LOCUS       NP_001381298             835 aa            linear   ROD 28-MAR-2024
DEFINITION  ubiquitin carboxyl-terminal hydrolase 5 isoform 2 [Rattus
            norvegicus].
ACCESSION   NP_001381298 XP_006237400
VERSION     NP_001381298.1
DBSOURCE    REFSEQ: accession NM_001394369.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 835)
  AUTHORS   Liu,Y., Soetandyo,N., Lee,J.G., Liu,L., Xu,Y., Clemons,W.M. Jr. and
            Ye,Y.
  TITLE     USP13 antagonizes gp78 to maintain functionality of a chaperone in
            ER-associated degradation
  JOURNAL   Elife 3, e01369 (2014)
   PUBMED   24424410
REFERENCE   2  (residues 1 to 835)
  AUTHORS   Tsihlis,N.D., Kapadia,M.R., Vavra,A.K., Flannery,W.D.,
            Oustwani,C.S., Jiang,Q. and Kibbe,M.R.
  TITLE     Nitric oxide may inhibit neointimal hyperplasia by decreasing
            isopeptidase T levels and activity in the vasculature
  JOURNAL   J Vasc Surg 58 (1), 179-186 (2013)
   PUBMED   23375434
  REMARK    GeneRIF: Local administration of NO may prevent neointimal
            hyperplasia by inhibiting isopeptidase T levels and activity in the
            vasculature, thereby inhibiting the 26S proteasome in vascular
            smooth muscle cells.
REFERENCE   3  (residues 1 to 835)
  AUTHORS   Dayal,S., Sparks,A., Jacob,J., Allende-Vega,N., Lane,D.P. and
            Saville,M.K.
  TITLE     Suppression of the deubiquitinating enzyme USP5 causes the
            accumulation of unanchored polyubiquitin and the activation of p53
  JOURNAL   J Biol Chem 284 (8), 5030-5041 (2009)
   PUBMED   19098288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Aug 31, 2021 this sequence version replaced XP_006237400.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.727707.1,
                                           SRR26643297.17425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..835
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     Protein         1..835
                     /product="ubiquitin carboxyl-terminal hydrolase 5 isoform
                     2"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 5 (isopeptidase T);
                     ubiquitin carboxyl-terminal hydrolase 5; ubiquitin
                     specific peptidase 5 (isopeptidase T); ubiquitin
                     carboxyl-terminal hydrolase 5-like"
                     /calculated_mol_wt=93170
     Region          16..79
                     /region_name="zf-UBP_var"
                     /note="Variant UBP zinc finger; pfam17807"
                     /db_xref="CDD:407678"
     Region          199..272
                     /region_name="zf-UBP"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; pfam02148"
                     /db_xref="CDD:460464"
     Region          327..831
                     /region_name="Peptidase_C19B"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; cd02658"
                     /db_xref="CDD:239123"
     Site            order(330,335,795,811)
                     /site_type="active"
                     /db_xref="CDD:239123"
     Region          632..679
                     /region_name="UBA1_UBP5"
                     /note="UBA1 domain found in ubiquitin carboxyl-terminal
                     hydrolase 5 (UBP5); cd14383"
                     /db_xref="CDD:270566"
     Region          700..742
                     /region_name="UBA2_UBP5"
                     /note="UBA2 domain found in ubiquitin carboxyl-terminal
                     hydrolase 5 (UBP5); cd14386"
                     /db_xref="CDD:270569"
     Site            order(725,730..731,734..735,738..739,742)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270569"
     CDS             1..835
                     /gene="Usp5"
                     /coded_by="NM_001394369.1:47..2554"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:297593"
                     /db_xref="RGD:1308438"
ORIGIN      
        1 maelseeall svlptirvpk agdrvhkdec afsfdtpese gglyicmntf lgfgkqyver
       61 hfnktgqrvy lhlrrtrrpk eedssagtgd pprkkptrla igveggfdlt edkfeydedv
      121 kivilpdyle iardglgglp divrdrvtsa veallsadsa srkqevqawd gevrqvskha
      181 fnlkqldnpa rippcgwrcs kcdmrenlwl nltdgsilcg rryfdgsggn nhavehyret
      241 gyplavklgt itpdgadvys ydeddmvldp slaehlshfg idmlkmqktd ktmteleidm
      301 nqrigeweli qesgvplkpl fgpgytgirn lgnscylnsv vqvlfsipdf qrkyvdklek
      361 ifqnaptdpt qdfstqvakl ghgllsgeys kpalesgdge qvpeqkevqd giaprmfkal
      421 igkghpefst nrqqdaqeff lhlinmvern crssenpnev frflveekik clatekvkyt
      481 qrvdyimqlp vpmdaalnke elleyeekkr qaeeekvalp elvraqvpfs scleaygape
      541 qvddfwstal qaksvavktt rfasfpdylv iqikkftfgl dwvpkkldvs iempeeldis
      601 qlrgtglqpg eeelpdiapp lvtpdepkap mldesvviql vemgfpmdac rkavyytgns
      661 gaeaamnwvm shmddpdfan plilpgssgp gstsaaadpp pedcvativs mgfsrdqalk
      721 alratnnsle ravdwifshi ddldaeaamd isegrsaads isesvpvgpk vrdgpgkyql
      781 fafishmgts tmcghyvchi kkegrwviyn dqkvcasekp pkdlgyiyfy qrvvs
//
