase 5 (isopeptidase T); ubiquitin carboxyl-terminal
                     hydrolase 5-like"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 5 isoform
                     2"
                     /protein_id="NP_001381298.1"
                     /db_xref="GeneID:297593"
                     /db_xref="RGD:1308438"
                     /translation="MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLY
                     ICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRPKEEDSSAGTGDPPRKKPTRLAIG
                     VEGGFDLTEDKFEYDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSA
                     SRKQEVQAWDGEVRQVSKHAFNLKQLDNPARIPPCGWRCSKCDMRENLWLNLTDGSIL
                     CGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHL
                     SHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNS
                     CYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKP
                     ALESGDGEQVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERN
                     CRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEK
                     KRQAEEEKVALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFP
                     DYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTP
                     DEPKAPMLDESVVIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPL
                     ILPGSSGPGSTSAAADPPPEDCVATIVSMGFSRDQALKALRATNNSLERAVDWIFSHI
                     DDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVC
                     HIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVVS"
     exon            158..283
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            284..350
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            351..484
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..630
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            631..815
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            816..910
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1104
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1176
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1264
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1390
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1544
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1719
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1808
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1931
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2075
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2221
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2375
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2460
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..3091
                     /gene="Usp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtacagtg ggagctgccg tgtgaggagg agctgctgcc ggtgtcatgg cggagctgag
       61 tgaggaggcg ctgctgtcag tgttaccgac gatccgtgtc cccaaggcgg gagaccgggt
      121 ccacaaagac gagtgtgctt tctctttcga caccccggaa tctgagggtg gcctttatat
      181 ctgcatgaac acattcctgg gatttgggaa acagtatgtg gagagacatt tcaacaagac
      241 aggccagcgt gtctacctgc accttcggag gacccggcga ccgaaagaag aggactccag
      301 cgcaggcact ggagacccac cccggaagaa gcccacccgg ctggccattg gtgttgaagg
      361 tgggtttgac ctcaccgagg acaagtttga atatgatgag gacgtgaaga ttgtcatttt
      421 gccagattac ctggagatcg ctcgggatgg gttggggggg cttcccgaca ttgtcagaga
      481 tcgggtgacc agtgcagtgg aagccctact ttcggctgat tcagcctctc ggaagcagga
      541 ggtacaggct tgggatgggg aagtccgtca ggtgtctaag catgccttca acctcaagca
      601 gttggacaac cccgctcgga tccctccctg tggctggagg tgctccaagt gtgacatgag
      661 agagaacctg tggctcaacc tgacagatgg ctccatcctg tgcggccggc gctactttga
      721 tggcagcggg ggcaacaacc atgctgtgga gcactacagg gagactggct accccttagc
      781 tgttaagctg ggcaccatca cacccgatgg agctgatgtg tactcttacg acgaggatga
      841 catggtcctg gaccctagcc tggcagagca cctgtctcac tttggcatcg acatgctgaa
      901 gatgcagaag acggacaaaa caatgactga gctggagata gacatgaacc agcggattgg
      961 tgagtgggag ctgatccagg agtcaggcgt gccactcaag cctctcttcg ggcctgggta
     1021 cacaggcatc cggaacctgg gtaacagctg ctacctcaac tccgtggtcc aggtgctctt
     1081 cagcatccct gactttcaga ggaagtatgt ggataaattg gagaagatct tccagaatgc
     1141 cccaacggac cctacccaag acttcagcac ccaggtggcg aagctggggc acggccttct
     1201 ctctggagaa tattctaagc cagcactgga gtcaggtgat ggggagcagg taccagaaca
     1261 aaaggaagtt caagatggca ttgcccctcg gatgttcaag gcccttattg gcaagggcca
     1321 ccctgagttc tccactaacc ggcagcagga tgctcaggaa ttcttcctac atcttatcaa
     1381 catggtggag aggaattgcc ggagttctga aaatccaaat gaagtgttcc gcttcttggt
     1441 ggaagagaag atcaagtgcc tggccacaga gaaggttaag tacactcagc gagttgacta
     1501 catcatgcag ttgcctgtgc ccatggatgc agcccttaac aaagaggagc ttctagagta
     1561 tgaagagaag aagcggcaag cagaagagga gaaagtagca ctgccagagc tggttcgggc
     1621 ccaggtgccc ttcagctcct gcctggaagc ctatggggcc cccgagcagg tggatgactt
     1681 ctggagtaca gctctacagg cgaagtcggt tgctgtcaag actacacggt ttgcctcctt
     1741 ccctgactac ctggtcatcc agatcaagaa gttcaccttt ggcttagact gggtgcccaa
     1801 gaagctggat gtgtccattg agatgccaga ggagctagat atttcccagc tgaggggcac
     1861 agggctacag cccggagagg aggagctgcc tgacattgcc ccacccctgg tcactccgga
     1921 tgagcccaaa gcgcccatgc tggacgagtc cgtcgtcata cagttggtgg agatgggctt
     1981 ccctatggac gcctgccgga aagccgtgta ctatacaggg aacagtggtg ctgaagcagc
     2041 catgaactgg gtcatgtcac acatggatga cccagatttt gccaatcccc tcatcctgcc
     2101 tgggtccagt gggcctggct ccacaagtgc agcagccgat cccccaccag aggactgtgt
     2161 ggccaccatt gtctccatgg gcttctcacg ggaccaggcc ctgaaagctc tacgggccac
     2221 gaacaatagc ttagagcggg ctgtagactg gatcttcagt cacattgatg acctagatgc
     2281 agaagctgct atggacatct cagagggacg ctcagctgct gactccatct ctgagtctgt
     2341 accagtggga cctaaagtcc gggatggtcc tggaaagtat cagctctttg ccttcattag
     2401 tcacatgggc acgtctacta tgtgtggtca ctatgtctgc catatcaaga aggaaggcag
     2461 atgggtgatc tacaatgacc agaaagtgtg tgcctcggaa aagccaccca aggacctggg
     2521 ctacatctac ttctaccaga gagtggtcag ctaagagcct gccctcaacc ctcaccactt
     2581 caggcagggg gcagaccatc tggcatgagg gatggacggg ctgagggacg gacttcatcc
     2641 ccctgctctg tacccttttt ctttttgtcc ccagcagcag gagagggctg gaggccatag
     2701 gagaatggcc aaagaggagg ggtggtcatt agacttgggg acagagcagg gatgggacag
     2761 gaaggggcca actgcctgtc cacaatggga ccttgttgct tccttccctg ccccttgaat
     2821 ccacagtgct ctgcttctct gtgatggccc aacccctgcc atggggaggg gtcttacctg
     2881 tgtgtgcgtg gatgtggctt tatgcatctc tccaggggag ggagcgactg tgcctcccct
     2941 ccccttatgt gtttgctccc ttgtggtgag gcaaaggagg ctatgaggga aataggactc
     3001 tcccccacac cctttgccct tctgcctcag cctcccttct gtctttacgg tcctctggaa
     3061 aaatgccaaa atacatgatg tgaataaagt a
//
